• Reperfusion plays an important role in the pathophysiology of cerebral ischemia. (nih.gov)
  • Magnetic resonance imaging (MRI) and histological studies in rat focal ischemia models using transient middle cerebral artery (MCA) occlusion indicate that reperfusion after an ischemic episode of 2- to 3-hour duration does not result in reduction of the size of the infarct. (nih.gov)
  • Experimental ischemia of 15, 30, or 60 min length, followed by 30 min of reperfusion, was produced in situ in the cat small intestine by means of an adjustable arterial clamp. (edu.au)
  • The rate of free radical formation was followed intermittently with ESR and a modified spin trapping technique in the control period prior to ischemia and at various times during reperfusion. (edu.au)
  • Cumulative radical production during the 30 min reperfusion period rose from about 3 μmol × 100 g−1 after 15 min ischemia to approximately 4.5 μmol × 100 g−1 after 30 min and 8-10 μmol × 100 g−1 after 60 or 120 min ischemia. (edu.au)
  • However, whether GRh2 has a protective effect on ischaemia/reperfusion (I/R) in the myocardium has yet to be elucidated. (spandidos-publications.com)
  • Heusch G: Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. (spandidos-publications.com)
  • Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)
  • Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
  • Abouzaki NA, Christopher S, Trankle C, Van Tassell BW, Carbone S, Mauro AG, Buckley L, Toldo S and Abbate A: Inhibiting the inflammatory injury after myocardial ischemia reperfusion with plasma-derived Alpha-1 Antitrypsin: A post hoc analysis of the VCU-α1RT study. (spandidos-publications.com)
  • Harvest tissue source does not alter the protective power of stromal cell therapy following intestinal ischemia and reperfusion injury. (logosbio.com)
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
  • Composite flaps used in reconstructive surgery may intra- and postoperatively suffer from hypoperfusion and/or ischemia-reperfusion influencing wound healing. (scielo.br)
  • In Ischemia-Reperfusion (I/R) group before repositioning and suturing the flap pedicles were clamped for 60 minutes. (scielo.br)
  • 2. Siemionow M, Arslan E. Ischemia/reperfusion injury: a review in relation to free tissue transfers. (scielo.br)
  • Klarik Z, Tamas R, Toth E, Kiss F, Kovacs EL, Jäckel M, Furka I, Nemeth N. Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion. (scielo.br)
  • Review: Ischaemia-reperfusion injury in flap surgery. (scielo.br)
  • Intra- and postoperative monitoring of flap microcirculation may provide useful information for better understanding and following-up the ischemia-reperfusion-related alterations in tissue perfusion 6 6. (scielo.br)
  • 8. Eltzschig H, Eckle T. Ischemia and reperfusion - from mechanism to translation. (scielo.br)
  • Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. (spandidos-publications.com)
  • The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
  • A model of cerebral ischemia‑reperfusion was established using the MCAO method. (spandidos-publications.com)
  • These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
  • yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)
  • An ischemic stroke consists of two related pathological injury processes: Primary ischemia-induced brain injury and secondary ischemia reperfusion injury ( 3 ). (spandidos-publications.com)
  • A study has shown that neurons in the ischemic penumbra may undergo apoptosis hours or days after ischemia and alleviating ischemia reperfusion injury is an achievable therapeutic goal in the early intervention of ischemic stroke aimed at limiting the amount of infarction ( 4 ). (spandidos-publications.com)
  • Those factors include mechanical and reperfusion injuries, ischemia, various burns, UV rays, and radiation [ 4 - 6 ]. (hindawi.com)
  • but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)
  • As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)
  • 1. The treatment potential of Gastrodia-Uncaria water extract on cerebral ischaemia was demonstrated in terms of reduction of brain infarct volume of the brain, improvement of the motor behaviour recovery, stimulation of anti-oxidative enzyme, inhibition of matrix metalloproteinase, induction of neurotrophins, and maintenance of brain tissue integrity. (hkmj.org)
  • This article describes the pathophysiology of, and treatment strategy for, cerebral ischemia. (nih.gov)
  • Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
  • Murine brain-specific angiogenesis inhibitor 1 and 2 (mBAI1, mBAI2) are involved in angiogenesis after cerebral ischemia. (nih.gov)
  • In the in vivo focal cerebral ischemia model, BAI3 expression decreased from 0.5 h after hypoxia until 8 h, but returned to control level after 24 h. (nih.gov)
  • In this review, we discussed the recent findings of spatio-temporal evolution of BBB injury in the early stages of cerebral ischemia and its association with intracerebral hemorrhage following tPA thrombolysis. (nih.gov)
  • When ischemic stroke occurs, cerebral ischemia and hypoxia cause the release of excessive excitatory amino acids, mainly glutamic acid and aspartic acid, which exert excitotoxic effects on the central nervous system. (spandidos-publications.com)
  • These excitotoxic effects play important roles in neuronal and blood-brain barrier damage after cerebral ischemia ( 5 , 6 ). (spandidos-publications.com)
  • Cerebral hyperexcitability in migraine experiencers might sensitize brain tissue to ischemia. (medscape.com)
  • [ 1 ] A recent hypothesis to explain the migraine-stroke association, based on experimental data obtained in mice expressing familial hemiplegic migraine type 1 mutations, is that the cerebral hyperexcitability phenotype associated with migraine might sensitize brain tissue to ischemia. (medscape.com)
  • Along with the observation that migraine mutants had an elevated minimum cerebral blood flow threshold required for tissue survival and developed larger infarcts, these findings directly support the hypothesis that brain tissue in migraineurs is more susceptible to ischemic injury. (medscape.com)
  • Based on these premises, taking advantage of the reliability of computed tomography perfusion (CTP) imaging in the estimation of cerebral tissue viability in both clinical and research settings, [ 4 ] we conducted a case-control study comparing CTP maps of migraineurs and nonmigraineurs patients with acute ischemic stroke aimed at investigating whether a personal history of migraine is associated with vulnerability to brain ischemia. (medscape.com)
  • Of note, ischemia-induced BBB damage in the early stroke stages is increasingly appreciated to negatively affect the safety and efficacy profiles of thrombolytic therapy for ischemic stroke. (nih.gov)
  • Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage. (medscape.com)
  • 1 Coronary artery disease can lead to inadequate tissue oxygenation, a state known as ischemia. (cms.gov)
  • Chronic limb threatening ischemia (CLTI), also known as critical limb ischemia (CLI), is an advanced stage of peripheral artery disease (PAD). (wikipedia.org)
  • Critical limb ischemia includes rest pain and tissue loss. (wikipedia.org)
  • citation needed] Critical limb ischemia is diagnosed by the presence of ischemic rest pain, and an ulcers that will not heal or gangrene due to insufficient blood flow. (wikipedia.org)
  • Other factors which may point to a diagnosis of critical limb ischemia are a Buerger's angle of less than 20 degrees during Buerger's test, a capillary refill of more than 15 seconds or diminished or absent pulses. (wikipedia.org)
  • citation needed] Critical limb ischemia is different from acute limb ischemia. (wikipedia.org)
  • Acute limb ischemia is a sudden lack of blood flow to the limb, for example caused by an embolus whereas critical limb ischemia is a late sign of a progressive chronic disease. (wikipedia.org)
  • citation needed] As of 2015 pCMV-vegf165, a gene-therapy was being studied in critical limb ischemia. (wikipedia.org)
  • citation needed] Tissue loss is the development of arterial insufficiency ulcers or gangrene due to peripheral artery disease. (wikipedia.org)
  • Treatment mirrors that of other symptoms of peripheral artery disease, and includes modifying risk factors, revascularization via vascular bypass or angioplasty, and in the case of tissue loss, wound debridement. (wikipedia.org)
  • Expression of both hypoxia-inducible factor-1 and cyclo-oxygenase-2 was assessed in the peri-infarct myocardium and considered as tissue markers of ischaemia. (unicatt.it)
  • The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
  • Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
  • Avoid extravasation of LEVOPHED into the tissues, as local necrosis might ensue due to the vasoconstrictive action of the drug. (nih.gov)
  • Intimal hypertrophy or secondary clot formation can narrow the vessel lumen and cause tissue ischemia or necrosis. (merckmanuals.com)
  • however, large radiation doses to the skin can cause permanent hair loss, damaged sebaceous and sweat glands, atrophy, fibrosis, decreased or increased skin pigmentation, and ulceration or necrosis of the exposed tissue. (cdc.gov)
  • 2. Intravascular administration of tissue plasminogen activator is well tolerated with oral administration of Gastrodia-Uncaria water extract, which may reduce the risk of tissue plasminogen activator-induced intracranial haemorrhage. (hkmj.org)
  • Early ischemic blood brain barrier damage: a potential indicator for hemorrhagic transformation following tissue plasminogen activator (tPA) thrombolysis? (nih.gov)
  • Tissue plasminogen activator (tPA) thrombolysis, remains to be the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. (nih.gov)
  • These mechanical forces pulled vessels from the preexisting vascular bed as vascular loops with functional circulation that expanded as an integral part of the growing granulation tissue through vessel enlargement and elongation. (nature.com)
  • The expression of vascular endothelial growth factor following ischemia showed an inverse pattern. (nih.gov)
  • This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
  • 1993) A kallikrein-like enzyme in human vascular tissue. (nature.com)
  • Recurrent, unabated ischemia is the underlying cause of tissue loss in peripheral arterial disease (PAD) or peripheral vascular disease (PVD). (frontiersin.org)
  • Local intra-arterial thrombolysis is the preferred treatment option for acute lower limb ischaemia (ALLI) in many vascular centres. (springer.com)
  • 9 Moreover, the response includes constriction of the peripheral (superficial) vascular system, which may result in non-freezing injuries or hasten the onset of actual freezing of tissues (frostbite). (health.mil)
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
  • HbS, cause intermittent vascular obstruction, leading to tissue ischaemia and consequent chronic damage in organs and endocrine glands. (bvsalud.org)
  • The presence of diabetes mellitus is rarely addressed in acute lower limb ischaemia (ALLI). (springer.com)
  • The patient had severe cardiac dysfunction and atrial fibrillation and presented with acute ischemia in the right lower limb 24 h after receiving an inferior vena cava filter. (medscape.com)
  • The development of effective neuroprotection methods and the establishment of reliable imaging modalities for an early and accurate diagnosis of the extent and degree of the ischemia are imperative. (nih.gov)
  • Formation of new vessels in granulation tissue during wound healing has been assumed to occur solely through sprouting angiogenesis. (nature.com)
  • Using neovascularization models based on the chick chorioallantoic membrane and the healing mouse cornea, we found that tissue tension generated by activated fibroblasts or myofibroblasts during wound contraction mediated and directed translocation of the vasculature. (nature.com)
  • This model explains the rapid appearance of large functional vessels in granulation tissue during wound healing. (nature.com)
  • Gabbiani, G., Ryan, G.B. & Majne, G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. (nature.com)
  • Although skeletal muscle is the major carnosine depot, the role of the dipeptide in preventing skeletal muscle injury has not been studied, and it is unclear whether carnosine affects ischemic damage or post injury events underlying wound healing and tissue angiogenesis. (frontiersin.org)
  • Effect of short-term ischemia on microcirculation and wound healing of adipocutaneous flaps in the rat 1 1 Research performed at Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary. (scielo.br)
  • We aimed to follow-up the effect of ischemia on adipocutaneous flaps' wound healing and microcirculation. (scielo.br)
  • Short-term ischemia could influence flap microcirculation and wound healing, and may result in hypertrophized mammary glands. (scielo.br)
  • Avoid antibiotics and wound cultures in emergency department patients with uncomplicated skin and soft tissue abscesses after successful incision and drainage and with adequate medical follow-up. (aafp.org)
  • Discolouration of tissues both within and at the wound margins. (dermnetnz.org)
  • Hyperbaric normothermic perfusion dramatically extends the viability of composite tissues ex-vivo. (sages.org)
  • Acute or chronic inflammation induced by ischemia has also been suggested to play an important role in the process of malignant cardiac remodeling [ 3 ]. (hindawi.com)
  • Our results indicate that the expression and distribution of BAI3 in normal brain, but not its developmental expression, are very similar to those of BAI1 and BAI2, and that BAI3 may participate in the early phases of ischemia-induced brain angiogenesis and in brain tumor progression. (nih.gov)
  • Within two minutes of ischemia, extracellular pH can drop from about 7.3 to about 6.7. (benbest.com)
  • It is currently unclear whether ongoing or recurrent ischaemia is an independent determinant for increased apoptosis in peri-infarct viable myocardium. (unicatt.it)
  • The latter two conditions are jointly referred to as tissue loss, reflecting the development of surface damage to the limb tissue due to the most severe stage of ischemia. (wikipedia.org)
  • A similar study, BASIL 2 (Bypass Versus Angio plasty in Severe Ischaemia of the Leg), is being conducted in the United Kingdom. (wikipedia.org)
  • The symptoms of brain ischemia range from mild to severe. (wikipedia.org)
  • Severe ischemia of the toes with absent pedal pulses but normal proximal pulses in a man aged 35-50 years who smokes cigarettes may be the result of thromboangiitis obliterans (Buerger disease) . (medscape.com)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • The symptoms of brain ischemia reflect the anatomical region undergoing blood and oxygen deprivation. (wikipedia.org)
  • citation needed] Compression of blood vessels may also lead to brain ischemia, by blocking the arteries that carry oxygen to the brain. (wikipedia.org)
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • During a heart attack, blood flow in the heart is affected and heart tissue can begin to lose oxygen and die. (healthline.com)
  • Ischemia is when there is no oxygen or not, merely enough oxygen to fuel the tissue level in the body. (bartleby.com)
  • Aniline induces methemoglobinemia, which impairs the delivery of oxygen to tissues. (cdc.gov)
  • Insufficient delivery of oxygen and destruction of red blood cells may cause cardiopulmonary complaints with the development of ischemia, arrhythmia and shock. (cdc.gov)
  • Spinal Cord Ischemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Spinal Cord Ischemia" by people in Harvard Catalyst Profiles by year, and whether "Spinal Cord Ischemia" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Spinal Cord Ischemia" by people in Profiles. (harvard.edu)
  • Intranasal administration of polysulfide prevents neurodegeneration in spinal cord and rescues mice from delayed paraplegia after spinal cord ischemia. (harvard.edu)
  • Preoperative Spinal Drain Placement is Associated with Reduced Risk of Spinal Cord Ischemia in Patients Undergoing Thoracic Endovascular Aortic Repair for Aortic Dissection. (harvard.edu)
  • The main symptoms of brain ischemia involve impairments in vision, body movement, and speaking. (wikipedia.org)
  • Symptoms of brain ischemia can include unconsciousness, blindness, problems with coordination, and weakness in the body. (wikipedia.org)
  • Ischemia within the arteries branching from the internal carotid artery may result in symptoms such as blindness in one eye, weakness in one arm or leg, or weakness in one entire side of the body. (wikipedia.org)
  • Ischemia within the arteries branching from the vertebral arteries in the back of the brain may result in symptoms such as dizziness, vertigo, double vision, or weakness on both sides of the body[citation needed]. (wikipedia.org)
  • Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
  • 30%) with acute symptoms of right lower-extremity ischemia. (medscape.com)
  • In 1974, Hossmann and Zimmermann demonstrated that ischemia induced in mammalian brains for up to an hour can be at least partially recovered. (wikipedia.org)
  • In this study, we tested the hypothesis that carnosine protects against post ischemia by augmenting HIF-1α angiogenic signaling by Fe 2+ chelation. (frontiersin.org)
  • The evidence for a hypothesis for delayed ischemia based on the hypersensitivity of the mineralization process to local water content. (cdc.gov)
  • Alarmines activate the congenital immune system inducing inflammation and promoting tissue recovery [ 5 , 6 ]. (hindawi.com)
  • It can be used to evenly warm deep tissues without heating the skin. (healthline.com)
  • Ultrasound diathermy uses sound waves to treat deep tissues. (healthline.com)
  • Deep incisional SSI - infection involves deep tissues, such as facial and muscle layers. (dermnetnz.org)
  • Transient forebrain ischemia leads to delayed death of the CA1 neurons in the hippocampus. (nih.gov)
  • Immunohistochemical and biochemical investigations of Ca2+/calmodulin-dependent protein kinase II(CaM kinase II) and protein phosphatase (calcineurin) after transient forebrain ischemia demonstrated that the activity of CaM kinase II was decreased in the CA1 region of the hippocampus early (6-12 hours) after ischemia. (nih.gov)
  • Induction of transient chemical ischemia resulted in unexpectedly large Na + influx, accompanied by considerable cell swelling. (jneurosci.org)
  • METHODS AND RESULTS: In order to assess the link between infarct-related artery (IRA) occlusion, ischaemia, and apoptosis, 30 subjects dying 7-120 days after AMI (16 with IRA occlusion and 14 with patent IRA) and five control subjects were selected at autopsy. (unicatt.it)
  • Relief of ischaemia after AMI may prove of benefit in preventing apoptosis and its consequences. (unicatt.it)
  • Wounds break the continuity of the skin and allow organisms to gain access to tissues and cause infection. (dermnetnz.org)
  • Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes. (researchgate.net)
  • Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)
  • [ 1 ] Failure of CRP to return to normal signifies tissue damage in the cardiac or other tissues. (medscape.com)
  • We hypothesized that an imbalance of Ca2+/calmodulin dependent protein phosphorylation-dephosphorylation may be involved in delayed neuronal death after ischemia. (nih.gov)
  • Using tissue slices of hippocampi of mice of either sex, loaded with the Na + indicator ING2, we show that improved rapidFLIM enables quantitative, dynamic imaging of neuronal Na + signals at a full-frame temporal resolution of 0.5 Hz. (jneurosci.org)
  • Evidence of ischaemia was significantly more frequent in cases with IRA occlusion (53%) than in cases with patent IRA (15%) or control hearts (0%, P=0.026). (unicatt.it)
  • Injury to the skin and underlying tissues from acute exposure to a large external dose of radiation is referred to as cutaneous radiation injury (CRI). (cdc.gov)
  • Damage or death of the bowel tissue is a serious condition. (medlineplus.gov)
  • Damage or death of the bowel tissue may require a colostomy or ileostomy. (medlineplus.gov)
  • At the same time mucosal damage became more pronounced, suggesting a causal connection between tissue damage and radical formation. (edu.au)
  • Accordingly, this discovery raised the possibility of intervening after brain ischemia before the damage becomes irreversible. (wikipedia.org)
  • 1000 volts) exposure may, in regulating body temperature, fluid and however, cause damage to deeper tissues electrolytes. (who.int)
  • Degraded protein components that are found within TISSUES, bodily fluids, and cells under certain pathological conditions. (bvsalud.org)
  • Treating injuries with heat can increase blood flow and make connective tissue more flexible. (healthline.com)
  • Background: The healing of foot wounds in patients with diabetes mellitus is frequently complicated by critical limb threatening ischemia (neuro-ischemic diabetic foot syndrome, DFS). (mdpi.com)
  • Ischemia leads to alterations in brain metabolism, reduction in metabolic rates, and energy crisis. (wikipedia.org)
  • Cutaneous Vasculitis Cutaneous vasculitis refers to vasculitis affecting small- or medium-sized vessels in the skin and subcutaneous tissue but not the internal organs. (merckmanuals.com)
  • Different concentrations of gases can induce osmosis across sections of articular cartilage and other tissues. (cdc.gov)
  • However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. (researchgate.net)
  • Mesenchymal cell activation is the rate-limiting step of granulation tissue induction. (nature.com)
  • Friable, bleeding granulation tissue despite appropriate care and management. (dermnetnz.org)
  • We found that wild type (WT) C57BL/6 mice, subjected to hind limb ischemia (HLI) and supplemented with carnosine (1g/L) in drinking water, had improved blood flow recovery and limb function, enhanced revascularization and regeneration of myocytes compared with HLI mice placed on water alone. (frontiersin.org)
  • Concordantly in this same region, the heart's local microstructural tissue helicity is also selectively increased in exercised mice. (researchgate.net)
  • In humans, angiotensin-converting enzyme inhibitors, a potent class of antihypertensive agents, lower blood pressure at least partially by favoring enhanced kinin accumulation in plasma and target tissues. (nature.com)
  • We investigated whether a personal history of migraine is associated with vulnerability to brain ischemia in humans. (medscape.com)
  • hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
  • Patchy areas of ischemia involving the feet, especially in the presence of palpable pedal pulses, suggest the possibility of atheroembolism of plaque fragments from ulcerated, though nonocclusive, proximal atherosclerotic plaques or from thrombus lining the wall of an infrarenal aortic aneurysm (see Abdominal Aortic Aneurysm ). (medscape.com)
  • Sometimes, the only way to detect intestinal ischemia is with a surgical procedure. (medlineplus.gov)
  • Treatment of necrotizing fasciitis involves early recognition and surgical debridement of necrotic tissue, combined with high-dose broad-spectrum intravenous antibiotics. (aafp.org)