Tissue proteins. Medical search. Frequent questions

Prion protein and antibodies POM1 and POM3, which recognize epitopes in the terminus (around amino acids (aa) 140-152) and charged clusters of prion protein (aa95-100) were used to their role in myelin maintenance. (wikipedia.org)
Monoclonal antibodies targeting endosialin have entered clinical trials, including soft tissue sarcomas. (hindawi.com)
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
Globular proteins work in the water environment as antibodies and enzymes. (organicfacts.net)
Proteins are vital to building a stronger immune system.The body runs a mechanism of self-defense and protects itself from various infections and diseases with the help of antibodies. (organicfacts.net)
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (dialabo.com)

Insights into gene tissue specificity and protein-protein interactions in the context of purifying selection in humans. (qxmd.com)
How much are natural selection and gene characteristics, such as the number of protein-protein interactions (PPIs), tissue specificity (𝞽), and expression level, connected? (qxmd.com)

BioChain's membrane proteins are prepared from a large variety of documented and compliant quality tissues, including normal and diseased tissues from human and other species. (biochain.com)
Tissue membrane protein is prepared from whole tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. (biochain.com)
Moreover, a significant loss of Mrp2 protein in the membrane fraction of rat cryopreserved hepatocytes was observed. (aspetjournals.org)
The CCN genes encode secreted proteins associated with the Extracellular Matrix (ECM) and cell membrane. (neuromics.com)
Membrane proteins work in the cell membrane and perform functions like membrane transport and signaling. (organicfacts.net)

Here, we aimed to spatially characterise the human Parkinsonian nigro-striatal N- glycome, and related transcriptome/proteome, and its correlation with endoplasmic reticulum stress and unfolded protein response (UPR), providing a comprehensive characterisation of the PD molecular signature. (biorxiv.org)
Background: In obesity, excess nutrients and an increased demand for protein synthesis contribute to unfolded proteins accumulating within the endoplasmic reticulum and consequent activation of unfolded protein response (UPR). (endocrine-abstracts.org)
In this study, expression of proteins associated with endoplasmic reticulum (ER) stress, apoptosis and autophagy were analyzed in normal, NAFL and NASH human livers by western blotting. (oncotarget.com)

The influence of lipoic acid on total protein concentration in the liver and spleen tissue in rats during lipopolysaccharide-induced oxidative stress]. (bvsalud.org)
THE AIM OF THE STUDY To evaluate the influence of lipoic acid on total protein concentration in the liver and spleen in rats during endotoxemia . (bvsalud.org)
Five hours after last injection rats were sacrificed, and the liver and spleen were harvested for subsequent total protein assay. (bvsalud.org)
Lipoic acid administration led to a significant increase in total protein concentration in the liver and spleen tissue of endotoxemic rats when compared to control. (bvsalud.org)

Oxidation of cysteine thiols by physiological reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. (nih.gov)
Remarkably, dietary selenium supplementation elevated facultative incorporation into UCP1, elevated energy expenditure through thermogenic adipose tissue, and protected against obesity. (nih.gov)
A surprisingly wide range of Cre drivers - including six different neuronal promoters as well as the adipose-specific Adipoq Cre promoter - exhibited off-target recombination in the epididymis, with a subset of drivers also exhibiting unexpected activity in other tissues such as the reproductive accessory glands. (elifesciences.org)
UPR in adipose tissue (AT) is critical to the initiation and integration of inflammation and insulin signalling pathways in obese and type 2 diabetes mellitus (T2DM) patients. (endocrine-abstracts.org)
We examined the acute effects of different dietary protein sources (0.19 g, dissolved in 1 ml of water) on skeletal muscle, adipose tissue and hypothalamic satiety-related markers in fasted, male Wistar rats (~250 g). (biomedcentral.com)
Higher amounts of whey versus egg protein stimulate the greatest post-treatment anabolic skeletal muscle response, though test proteins with higher amounts of WPH more favorably affected post-treatment markers related to adipose tissue lipolysis. (biomedcentral.com)
an effect which may be explained by an increased expression of adipose tissue lipolysis-related gene expression patterns following chronic supplementation [ 12 ], an increase in protein-induced thermogenesis (reviewed in [ 15 ]), and/or a consistent reduction in food intake given its satiety-stimulatory effects as discussed above. (biomedcentral.com)
The adipose tissue is an important reservoir of adult stem cells which have capacity of differentiating in osteoblasts with potential implication in reaching bone regeneration. (bvsalud.org)
To evaluate the immunoexpression of BMP-2 protein on the bone repairing of critical size defects (CSD) surgically created in rat calvaria and treated by autogenous macerated adipose tissue. (bvsalud.org)
The animals were randomly divided into two groups: group C (control) and group AT (macerated adipose tissue grafting). (bvsalud.org)
In group AT, the defect was filled with autogenous macerated adipose tissue. (bvsalud.org)
In group AT, both at 7 and 90 post-operative days, the main healing type was the presence of dense conjunctive tissue exhibiting bundles of collagen fibers disposed in beams permeating the remaining adipose tissue with rare heterotopic bone formation associated to fibrosis and different types of tissue necrosis. (bvsalud.org)
Within the limits of this present study, it can be concluded that the adipose tissue grafting did not favor bone neoformation in critical size defects and BMP-2 signaling was not observed. (bvsalud.org)

Moreover, for genes that are expressed in multiple tissues or at multiple stages of development, the use of tissue-specific expression of the Cre recombinase allows gene function to be perturbed in specific cell types and/or at specific times. (elifesciences.org)
We found that prions can convert, but the efficiency of conversion is affected by polymorphic variation in the cervid and human prion protein genes. (cdc.gov)
Description: The Matched Pair Paraffin Tissue (MPPT) slides are designed for identifying tumor-specific/metastasis genes or proteins. (copgfp.com)
We observed that the variance of expression of tissue-specific genes seems not related to their level of selection constraints, which is the opposite of what is found on non-tissue-specific genes. (qxmd.com)

The spike protein was associated with neutrophil-related pathways and dysregulation of the proteins involved in the PI3K-AKT as well as complement and coagulation pathway," the paper explains. (newstarget.com)
Overall, our findings suggest that SARS-CoV-2 spike protein trafficking from CNS borders into the brain parenchyma and identified differentially regulated pathways may present insights into mechanisms underlying immediate and long-term consequences of SARS-CoV-2 and present diagnostic and therapeutic opportunities. (newstarget.com)
These result in imbalances in the connectivity of neuronal circuitry, and also negatively impact the intracellular connectivity of neuronal proteins and protein pathways, contributing to cognitive decline associated with AD 6 . (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

The result indicated that neuronal expression and regulated proteolysis of prion protein are essential for myelin maintenance. (wikipedia.org)
Endosialin (CD248, TEM-1) is expressed in pericytes, tumor vasculature, tumor fibroblasts, and some tumor cells, including sarcomas, with limited normal tissue expression, and appears to play a key role in tumor-stromal interactions, including angiogenesis. (hindawi.com)
We evaluated a cohort of 94 soft tissue sarcoma samples to assess the correlation between gene expression and protein expression by immunohistochemistry for endosialin and PDGFR- β , a reported interacting protein, across available diagnoses. (hindawi.com)
Within cohorts of soft tissue diagnoses assembled by tissue type (liposarcoma, leiomyosarcoma, undifferentiated sarcoma, and other), endosialin expression was significantly correlated with a better outcome. (hindawi.com)
A robust correlation between protein and gene expression data for both endosialin and PDGFR- β was observed. (hindawi.com)
Since expression does vary across histologic groups, endosialin may represent a selective target in soft tissue sarcomas. (hindawi.com)
We found that the expression of miR-18a was abnormally reduced in the HBV-positive HCC tissue samples compared with HBV-negative HCC samples. (medscimonit.com)
We also observed a clear increase in CTGF mRNA and protein expression levels in HBV-positive HCC human tissue samples in comparison with the HBV-negative controls, indicating a possible negatively associated relationship between miR-18a and CTGF. (medscimonit.com)
However, it is well known that putative tissue-specific promoters often drive unanticipated 'off-target' expression. (elifesciences.org)
In our efforts to explore the biology of the male reproductive tract, we unexpectedly found that expression of Cre in the central nervous system resulted in recombination in the epididymis, a tissue where sperm mature for ~1-2 weeks following the completion of testicular development. (elifesciences.org)
HSP90 inhibition may also enhance synaptic protein expression via activation of heat shock factor 1 (HSF-1) transcriptional regulation 16 . (nature.com)
This is accomplished by increasing both the interaction strength and number of interactions among participant proteins, which is not necessarily accompanied by a change in expression levels. (nature.com)
Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. (abcam.com)
However, the expression of a majority of the ER chaperones and foldases analyzed, including glucose-regulated protein 78 and ER protein 44, was lower in NASH than in the normal tissues. (oncotarget.com)
Levels of apoptosis markers, such as cleaved poly (ADP-ribose) polymerase, were also lower in NASH tissues, in which expression of some B-cell lymphoma-2 family proteins was up- or down-regulated compared to the normal tissues. (oncotarget.com)
This format allows a rapid analysis of protein expression and localization across normal and cancerous tissue. (copgfp.com)
We discovered a positive correlation between genetic constraints, PPIs, and expression levels in all tissues. (qxmd.com)

Nerve tissue is a biological molecule related to the function and maintenance of normal nervous tissue. (wikipedia.org)
Protein Biotechnologies, Inc. manufactures biological products and provides contract laboratory services for the life science research community. (biosciregister.com)
Together, these findings reveal the existence of facultative protein selenation, which correlates with impacts on thermogenic adipocyte function and presumably other biological processes as well. (nih.gov)
Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
It is the leasts conserved one of the four domains at the level of nucleotide sequence, but it appears to be critical for several of the biological functions attributed to the CCN proteins. (neuromics.com)
This product is an active protein and may elicit a biological response in vivo, handle with caution. (abcam.com)
Background A detailed assessment of the biological status of tissues can be achieved by performing as many multiple target detections as possible on the same tissue slide of protein, DNA, and RNA. (bmj.com)
Proteins are a group of biological compounds which are present in every live cell, organ, and tissue of the body. (organicfacts.net)

The rate-limiting step in steroid hormone production in the adrenal cortex and gonads, the translocation of cholesterol from the outer to the inner mitochondrial membranes, is mediated by the steroidogenic acute regulatory protein (StAR). (elsevierpure.com)

These authors demonstrated monoclonal antibody FB5 reactivity in a significant proportion of tumor blood vessels, including those of sarcoma, while ostensibly being absent from normal tissues. (hindawi.com)
The cross-reactions of MRP2/Mrp2 protein of different species with anti-human MRP2 polyclonal antibody were found by Western blotting. (aspetjournals.org)
However, because of the unknown binding affinity of antibody to MRP2/Mrp2 protein across species and lack of purified MRP2/Mrp2 proteins for calibration, the immunoblotting assay was excluded from the absolute quantification of MRP2/Mrp2 protein for multiple species. (aspetjournals.org)
Human IgG antibody Laboratories manufactures the tissue teck sakura 18 rue hergeparc reagents distributed by Genprice. (copgfp.com)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)

Prion protein triggers are an important factor in the signals that ensure myelin maintenance and are distinct from those that direct myelination. (wikipedia.org)
We used a cell-free seeded protein misfolding assay to determine whether CWD prions from elk, white-tailed deer, and reindeer in North America can convert the human prion protein to the disease-associated form. (cdc.gov)
The molecular basis of prion replication is a change in conformation of the normal cellular prion protein (PrP C ) into the abnormal and misfolded conformer (PrP Sc ) that is partially protease-resistant (PrP res ). (cdc.gov)
In contrast to these in vivo approaches, we have used protein misfolding cyclic amplification (PMCA) to investigate the molecular compatibility of bovine, ovine, and cervid prions with full-length, glycosylated and glycosylphosphatidylinositol-anchored human prion protein (PrP) ( 15 , 16 ). (cdc.gov)

Heretofore, the localization of StAR in human adult and fetal tissues has not been defined. (elsevierpure.com)
Protein localization predicted from several bioinformatic algorithms. (proteinatlas.org)

Proteins entering the gastrointestinal tract are metabolized into constituent amino acids by gastric, pancreatic, and small intestinal enzymes and are reabsorbed. (medscape.com)
Health benefits of proteins include production and smooth functioning of enzymes and hormones and a proper cellular and muscular health. (organicfacts.net)
[ 5 ] They also inhibit the release of destructive enzymes that attack the injury debris and destroy normal tissue indiscriminately. (medscape.com)

Proteolysis of the secreted full-length CCN proteins that has been reported in the case of CCN2 and CCN3 might result in the production of CCN-derived peptides with high affinity for ligands that full-length CNN proteins bind only poorly. (neuromics.com)
and b) liberate bioactive peptides that are able to exhibit physiological responses that otherwise would be diminished from consuming intact protein sources. (biomedcentral.com)

The serum protein level reflects the balance between protein synthesis, metabolism, and protein loss. (medscape.com)

This study was designed to improve our understanding of the role of miR-18a and its target (connective tissue growth factor (CTGF), which are mediators in HBX-induced hepatocellular carcinoma (HCC). (medscimonit.com)
Connective Tissue Growth Factor belongs to the CCN family of proteins. (neuromics.com)
The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). (neuromics.com)

Exposure to radiation can wreak indiscriminate havoc on cells, tissues, and organs. (sciencedaily.com)
The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. (mdpi.com)
A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)

The pathophysiology of this disorder is directly related to the excessive leakage of plasma proteins into the lumen of the gastrointestinal tract. (medscape.com)
Local blood flow increases to transport the polymorphonuclear leukocytes, macrophages, and plasma proteins to the injured area. (medscape.com)
The resulting infiltration of tissues by the leukocytes, plasma proteins, and fluid causes the redness, swelling, and pain that are characteristic of inflammation. (medscape.com)

A new study now finds that cellular survival after radiation exposure depends on behavior of the tumor-suppressor protein p53 over time. (sciencedaily.com)
After radiation exposure, all four tissues expressed elevated p53 along with other markers of DNA and cellular damage as expected. (sciencedaily.com)
Biochips market 2019-2024 Analyzed by Type - DNA, Protein, Lab-On-Chip and Other (Cellular chips, Tissue chips, Drug of Abuse Chips. (medgadget.com)
CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. (neuromics.com)
Meaning 'first' or 'of prime importance' in Greek, proteins participate in every cellular process occurring in the body. (organicfacts.net)

A new pre-print paper published at bioRxiv reveals that long after a person gets "vaccinated" for the Wuhan coronavirus (Covid-19) with an mRNA series of injections, the spike proteins generated as a result of the shots persist in their brain tissue. (newstarget.com)
Even long after a "positive" covid test and infection has passed, spike proteins continue to remain lodged in the human brain. (newstarget.com)
Researchers say these lingering spike proteins could contribute to long-term neurological symptoms such as brain "fog" and brain tissue loss. (newstarget.com)
Do covid jab spike proteins EVER leave the body? (newstarget.com)
It turns out that numerous peer-reviewed studies even back then revealed that spike proteins from the injections lodge themselves throughout the body and stay there, deactivating a person's telomerase, causing premature aging and possibly death. (newstarget.com)
In the case of covid shots, their spike proteins appear to accelerate the breakdown of telomerase, resulting in rapid aging and premature death for many. (newstarget.com)
We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)

Pertinent to AD pathophysiology, heat shock protein 90 (HSP90)/co-chaperone complex folds tau or hyperphosphorylated tau, whereas heat shock protein 70-carboxyl-terminus of HSP70 Interacting protein (HSP70-CHIP) complex mediates degradation 13 , 14 . (nature.com)

Advances in the field of molecular biotechnology have made it possible to extract proteins from formalin fixed and paraffin embedded (FFPE) tissue blocks. (cytojournal.com)
Protein was extracted from Cellient-methanol fixed and paraffin embedded blocks with CHAPS buffer method as well as FFPE and Mammalian Qiagen ® kits. (cytojournal.com)
FFPE tissues used Tonsil, breast MTA. (bmj.com)

Protein concentration was determined with Bio-Rad protein assay. (abcam.com)
2 RNase protection assay and RT-PCR were used to quantitatively determine SP-C mRNA and protein was detected by the Western blot. (bmj.com)

Protein-losing enteropathy is characterized by more loss of proteins via the gastrointestinal tract than synthesis leading to hypoalbuminemia. (medscape.com)
StAR protein was not detected in the placenta, documenting that placental progestin synthesis occurs through StAR- independent mechanisms. (elsevierpure.com)
It is extremely important to create a balance between the rate of muscle protein synthesis and the breakdown of these muscle proteins. (organicfacts.net)

Mouse heart tissue lysate is ready to load on SDS-PAGE for Western blotting. (abcam.com)

We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)

Additionally, we developed protocols for the combined detection of Protein/mRNA and Protein/DNA/mRNA on the same slide. (bmj.com)

Neuronal apoptosis inhibitory protein (NAIP) belongs to the family of proteins called the inhibiter of apoptosis family (IAP), these proteins are one of the key regulators of apoptosis. (wikipedia.org)
The interaction between NAIP and hippocalcin, a neuronal calcium-sensor protein, has been observed to take place in the zinc-binding region along with other specific amino acids. (wikipedia.org)
Hippocalcin is a neuronal calcium-sensor protein which has two to three regions that can bind with calcium ions. (wikipedia.org)

We investigated commonly available CHAPS (3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate) buffer, as well as two commercially available Qiagen ® kits and compared their effectiveness on MFPE tissue for protein yields. (cytojournal.com)

We report the identification of disease-related protein structural differences directly within the tissue environment. (nih.gov)
Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)
Biochips are playing a key role in clinical diagnosis i.e. they help in diagnosis of disease even before the symptoms are observed Biochips which can identify the presence of different proteins, Nucleic acids, different bacteria etc. in a single analysis help to diagnose the disease. (medgadget.com)
In the current era of minimally invasive techniques for obtaining tissue samples for diagnostic and prognostic markers, cellblocks containing "limited material" specimens are routinely used to provide the valuable information about pre-disease and disease processes. (cytojournal.com)
Parkinson's Disease (PD) associated state of neuroinflammation due to the aggregation of aberrant proteins is widely reported. (biorxiv.org)
Mechanisms for gastrointestinal protein loss include lymphatic obstruction, mucosal disease with erosions, ulcerations, or increased mucosal permeability to proteins as a result of cell damage or death. (medscape.com)

Protein class the gene product belongs to according to selected gene lists. (proteinatlas.org)

4) chronic tissue and organ damage characterized by thrombotic endothelialitis, endothelial inflammation, hyperactivated platelets, and fibrinaloid microclots. (cdc.gov)

The evaluation of the osteoblastic differentiation can be verified through immunohistochemical markers such as bone morphogenetic protein- 2 (BMP-2). (bvsalud.org)

UPEP detects 2 types of protein: albumin and globulins. (medlineplus.gov)

The protein is also a famous tumor suppressor -- around half of human cancers have p53 mutations that render it defective or suboptimal. (sciencedaily.com)
MFPE blocks were made by Cellient™ automated system using human tissue specimens from normal and malignant specimens collected in ThinPrep™ Vials. (cytojournal.com)
We found that scrapie samples failed to convert human PrP C to PrP res , whereas cattle BSE converted the human protein efficiently ( 15 - 17 ). (cdc.gov)
The Tissue Teck Sakura 18 Rue Hergeparc reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (copgfp.com)

Selenium was selectively incorporated into regulatory sites on key metabolic proteins, including as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1). (nih.gov)

Endosialin likely interacts with a network of extracellular and hypoxia activated proteins in sarcomas and other tumor types. (hindawi.com)
Module IV resembles the CT domain of several extracellular protein including, Von Willebrand's factor and mucins. (neuromics.com)

Neutrophils and activated macrophages (CD11c+ CD11bhi) persisted after recovery in lung tissues of anti-AREG-treated mice. (cdc.gov)

Scientists have known these differences involve the protein p53, a well-studied tumor-suppressor protein that initiates a cell's auto-destruct programs. (sciencedaily.com)

In addition to such coarse-grained signals of organismal physiology, it is increasingly understood that more detailed molecular signals can be communicated between distant tissues. (elifesciences.org)

Protein-losing enteropathy is characterized by the severe loss of serum proteins into the intestine. (medscape.com)

Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
Thin-layer chromatography of dinitrophenyl derivatives prepared from Pronase-digested microsomal protein and sodium dodecyl sulfate-polyacrylamide disc gel electrophoresis of solubilized microsomes indicated that the radiolabeled products were covalently bound to amino acid residues of microsomal protein. (aspetjournals.org)
The amount of amino acid present in proteins determines their nutritional value which may vary for different foods. (organicfacts.net)

We previously reported that hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) is considered to be the major cause of the interspecies differences detected by efflux of fluorescent substrates in isolated hepatocytes. (aspetjournals.org)

[ 1 ] Normal protein loss in the gastrointestinal tract mainly consists of sloughed enterocytes and pancreatic and biliary secretions. (medscape.com)
Albumin loss through the gastrointestinal tract normally accounts for 2-15% of the total body degradation of albumin, but, in patients with severe protein-losing gastrointestinal disorders, the enteric protein loss may reach up to 60% of the total albumin pool. (medscape.com)
When the rate of gastrointestinal protein loss exceeds the body's capacity to synthesize new proteins, hypoproteinemia develops. (medscape.com)

We introduce the term protein connectivity-based dysfunction (PCBD) to define this mechanism. (nature.com)

Levels of some ER stress-transducing transcription factors, including cleaved activating transcription factor 6, were higher in NASH than in the normal tissues. (oncotarget.com)
The level of the autophagy substrate p62 was not different in NASH and normal tissues, although some autophagy regulators were up- or down-regulated in the NASH tissues compared to the normal tissues. (oncotarget.com)
Levels of most of the proteins analyzed in NAFL tissues were either similar to those in one of the other two types, NASH and normal, or were somewhere in between. (oncotarget.com)
Slices from normal and malignant tissues are mounted on each MPPT slide which can then be treated as a single histological slide for H&E staining, immunohistochemistry, or in situ hybridization. (copgfp.com)

After intraperitoneal and oral administration of [ 14 C]HCP (5 mg/kg) to male rats treated with phenobarbital, radiocarbon was covalently bound mainly to proteins of the liver, plasma, and kidney. (aspetjournals.org)
Covalently bound radioactivity in the liver was associated primarily with proteins in the microsomal and 105,000 x g supernatant fractions. (aspetjournals.org)
By using our newly developed liquid chromatography-tandem mass spectrometry quantification method, we were able to measure the absolute amount of MRP2/Mrp2 in liver tissues and isolated hepatocytes across species. (aspetjournals.org)
Freshly isolated hepatocytes conserved MRP2/Mrp2 protein levels that are comparable with those in the liver tissues. (aspetjournals.org)
Lipoic acid administration during early phase of LPS-induced oxidative stress increase protein level in the liver and spleen tissue , which indicate an increase of antioxidant properties of an organism. (bvsalud.org)

In the current study, Lahav, Weissleder, and their team looked at tissues in mice that have very different sensitivities to ionizing radiation yet are known to express comparable levels of p53 -- the spleen and thymus, which are highly vulnerable, and the large and small intestines, which are more radioresistant. (sciencedaily.com)

Surfactant protein-C (SP-C) increases the surface adsorption and lowers surface tension of lung surfactant. (bmj.com)

Anatomy9

Organisms5

Diseases2

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes10

Disciplines and Occupations1

Technology, Industry, Agriculture1

Antibodies9

Specificity2

Membrane5

Endoplasmic reticulum3

Total protein4

Adipose13

Genes4

Pathways4

Expression17

Biological8

Mitochondrial1

Antibody7

Prion protein4

Localization2

Enzymes3

Peptides2

Metabolism1

Connective Tissue3

Organs5

Plasma proteins3

Cellular5

Spike proteins7

Heat shock prot1

FFPE3

Assay2

Synthesis3

Lysate1

Antigens1

MRNA and protein1

Neuronal3

QIAGEN1

Disease6

Belongs1

Inflammation1

Markers1

Types of Protein1

Human4

Selectively1

Extracellular2

Macrophages1

Tumor suppressor1

Molecular1

Intestine1

Amino acid3

Differences1

Gastrointestinal3

Mechanism1

Normal4

Liver5

Spleen1

Lung1