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Tissue Plasminogen ActivatorUrokinase-Type Plasminogen ActivatorPlasminogen Activator Inhibitor 1PlasminogenPlasminogen ActivatorsReceptors, Urokinase Plasminogen ActivatorFibrinolysisFibrinolytic AgentsPlasminogen InactivatorsFibrinolysinThrombolytic TherapyFibrinPlasminogen Activator Inhibitor 2StrokeStreptokinaseBrain IschemiaCerebral Hemorrhagealpha-2-AntiplasminRecombinant ProteinsAnnexin A2Receptors, Cell SurfaceFibrinogenIntracranial ThrombosisHemostasisThrombosisInjections, IntravenousFibrin Fibrinogen Degradation ProductsTime FactorsBlood CoagulationTreatment OutcomeInfarction, Middle Cerebral ArteryIntracranial HemorrhagesSerpin E2HeparinAcute DiseaseIsoflurophateKringlesCarboxypeptidase BIntracranial EmbolismInfusions, IntravenousCells, CulturedReperfusionAminocaproic AcidRetinal HemorrhageSerine Proteinase InhibitorsEndothelium, VascularThrombinKineticsIntracranial Embolism and ThrombosisRNA, MessengerNational Institute of Neurological Disorders and StrokeInfusions, Intra-ArterialCarotid Artery ThrombosisAntifibrinolytic AgentsUltrasonic TherapyCarboxypeptidase UMolecular Sequence DataInjections, Intra-ArterialDose-Response Relationship, DrugUmbilical VeinsHemorrhageVitronectinCerebral InfarctionBlood Coagulation FactorsMatrix Metalloproteinase 9GlycoproteinsThrombectomyProspective StudiesSerpinsCell LineElectrophoresis, Polyacrylamide GelAmino Acid SequenceMyocardial InfarctionProtein BindingCerebrovascular DisordersDisease Models, AnimalTomography, X-Ray ComputedPeptide FragmentsClot Retractionvon Willebrand FactorEnzyme PrecursorsDrug Therapy, CombinationLow Density Lipoprotein Receptor-Related Protein-1Binding SitesMice, Inbred C57BLThrombomodulinEnzyme-Linked Immunosorbent AssayBrainUltrasonography, Doppler, TranscranialEnzyme ActivationRabbitsBase SequenceTumor Cells, CulturedAntithrombin IIICoronary ThrombosisMice, KnockoutHepatic Veno-Occlusive DiseaseSeverity of Illness IndexCerebral AngiographyGene Expression Regulation
RecombinantStreptokinaseInhibitorAcuteFibrinolysisReceptorsReceptorHeparinFibrinolytic systemPlasminThrombinAssayThrombolytic drugsTypeProteolyticExtracellularVitroMoleculeProteinDegradationFluidHumanCommonlyExpressionFibrosisClotsConcentrationFactorClinicalAngiogenesisDoseTreatmentProcessesOutcomeStimulationDiseasePatientsCells
Recombinant7
  • Currently available thrombolytic agents include streptokinase, urokinase, and alteplase (recombinant tissue plasminogen activator, rtPA). (wikipedia.org)
  • The patients were treated using urokinase or recombinant tissue plasminogen activator. (nih.gov)
  • Additional there was no difference of effectiveness or side effects using urokinase or recombinant tissue plasminogen activator. (nih.gov)
  • Intravenous recombinant tissue plasminogen activator (rTPA) is now approved by the Food and Drug Administration (FDA) for the treatment of acute ischemic stroke within 3 hours of symptom onset (8) . (ajnr.org)
  • Lastly, success has been reported with recombinant tissue-type plasminogen activator or tPA like Alteplase when used to treat catheter obstruction by fibrin clot. (ndtv.com)
  • Recombinant tissue plasminogen activator (rt-PA) has been used primarily to treat catheter thrombosis. (druglib.com)
  • However, successful treatment of occluded central venous catheter (non HD) with recombinant tissue plasminogen activator (rt-PA) or alteplase was recently achieved in more than 1,000 patients with success (function restored in 798 patients [75. (druglib.com)
Streptokinase2
Inhibitor7
Acute2
Fibrinolysis2
Receptors2
Receptor3
  • NFKB Inhibitors, PPARα and PPARγ receptor ligands, and SIRT1 activators negatively affect MMP-9 secretion caused by UPA. (urokinases.com)
  • The late urokinase plastinogenic activator receptor is related to liver and fibrosis inflammation and has been advised to participate in the development of liver cirrhosis. (urokinases.com)
  • Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) are the central molecules for uPA/uPAR/plasmin-dependent proteolysis, which is thought to play a significant role in the development of pregnancy, as well as its many complications during pregnancy. (ispub.com)
Heparin2
  • Alternatively, one could also instill Urokinase (5000U), a thrombolytic agent, into the catheter for one hour and then remove it followed by instillation of heparin in the dialysate for several exchanges. (ndtv.com)
  • In addition, neonates have low levels of antithrombin and plasminogen, which cause relative resistance to heparin and thrombolytic agents, respectively. (medscape.com)
Fibrinolytic system2
  • To assess the therapeutic efficacy of agents capable of stimulating the fibrinolytic system, such as tissue plasminogen activator (t-PA) and urokinase (UK) on endotoxin-induced disseminated intravascular coagulation (DIC) in the rabbit. (cun.es)
  • Urokinase- and tissue-type plasminogen activators (uPA and tPA, repectively) are major components of the fibrinolytic system. (123dok.co)
Plasmin8
  • The plasminogen/plasmin system has an important impact on this process, particularly by degrading the extracellular matrix components with resulting interference of the repair processes. (nih.gov)
  • This paper presents the immunoblotting analysis of fibronectin, tissue and urokinase-type plasminogen activators and plasminogen/plasmin in the tear fluid of control subjects and patients affected by various ocular pathologies (corneal ulcers, thermal or chemical burns, herpetic keratitis). (nih.gov)
  • A significant modification was noted in the protein profiles of fibronectin, tissue and urokinase-type plasminogen activators and plasminogen/plasmin in the cases of corneal ulcers and thermal or chemical burns relative to the pattern observed in the control subjects, while in cases of herpetic keratitis, only plasminogen/plasmin showed slight variations. (nih.gov)
  • Fibrin-bound plasminogen will be converted by thrombolytic drugs to plasmin, the rate-limiting step in thrombolysis. (medscape.com)
  • The thrombolytic agents available today are serine proteases that work by converting plasminogen to the natural fibrinolytic agent plasmin. (medscape.com)
  • The ability of these substances to catalyze the conversion of plasminogen to plasmin is affected only slightly by the presence or absence of local fibrin clot. (medscape.com)
  • Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. (abcam.com)
  • The plasminogen activator (PA)-plasmin proteolytic system has recently received considerable attention because of its participation in a wide variety of biological activities and in pathological conditions involving tissue destruction. (ispub.com)
Thrombin1
  • Our data show that activities and transcription of PAs are differentially regulated by the microglial activators that we tested (lipopolysaccharides, gangliosides, thrombin). (123dok.co)
Assay1
Thrombolytic drugs1
  • Tissue plasminogen activator (t-PA) and single chain urokinase - plasminogen activator (scu-PA) are relatively "fibrin-specific" thrombolytic drugs with short plasma half lives of 6-8 minutes. (northwestern.edu)
Type7
  • Plasminogen activators (urokinase-type, and tissue-type). (embl.de)
  • A Urokinase type Plasminogen Activator specific antibody has been precoated onto 96-well plates and blocked. (abcam.com)
  • Standards or test samples are added to the wells and subsequently a Urokinase type Plasminogen Activator specific biotinylated detection antibody is added and then followed by washing with wash buffer. (abcam.com)
  • The density of yellow coloration is directly proportional to the amount of Urokinase type Plasminogen Activator captured in plate. (abcam.com)
  • RESULT A. Differential regulations of expressions of urokinase type plasminogen activators in microglia and astrocyte by microglial activators. (123dok.co)
  • tissue-type plasminogen activator ), aktywujący plazminogen w obecności powstałego włóknika. (czytelniamedyczna.pl)
  • it inhibits tissue-type plasminogen activators (tPA) and urokinase-type plasminogen activators (uPA). (medscape.com)
Proteolytic1
Extracellular3
  • Data collected shows that the activity of the urokinase plasminogen activator, even though it has extracellular proteases, it does not need to lead to reprogramming the epithelial-mesenchymal and increased cell migration but can have different results depending on the intracellular environment. (urokinases.com)
  • During the whole period of woman life there are many processes which involve degradation of extracellular matrix (tissue morphogenesis, angiogenesis, bone remodelling, wound healing, trophoblast implantation, involution of postpartum uterus or involution of postlactation mammary gland). (ispub.com)
  • Alternative polarization with interleukin-4 and IL-13 led to a macrophage phenotype characterized by increased tissue factor (TF) production and release and by an increase in extracellular vesicle production. (haematologica.org)
Vitro1
  • Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
Molecule1
  • The fibrinolytic potential of human urine was first described in 1947, and the active molecule was named urokinase. (medscape.com)
Protein3
  • Glandular (tissue) kallikreins (including EGF-binding protein types A, B, and C, NGF-gamma chain, gamma-renin, prostate specific antigen (PSA) and tonin). (embl.de)
  • Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. (lookformedical.com)
  • Constituent composed of protein and phospholipid that is widely distributed in many tissues. (lookformedical.com)
Degradation2
  • This disease impacts all joint tissues and is characterized by progressive cartilage degradation, synovitis, abnormal subchondral bone remodeling, and osteophyte formation [ 2 ]. (aging-us.com)
  • Proinflammatory polarization is associated with increased tissue degradation and propagation of inflammation whereas alternative polarization within a Th2 cytokine environment is associated with wound healing and angiogenesis. (haematologica.org)
Fluid1
  • It has good tissue penetration but does not enter cerebrospinal fluid. (medscape.com)
Human3
  • The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse. (nih.gov)
  • In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)
  • It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES. (bvsalud.org)
Commonly2
Expression1
  • TNFα mediated MMP-9 expression in the THP-1 monocy that was induced by urokinase (UPA). (urokinases.com)
Fibrosis1
  • Disease-modifying treatment aims at inhibiting tissue fibrosis and vascular and immune system alterations, which are the three crucial components of disease pathogenesis. (medscape.com)
Clots3
  • Plasma or blood clots containing a trace label of 125I fibrin were suspended in plasma containing plasminogen activator and intermittently exposed to continuous wave 1-MHz ultrasound at intensities up to 8 W/cm2. (jci.org)
  • Exposure of clots to ultrasound in the absence of plasminogen activator did not increase lysis. (jci.org)
  • Ultrasound at 1 W/cm2 and above also potentiated lysis of retracted whole blood clots mediated by rt-PA or urokinase. (jci.org)
Concentration2
  • Moreover, newborns need 11 times the usual concentration of urokinase given to adults and 5 times the usual concentration of tissue plasminogen activator (t-PA) in order to achieve the same rate of plasminogen activation. (medscape.com)
  • Low concentration of copper could affect the gill and hepatopancreas structure in M. nipponense, but high level oxidative stress caused by high copper concentration could cause oxidative damage to these tissue, resulting in the destruction of gill and hepatopancreas. (bvsalud.org)
Factor2
  • Hepatocyte growth factor activator. (embl.de)
  • At the site of injury, tissue factor (TF) and factor VIIa activate factors X and IX. (medscape.com)
Clinical1
Angiogenesis1
  • Besides scavenging debris, promoting angiogenesis, tissue remodeling and repair, alternatively activated macrophages are able to fine tune inflammatory responses. (haematologica.org)
Dose1
  • The average dose of urokinase was higher in the hemorrhage group, and mortality was higher in patients who hemorrhaged. (ajnr.org)
Treatment2
  • Treatment with urokinase or plasminogen activator Network (T-PA) in relation to DNASE through chest tubes has been effective in reducing the need for operation. (urokinases.com)
  • In conclusion, treatment with urokinase is safer and equally effective when compared to treatment with T-PA / DNASE. (urokinases.com)
Processes1
  • Fibrinolytic enzymes and metalloproteinases are involved in various physiological and pathological processes that require tissue remodeling and cell migration. (czytelniamedyczna.pl)
Outcome1
  • Our purpose was to assess long-term outcome and hemorrhagic risk in patients with anterior circulation ischemic stroke treated with intraarterial urokinase. (ajnr.org)
Stimulation1
  • The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
Disease1
  • Often the trophoblastic disease is diagnosed after all tissue has been formalin fixed, making karyotyping impossible. (au.dk)
Patients2
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
Cells3
  • In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
  • Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. (haematologica.org)
  • 6 In addition, these cells are present during early wound healing and proinflammatory macrophages are characterized by a pronounced ability to degrade tissue. (haematologica.org)