Tissue inner cell. Medical search. Frequent questions

We are interested in how animal cells and tissues generate, maintain and adapt their shape as they grow, divide and reorganize during physiological responses. (fresnel.fr)
Use this form to propose a name for biological substances to be included in products regulated under the Biologicals Framework, i.e. human and living animal cells and tissues. (tga.gov.au)

This may ultimately influence the function of tissues and organs in health and disease. (springer.com)
Cells Tissues Organs (2021) 209 (4-6): 209-214. (karger.com)
Cells Tissues Organs (2019) 207 (1): 15-20. (karger.com)
Cells Tissues Organs (2008) 188 (1-2): 139-149. (karger.com)
Cells Tissues Organs (2008) 187 (3): 186-198. (karger.com)
Bone marrow-derived stem cells Hematopoietic stem cells Adipogenesis Fibrin gel culture, 3-dimensional cultures Original Paper Cells Tissues Organs 2008;187:186 198 DOI: 10.1159/000111804 Accepted after revision: August 29, 2007. (karger.com)
Cells Tissues Organs (2005) 180 (4): 195-203. (karger.com)
Classical definitions of memory T cells derive from the belief that T cells localize and recirculate predominantly throughout the blood and secondary lymphoid organs ( 7 , 8 ). (frontiersin.org)
Today, the regrowth of Prometheus' liver has become a symbol to medical researchers for the possible renewal of damaged human organs through the use of human stem cells. (derstandard.at)
In adults, stem cells act as a repair system for the body, replenishing specialised cells, and maintaining the normal turnover of regenerative organs such as blood, skin or intestinal tissues. (derstandard.at)
39 An establishment that stores cells, tissues or organs must ensure that any of them that are untested or for which the results of tests on donor blood samples are positive or reactive for transmissible disease agents or markers or are unavailable are segregated from all other cells, tissues and organs. (gc.ca)
41 (1) A source establishment that distributes cells, tissues or organs under section 40 must keep a copy of the notice of exceptional distribution in its records. (gc.ca)
ii) if the cells, tissues or organs were imported, the establishment that imported them. (gc.ca)
2) If the establishment that receives a notice under subsection (1) is the establishment that imported the implicated cells, tissues or organs, it only has to notify the source establishment. (gc.ca)
Although the number of transplantations each year has grown rapidly over the past two decades, the demand for transplantation using human cells, tissues and organs has also increased significantly, resulting in a continuing shortage of human material, particularly organs. (who.int)
As few countries are near to being self- sufficient in the provision of cells, tissues and organs for transplantation, new ways have been sought to increase the donation of human material. (who.int)
the trafficking of tissues and organs, the Secretariat has collaborated with scientific and professional bodies that are addressing the technical and ethical issues raised by various means to increase transplantation. (who.int)
Likewise, commercial trade in cells, tissues and organs - and even trafficking involving human beings who are kidnapped or lured into other countries where they are forced to be "donors" - continues to be a serious problem, particularly in countries with substantial transplant tourism. (who.int)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)

Published today (12 May 2022) in Science , both studies explore the similarities and differences of immune cells across different tissues, which are understudied, compared to those circulating in the blood. (sanger.ac.uk)
We also review recent discoveries about ILC2 plasticity and heterogeneity in different tissues, as revealed partly through single-cell RNA sequencing of transcriptional responses to various stimuli. (broadinstitute.org)
The use of expression levels of transcription factor-encoding genes according to hierarchical anatomical classifications covering different tissues and cell types makes it possible to filter out irrelevant binding site predictions and to identify candidates of potential functional importance for further experimental testing. (lu.se)

Cell and Tissue Research presents regular articles and reviews in the areas of molecular, cell, stem cell biology and tissue engineering. (wikipedia.org)
Areas of research frequently published in Cell and Tissue Research include: neurobiology, neuroendocrinology, endocrinology, reproductive biology, skeletal and immune systems, and development. (wikipedia.org)
Autophagy (journal) Cell Biology International Cell Cycle (journal) Cell and Tissue Research - incl. (wikipedia.org)
miRNeasy Tissue/Cells Advanced Kits are intended for molecular biology applications. (qiagen.com)
The EZ2 RNA/miRNA Tissue/Cells Kit is intended for molecular biology applications. (qiagen.com)
The International Journal of Biochemistry & Cell Biology, 36, 568-584. (scirp.org)
Huang, G.T., Gronthos, S. and Shi, S. (2009) Mesenchymal stem cells derived from dental tissues vs. those from other sources: Their biology and role in regenerative medicine. (scirp.org)
Cell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. (selectscience.net)
The cells derived from these tissues constitute a model system for studying the brain cell biology of these disorders, according to Gage. (salk.edu)
Tissue engineering is an interdisciplinary field that involves mainly medical area, biology and engineering. (bvsalud.org)
Additional investigation of the role of mast cells during arthroplasty failure is warranted, providing a better understanding of underlying biology and informing potential diagnostic and treatment targets. (bvsalud.org)

In breast cancer, we know that the cancer is embedded in very fatty tissue, because the breast is made up largely of adipose tissue. (newsweek.com)
As a person becomes obese, that can change the adipose tissue, or change this microenvironment where the cancer can start or progress. (newsweek.com)
The cellular character of the adipose tissue of 21 nonobese and 78 obese patients has been examined. (jci.org)

Previous work has shown that gradients or asymmetries in biochemical signals at the cell and tissue level can serve as instructive cues to pattern force generation. (nature.com)
Thus, acting on ion channels in the plasma membrane, mechanical stress can elicit a multitude of biochemical processes - both transient and long-lasting - inside a cell. (springer.com)
Our lab pursues a strongly interdisciplinary approach that bridges the molecular, cellular and tissue scales, combining genetics, biochemical and cell biological approaches with cutting-edge biophysical and live imaging approaches developed in the MOSAIC group. (fresnel.fr)
Based on this suggested technique, we developed a bioprinted 3D esophageal structure with multi-layered features and converged with biochemical microenvironmental cues of esophageal tissue by using decellularizedbioinks from mucosal and muscular layers of native esophageal tissues. (nature.com)
In vitro examinations showed the effectiveness of laminin for hard tissue formation from the results of biochemical and immunochemical analysis. (scirp.org)

Forces that shape cells and tissues can be produced by the contraction of actin filament (F-actin) meshworks by the molecular motor Myosin II (myosin). (nature.com)
These systems demonstrate how molecular signals can polarize the actomyosin cytoskeleton and its upstream regulators, directing force generation across a tissue. (nature.com)
The topics are discussed in a form of review articles, written by leading researchers who study the mechanosensitivity process at the molecular, cellular, tissue and whole organ levels. (springer.com)
They have developed a method that can differentiate between the active motions characteristic of living cells and those driven by the random molecular movements that give rise to passive diffusion. (genengnews.com)
Caplan, A.I. and Bruder, S.P. (2001) Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century. (scirp.org)
The interdependence of these cell types is currently poorly understood, and the nature, function and molecular basis of underlying heterologous cell-cell interactions are mostly unclear. (uni-saarland.de)
Using a molecular-biological trick, the investigators induced an overproduction of Tlx by the brain stem cells of mice. (dkfz.de)

of graft-versus-host disease, which is observed as a major complication of hematopoietic stem cell transplantation. (karger.com)
The other preserves the cord tissue mostly as-is and leaves any sort of processing until after the cord tissue has been retrieved and is being prepared for transplantation. (cryo-cell.com)
But we realized that cell transplantation may not always be suitable for catastrophic events, such as a heart attack in which there is major myocardial damage. (derstandard.at)
These new transplantation systems enhance the viability of cells and stimulate their outward migration so that they can populate and help regenerate injured tissues. (derstandard.at)

Researchers have explored combinations of biomaterials, cells, and bioactive factors, using them to generate new cartilage and bone tissue in vitro and in vivo . (corning.com)
Rebar N. Mohammed Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. (karger.com)
A study is being highlighted by some in the cord blood-banking industry about a technique in development that uses cord tissue to repair a specific type of cleft lip and palate caused by bone material that has not properly fused together. (cryo-cell.com)
While the cause of cleft lip and cleft palate are not completely known, it can occur when the bone of the gum ridge or front portion of the roof of the mouth fails to form properly and prevents the skin tissue from coming together. (cryo-cell.com)
A newer technique uses stem cells from the bone marrow and a scaffolding material to form the base of the affected area. (cryo-cell.com)
As cord tissue is a gelatinous tissue (opposed to the liquid bone marrow), it will be possible to construct the bone area without scaffolding, and as clefts are formed early in pregnancy and can be diagnosed during ultrasounds, it is possible for families to collect and store their babies cord tissue easily at the time of birth in preparation for the procedure. (cryo-cell.com)
Researchers are also hopeful that cord tissue will enhance bone growth and accelerate healing over the other methods. (cryo-cell.com)
Several technologies have been described over the past 10 years to create functional heart tissue by using stem cells that have been isolated from other tissues such as bone marrow, skeletal muscle, and umbilical cord blood. (derstandard.at)
The effect of laminin on hard tissue formation using rat bone marrow cells was assessed. (scirp.org)
Rat bone marrow cells were obtained from femora of 6-week-old male Fischer 344 rats. (scirp.org)
Rat bone marrow cells in 200 m l culture medium at 1 × 10 6 cells/ml were seeded in the scaffolds. (scirp.org)
For i n vitro examinations, 1 × 10 5 rat bone marrow cells in 2 ml culture medium were then cultured with the addition of dexamethasone and laminin. (scirp.org)
Rat bone marrow cells were also cultured in laminin-coated culture plates. (scirp.org)
It is concluded that laminin is useful for bone formation, as in an in vitro culture study using bone marrow cells, in hydroxyapatite scaffolds in vivo . (scirp.org)
Yoshikawa, M. , Kakigi, H. , Yabuuchi, T. and Hayashi, H. (2014) Effects of laminin on hard tissue formation by bone marrow cells in vivo and in vitro . (scirp.org)
Derubeis, A.R. and Cancedda, R. (2004) Bone marrow stromal cells (BMSCs) in bone engineering: Limitations and recent advances. (scirp.org)
The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)
The only cure for CGD is a bone marrow or stem cell transplant. (medlineplus.gov)

Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)

In addition, autologous CSCs can be employed without the ethical and immunological problems associated with the use of embryonic stem cells. (derstandard.at)
Different experimental strategies and approaches to obtain mature hair follicles have been designed based upon current knowledge of the epithelial and dermal cells involved in embryonic hair generation and adult hair cycling, and in the epithelial-mesenchymal interactions among them. (wjgnet.com)
In his New York State supported stem cell program (N09G-302), he is examining embryonic stem (ES) cells to model and replace diseased human retinal cells. (researchandmarkets.com)
TS-REX was applied to predict regulators of Polycomb group genes in six human tumor tissues and in human embryonic stem cells. (lu.se)

42 A source establishment that distributes a cell, tissue or organ under section 40 before the donor suitability assessment is complete must, after the distribution, complete the assessment, carry out any other appropriate follow-up testing and notify the relevant transplant establishment of the results. (gc.ca)
Surgeons usually use ectopic conduit tissues including stomach and intestine, presumably inducing donor site morbidity and severe complications. (nature.com)
However, for humans, postnatal tissue would be the preferred donor source. (ca.gov)
A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)

One uses enzymatic digestion before the cryo-preservation process to isolate the stem cells. (cryo-cell.com)
An oversimplified system like cells in petri dishes doesn't mimic what happens in the body, while in an animal model, it's difficult to isolate and study parameters that govern the invasiveness of a cell," said Betty Li , a senior Institute of Biomedical Engineering PhD student and lead author of the paper. (utoronto.ca)
An outbreak of an unidentified rash illness in humans, associated with sick prairie dogs, occurred in the upper midwestern United States in 2003, and EM detected a poxvirus from a cell culture isolate, which was later characterized as monkeypox virus ( 7 , 8 ). (cdc.gov)

In order to distinguish between KA and SCC, further histologic studies can be used, including proliferating-cell nuclear antigen immunostaining. (medscape.com)
[ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
In contrast, cells within an SCC that stain positive with proliferating-cell nuclear antigen immunostaining are more diffusely distributed. (medscape.com)

Engineering cartilage has typically involved 'encapsulating chondrocytes, or stem cells which can be differentiated along a chondrogenic linage, in a supportive matrix such as a hydrogel or scaffold,' Advanced Healthcare Materials explains. (corning.com)
ideally, the scaffold eventually is replaced by biological tissue. (corning.com)
The mesh acted as a scaffold on which the stems cells were grown into morphologically recognizable cardiac tissue. (derstandard.at)
We then joined the cardiac tissue built from the mesh scaffold onto the diseased structure of the heart to stimulate the regeneration of the optimal cell types for that particular portion of the heart. (derstandard.at)
Conclusion: Colon can form from human progenitor cells on a scaffold in a mouse host. (ca.gov)

As with all tumors, whether benign or malignant, identification of the cell or cell layer of origin is of the utmost importance. (medscape.com)
We present the largest case series to date comprising 50 patients with benign and atypical soft tissue granular cell tumors in an effort to better define the pathologic features in this subset of lesions. (medscape.com)
As with all tumors, whether benign or malignant, the paradigm of comprehension depends on identifying the cell or cell layer of origin. (medscape.com)
On the other hand, clear cell acanthoma is a rare, benign epithelial cutaneous tumor. (medscape.com)
This presence of melanin provides pigmentation to the benign tumor, and this occurrence has been termed pigmented clear cell acanthoma. (medscape.com)
This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)
Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)

Intriguingly, this process coincides with partitioning of both Langerhans cells and dendritic epidermal T-cells to interscale epidermis, suggesting functional segregation of pigmentation and immune surveillance. (uni-saarland.de)

The EZ2 RNA/miRNA Tissue/Cells Kit makes it easy and safe to purify total RNA - including miRNA and other small RNA - from cultured cells and various human or animal tissues. (qiagen.com)
To enable tissue renewal, human tissues constantly eliminate millions of cells, without jeopardizing tissue integrity, form and connectivity. (pasteur.fr)
Human epithelia are tissues found in several parts of the body (such as the epidermis and internal mucosa). (pasteur.fr)
The same protective mechanism based on local EGFR-ERK activation was discovered independently in human cell lines by the research group led by Olivier Pertz at the University of Bern in Switzerland (the results are published in the same journal 2 ). (pasteur.fr)
TRI Reagent ® performs well with large or small amounts of tissue or cells and works with many samples including human, plant, yeast, bacterial and viral samples. (sigmaaldrich.com)
Treatment of human Hep G2 cells with 1 ng/ml TNF-alpha increased [14C]putrescine cross-linking to cellular proteins. (nih.gov)
Hep G2 cells, transiently transfected with a luciferase reporter containing 1.67 kb of the human tTG promoter, showed an increase in reporter activity after addition of TNF-alpha. (nih.gov)
Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)
The question for us at University of Rome "Sapienza" in Italy is: Why not use stem cells to repair the human heart? (derstandard.at)
Two new papers from the Human Cell Atlas shed new light on the types and traits of immune cells that can be found in the human body, from developmental stages to adulthood. (sanger.ac.uk)
Two new papers from the Wellcome Sanger Institute, the University of Cambridge and collaborators have created open-access atlases of the immune cells in the human body. (sanger.ac.uk)
These studies are part of the international Human Cell Atlas (HCA) consortium , which is aiming to map every cell type in the human body as a basis for both understanding human health and for diagnosing, monitoring, and treating disease. (sanger.ac.uk)
The complementary studies shed light on health and disease, and will contribute towards a single Human Cell Atlas. (sanger.ac.uk)
The human immune system is made up of many different types of cells that can be found throughout the body, all playing crucial roles. (sanger.ac.uk)
The team used data from the other Human Cell Atlas study** to prove that these particular immune cells are not found in adults. (sanger.ac.uk)
This comprehensive atlas of human immune development reveals tissues involved in the formation of blood and immune cells, enhancing our understanding of immune and blood disorders. (sanger.ac.uk)
We have created a catalogue of immune cells within the adult human body, allowing us to automatically identify cell types across multiple tissues. (sanger.ac.uk)
Guidance for Industry: Use of Nucleic Acid Tests to Reduce the Risk of Transmission of West Nile Virus from Living Donors of Human Cells, Tissues, and Cellular and Tissue-Based Product s (HCT/Ps) , dated 9/2016. (fda.gov)
Human esophageal tissue consists of the mucosa, submucosa, and muscular layers. (nature.com)
2009) Progestin and thrombin regulate tissue factor expression in human term decidual cells. (scirp.org)
Ethics of Gene Editing in Human Stem Cells 9. (researchandmarkets.com)
Project preparation includes setting up facilities and approvals for work with human DIAS cells, identifying sources and acquiring human skin for DIAS cell isolation, and hiring and training personnel. (ca.gov)
Scientific progress includes a publication on co-cultures using stem cells, work on culturing larger numbers of cells using low oxygen tension, comparing stem cells from human skin of different anatomical locations, and gaining an understanding of the niches where skin stem cells may reside. (ca.gov)
The project now has a consistent source of human dermis tissue from which stem cells can be isolated. (ca.gov)
Spherical culture of human skin-derived stem cells has been performed. (ca.gov)
Since much of the prior work on directing stem cells from the skin to form neocartilage has been done using animal-derived stem cells, in the next project period neocartilage will be formed using human stem cells instead. (ca.gov)
Comparing animal skin and human skin showed notable differences, including morphology, response to enzymatic digestion, and the rate at which cells attach to tissue culture plastic. (ca.gov)
As a result, protocols that successfully yielded DIAS cells using animal models could not be directly applied to isolating DIAS cells from human skin. (ca.gov)
During the first six months of this reporting period, human DIAS cells were isolated and used to engineer neocartilage. (ca.gov)
Characterizing the human DIAS cell population showed that cells shared similar characteristics with stem and progenitor cells previously identified by other groups as originating from various niches of the skin. (ca.gov)
Neocartilage constructs generated from human DIAS cells also contained five times higher compressive modulus and close to twice the tensile modulus of constructs generated using sheep DIAS cells. (ca.gov)
For the scaling-up of constructs to be used in an athymic mouse study, an experiment was conducted to finalize our protocol for generating human DIAS cell constructs, using what have been learned both from Milestone 1 and also from literature sources. (ca.gov)
A group of researchers from the University of Toronto has developed a credit-card sized tool for growing cancer cells outside the human body, which they believe will enhance their understanding of breast cancer metastasis. (utoronto.ca)
The device, described in a paper published on July 15 in Science Advances , reproduces various environments within the human body where breast cancer cells live. (utoronto.ca)
Human memory B cells and marginal zone (MZ) B cells share common features such as the expression of CD27 and somatic mutations in their IGHV and BCL6 genes, but the relationship between them is controversial. (lu.se)
Human tissue-engineered colon forms from postnatal progenitor cells: an in vivo murine model. (ca.gov)
In previous work, human fetal intestinal cells developed epithelium without mesenchyme following implantation in mice. (ca.gov)
We generated tissue-engineered colon (TEC) from postnatal human organoid units. (ca.gov)
Immunofluorescence staining confirmed human origin, identified differentiated epithelial cell types and verified the presence of supporting mesenchyme. (ca.gov)
Immunofluorescence staining demonstrated human origin and the three differentiated cell types of mature colon epithelium. (ca.gov)
La Jolla, CA - Salk Institute scientists have isolated cells from the brains of human cadavers that can grow, divide and form specialized classes of brain cells. (salk.edu)
The study was done in collaboration with Phillip Schwartz and Stuart Stein at Children's Hospital of Orange County, Calif. The study, titled "Progenitor cells grown from postmortem human brain," was supported by the National Institutes of Health, the National Institute of Aging, the Lookout Fund and the Christopher Reeves Paralysis Foundation. (salk.edu)

Such tumor-specific T RM cells are recognized as both necessary and sufficient for long-lived protection against tumors in peripheral tissue locations. (frontiersin.org)
Cancer can be considered a disease of immune dysfunction, with a failure of immune recognition leading to the outgrowth of malignant cells as tumors ( 1 ). (frontiersin.org)
Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown for the first time that malignant brain tumors arise directly from brain stem cells. (dkfz.de)
Overproduction of Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. (dkfz.de)
Objectives Granular cell tumors are rare neoplasms of neural origin. (medscape.com)
Despite the mesenchymal nature of these tumors, they rarely occur in the soft tissue, and as a result, this subset is not well characterized. (medscape.com)
Methods All cases of soft tissue granular cell tumors from the Ohio State Medical Center and the Medical College of Wisconsin over a 10-year period were reviewed for histologic and clinical findings. (medscape.com)
Conclusions Compared with granular cell tumors overall, the soft tissue subset shows a larger average size and higher propensity for incomplete resections, with atypical features being relatively common. (medscape.com)
Our findings suggest that soft tissue granular cell tumors may be slightly more aggressive than their dermal or organ-confined counterparts. (medscape.com)
Granular cell tumors (GCTs) are rare lesions believed to be of neural origin. (medscape.com)
GCTs of the soft tissue are rare and not well characterized, representing only 0.5% of all soft tissue tumors. (medscape.com)
Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)

Pioneering tissue engineering studies used traditional 2D substrates, but in recent years, research has focused on the development of biomimetic 3D scaffolds and cell culture platforms to repair and regenerate osteoarthritis' osteochondral defects, according to Bio-Design and Manufacturing . (corning.com)
From the in vivo examination, laminin coating of the scaffolds induced hard tissue in the pores with the cells. (scirp.org)
MSCs have great therapeutic potential in tissue engineering, they can be expanded in vitro, and combined with scaffolds they can be inserted into wounds to promote healing and tissue replacement. (bvsalud.org)
tissue scaffolds. (bvsalud.org)

The mechanisms that regulate the ability of epithelia to maintain their integrity in contexts involving large numbers of eliminated cells remain poorly understood, despite the fact that this situation occurs regularly during embryogenesis or the maintenance of adult tissues. (pasteur.fr)
For example, more than ten billion cells can be eliminated every day in an adult intestine. (pasteur.fr)
This means that CSCs represent a logical source for cardiac regeneration therapy because, unlike other adult stem cells, they are intrinsically programmed to generate cardiac tissue in the lab and thus increase cardiac tissue viability in humans. (derstandard.at)
The other study looks at immune cells in multiple tissues from adult individuals, providing a framework for prediction of cell type identity and insights into immunological memory. (sanger.ac.uk)
In the second study **, scientists from the Wellcome Sanger Institute, the University of Cambridge, and their collaborators simultaneously analysed immune cells across 16 tissues from 12 individual adult organ donors. (sanger.ac.uk)
The therapy would consist of using a skin biopsy to harvest dermis-isolated, adult stem cells (DIAS cells), which will undergo processing to yield neocartilage. (ca.gov)
In the adult brain, the Tlx protein is responsible for generating new neurons from tissue stem cells. (dkfz.de)
In the adult animal, Tlx is expressed exclusively in brain stem cells. (dkfz.de)
Previous attempts to recover progenitor cells from adult tissue had failed, but the Gage laboratory applied growth factors to extracted tissue that appear to have made a crucial difference. (salk.edu)
In addition to isolating single cells in order to determine if true stem cells are present in adult brain tissue, Gage also plans to transplant recovered cells into animals to test if the cells can survive and differentiate in vivo. (salk.edu)
Testing in whole animals is the only way to know if adult tissue can be a source of stem or progenitor cells for transplant purposes to treat neurodegenerative disease," said Gage. (salk.edu)
An adult source of stem cells would circumvent the need to derive such cells from fetal tissue, currently an issue of ethical debate. (salk.edu)

The technology can mimic cartilage's natural mechanical properties, and it can be bioprinted to engineer 3D structures with cells along gradients and more complex biological cues. (corning.com)
These observations are important as they illustrate the incredible self-organizing ability of biological tissues, a property that enables them to withstand stressful conditions. (pasteur.fr)
Barry, F.P. and Murphy, J.M. (2004) Mesenchymal stem cells: Clinical applications and biological characterization. (scirp.org)
The Biologicals Framework covers blood, blood components, tissue & cellular products, tissue & cell based derivatives and other emerging biological therapies. (tga.gov.au)

In addition, a discussion of the clinical implications, as a result of the latest developments in research in tissue and organ mechanosensitivity will provide valuable insights for clinicians, whilst pharmacological and pharmacokinetics focused reviews, will be of particular interest to researchers, searching for targets for new drugs and therapies. (springer.com)
The Cell and Tissue Imaging Center is a fully staffed microscopy core facility available to all St. Jude researchers. (stjude.org)
But medical researchers hope to be able to use technologies derived from stem cell research to treat a much wider variety of diseases. (derstandard.at)
Using this technique in animals, the researchers have observed an increase in physiological functions such as the cardiac ejection fraction - a measure of the efficacy of the heart's contraction - and an improvement of cardiac chamber volumes following the placement of these tissue structures on the surface of the animal's damaged hearts. (derstandard.at)
Researchers were able to identify a new type of B cell, and distinctive T cells that appear in the early stages of life. (sanger.ac.uk)
Using CellTypist and further in-depth analysis, the researchers created a cross-tissue immune cell atlas that revealed the relationship between immune cells in one tissue and their counterparts in others. (sanger.ac.uk)
A study by researchers at the University of North Carolina Lineberger Comprehensive Cancer Center found cancer cells grow more rapidly in "fatty, obese tissue," particularly cells that cause breast cancer. (newsweek.com)
In the paper, the researchers describe how they used a collagen matrix coated with a layer of basal membrane extract to mimic the structure of the breast tissue seen by breast cancer cells during the first step of metastasis. (utoronto.ca)
By placing cancer cells outside of these tissue mimics, researchers could observe the invasion process in detail, including measurements of speed and location. (utoronto.ca)
The research team at the Department of Biosciences and Nutrition at Karolinska Institutet's campus in Huddinge, led by Marco Gerling and Rune Toftgård, has been working alongside researchers in Holland looking at the possibility of influencing cell growth in colon cancer by altering hedgehog signalling. (medicalxpress.com)
In view of the fact that tumours consist of different types of cells apart from the cancer cells themselves, the researchers used various databases to analyse gene expression in colon cancer. (medicalxpress.com)
To investigate the importance of the hedgehog signalling from cancer cells to connective tissue cells , the researchers used a mouse model in which the signalling pathway could be switched on specifically in the connective tissue cells . (medicalxpress.com)
The researchers were able to show that the connective tissue cells with activated hedgehog signalling change their gene expression and send a signal back to the tumour cells, inhibiting the development and growth of tumours. (medicalxpress.com)
The results show that non-cancerous cells in tumours have a great capacity to influence how tumours develop," says Marco Gerling, one of the researchers. (medicalxpress.com)

Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. (nih.gov)

Through medical research, stem cells can now be grown and transformed into a variety of specialised cells with characteristics consistent with tissues such as muscles or nerves. (derstandard.at)
Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. (selectscience.net)

Understanding the tissue-specific pathways that regulate ILC2 diversity and function is a critical step in the development of potential therapies for allergic diseases. (broadinstitute.org)

In the long term we hope to be able to provide a detailed explanation of how the activation of hedgehog signalling in the cells surrounding the tumour can prevent the growth of tumours and to use this knowledge to develop new types of treatment that can restrain the development of cancer. (medicalxpress.com)

While a great deal of effort has focused on defining their role in immunity to infections, studies now reveal T RM cells as a vital component of the host immune response to cancer. (frontiersin.org)
Tumor development has been said to occur in three distinct steps: inefficient elimination of early transformed cells, development of a state of equilibrium between tumor cells and immune cells, and tumor escape from immune pressure ( 2 ). (frontiersin.org)
While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
The recent success of T cell immune checkpoint inhibitor (ICI) therapies for cancer has revealed CD8 T cells as potent mediators of immunity against advanced cancers ( 4 , 5 ). (frontiersin.org)
The cost of surgery and the time of hospitalization would be reduced, and the standard use of life-long immune suppression medications would be unnecessary in the case of an engineered myocardium using a patient's own tissue. (derstandard.at)
Previously underexplored immune cell populations have been mapped across multiple tissues in development and adulthood to provide new insights into how our immune system works. (sanger.ac.uk)
One study focuses on the early development of the immune system and the localisation of immune cells across several tissues. (sanger.ac.uk)
Knowing more about immune cell traits and reactions in these tissues at different stages of life could help future research into therapies that aim to produce or enhance an immune response to fight disease, such as vaccinations or anti-cancer treatments. (sanger.ac.uk)
In cooperation with the other studies it enables mapping of the immune system from development to adulthood, revealing cell types that are lost as we grow up. (sanger.ac.uk)
The team developed a database and algorithm that automatically classifies different cell types, called CellTypist, to handle the large volume and variation of immune cells. (sanger.ac.uk)
They found similarities across certain families of immune cells, such as macrophages, as well as differences in others. (sanger.ac.uk)
By using single-cell sequencing data we have been able to reveal around a hundred different kinds of immune cells including macrophages, B cells, and T cells, uncovering crucial information about how the immune system works. (sanger.ac.uk)
Ability to visualize multiple targets simultaneously is important in cancer immunology research, where it is necessary to catalog subsets of immune and cancer cells within the tumor microenvironment. (cellsignal.com)
Next to keratinocytes (the main epithelial cell type of the skin), the epidermis hosts melanocytes for skin pigmentation and resident immune cells as first-line host defense. (uni-saarland.de)
Analysis of non-pigmented mice and of mice lacking melanocytes or resident immune cells revealed that immunocyte patterning is melanocyte- and melanin-independent, and, vice versa, immune cells do not control melanocyte localization. (uni-saarland.de)
Instead, genetically enforced progressive scale fusion upon Lrig1 deletion showed that melanocytes and immune cells dynamically follow epithelial scale:interscale patterns. (uni-saarland.de)
While preliminary, these findings provide evidence for a role of mast cells in the immune response in PJI. (bvsalud.org)
Chronic granulomatous disease (CGD) is an inherited disorder in which certain immune system cells do not function properly. (medlineplus.gov)
In CGD, immune system cells called phagocytes are unable to kill some types of bacteria and fungi. (medlineplus.gov)

The esophageal tissue refers to the hollow organ between the oropharynx and the stomach, which allows food to pass to the stomach through peristalsis. (nature.com)

Many types of cancer are caused by gene mutations in the signalling pathways that control cell growth, such as the hedgehog signalling pathway. (medicalxpress.com)

and recall of stored tissues from donors found after donation to have been infected. (cdc.gov)

How epithelial cells actively respond to mechanical constraints by adjusting how they generate force is important to understand tissue morphogenesis. (nature.com)
The persistence of such responses is fundamentally thought to be based on the ability of T cells to act as potent effectors and, subsequently, generate long-lived memory ( 6 ). (frontiersin.org)

Stem cell therapies already exist in medical practice. (derstandard.at)
No long-term solutions exist for cartilage degeneration, but cellular therapies hold promise toward replacing degenerated cartilage with healthy tissue. (ca.gov)
Toward developing a long-term solution for this vexing problem, cellular therapies hold the promise of replacing degenerated cartilage with healthy tissue. (ca.gov)

In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
Both populations disseminate widely between distant lymphoid tissues and blood, and both diversify their IGHV repertoire in gut germinal centres (GC), but nevertheless remain largely. (lu.se)

The two types of esophageal tissue derived-decellularized extracellular matrix bioinks can mimic the inherent components and composition of original tissues with layer specificity. (nature.com)
TS-REX covers ESTs from H. sapiens and M. musculus, and allows the characterization of both presence and specificity of transcription factors in user-specified tissues or cell types. (lu.se)

The internalized ventral cells give rise to the mesoderm that differentiates into muscle and other internal cell types such as the fat body, macrophages or lymph glands. (nature.com)
This is true even for difficult tissue types such as fibrous tissue (e.g., muscle) or fatty tissue (e.g., brain) (see Comparable miRNA recovery. Total RNA, including small RNA, was isolated from 10 mg stabilized rat tissue (brain, kidney and liver) using the EZ2 RNA/miRNA Tissue/Cell Kit and the miRNeasy Tissue/Cells Advanced Mini Kit (red bars). Four microliters of recovered RNA in a total volume of 20 µl was used for miRNA detection on the miR16. The two kits show comparable performance, even for difficult tissue types like muscle or brain. "> Comparable miRNA recovery ). (qiagen.com)
The LMU team analyzed the motions of two types of hair-like cell protrusions made up of proteinaceous filaments-the so-called flagella found on the unicellular green alga Chlamydomonas reinhardtii and the primary cilium found on many epithelial tissues in multicellular organisms. (genengnews.com)
Stem cells are characterised by their unique ability to constantly renew themselves and differentiate into a diverse range of other specialised cell types. (derstandard.at)
But the benefits using these types of stem cells have ranged from marginal, to transient, to nil. (derstandard.at)
Through this, they were able to identify around 100 distinct cell types. (sanger.ac.uk)
We recently delineated a cellular hierarchy among epidermal cell types that determines skin patterning. (uni-saarland.de)
Mutations that lead to the activation of hedgehog signalling are the cause of almost all cases of basal cell carcinoma (a common form of skin cancer) and certain types of brain tumours . (medicalxpress.com)
Importantly, the recovered cells had the ability to differentiate into different types of brain cells. (salk.edu)
Dissociating cells from specific tissue types requires specific parameters for tissue agitation to obtain a high volume of viable, culturable cells. (jove.com)
However, when applying this concept to genomes of multicellular organisms such as mammals, one has to deal with a large number of false positive predictions since many transcription factor genes are only expressed in specific tissues or cell types. (lu.se)
As a result of being capable of differentiating into a variety of cell types, it can be presumed that stem cell therapy has an advantage when compared to other tissue repair methods. (bvsalud.org)

Our work aims at providing insights into (1) the interplay between the dynamic organization of cytoskeletal filaments and cell shape changes, and (2) the reciprocal links between tissue growth, morphogenesis and tissue mechanics. (fresnel.fr)

Pittenger, M.F. and Martin, B.J. (2004) Mesenchymal stem cells and their potential as cardiac therapeutics. (scirp.org)

Genomic DNA removal is likewise comparable to manual column-based purification (see Efficient mRNA recovery and gDNA removal. Total RNA was purified from 10 mg stabilized rat tissues (brain, kidney, liver and heart) using the EZ2 RNA/miRNA Tissue/Cell Kit and the miRNeasy Tissue/Cells Advanced Mini Kit. Real-time RT-PCR for pgk1 was performed with or without reverse transcriptase. Both kits show comparable mRNA recovery and good gDNA removal. "> Efficient mRNA recovery and gDNA removal ). (qiagen.com)
Digital PCR analysis shows higher RNA concentration in samples processed with the EZ2 RNA/miRNA Tissue/Cells Kit (see Higher RNA concentration. Total RNA was purified from stabilized rat tissues (brain, 10 mg; kidney, 10 mg; heart, 10 mg; pancreas, 5 mg; and liver, 5 mg) using the EZ2 RNA/miRNA Tissue/Cell Kit and a manual column-based system. Digital PCR was performed. Greater RNA concentration was consistently observed in samples purified with the EZ2 RNA/miRNA Tissue/Cell Kit. "> Higher RNA concentration ). (qiagen.com)
To further study the role of tTG in liver disease, we initiated investigations into the effect of a proinflammatory mediator, tumor necrosis factor (TNF)-alpha, on tTG activity in cultured liver cells. (nih.gov)

One of several postulated roles for tissue transglutaminase (tTG) is the stabilization and assembly of extracellular matrix via peptide cross-linking. (nih.gov)
Electrospinning was considered a promising technology because it can recapitulate microstructures mimicking the environment of the extracellular matrix (ECM) in native tissue. (nature.com)
During abruptions, decidual cell and neutrophil-derived proteases effectively degrade the decidual and fetal membrane extracellular matrix to promote preterm premature rupture of the membranes and preterm delivery (PTD). (scirp.org)
these are cartilage extracellular matrix component important in imparting mechanical function to the tissue. (ca.gov)
Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. (selectscience.net)
Mast cell activation was evidenced by the release of tryptase into the extracellular space surrounding mast cells . (bvsalud.org)

Type 2 innate lymphoid cells in the induction and resolution of tissue inflammation. (broadinstitute.org)
Recent research has shown that type 2 innate lymphoid cells (ILC2s) contribute to steady-state tissue integrity and exert tissue-specific functions. (broadinstitute.org)

The resulting infiltration of tissues by the leukocytes, plasma proteins, and fluid causes the redness, swelling, and pain that are characteristic of inflammation. (medscape.com)

KA lesions can easily be mistaken for squamous cell carcinoma (SCC). (medscape.com)
As a result, cell division activity in the subventricular zone increased, the cells left their habitual environment called stem cell niche, and started forming glioblastoma-like tissue lesions. (dkfz.de)
Case reports in the literature report clear cell acanthomas with multiple lesions, (ie, polypoid clear cell acanthoma). (medscape.com)

The scientists observed that when the mechanism is deactivated, the simultaneous elimination of several neighboring cells compromises tissue integrity. (pasteur.fr)
The scientists' research also shows that inhibiting this protective mechanism has a drastic effect on epithelial tissue: cell elimination becomes random and neighboring cells can be eliminated simultaneously, leading to repeated losses of connectivity. (pasteur.fr)
By using a new optogenetic tool that can control cell death in time and space and bypass the protective mechanism, the scientists confirmed that epithelial integrity was compromised when neighboring cells were eliminated simultaneously. (pasteur.fr)

Key mesenchymal components (smooth muscle, intestinal subepithelial myofibroblasts and ganglion cells) were seen. (ca.gov)

The disorder tends to affect arteries containing elastic tissue, most often the temporal, cranial, or other carotid system arteries. (msdmanuals.com)

We use a variety of model systems ranging from biomimetic systems (in vitro reconstitution of cytoskeleton using purified components) to single cells and developing Drosophila tissues. (fresnel.fr)

We're interested in something called the 'microenvironment,' which is basically cells around the tumor and the chemicals those cells produce," Liza Makowski, a UNC Lineberger member and associate professor in the UNC Gillings School of Global Public Health, said in a statement released Friday. (newsweek.com)

In contrast, the hedgehog signalling pathway and expression of its target genes are specifically activated in the surrounding cells of the connective tissue. (medicalxpress.com)
When mice were treated with substances that induce colon cancer , the mice with activated hedgehog signalling in the connective tissues developed significantly fewer tumours than those with a normal hedgehog function. (medicalxpress.com)

There are a couple of different processing methods for cord tissue banking. (cryo-cell.com)
Cell culture methods are relatively unbiased, restricted only by the ability of the virus to grow in a particular cell line. (cdc.gov)

For phenol-free purification of micro RNA and total RNA from tissues and cells, including small samples. (qiagen.com)

These early classifications of T cell memory were quickly brought to bear on the question of what T cell subset provides the best immunity against cancer. (frontiersin.org)

During Drosophila gastrulation, actomyosin contraction in ventral cells generates a long, narrow epithelial furrow, termed the ventral furrow, in which actomyosin fibres and tension are directed along the length of the furrow. (nature.com)
In the Drosophila thorax, opposing gradients of Dachsous and Four-jointed expression, which are constituents of the Fat/Dachsous/Four-jointed planar cell polarity pathway, result in the polarized localization of the myosin Dachs 9 . (nature.com)
In the Drosophila embryo, apical constriction in a strip of epithelial cells along the ventral midline results in the folding of the tissue and the internalization of ventral cells, forming a ventral furrow (VF). (nature.com)

Whether this responsiveness to external force and geometry is important to orient force generation during the development of a tissue is poorly understood. (nature.com)

38 An establishment that stores tissues must ensure that those that are intended for autologous use are segregated from those intended for allogeneic use. (gc.ca)

Now, potential engineered-tissue cartilage products are beginning to be formed through biofabrication. (corning.com)
This Development Candidate Feasibility Award is a first step toward the overall goal of developing a cell-based cartilage repair therapy using stem cells derived from the skin. (ca.gov)

Mononuclear cell infiltrates in the adventitia form granulomas containing activated T cells and macrophages. (msdmanuals.com)

Vero E6 cells, considered one of the most permissive of all cell lines, provide an extremely versatile medium for recovery of unknown pathogens. (cdc.gov)

The EZ2 RNA/miRNA Tissue/Cells protocol isolates a similar amount of total RNA, including small RNA, to manual column-based protocols. (qiagen.com)
The EZ2 RNA/miRNA Tissue/Cells protocol uses manual lysis in Buffer RLT protect the RNA molecules. (qiagen.com)
RNase-free water and Proteinase K are then added, and the mixture is incubated for 10 minutes at room temperature (see EZ2 RNA/miRNA Tissue/Cells workflow. Disrupt and homogenize the sample. Lyse with Proteinase K. Transfer sample to the EZ2 Connect instrument. Start the run. When the run is finished, retrieve purified RNA or miRNA elute. "> EZ2 RNA/miRNA Tissue/Cells workflow ). (qiagen.com)
Once the run is finished, purified RNA or miRNA will be ready for downstream applications (see EZ2 RNA/miRNA Tissue/Cells workflow. Disrupt and homogenize the sample. Lyse with Proteinase K. Transfer sample to the EZ2 Connect instrument. Start the run. When the run is finished, retrieve purified RNA or miRNA elute. "> EZ2 RNA/miRNA Tissue/Cells workflow ). (qiagen.com)

The investigators obtained postmortem or biopsy tissue from 23 individuals, ranging in age from 11 weeks to 72 years old. (salk.edu)
The study employed postmortem and biopsy tissue from individuals with a number of neurological disorders including epilepsy and myofibromatosis. (salk.edu)

Resident memory (T RM ) cells are a distinct tissue-localized T cell lineage that is crucial for protective immunity in peripheral tissues. (frontiersin.org)
Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
whereas T EM cells were shown to recirculate predominantly through blood, and peripheral tissues ( 10 ). (frontiersin.org)

Title : Tissue cultures of KB epithelial cells for poliomyelitis virus tests Personal Author(s) : Luoto, Lauri;Pickens, Edgar G. (cdc.gov)

Together, our in vivo and in silico data provide a framework for understanding how cells orient force generation, establishing a role for geometrical and mechanical patterning of force production in tissues. (nature.com)

Anatomy58

Organisms13

Diseases8

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Psychiatry and Psychology1

Phenomena and Processes57

Disciplines and Occupations2

Information Science3

Animal cells and tissues2

Organs23

Different tissues3

Biology11

Adipose tissue3

Biochemical5

Molecular7

Transplantation4

Bone19

Dental tissues2

Embryonic4

Donor4

Isolate3

Proliferating-cell nu3

Scaffold5

Benign7

Segregation1

Human42

Tumors14

Scaffolds4

Adult12

Biological4

Researchers14

Intestine1

Characteristics2

Regulate1

Tumour1

Immune19

Organ1

Pathways1

Donors1

Generate2

Therapies3

Populations2

Specificity2

Types12

Morphogenesis1

Mesenchymal stem1

Liver3

Extracellular6

Lymphoid cells2

Inflammation1

Lesions3

Mechanism3

Intestinal1

Elastic Tissue1

Vitro1

Microenvironment1

Connective2

Methods2

Phenol1

Classifications1

Drosophila3

Poorly understood1

Autologous1

Cartilage2

Macrophages1

Vero1

MiRNA4

Biopsy2

Peripheral3

Cultures1

Vivo1