Tissue models of myocardial infarction models cardiovascular. Medical search. Frequent questions

Hotez added that the increased risk of cardiovascular events with influenza has also been reported to be prolonged after the acute infection. (medscape.com)
Rapid and correct diagnosis of acute myocardial infarction (AMI) plays a crucial role in saving patients' life. (hindawi.com)
Acute myocardial infarction (AMI) is one of the leading causes for death worldwide, and it is the single largest cause of death in the United States, responsible for 1 out of every 6 deaths [ 1 , 2 ]. (hindawi.com)
Hemorrhage is a frequent complication in acute myocardial infarction (AMI) and is speculated to be an independent predictor of adverse outcomes [1]. (biomedcentral.com)
In a limited number of studies of patients with compromised myocardium (severe congestive heart failure, acute myocardial infarction, hypertrophic cardiomyopathy), administration of intravenous diltiazem produced no significant effect on contractility, left ventricular end diastolic pressure, or pulmonary capillary wedge pressure. (nih.gov)
HDL infusion has been proposed as an acute therapy for patients with acute coronary syndrome who are at imminent risk for developing myocardial infarction. (nih.gov)
Following acute sodium current inhibition, conduction slowing was also present in right , but not left, ventricular tissue from wild-type mice . (norheart.no)
[ 2 ] In 1958, streptokinase was first used in patients with acute myocardial infarction (AMI), and this changed the focus of treatment. (medscape.com)
Acute myocardial infarction (AMI) is the most serious manifestation of coronary artery disease. (springeropen.com)
Cardiovascular illnesses are the leading cause of death worldwide, accounting for almost 33% of all deaths, with acute myocardial infarction (AMI) being a major contributor [ 53 ]. (springeropen.com)
Acute myocardial infarction and the resulting ischemic heart disease are the single most prevalent cause of morbidity and mortality in the western world. (lsuhs.edu)
Following acute myocardial infarction, serum LPA concentration rises by six-fold over control subjects, suggesting LPA may contribute to the pathogenesis of myocardial infarction. (lsuhs.edu)
Acute myocardial infarction caused by thrombus within the coronary arteries is the major culprit in cardiovascular disease. (hhs.gov)
In this Phase I SBIR, our combined groups propose to characterize fibrin targeted NDs (FTND) and evaluate their effectiveness in vivo in disrupting the microvascular thrombi in a biologically relevant model reflective of MVO during acute myocardial infarction. (hhs.gov)
In cardiovascular diseases such as atherosclerosis and its main sequelae, ischemic stroke and acute myocardial infarction (AMI), macrophage functions are central to both disease development and healing. (elifesciences.org)
C-reactive protein (CRP) is a marker of inflammation that is naturally present in the plasma at levels that may rise due to inflammatory processes, associated with a greater risk of cardiovascular events such as acute myocardial infarction. (bvsalud.org)
Periodontitis is a chronic infection capable of inducing an inflammatory response that increases the level of proteins during the acute phase, such as C-reactive protein, and considering that these proteins are independent risk factors for cardiovascular diseases, this could explain the connection between periodontal disease and heart disease that is, periodontal diseases increase the risk of cardiovascular diseases. (bvsalud.org)

These animal models may be used as whole animal models, where measurements like pressure, heart rate and electrocardiogram are used as biomarkers of ischemia and MI. (datasci.com)
but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)
As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)
Despite the advances in medical treatment and interventional procedures to reduce mortality in patients with CAD, the number of patients with refractory myocardial ischemia and congestive heart failure is rapidly increasing. (ca.gov)
Subsequent studies with hESC-derived endothelial progenitor cells decreased MI size and improved LV function in a mouse model of myocardial ischemia. (ca.gov)
Above all, PGRN also provides protection in the initial phase following myocardial ischemia-reperfusion injury. (biomedcentral.com)
A highly toxic aldehyde formed by reactive oxygen species (ROS) is 4-hydroxy-2-nonenal (HNE) through lipid peroxidation following myocardial ischemia/reperfusion (I/R) injury. (lsuhs.edu)
This study provides important findings on the distinct functions of resident and recruited macrophages during cardiac healing after myocardial ischemia. (elifesciences.org)
The lack of blood supply to any tissue is termed ischemia. (msdmanuals.com)
A heart attack, also termed myocardial infarction (MI), is death of heart tissue due to ischemia. (msdmanuals.com)

That response induced the secretion of key proatherogenic cytokines, such as interluekin-6 and interleukin-1 beta, which have been implicated in the pathogenesis of atherosclerosis and in an increased risk of cardiovascular events. (medscape.com)
Since this time, a number of papers have been published on the relationship between copper intake and cardiovascular disease in animals, including several showing that copper supplementation prevents atherosclerosis in one of the most commonly used animal models of cardiovascular disease ( 6 , 7 , 8 ). (blogspot.com)
His laboratory has developed small synthetic peptide mimetics of apoA-I, and like the full-length protein, these peptides mobilize excess cholesterol from cells and have been shown to reduce atherosclerosis and inflammation in animal models. (nih.gov)
At that time there weren't any good animal models to study diabetes-accelerated atherosclerosis, the process that leads to cardiovascular disease. (asbmb.org)
we generated a new mouse model that we still use a lot to study mechanisms whereby diabetes promotes atherosclerosis. (asbmb.org)
Atherosclerosis is a major cause of mortality and morbidity, which is mainly driven by complications such as myocardial infarction and stroke. (nature.com)
Recently, EndMT has been increasingly recognized as a vital process that contributes to various cardiovascular pathologies in adults, which include atherosclerosis, valvular heart disease, cardiac fibrosis, and myocardial infarction. (dovepress.com)
Necropsy analyses of patients who suffered a fatal cerebral stroke indicate a high prevalence of coronary atherosclerosis and myocardial infarction. (justia.com)
MiR-126 facilitates vascular re-modeling, decreases fibrosis in multiple organs, and has been reported to be beneficial in the treatment of atherosclerosis and re-stenosis. (justia.com)
Coronary atherosclerosis appears in the majority of the diabetes population, with the mortality of up to 20% diabetic subjects caused by myocardial infarction ( 9 ). (spandidos-publications.com)

Wnt upregulation in murine models resulted in stimulation of angiogenesis and suppression of fibrosis after ischemic insult. (bvsalud.org)
The aim of our study was to understand the impact of hemorrhage on infarct as well as remote myocardial remodeling following an ischemic event. (biomedcentral.com)
We use models of hemodynamic stress (hypertension), ischemic stress (myocardial infarction) and also infective injury (viral myocarditis) in order to study the role of macrophages in tissue damage and repair. (utoronto.ca)
The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
Post-stroke neurological deficits increase the risk of cardiovascular diseases roughly by three times, and the ischemic brain transmits indirect cell death signals to the heart. (justia.com)
During an AMI, the first ischemic insult initiates a cascade of unanticipated biochemical and metabolic changes inside the heart tissue. (springeropen.com)

Recent investigations have implicated the Wnt signaling cascade as a key modulator of cardiac tissue repair after myocardial infarction. (bvsalud.org)

Obesity leads to metabolic syndrome and type 2 diabetes mellitus (DM2), which are associated with increased morbidity and mortality, predominantly as a result of cardiomyopathy and other cardiovascular complications. (nymc.edu)
After my postdoc period, I set up my own lab here at the University of Washington, and that's when I had the opportunity to really focus on cardiovascular complications of diabetes by generating a mouse model of that disease. (asbmb.org)
The major causes of death in stroke-related moralities are a consequence of neurological damage and/or cardiovascular complications. (justia.com)
Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. (spandidos-publications.com)
The main risk factor raising the mortality and morbidity of type 1 DM is cardiovascular complications. (spandidos-publications.com)
Herbal and traditional Chinese medicine have also exhibited a strong impact on treatment of cardiovascular complications in diabetes ( 17 ). (spandidos-publications.com)
Diabetes mellitus is a progressive disease of the vasculature, leading to increased risk of both microvascular complications such as diabetic nephropathy (DN) and retinopathy (DR), and cardiovascular disease (CVD), including myocardial infarction and stroke [ 1 , 2 ]. (biomedcentral.com)
One such factor that has been identified as a pathogenic risk determinant for the development of microvascular and cardiovascular complications is connective tissue growth factor (CTGF). (biomedcentral.com)

Novel insights into LV remodeling after murine myocardial infarction by in vivo magnetic resonance tissue velocity mapping. (ox.ac.uk)
This immunopeptidomics-based pipeline was carefully validated in a murine colon tumor model CT26. (elifesciences.org)
Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology. (otago.ac.nz)

Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. (cdc.gov)
Patients can develop myocardial injuries after stroke even when patients do not have pre-existing cardiac diseases. (justia.com)
To date, there have been few effective modalities in the treatment of cardiovascular disease and/or disorder subsequent to stroke, including in subjects with a glucose metabolism disorder. (justia.com)
The present disclosure provides experimental support regarding the treatment of cardiovascular disease or disorder subsequent to stroke, using a novel composition. (justia.com)
10- 14 These cardiovascular effects can potentially contribute to the worse outcomes observed with high flow oxygen therapy in myocardial infarction, 15 stroke, 16 neonatal resuscitation 17 and fulminant sepsis, 18 although the enhanced production of reactive oxygen species causing reperfusion injury may also play a role. (bmj.com)

Using an ex vivo model, the researchers also found that atherosclerotic tissue could be directly infected by the virus. (medscape.com)
The development of a method to reliably identify high-risk atherosclerotic plaques is seen as one of the major quests of contemporary cardiovascular medicine. (nature.com)
In contrast, our study demonstrates that autofluorescence in the NIR range uniquely characterizes atherosclerotic plaques with intraplaque hemorrhage and may allow classification of atherosclerotic plaques into lesions of low or high risk for future cardiovascular events. (nature.com)
This mouse model was instrumental for the description of NIRAF as a potential indicator of an atherosclerotic plaque's risk in causing future cardiovascular events. (nature.com)
Besides establishing fluorescence emission tomography (FLECT) as a preclinical tool for the detection of plaques with intraplaque hemorrhage and its potential use in testing and monitoring of plaque-stabilizing drugs, our report has the potential to support technical developments for imaging technologies that will ultimately allow to risk stratify atherosclerotic plaques in patients and, in particular, to identify plaques that are prone to cause cardiovascular events. (nature.com)
While the bioactive glycerophospholipid lysophosphatidic acid (LPA) plays a well-known role in atherosclerotic disease, its role in myocardial function remains virtually unexplored. (lsuhs.edu)

This landmark publication was the first to place HO-1 in the realm of cardiovascular disease/research. (nymc.edu)
Additionally, our research approach proved to be a powerful tool in the identification of novel biomarkers for cardiovascular and metabolic disease (e.g. circulating endothelial cells and progenitor stem cells [EPCs] for better prognosis). (nymc.edu)
Even though cardiovascular diseases (CVDs) are the main of cause of the global burden of diseases attributable to PM exposure, it remains difficult to show reliable associations between exposure to wildland fire smoke and cardiovascular disease risk in population-based studies. (frontiersin.org)
In the last few years, the dysregulation of tissue expression levels of miRNAs has been directly linked to cardiac disease. (hindawi.com)
In patients with cardiovascular disease, diltiazem hydrochloride injection administered intravenously in single bolus doses, followed in some cases by a continuous infusion, reduced blood pressure, systemic vascular resistance, the rate-pressure product, and coronary vascular resistance and increased coronary blood flow. (nih.gov)
Researchers described technological advances as well as novel miRNA therapeutics such as for cardiovascular disease, cancer, and muscular dystrophy. (genengnews.com)
In 1963, Dr. W. F. Coulson and colleagues found that 22 of 33 experimental copper-deficient pigs died of cardiovascular disease. (blogspot.com)
11 of 33 died of coronary heart disease, the quintessential modern human cardiovascular disease. (blogspot.com)
For more than three decades, Dr. Klevay has been a champion of the copper deficiency theory of cardiovascular disease. (blogspot.com)
Yet questions have been raised about the relevance of this method to human cardiovascular disease, because studies have shown that the amount of time it takes copper to oxidize LDL in a test tube doesn't predict how much oxidized LDL you'll actually find in the bloodstream of the person you took the LDL from ( 10 , 11 ). (blogspot.com)
The Lipoprotein Metabolism Laboratory, led by Dr. Alan T. Remaley, seeks to better understand lipoprotein metabolism and to translate new insights gained from basic biochemistry, cell biology, and transgenic animal models into much-needed clinical advances in the treatment and prevention of cardiovascular disease. (nih.gov)
Cholesterol has a bad reputation, associated with cardiovascular disease, the leading worldwide cause of morbidity and mortality. (nih.gov)
The exposure to patients with rare diseases often leads to new insights into common disease processes that can be obtained in no other manner and inspires him and his co-workers to translate their basic science findings in cholesterol metabolism into new therapies for cardiovascular disease. (nih.gov)
These approaches will define regulatory mechanisms for heart regeneration and derive new regenerative approaches to cardiovascular disease. (fondationleducq.org)
I am interested in many aspects of cardiovascular medicine, especially valvular heart disease, but also ischaemic heart disease, cardiomyopathies, and atrial fibrillation. (otago.ac.nz)
Furthermore, recent developments in engineering target-specific and activatable fluorescent probes provide NIRF with high specificity and sensitivity, making it an attractive modality in studying cancer and cardiovascular disease. (jove.com)
The leading cause of worldwide mortality is cardiovascular disease. (utoronto.ca)
In the US, it is estimated that cardiovascular disease affects 60 million patients costing the healthcare system approximately $186 billion annually. (ca.gov)
Caffeine affects two regulators of low-density lipoprotein (LDL) cholesterol, reducing levels of the lipoprotein and thereby lowering cardiovascular disease risk (CVD) according to a study by researchers from the Department of Medicine, McMaster University, Hamilton, Canada. (hospitalhealthcare.com)
They concluded that the study offers compelling evidence for the development of caffeine-related compounds that might be able to mitigate the risk of cardiovascular disease. (hospitalhealthcare.com)
We're now basing our research on data from human studies to be sure that we're studying the most important drivers of cardiovascular disease risk in diabetes in humans. (asbmb.org)
These subjects didn't have any cardiovascular disease when the plasma samples were collected, but they were followed over time so that we knew who developed a myocardial infarction later on. (asbmb.org)
Here, I briefly discuss the need for more stringent considerations for EV-therapeutic effects with a focus on EV biodistribution profiles in appropriate disease models and routes of EV administration with a particular focus on the vasculature. (trillium.de)
There are important considerations when designing EV-therapeutics, such as biodistribution profiles in appropriate disease models and exploration of different methods of delivery, which are possibly, overlooked in current EV research investigations. (trillium.de)
The present disclosure provides a method for the treatment or prevention of a cardiovascular disorder or disease in a subject who has suffered cerebrovascular injury, the method comprising administering a therapeutically effective amount of a miR-126 containing agent or an agent that induces expression of miR-126 to the subject in need thereof. (justia.com)
Advances in congestive heart health: other human Infarction color-furnishing is Aim disease in acids with pertinent unpleasantness model. (siriuspixels.com)
Cardiovascular disease represents one of the most common causes of death among methamphetamine users. (lsuhs.edu)
In developed countries, cardiovascular disease is the main complication causing death resulted from diabetes ( 5 , 6 ). (spandidos-publications.com)
ABSTRACT Cardiovascular disease is the leading cause of death and disability worldwide accounting for 840,678 deaths in the US in 2016. (hhs.gov)
1 We proposed that a different alignment may be preferable for clinicians in demonstrating its beneficial characteristics, enhancing both the "pick up" of oxygen despite cardiorespiratory disease and the "drop off" of oxygen to the tissues despite falling oxygen saturation (fig 1). (bmj.com)
Connective tissue growth factor (CTGF), is a secreted matricellular factor that has been linked to increased risk of cardiovascular disease in diabetic subjects. (biomedcentral.com)
Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. (cdc.gov)
Obesity is a well-established risk factor for coronary heart disease ence the relationship between waist circumference and CHD in (CHD) (1-4) and has been associated with higher rates of death at- race-sex subgroups by using data from the longitudinal cohort in tributable to cardiovascular disease (CVD) (5). (cdc.gov)
For this study, we chose to investigate CHD outcomes as they comprise the majority of cardiovascular disease events (16). (cdc.gov)
My grandfather died of heart disease and my father had an episode of myocardial infarction few days back. (who.int)
Periodontal disease is responsible for a host immune-inflammatory response, contributing towards clarifying its association with cardiovascular disease. (bvsalud.org)
Periodontal disease is an inflammatory process with the presence of edema, redness and gingival bleeding, a clinical condition compatible with gingivitis that, as it progresses, causes the resorption of the alveolar bone tissue, destruction of the cementum and periodontal ligament, characterizing periodontitis. (bvsalud.org)
Hypertension, cardiovascular disease (CVD) and diabetes were the most frequent comorbidities reported. (who.int)

The Vascular Research Centre is an institute of basic biomedical research at the Department of Medicine of Goethe University, which is closely integrated into three Collaborative Research Centres, the Cardio-Pulmonary Institute (CPI) Cluster of Excellence of the Universities of Frankfurt & Giessen, along with the Max Planck Institute for Heart and Lung Research in Bad Nauheim, and the German Centre for Cardiovascular Research (DZHK). (uni-frankfurt.de)

The findings may not only explain the link between COVID and the increased risk of cardiovascular events but mark a starting point for new therapeutic approaches. (medscape.com)
Giannarelli noted that influenza is also associated with an increased risk of cardiovascular events, but there has been no evidence to date that it directly affects coronary arteries. (medscape.com)

My current research program focuses on understanding the cellular and molecular mechanisms of HO-1 cytoprotective actions and developing therapeutic strategies for treatment of cardiovascular and metabolic diseases. (nymc.edu)
Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). (biomedcentral.com)
Many types of cardiovascular diseases (CVDs) are associated with complex immune responses that can significantly contribute to their progression and remission. (biomedcentral.com)
Provided herein are methods for the prevention and treatment of cardiovascular diseases and disorders in a subject diagnosed as having suffered a cerebrovascular injury by administering agents that contain or induce the expression of microRNA-126. (justia.com)
We investigate signal transduction processes in cells of the cardiovascular system and their relevance for diseases of this system. (uni-frankfurt.de)
Cardiovascular diseases are the main cause of death in the western world. (uni-frankfurt.de)
They are essential for host defense against infections but are also involved in different cardiovascular diseases. (elifesciences.org)
It uses sophisticated lab robotics and automation to carry out as many as 1.5 million experiments a week for diseases that can be modelled on the cellular level. (insideprecisionmedicine.com)
ABSTRACT Associations of oral diseases with noncommunicable diseases such as diabetes, cardiovascular diseases, chronic respiratory diseases, osteoporosis and chronic renal failure are widely reported in the literature from developed countries. (who.int)
Online searches were made to find literature for the study of other tissues and organs and on oral diseases, e.g. dental caries, perio- as a potential source of pathology affecting dontal diseases and tooth loss, and on NCD, other systems and organs" [ 6 ]. (who.int)
This is one of the basis that supports the hypothesis that persistent bacterial attacks, associated with irregular host inflammatory response, may have consequences beyond the periodontal tissues and may even influence the occurrence of some systemic diseases (2,3). (bvsalud.org)

Effective risk assessment and stratification are essential for the clinical management of ST-segment elevation myocardial infarction (STEMI) patients. (ismrm.org)
ST-Elevation Myocardial Infarction (STEMI), results in death and disability due to damage to cardiac myocytes and decreased cardiac function. (hhs.gov)

Macrophages residing in vascular tissue can undergo self-renewal and can remain in the tissue for many years, the investigators point out. (medscape.com)
And just as was seen in cultured macrophages and foam cells, infection of vascular tissue triggered an inflammatory response. (medscape.com)
The investigations are particularly aimed at understanding and developing therapies against myocardial infarction and vascular neoplasia. (uni-frankfurt.de)
High flow oxygen resulting in hyperoxia also has the potential to cause significant adverse cardiovascular effects with increased systemic vascular resistance and blood pressure, decreased cardiac output and reduced coronary, cerebral and renal blood flow. (bmj.com)
Li C, Alfonso-Garcia A, McMasters J, Bec J, Weyers B, Uyesaka L, Griffiths L , Panitch A, Marcu L. Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor. (mayo.edu)
Tissue plasminogen activator (tPA) is a naturally occurring fibrinolytic agent found in vascular endothelial cells and is involved in the balance between thrombolysis and thrombogenesis. (medscape.com)

Approximately two-thirds of patients sustaining a myocardial infarction do not make a complete recovery and often are left with debilitating congestive heart failure. (ca.gov)

In addition to expression changes in tissues, more recent studies have indicated that miRNAs are detectable in serum, plasma, urine, and other body fluids in a highly stable form that is protected from endogenous RNase activity [ 4 ]. (hindawi.com)
At the end of the experiment, serum and cardiac tissues were collected. (springeropen.com)

Dr Simpson's research is focussed on the theory and modelling of nuclear collisions, and in understanding how the internal structure of nuclei influences nuclear reaction outcomes. (aips.net.au)
Biomarkers of microvascular health could then represent possible markers for the early detection of poor cardiovascular outcomes. (frontiersin.org)
Five asthma outcomes-two quality and three morbidity measures-were modeled using generalized estimating equations with a logit link function. (cdc.gov)

Myocardial fibrosis, characterized as interstitial fibroblast proliferation and excessive collagen deposition, is the structural basis of myocardial stiffness and the key process of cardiac function transformation from the compensatory phase to heart failure. (dovepress.com)
To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. (spandidos-publications.com)
Inhibition of pro-inflammatory myeloid cell responses by short-termS 100A9 blockade improves cardiac function after myocardial infarction. (lu.se)

MiRNAs regulate both transcriptional and post-transcriptional gene expression as well as regulate several circuits involved in tissue repair, inflammation, hypoxia-response, and angiogenesis. (justia.com)

All of these factors are known to result in myocardial apoptosis(5) and the acceleration of allograft rejection or chronic allograft dysfunction. (researchsquare.com)
Regardless, the impaired oxygen delivery at the tissue level results in depressed cellular respiration and potential organ dysfunction. (bmj.com)

Weinberger et al , 2020 ), where they contribute to organ functions ( Hulsmans et al , 2017 ) and maintenance of tissue homeostasis ( Nicolas-Avila et al , 2020 ). (elifesciences.org)

The in vivo cell culture process as the main part of tissue engineering was investigated through mathematical modelling and computational fluid dynamic (CFD) simulation of cartilage cell growth. (sharif.edu)
Tissue engineered bovine saphenous vein extracellular matrix scaffolds produced via antigen removal achieve high in vivo patency rates. (mayo.edu)

In subsequent years, He worked in the field of pharmaceutical research and development business and pre-clinical studies using mice and rabbit models. (stmatthews.edu)
These myeloid subsets are a heterogeneous population of cells with distinct origins and functions, and participate in the initial inflammatory and subsequent wound healing responses after myocardial tissue injury. (utoronto.ca)
The subsequent inflammatory reaction is an important determinant of tissue damage. (uni-frankfurt.de)

Our results demonstrate that human embryonic stem cell (hESC)-derived hemangioblasts can create new blood vessels and improve blood flow in a rodent model of myocardial infarction. (ca.gov)
Using a novel rodent model, this project is uniquely positioned to make a significant contribution to the understanding of methamphetamine-associated cardiomyopathy and cardiac arrhythmias. (lsuhs.edu)

We also found that the virus persists in these foam cells that could be responsible for long-term, low-grade inflammation in the vasculature that could contribute to the long-term cardiovascular manifestations in patients who have recovered from COVID," she said. (medscape.com)
Taken together, these studies suggest that CTGF may have substantial value both as a pathogenic risk marker of inflammation-induced tissue injury and as a therapeutic target. (biomedcentral.com)

3) Develop pre-clinical mammalian models of regenerative therapy through the delivery of cardiomyocyte mitogens and the engineering of cardiac tissue patches from stem cell-derived cardiomyocytes. (fondationleducq.org)
Over the past three decades, clinical and pharmacological studies have accumulated a body of evidence that not only demonstrated these therapeutic effects, but also provided significant insights into the pharmacokinetic behavior, therapeutic profile, and mode of action of scutellarin in humans and animal models. (cdc.gov)
It's been a rewarding progression in my career, going from studying single cells in culture to animal models to translational and clinical studies. (asbmb.org)
How do you apply an insight from a large clinical trial to a mouse model? (asbmb.org)
Our results using the mTP model identified intensive glucose control treatment and smoking as clinical factors that were associated with decreased and increased odds of observing non-zero CTGF values respectively. (biomedcentral.com)
The mTP model identified new clinical determinants that modulate the levels of CTGF in diabetic subjects. (biomedcentral.com)

He found that 19 of the 21 cattle had abnormal hearts, showing atrophy and abnormal connective tissue infiltration (fibrosis) of the heart muscle ( 1 ). (blogspot.com)
A cardiac fibrosis model was established in Sprague-Dawley rats through a subcutaneous injection of isoproterenol (ISO, 5 mg/kg/d). (dovepress.com)
Echocardiographic parameters, myocardial fibrosis, NOX2 expression and EndMT were assessed. (dovepress.com)
1 Thus, it is imperative to understand the mechanisms involved in inhibition of myocardial fibrosis. (dovepress.com)

Cleft differences were similar in both mice groups, but conduction velocities were only impaired during increased pacing of the right ventricle in the genetically modified mouse model . (norheart.no)

After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
His scientific interests are focused on the role macrophages in cardiac tissue injury and regeneration. (utoronto.ca)
Alternatively, macrophages can also mediate significant cardiac tissue injury. (utoronto.ca)
One of the major impediments limiting progress has been the prevailing assumption that bone marrow-derived circulating monocytes are the source of all tissue macrophages. (utoronto.ca)
Primitive embryonic-derived macrophages promote cardiac tissue repair while bone marrow-derived macrophages promote tissue injury. (utoronto.ca)
We are focused on understanding the role that myeloid cells (monocytes, macrophages and dendritic cells) play within the myocardium during steady state and following tissue injury. (utoronto.ca)
We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner. (elifesciences.org)
Using state-of-the-art fate-mapping models and genetic and pharmacological targeting approaches, the authors provide solid evidence that the absence of resident macrophages do not influence infarct size but instead alter the immune cell crosstalk in response to injury. (elifesciences.org)

The pharmacological properties of herbal remedies, including the amelioration of insulin sensitivity, the promotion of insulin secretion, the increase of glucose uptake by adipose and muscle tissues, the inhibition of sugar absorption in intestines and the generation of sugar by hepatocytes, have been demonstrated in several studies ( 15 , 16 ). (spandidos-publications.com)

Both human and animal models of diabetes and obesity were utilized to examine the use of stem cell intervention and gene therapy to amplify HO-1 levels. (nymc.edu)
Her current work focuses on the study of brain circuitry involved in glucose homeostasis in different pathological conditions, such as diabetes and sleep apnoea, and how dysregulation of these neural networks affects cardiovascular function. (hri.org.au)
Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. (spandidos-publications.com)
The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. (spandidos-publications.com)

Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)

Thrombus resolution is similar to granulation tissue formation during wound healing [ 10 ]. (biomedcentral.com)

Despite advancements in restoring epicardial artery patency via reperfusion therapy, microvascular obstruction (MVO) limits cardiovascular recovery at the tissue level and results in poorer prognosis, including death. (hhs.gov)

Animal and cellular models are used to study the various aspects of MI. (datasci.com)
Thereby, functionally manipulating recipient cells, for example to perturb pro-inflammatory signalling, inhibit cellular proliferation, differentiation and to promote regeneration and repair in a broad range of pathological tissues. (trillium.de)
Based on a minimally invasive myocardial infarction model and a restenosis model in the mouse carotid artery, cellular reactions and dynamics will be investigated by single-cell sequencing and an accompanying analysis of redox regulation throughout the process. (uni-frankfurt.de)

we're combining data that we get from large human cardiovascular outcome studies with the mechanistic mouse models that we have in the lab. (asbmb.org)

The key mechanisms underlying myocardial I/R injury include increased intracellular calcium concentration, sudden generation of reactive oxygen species (ROS) and inflammatory cytokines, adenosine triphosphate (ATP) depletion, and development of metabolic acidosis. (researchsquare.com)

We hypothesized that individual and neighbor- with cardiovascular events (6-8) and differences in the relation- hood factors would differentially influence the relationship ship between waist circumference and CVD mortality between between waist circumference and CHD in race-sex subgroups and non-Hispanic African American and non-Hispanic White popula- that African American participants would have less favorable tions (9). (cdc.gov)

Using genetic and surgical mouse models, we are trying to understanding how individual myeloid subsets are activated, what factors regulate their entry into the myocardium and subsequently, their persistence and fate in the myocardium. (utoronto.ca)

Our studies demonstrated that HO-1 expression in epicardial tissue provides protection to heart function and attenuates myocardial infarction (MI) and heart failure. (nymc.edu)
Therefore, attenuating myocardial I/R injury during the heart transplant procedure would have a favorable impact on improving short- and long-term graft function and recipient's survival(6). (researchsquare.com)
Instead of re-growing functional heart tissue, the human heart, in response to a heart attack, produces a non-function scar. (fondationleducq.org)
CMR imaging has become a beneficial imaging modality to assess myocardial morphology, function and infarct characteristics simultaneously. (ismrm.org)
We also have several integrated translational projects that focus on the corresponding human myeloid subsets, how they are activated and how their activation state relates to myocardial function and myocardial recovery in patients following myocardial tissue injury (myocardial infarction). (utoronto.ca)
We will characterize for the first time how the neurogranin pathway in the endothelium could regulate the nitric oxide production and cardiovascular function. (lsuhs.edu)
Assays investigating tissue damage (histology) and function (echocardiography) will be used as further readouts. (uni-frankfurt.de)

Identifying cardioprotective mechanisms of Wnt is imperative to reducing debilitating cardiovascular adverse events in oncologic patients undergoing treatment. (bvsalud.org)
I thought better animal models would be needed in order to understand mechanisms and move the research area forward. (asbmb.org)

This study quantitatively evaluated relationship between microvascular obstruction and regional myocardial strain by Cardiac MRI after ST-segment-elevation myocardial infarction. (ismrm.org)

The experiments were conducted on ventricular tissue from male rats five weeks after a myocardial infarction due to artery occlusion. (norheart.no)
When plaque rupture occurs f.e. in a coronary artery this will lead to a myocardial infarction often followed by death. (europa.eu)

Giannarelli says it's important for doctors and patients to be aware of an increased cardiovascular risk after a SARS-CoV-2 infection and to pay extra attention to traditional risk factors, such as blood pressure and cholesterol. (medscape.com)
In a recent article published online in Nature Cardiovascular Research , Giannarelli and colleagues analyzed human autopsy tissue samples from coronary arterial walls of patients who had died from COVID in the early stages of the pandemic in New York. (medscape.com)
Early detection of remote tissue alterations will potentially aid better management of the high-risk patients who are prone to adverse long-term consequences. (biomedcentral.com)
Since appropriate animal models for plaque rupture are lacking, we use as a starting point a large number (~600) of well characterized carotid endarterectomy specimen from patients that are well documented and undergo a follow up. (europa.eu)
Next to this approach, we will screen for proteins that differ between for proteins that differ between patients that had a cardiovascular event and control patients, an approach that can redefine the definition of the vulnerable plaque (Objective 2). (europa.eu)

The protein levels of ß-catenin in lung tissue of offspring rats were detected by ELISA that of LEF-1 by Western blotting. (bvsalud.org)
The protein levels and mRNA expression of Wnt2, Wnt7b, FZD4, FZD7, LRP5, and LRP6 in the lung tissue of the PNE offspring rats were significantly increased. (bvsalud.org)

La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clínicas de vacunación para niños de 6 meses en adelante. (stanfordchildrens.org)
In 2019, Polina continued her research in the newly established Cardiovascular Neuroscience unit at the HRI. (hri.org.au)

Myocardial infarction (MI) occurs when the heart muscle is starved for oxygen long enough that cardiac cells die. (datasci.com)
DSI and the Harvard Bioscience family have solutions for cardiomyocyte isolation, isolated heart perfusion, telemetry that measures pressure, heart rate and electrocardiograms in freely moving subjects, as well as hardwired solutions capable of combining telemetry with other systems used in tissue research. (datasci.com)
Diltiazem has no significant electrophysiologic effects on tissues in the heart that are fast sodium channel dependent, e.g. (nih.gov)
The human heart shows limited natural muscle regeneration in response to myocardial infarction. (fondationleducq.org)
There is currently no therapy that successfully regenerates heart tissue, and this despite more than a decade of stem cell research that initially appeared to be very promising in this regard. (fondationleducq.org)
The development of peptide-modified scaffolds for the treatment of chronic heart failure has produced initial proof of concept studies that a tissue engineering approach for restoration of an injured heart is possible. (ca.gov)
Histopathological examination of heart tissue was performed. (springeropen.com)
Our lab is also investigating the role of hydrogen sulfide (H 2 S), a gasotransmitter abundant in the cardiovascular system, (playing an essential role in maintaining the redox balance of the heart) in methamphetamine induced oxidative stress as a precursor of pro-arrhythmic substrate in the heart. (lsuhs.edu)
This blockage causes unstable angina or a heart attack (myocardial infarction), depending on the location and amount of blockage. (msdmanuals.com)
A heart attack is death of heart tissue due to lack of blood supply. (msdmanuals.com)
Blood Supply of the Heart The heart and blood vessels constitute the cardiovascular (circulatory) system. (msdmanuals.com)
If the blood supply is greatly reduced or cut off for more than a few minutes, heart tissue dies. (msdmanuals.com)

Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)
Naturally targeting vectors such as EV, can localise to specific cells, penetrate deep within tissues, easily pass through the cell membrane to deliver therapeutic molecules such as RNA and show no toxicity or immunogenicity [13]. (trillium.de)

An in vitro model of EndMT was developed using human umbilical vein endothelial cells (HUVECs) via treatment with transforming growth factor-β (TGF-β) at 10 ng/mL for 24 h. (dovepress.com)
Basement Membrane of Tissue Engineered Extracellular Matrix Scaffolds Modulates Rapid Human Endothelial Cell Recellularization and Promote Quiescent Behavior After Monolayer Formation. (mayo.edu)

HO-1 also serves as the mediator of cross-talk between adipose tissue and the vasculature. (nymc.edu)
Lipodystrophy refers to the loss of adipose tissue. (medscape.com)

In the border zone between normal and scarred ventricular tissue, action potentials and calcium transients are normal deep down in the tissue, but not in the superficial connective tissue structures. (norheart.no)

The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)
Cardiovascular MRI offers excellent soft tissue differentiation, 4D data acquisition with high spatial and temporal resolution. (lu.se)

The involvement of miRNAs in cancer research emerged from studies demonstrating their aberrant expression in neoplastic tissues. (genengnews.com)
Cardiovascular research , 114 (5), 724-736. (norheart.no)
23 students completed NORHEART's Introductory Course to Cardiovascular Research and Medicine in Oslo 17-21 October. (norheart.no)

Anatomy12

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20192

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