• Not long after FGF1 and FGF2 were isolated, another group of investigators isolated a pair of heparin-binding growth factors that they named HBGF-1 and HBGF-2, while a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells, which they called ECGF1 and ECGF2. (wikipedia.org)
  • Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)
  • Within developing tissues, cell proliferation, cell motility and other cell behaviors vary spatially, and this variability gives a complexity to the morphogenesis. (biologists.com)
  • Normally, HGF stimulates proliferation, motility and morphogenesis in a wide spectrum of cell types, contributing to embryonic development and to tissue repair in adulthood. (cancer.gov)
  • The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. (molvis.org)
  • Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
  • This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
  • Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
  • Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. (thermofisher.com)
  • Special areas of interest include signal transduction and information processing, gene expression and gene regulatory networks, metabolism, proliferation, differentiation and morphogenesis, among others, and the use of multi-scale modeling to connect molecular and cellular systems to the level of organisms and populations. (iospress.com)
  • and regulation of cell population proliferation. (nih.gov)
  • Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. (peprotech.com)
  • The present work introduces a computational implementation of some principles of a theory of organism development, namely that the default state of cells is proliferation and motility, and includes the principle of variation and organization by closure of constraints. (nature.com)
  • In the present model, the bioelectric context of cells and tissue is the field responsible for organization, as it regulates cell proliferation and the level of communication driving the system's evolution. (nature.com)
  • Starting from a depolarized (proliferative) cell, the organism grows to a certain size, limited by the increasingly polarized state after successive proliferation events. (nature.com)
  • The framework will allow to label for up to 10 markers to visualize at the same time ANXA1, centrosomes, chromosomes, cell-cell adhesion molecules, differentiation markers, proliferation, and apoptosis. (southampton.ac.uk)
  • Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. (joplink.net)
  • Promotes also differentiation and proliferation of hematopoietic cells. (joplink.net)
  • The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic cross talk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis, and injury repair. (nih.gov)
  • The Notch signaling pathway provides important intercellular signaling mechanisms essential for cell fate specification and it regulates differentiation and proliferation of stem or progenitor cells by para-inducing effects 3-4 . (bvsalud.org)
  • Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
  • These data demonstrate a critical role for DNMT3A in orchestrating intestinal epithelial homeostasis and response to tissue damage and suggest an involvement of impaired epithelial DNMT3A function in the etiology of IBD. (nature.com)
  • Dr. Iomini's research focuses on elucidating molecular networks controlling the morphogenesis, homeostasis, and repair of the anterior segment and ocular adnexa tissues, relevant to ocular conditions, including anterior segment dysgenesis, congenital glaucoma, myopia, and dry eye disease. (hopkinsmedicine.org)
  • In the field of tissue homeostasis, his work has contributed to understanding the conservation of cell death pathways in the animal kingdom and has demonstrated the physiological relevance of 'cell competition' in mammals. (cnic.es)
  • In the last ten years, his research has extended to the investigation of how tissue morphogenesis and homeostasis are determined by cell behaviour. (cnic.es)
  • The system reaches homeostasis, with a depolarized core (proliferative cells) surrounded by a rim of polarized cells (non-proliferative in this condition). (nature.com)
  • This theory would deal with the way an organism spontaneously grows from a single cell to a complete and complex organism, introducing organization at the different development stages and homeostasis for a mature organism. (nature.com)
  • This article will address the importance of polarizing processes and their molecular regulators in epidermal morphogenesis and homeostasis and discuss how alterations in polarity may contribute to skin disease. (uni-koeln.de)
  • Polarised epithelial cell divisions represent a critical mechanism for correct partitioning of fate determinants and genomic material into the daughter cells during tissue homeostasis and morphogenesis, and their disruption can lead to severe developmental disorders and diseases such as cancer. (southampton.ac.uk)
  • Our main scientific interest is the understanding of intestinal morphogenesis and cellular polarity during morphogenesis, homeostasis, and regeneration, as well as their implications in human diseases, such as intestinal bowel diseases (IBD), obesity, diabetes, and cancer. (uam.es)
  • However, this model cannot reconstitute the complexity of the architecture given in vivo, which includes different cell types, dynamic remodeling, and tissue homeostasis. (uam.es)
  • We used the zebrafish and mouse intestine as models systems to elucidate epithelial morphogenesis and intestinal homeostasis. (uam.es)
  • We are focused on the analysis of genes that regulate epithelial polarity during morphogenesis, B cell response and intestinal homeostasis, and particularly those controlling the following processes: Signaling, membrane trafficking, mechanical forces, and metabolic remodeling. (uam.es)
  • Characterization of the metabolic crosstalk among microbiota, epithelial cells, and immune cells controlling the intestinal homeostasis. (uam.es)
  • HGF was cloned as a growth factor for hepatocytes ( 1 , 2 ), is identical to scatter factor (SF) and was originally discovered as a fibroblast-derived cell motility factor for epithelial cells ( 3 ). (spandidos-publications.com)
  • This is consistent with the role played by mitochondria in supporting cell motility, previously described by the Altieri lab. (wistar.org)
  • In addition to modulation of mitochondrial behavior, the research team discovered that sEV released by hypoxic breast cancer cells induced major changes in gene expression in the normal recipient cells, with activation of multiple pathways of cell motility, cytoskeletal organization and cell-to-cell contact. (wistar.org)
  • This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
  • Cdc42-dependent actin polymerization can drive cell shape change, formation of filopodia, or organelle motility. (rupress.org)
  • Collectively, these models provide a range of experimental approaches to investigate the molecular and cellular mechanisms directing the morphogenesis of the craniofacial tissues and associated organs in health and disease. (grc.org)
  • Understanding the underlying mechanisms of these fundamental processes can provide new approaches to tissue regeneration and therapy for diseases such as cancer. (nih.gov)
  • EMBO Director Maria Leptin explained that "EMBO members are expert scientists who carry out pioneering research across all disciplines in the life sciences, from computer models or analysis of individual molecules and cell mechanisms to the study of higher-level systems in development, cognitive neuroscience, and evolution. (cnic.es)
  • His major contributions include the understanding of how gene activities regulate regionalization processes in the developing embryo and the discovery of mechanisms involved in quality control and organ regeneration. (cnic.es)
  • Widespread clinical applicability of immunotherapy to solid tumors depends on the understanding of response and resistance mechanisms that are mediated by evolving interactions between the immune system and cancer cells. (usc.edu)
  • We illustrate where such mechanisms of pattern formation arise in biological systems from cellular to tissue scales, with an emphasis on morphogenesis. (mpi-cbg.de)
  • Dr. Ewalds research interests include cellular mechanisms and molecular regulation of epithelial morphogenesis in development and cancer. (jhu.edu)
  • Yet, the precise mechanisms coordinating cell polarity and correct mitotic spindle dynamics and chromosome segregation fidelity, to ensure proper epithelial integrity and differentiation remain ill defined. (southampton.ac.uk)
  • Our work will lay the foundation for a more ambitious, collaborative project bringing together expertise in cell and molecular biology, cancer biology, physics, and mathematics, to investigate the causal relationship between ANXA1-mediated defects in cell divisions and tumour heterogeneity, and the underlying mechanisms. (southampton.ac.uk)
  • Moreover, with this system, we are obtaining essential information about the molecular mechanisms that regulate epithelial morphogenesis. (uam.es)
  • The group aims to understand the mechanisms of morphogenesis and cell differentiation within an embryo. (royalsociety.org)
  • In each of these cases, equally fascinating questions have been put forward, including those that address the cellular and molecular mechanisms that regulate the branching process itself, such as where the branches are initiated and how they extend and grow in the right direction. (unibas.ch)
  • The mechanisms of iron-overloading-associated HCC development include the increased reactive oxygen species (ROS), inflammation cytokines, dysregulated hepcidin, and ferroportin metabolism. (bvsalud.org)
  • of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
  • The scientific program will feature a wide range of topics to highlight how interdisciplinary research has enabled us to push boundaries in our understanding of craniofacial research, including talks investigating the physics and mechanics of craniofacial development and regeneration. (grc.org)
  • Invited presentations by leading researchers and clinician scientists in the field will present new findings in craniofacial morphogenesis and regeneration, with specific focus on the role that mechanics plays in shaping development. (grc.org)
  • This GRC will be held in conjunction with the "Craniofacial Morphogenesis and Tissue Regeneration" Gordon Research Seminar (GRS). (grc.org)
  • Several functional components of the epithelium contribute to this unique role, among them the secretion of a mucus layer and life-long regeneration of the different epithelial cell types from a stem cell compartment, allowing for quick repair of barrier defects 2 . (nature.com)
  • Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)
  • His contributions in this area demonstrate the importance of cell competition in maintaining pluripotency in early embryonic development and its possible role in cardiac regeneration. (cnic.es)
  • In adults, participates in wound healing as well as organ regeneration and tissue remodeling. (joplink.net)
  • and stem cell regeneration. (lu.se)
  • Our research is based in the organotypic culture model of three-dimensional epithelial cells growing in micropatterns "organ-on-a-chip", which are becoming one of the best in vitro models systems for the investigation of epithelial morphogenesis. (uam.es)
  • Embryonic development occurs with precisely timed morphogenetic cell movements directed by complex gene regulation. (duke.edu)
  • FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. (thermofisher.com)
  • This paper addresses a fundamental question in developmental biology, that is, how morphogenetic movements driving tissue folding are patterned to occur with the correct spatiotemporal dynamics. (elifesciences.org)
  • The Integrative Cell and Tissue Dynamics Group is looking for Postdoctoral Researcher to work on engineering organoid systems. (ibecbarcelona.eu)
  • A major challenge for the study of morphogenesis now is to objectively define tissue sub-regions exhibiting different dynamics. (biologists.com)
  • Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment, Developmental Cell (2020). (wistar.org)
  • His laboratory is also part of the Center for Cell Dynamics at the Johns Hopkins University. (hopkinsmedicine.org)
  • Patterned cell and matrix dynamics in branching morphogenesis. (nih.gov)
  • Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions. (nih.gov)
  • Btbd7 regulates epithelial cell dynamics and branching morphogenesis. (nih.gov)
  • We studied cell dynamics occurring during the emergence of feather array geometries in birds, which involves a gradual regionalisation of the skin through self-organisation. (cam.ac.uk)
  • The scope of the systems covered ranges from cellular to tissue, organ, systems studies, and up to populational dynamics. (nih.gov)
  • Development of new or improved laboratory/experimental techniques, instruments, or supporting software that measure the location and dynamics of molecules in situ, and organelles, cells, or tissues on the nanometer and micrometer length scales. (nih.gov)
  • Andrew Ewald is an Associate Professor of cell biology, oncology, and biomedical engineering in the Department of Cell Biology at Johns Hopkins Medicine and Center for Cell Dynamics. (jhu.edu)
  • Studies published in In Silico Biology generally use theoretical models and computational analysis to gain quantitative insights into regulatory processes and networks, cell physiology and morphology, tissue dynamics and organ systems. (iospress.com)
  • centrosome dynamics), and tumour cell fate, behaviour and heterogeneity. (southampton.ac.uk)
  • Cdc42 also affects other aspects of cell polarity, including microtubule dynamics, centrosome positioning, and Golgi reorientation. (rupress.org)
  • Altieri and colleagues went on to identify Integrin-Linked Kinase ( ILK ) as the main signaling component packaged in sEVs, responsible for both mitochondrial changes and increased migration of recipient cells. (wistar.org)
  • Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)
  • Activating the nuclear piston mechanism of 3D migration in tumor cells. (nih.gov)
  • Our research focuses on characterising the stem and progenitor cells that build the hypothalamus and characterising the molecular networks that direct hypothalamic morphogenesis, growth and differentiation. (sheffield.ac.uk)
  • [1] A review of recent literature on individual-based models, agent-based models, and multiagent systems shows that ABMs are used in many scientific domains including biology , ecology and social science . (wikipedia.org)
  • Dr. Carlo Iomini, Ph.D., is an Assistant Professor of Ophthalmology and Cell Biology at the Johns Hopkins University School of Medicine. (hopkinsmedicine.org)
  • Dr. Iomini received his undergraduate degree (Laurea) in Cell and Evolutionary Biology from the University of Milan, Italy, and his Ph.D. in Molecular Cell Biology from the National Museum of Natural History in Paris, France. (hopkinsmedicine.org)
  • He then completed a postdoctoral fellowship in Cell Biology and Genetics at Washington University in St. Louis and in Cell, Development, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City, where he joined the faculty as a Research Assistant Professor in 2007 and became an Assistant Professor in 2012. (hopkinsmedicine.org)
  • Besides past service on the Councils of several professional societies, Dr. Yamada is currently an editor of The Journal of Cell Biology and serves other editorial roles at multiple journals. (nih.gov)
  • Dr. Yamada served on the NIH Cell Biology Study Section and currently serves on the NIH Committee on Scientific Conduct and Ethics, NIH Steering Committee Diversity Working Group, and various other NIH committees. (nih.gov)
  • Forty-eight of the new members, including another 2 from Spain, are based in the 17 member states of the European Molecular Biology Conference (EMBC), the intergovernmental organization that finances EMBO. (cnic.es)
  • He has authored over 80 scientific articles, largely as corresponding author, which includes a single-authored book on Immuno Systems Biology (Springer) and edited book for the reputable Methods in Molecular Biology series. (a-star.edu.sg)
  • Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. (stanford.edu)
  • Although polarity proteins have been extensively studied in cell culture and in vivo in simple epithelia of lower organisms, their role in mammalian tissue biology is only slowly evolving. (uni-koeln.de)
  • Philippa Francis-West is a Professor in Developmental and Cell Biology at the Centre for Craniofacial and Regenerative Biology, King's College London. (royalsociety.org)
  • Molecular cell biology, Vol. 10, H. 12. (unibas.ch)
  • DNMT3A expression is downregulated in intestinal epithelial cells from IBD patients and upon tumor necrosis factor treatment in murine intestinal organoids. (nature.com)
  • In many of these cancers, HGF/Met signaling drives cell invasiveness and tumor metastasis, advancing disease beyond current effective therapies. (cancer.gov)
  • Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
  • The biological systems studied include human primary cells migrating in 3D, human tumor cells and tissues, and mouse organ development (salivary glands, lungs, and kidneys). (nih.gov)
  • Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. (peprotech.com)
  • they are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells. (wikipedia.org)
  • Scientific presentations will be accompanied by discussions on how these processes drive tissue diversity and shape of craniofacial structures, and how distinctive features of the vertebrate head have evolved. (grc.org)
  • Recently, novel formalisms have been developed to quantify tissue deformation and underlying cellular processes. (biologists.com)
  • Finally, we generalize its use to find homogeneous regions for cellular processes such as cell division, cell rearrangement, or cell size and shape changes. (biologists.com)
  • During tissue development, morphogenesis is accompanied by cellular processes such as cell division, cell rearrangement, cell size and shape changes, apical constriction and apoptosis. (biologists.com)
  • His studies show how cells build organs and how these same cellular processes can contribute to breast cancer metastasis. (jhu.edu)
  • An organism's growth and transformation during its life cycle is a tremendously complex succession of processes and events but even a simplistic and limited theory, dealing with only the general trend and generating a broad vision of tissue organization, can drive specific studies and experiments to further inform this field of research. (nature.com)
  • Prezygotic transcripts included multiple regulators that are most likely involved in developmental processes that take place long after fertilization, such as components of ErbB, hedgehog, notch, retinoid, TGFb, VEGF and Wnt signaling pathways, as well as transcripts involved in the development of nervous system. (biomedcentral.com)
  • LungMAP includes mouse and human data for cross correlation of developmental processes across species. (nih.gov)
  • Misplacement or enlargement of the initial invagination pit leads to early problems in cell behaviors that eventually result in a defective organ shape. (elifesciences.org)
  • Dr. Torres formed his group at the CNB-CSIC in Madrid in 1996, where he developed his research into vertebrate organ formation, including projects investigating the limbs and the heart. (cnic.es)
  • The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. (stanford.edu)
  • LungMAP is generating foundational data and analysis, creating a web portal for presentation of results and public sharing of data sets, establishing a repository of young human lung tissues obtained through organ donor organizations, and developing a comprehensive lung ontology that incorporates the latest findings of the consortium. (nih.gov)
  • The Rho GTPase Cdc42 is a master regulator of cell polarity that orchestrates reorganization of the cytoskeleton. (duke.edu)
  • The polarity of the epidermis is, for example, reflected in controlled changes in cell shape that accompany differentiation, oriented cell division, and the planar orientation of hair follicles and cilia. (uni-koeln.de)
  • The establishment and maintenance of polarity is organized by a diverse set of polarity proteins that include transmembrane adhesion proteins, cytoskeletal scaffold proteins, and kinases. (uni-koeln.de)
  • The GTPase Cdc42 was among the original genes identified with roles in cell polarity, and interest in its cellular roles from yeast to humans remains high. (rupress.org)
  • 183:1129-1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins. (rupress.org)
  • Nearly twenty years ago Cdc42 was recognized as an essential link between polarity cues and the machinery that generates cell polarity ( Bender and Pringle, 1989 ). (rupress.org)
  • In addition to promoting polarity, Cdc42 has acquired additional functions in animal cells ( Etienne-Manneville, 2004 ). (rupress.org)
  • Par proteins, like Cdc42, play conserved roles in cell polarity in many contexts, from early embryos to epithelial apical-basal polarity ( Goldstein and Macara, 2007 ). (rupress.org)
  • The making of such tissues or organs results from interactions at cell surfaces and communication between cells. (ens-lyon.fr)
  • The meeting will feature sessions on cell signaling, clinical genetics, sense organs, development of animal models of craniofacial disorders, state-of-the-art imaging techniques, and the use of tissue engineering approaches for regenerative repair of craniofacial tissues. (grc.org)
  • Complex three-dimensional organs arise from simple tissue primordia, and in many cases, these primordia are flat polarised epithelial sheets. (elifesciences.org)
  • HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
  • We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. (stanford.edu)
  • Here we performed single-cell RNA sequencing on 20 organs to reveal cell-type-specific responses to young and aged blood in heterochronic parabiosis. (stanford.edu)
  • Transcriptome profiling of the early stages in Atlantic cod revealed the presence of transcripts involved in patterning and development of tissues and organs long before activation of the zygotic genome. (biomedcentral.com)
  • During the following segmentation stage major events in the formation of tissues and organs take place. (biomedcentral.com)
  • Although an increasing number of interventions show promise for rejuvenation2, their effectiveness on disparate cell types across the body and the molecular pathways susceptible to rejuvenation remain largely unexplored. (stanford.edu)
  • Immunofluorescent double staining was used to detect YAP cellular localization with CD31 (an endothelial cell marker) antibody. (molvis.org)
  • Collagen I initiates endothelial cell morphogenesis by inducing actin polymerization through suppression of cyclic AMP and protein kinase A." Journal of Biological Chemistry 278, no. 1 (January 2003): 327-334. (thermofisher.com)
  • We recently used a proteomic-based screen to identify a novel mitotic complex including the membrane-associated Annexin A1 (ANXA1) protein that interacts with and regulates cortical recruitment of the LGN spindle orientation complex in mitotic mammary epithelial cells. (southampton.ac.uk)
  • Fütterer A, de Celis J, Navajas R, Almonacid L, Gutiérrez J, Talavera-Gutiérrez A, Pacios-Bras C, Bernascone I, Martin-Belmonte F , Martinéz-A C. (2017) DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells. (uam.es)
  • Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)
  • We found that disruption of ANXA1 function results in mitotic spindle misorientation and impaired cell-cell adhesion and genome instability, affecting the outcomes of cell division. (southampton.ac.uk)
  • Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell-matrix adhesion molecules, proteinases, and E-cadherin expression. (thermofisher.com)
  • Brain morphogenesis requires precise regulation of multiple genes to control specification of distinct neural progenitors (NPs) and neuronal production. (frontiersin.org)
  • HA is an abundant, naturally occurring component found in the skin and connective tissue cells. (prospecbio.com)
  • Collagen I is the most common fibrillar collagen for cell culture and is found in skin, bone, tendons, and other connective tissues. (thermofisher.com)
  • The study of craniofacial development utilizes a variety of vertebrate species, including those that are not commonly used for laboratory studies. (grc.org)
  • Whereas DNMT1 is the key maintenance methyltransferase, DNMT3A and DNMT3B represent the main de novo methyltransferases, as they can bind unmethylated DNA and establish novel DNA methylation marks not only during early development but also in differentiated cells in a signal-dependent manner 9 . (nature.com)
  • Recent efforts included translating basic knowledge of growth factor signaling to support the development of diagnostic and therapeutic agents that target HGF signaling in genitourinary and other malignancies. (cancer.gov)
  • Biostatistics areas of interest include development of advanced statistical techniques and methodologies for design of biological experiments, collection and analysis of the data from those experiments and interpretation of, and inference from, the results. (nih.gov)
  • Genes controlling hyphal development include ones that are upregulated during cell elongation and adherence to epithelia. (cdc.gov)
  • These govern multiple functions, including hyphal development and the secretion of pathogenic factors. (cdc.gov)
  • Applicants must propose hypothesis-driven developmental research with the prospect of gaining n ew and critical information about tissue mechanics relevant to vertebrate development and understanding the basis for developmental disorders. (nih.gov)
  • James Miller introduced the living systems theory 4 , where each system must include a number of critical subsystems, dealing with their structure, interaction, behavior and development, that can be applied from simple cells to full organisms. (nature.com)
  • Today, it is generally thought that the combination of determinants deposited by the mother during oogenesis and the inductive signals between different cells trigger the specification of different cell lineages during development of the embryo [ 7 , 8 ]. (biomedcentral.com)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
  • The genetic changes associated with this condition usually occur during the formation of reproductive cells (eggs and sperm) or in early fetal development. (medlineplus.gov)
  • Despite focusing on functional studies of correlatively pathogenic genes, less research has been done to investigate possibilities of their counter-regulatory genes as potential modulators of brain morphogenesis and therapeutic targets of malformation. (frontiersin.org)
  • Numerous genes transcribed in oocytes are involved in multiple aspects of cell maintenance and protection, including metabolism, signal perception and transduction, RNA processing, cell cycle, defense against pathogens and DNA damage. (biomedcentral.com)
  • This region includes several genes, including the FOXF1 gene. (medlineplus.gov)
  • Although DNMT3A and DNMT3B are highly homologous, their redundancy seems to be limited, and their unique biological function, e.g., specificity for methylation patterns in distinct cell types, is still elusive 9 . (nature.com)
  • Knowledge on the expression analysis of Notch signaling pathway molecules in SHED cultured in KGM could highlight its involvement in controlling the biological activity of these stem cells, particularly during odontogenesis and other developmental process. (bvsalud.org)
  • dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
  • The 2,3-BPG is required for efficient glycolysis and ATP production under anaerobic conditions, but is also a critical allosteric regulator of hemoglobin (Hb), acting to regulate oxygen release in peripheral tissues. (bvsalud.org)
  • Intestinal epithelial cells (IECs) have evolved to build a complex physiological barrier that separates the intestinal lumen from the underlying mucosal tissue. (nature.com)
  • This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)
  • Dr. Ewald's research lab identified a unique class of breast cancer cells that lead the process of invasion into surrounding tissues-a first step in cancer metastasis. (jhu.edu)
  • We apply these methods to genomic and immunological data collected from a patient with recurrent multifocal glioblastoma that elicited a complete response and eventually recurred while enrolled in City of Hope\'s ongoing IL13R 2-targeting chimeric antigen (CAR) T cell trial for patients with recurrent glioblastoma. (usc.edu)
  • This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)
  • We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour. (southampton.ac.uk)
  • interactions between cells. (lu.se)
  • multicellular interactions, including intracellular and Addresses intercellular biochemical signaling. (lu.se)
  • We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. (stanford.edu)
  • It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. (thermofisher.com)
  • When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. (prosci-inc.com)
  • trnp: A conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression. (nih.gov)
  • The CHS protein is expressed in the cytoplasm of cells of a variety of tissues and may represent an abnormality of organellar protein trafficking. (medscape.com)
  • Deletion of one copy of the FOXF1 gene in each cell reduces the production of the FOXF1 protein. (medlineplus.gov)
  • Using inter-species comparison in poultry, finch, emu, ostrich and penguin embryos, followed by perturbation of skin architecture ex vivo, we showed that oriented anisotropy of dermal cells prior to primordia formation is necessary for the regularity of the final array. (cam.ac.uk)
  • Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
  • I will emphasize the role of mechanical properties that lead to the shaping of tissues. (ens-lyon.fr)
  • During pattern formation, morphogenetic events provide a response of the naïve tissue to chemical and mechanical positional cues. (cam.ac.uk)
  • Her laboratory specializes in using engineered tissues and computational models to understand how mechanical forces direct developmental patterning events during tissue morphogenesis and during disease progression. (royalsociety.org)
  • Variations of orientation distributions and anisotropies may imply varying out-of-plane tissue mechanical properties around the eye globe. (bvsalud.org)
  • These growth factors typically act as systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. (wikipedia.org)
  • EV s are tiny structures enclosed in a double membrane layer and released by most cells to transfer different molecules and information to other cells. (wistar.org)
  • Our results indicate that proper brain morphogenesis is an outcome of interactive regulations of multiple molecules such as Gli3 and miR-7. (frontiersin.org)
  • Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. (joplink.net)
  • Aim: To detect the expression of molecules associated with Notch signaling pathway in stem cells from human exfoliated deciduous teeth (SHED) cultured in specific differentiation medium, namely, keratinocyte growth medium (KGM). (bvsalud.org)
  • RNA was reverse-transcribed to obtain the cDNA and then proceeded with PCR using specific primers for the Notch signaling pathway molecules (Notch1, Jagged-1, Jagged-2 and, Hes1) as well as stem cell marker (Nanog). (bvsalud.org)
  • Since the Notch signaling pathway molecules play an important role in differentiation of epithelial cells, it is important to identify the presence of notch signaling molecules in SHED during the process of cell differentiation. (bvsalud.org)
  • builds a bridge to today's molecular and cellular understanding self-organization in developing systems, including gastrulation, stem cell organoids, morphogen gradients, invertebrate systems, Evo-Devo, and emerging fields deriving from the discovery of embryonic induction. (elsevier.com)
  • The conference will link to recent advances on organizing principles in gastruloids and organoids - from stem cells to synthetic organizers. (elsevier.com)
  • Adipose mesenchymal stromal cells, haematopoietic stem cells and hepatocytes are among those cell types that are especially responsive. (stanford.edu)
  • All affected individuals, including adolescents and adults with atypical CHS and children with classic CHS who have successfully undergone allogenic hematopoietic stem cell transplantation (HSCT), develop neurologic findings during early adulthood. (medscape.com)
  • Multilineage differentiation of rhesus monkey embryonic stem cells in three-dimensional culture systems. (thermofisher.com)
  • Stem Cells 21 (2003): 281-295. (thermofisher.com)
  • Notch-1, Jagged-1, Jagged-2, and stem cell marker Nanog are expressed in SHED cultured in KGM which may be involved in the differentiation into epithelial-like cells in human dental pulp tissues. (bvsalud.org)
  • Stem cells from human exfoliated deciduous teeth (SHED) are multipotent stem cells derived from the pulp tissues of extracted deciduous teeth 1 . (bvsalud.org)
  • Stem cells from human exfoliated deciduous teeth (SHED) (ALLCells, Alameda, CA, USA) were employed in the current study. (bvsalud.org)
  • Dr. Bottaro's research on the role of epithelial growth factors in the onset and progression of solid tumors began with the discovery of the cell surface receptors for keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF). (cancer.gov)
  • In the LCMB he helped identify keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and their respective cell surface receptors. (cancer.gov)
  • First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an "orphan" receptor due to the fact its related ligand remained elusive. (peprotech.com)
  • Dr Nelson's contributions to the fields of tissue mechanics and morphogenesis have been recognized by a number of awards, including a Burroughs Wellcome Fund Career Award at the Scientific Interface (2007), a Packard Fellowship (2008), a Sloan Fellowship (2010), the MIT TR35 (2010), the Allan P. Colburn Award (2011), a Dreyfus Teacher-Scholar Award (2012), and a Faculty Scholars Award from the Howard Hughes Medical Institute (2016). (royalsociety.org)
  • The current research focus is on the Dchs1-Fat4-PCP-Hippo signaling pathway and the role of mechanics during cell differentiation. (royalsociety.org)
  • The simplification, however, risks missing potentially important aspects of the tissue architecture and mechanics. (bvsalud.org)
  • The patterning and fate determination gene products do not directly affect morphogenetic changes, but rather instruct the expression of downstream morphogenetic effectors that drive a tissue primordium down a path of defined physical changes. (elifesciences.org)
  • The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
  • decreases were seen in tissues and mucosal secretions, critically decreasing potential for virus transmission. (cdc.gov)
  • Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
  • When acting as a transporter for HA, LYVE1 can take on various roles, including moderating the uptake for catabolism within the lymphatic endothelial cells or delivering HA into the lumen of lymphatic vessels for reuptake in the lymph nodes. (prospecbio.com)
  • This volume begins by discussing the cell wall which, besides its roles in pathogenesis, is now a practical drug target. (cdc.gov)
  • A major focus of craniofacial research is to improve understanding of the etiology of craniofacial malformations, to develop diagnostics and therapies for these disorders, and to effectively repair craniofacial tissues. (grc.org)
  • Using such approaches, researchers can address how craniofacial cell populations work together, and how the surrounding environment impacts on form. (grc.org)
  • Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. (peprotech.com)
  • The three germ layers and the body plan of the mature organism are established during gastrulation, and the period is characterized by extensive cell movements and intracellular communications [ 21 , 22 ]. (biomedcentral.com)
  • In children diagnosed with IBD, genome-wide DNA methylation profiling of purified intestinal epithelial cells clearly distinguishes between healthy individuals and the IBD group 8 . (nature.com)
  • In order to maintain genome integrity cells employ a set of well conserved DNA damage checkpoints. (duke.edu)
  • CMV shares many attributes with other herpes viruses, including genome, virion structure, and the ability to cause latent and persistent infections. (medscape.com)
  • By correlating dynamic patterns of transcription factor expression with rigorous, quantitative analyses of cell behaviors across the salivary gland primordium in Drosophila , their results suggest Hkb and Fkh transcription factor patterning induces switches in cell behaviors at fixed positions to promote continued morphogenesis of the tubular structure. (elifesciences.org)
  • In the placodes of the forming tubes of the salivary glands in the Drosophila embryo, we previously identified spatially defined cell behaviors of cell wedging, tilting, and cell intercalation that are key to the initial stages of tube formation. (elifesciences.org)
  • We are using live-imaging and quantitative methods to compare wild-type placodes and mutants that either show disrupted cell behaviors or an initial symmetrical placode organization, with both resulting in severe impairment of the invagination. (elifesciences.org)
  • Our results provide key insights into the cellular basis of self-organisation and demonstrate that initial tissue morphology constrains pattern attributes, uncovering a morphogenetic mechanism contributing to pattern evolution. (cam.ac.uk)
  • Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
  • Neurologic involvement is variable but often includes peripheral neuropathy. (medscape.com)
  • The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
  • GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
  • In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)
  • This line of research has involved the introduction of new techniques, including new genetic and methodological tools for 3-dimensional microscopy of the developing embryo. (cnic.es)
  • Genetic deletion of Dnmt3a in intestinal epithelial cells ( Dnmt3a ΔIEC ) in mice confirms the phenotype of an altered epithelial ultrastructure with shortened apical-junctional complexes, reduced Goblet cell numbers and increased intestinal permeability in the colon in vivo. (nature.com)
  • They have been alternately referred to as "pluripotent" growth factors and as "promiscuous" growth factors due to their multiple actions on multiple cell types. (wikipedia.org)
  • Various growth factors, cytokines, and prostaglandins upregulate HGF gene expression, including basic fibroblast growth factor, oncostatin M, hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) ( 9 ). (spandidos-publications.com)
  • The discovery of germline mutations in the hepatocyte growth factor (HGF) receptor, Met, that predispose affected individuals to papillary renal cell carcinoma (HPRC) type 1, significantly strengthened mounting evidence of the oncogenic potential of this signaling pathway. (cancer.gov)
  • Fine tuning of morphogenesis is illustrated by the "enhanced filamentous growth" gene which, when knocked out, blocks the transition to the mycelial form. (cdc.gov)
  • A thin coating of diluted collagen solution supports cell attachment and growth of some primary cells, including hepatocytes. (thermofisher.com)
  • Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98. (thermofisher.com)
  • This is illustrated by its role in polarized cell growth in the yeast Saccharomyces cerevisiae . (rupress.org)
  • In its GTP-bound form, Cdc42 binds several effectors that help direct polarized cell growth: repolarizing actin and microtubules, directing polarized exocytosis via this reoriented cytoskeleton and by direct contact with exocytic machinery, and recruiting proteins such as septins that form a boundary restricting the region of cell growth. (rupress.org)
  • SHED was able to differentiate into epithelial like cells when cultured in keratinocyte growth medium (KGM) 2 . (bvsalud.org)