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  • Kinase Inhibitors
  • Pretreatment with the nonspecific antioxidant N-Acetylcysteine and the Rho kinase inhibitors (Fasudil and Y-27632) prevented MLC and MYPT-1 phosphorylation by UFP suggesting a O 2 ·− -mediated mechanism for PM 2.5 and UFP effects. (ahajournals.org)
  • peptides
  • Properties of signal peptide-specific systems are highlighted for the development of new therapeutic and antimicrobial applications, as compounds can target signal peptides from either host cells or pathogens and thereby selectively prevent translocation of those specific proteins. (springer.com)
  • Signals present at the N-terminus of the synthesized protein are termed signal peptides (SP) or signal sequences. (springer.com)
  • Check out links to articles that cite our custom service antibodies, peptides, and proteins in major peer-reviewed journals, organized by research category. (abgent.com)
  • confocal laser scan
  • The rats were sacrificed, and the synovial tissues and bone-implant interface were analyzed by immunohistochemically and morphologically with bone labeling of tetracyclin … More e and confocal laser scanning microscopy system. (nii.ac.jp)
  • In peri-implant bony tissues, not only osteolytic region but also osteogenetic region was clearly demonstrated by tetracycline labeling and confocal laser scanning microscopy. (nii.ac.jp)
  • Exchanging the catalytic domain of NtMMP1 with green fluorescent protein (GFP) facilitated subcellular localization by confocal laser scanning microscopy, showing the protein is normally inserted into the plasma membrane. (biomedcentral.com)
  • Sorafenib
  • Here we compared the most frequently investigated human HCC model cell line, HepG2, with VX2 cells in vitro in terms of sensitivity towards the broad specificity kinase inhibitor sorafenib and responsiveness to the addition of platelet-derived growth factor AB (PDGF-AB), vascular endothelial growth factor (VEGF) and hepatic growth factor (HGF), as well as insulin and interleukin-1β (IL1β). (cancerindex.org)
  • KINASES
  • It is an endogenous inhibitor of RAF KINASES and may play a role in regulating SIGNAL TRANSDUCTION. (labome.org)
  • In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model. (hindawi.com)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • therapeutic
  • Our results suggest the addition of a MTOR inhibitor may reduce NVP-AUY922 dose requirement and potentially improve its therapeutic index in mutant KIT-expressing GISTs. (jove.com)
  • The potential use of an inhibitor of AURKA as a therapeutic agent against GISTs was also tested in GIST cell lines. (jove.com)
  • An AURKA inhibitor may have potential as a therapeutic agent for both IM-sensitive and IM-resistant GISTs. (jove.com)
  • regulatory
  • 1 . As part of this interactive and integrated network, the adipose tissue per se is involved in the coordination of diverse processes including not only energy metabolism but also endocrine and immune regulatory functions. (nature.com)
  • are GS-associated regulatory proteins. (aspetjournals.org)
  • vitro
  • In an in vitro study, MLN8237, an AURKA inhibitor, inhibited growth of both IM-sensitive and IM-resistant GIST cells in a concentration-dependent manner, and exhibited synergistic cytotoxicity with IM in GIST cells. (jove.com)
  • selectively
  • Here, we report the preclinical pharmacological profile of GSI-953 (begacestat), a novel thiophene sulfonamide γ-secretase inhibitor (GSI) that selectively inhibits cleavage of APP over Notch. (aspetjournals.org)
  • localization
  • The involvement of autophagy in rapamycin-induced KIT downregulation was further confirmed by co-localization of KIT and autophagosome, and partial recovery of KIT expression level by either siRNA-mediated BECN1 and ATG5 silencing or autophagy inhibitors after rapamycin. (jove.com)
  • We determined the subcellular localization of NtMMP1 using a fluorescent reporter protein, and analyzed the expression profile during normal fermentation and after challenge with bacterial pathogens. (biomedcentral.com)
  • Sumoylation is a dynamic process with highly diverse outcomes, ranging from changes in subcellular localization, signal transduction, transcriptional regulation to altered activity and stability of the modified protein. (atlasgeneticsoncology.org)
  • macrophages
  • In the analyses on the retrieved tissue from the patients with loose artificial hip joints, same types of cells, namely, monocyte/macrophages, foreign body type-gian cells, activated fibroblasts, and vascular endothelial cells, were found as well as polyethylene wear debris. (nii.ac.jp)
  • Although adipocytes have been recognized as secretory cells with endocrine functions for some time, the importance of macrophages and stromal vascular cells within the adipose tissue of obese animals and humans is now well accepted. (nature.com)
  • membranes
  • Coagulation is initiated by formation of a tissue factor/factor VIIa complex on PS-exposed membranes and propagated through the assembly of intrinsic tenase (factor VIIIa/factor IXa), prothrombinase (factor Va/factor Xa), and factor XIa complexes on PS-exposed activated platelets. (bloodjournal.org)
  • Since protein synthesis occurs in the cytosol, translocation of proteins across biological membranes is essential for cellular function. (springer.com)
  • Because HPV infects epithelial cells, the outermost layer of the skin and the mucous membranes, protein inhibitors such as E2R could be applied in a topical form. (infectioncontroltoday.com)
  • translocation
  • The essential nature of this protein translocation process has led to the evolution of several factors that specifically target the translocon and block translocation. (springer.com)
  • In general, translocation from the cytosol requires three key steps: (1) substrate recognition and targeting to the destination membrane, while maintaining the substrate in a translocation-competent state (2) translocation across or integration into that membrane, which usually requires energy expenditure in the form of GTP, ATP or proton motive force and (3) release, folding and maturation of the protein substrate. (springer.com)
  • Targeting signals contain the principal information that drives protein translocation. (springer.com)
  • multitude
  • In addition to managing the most important energy reserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively, deleterious effects on the homeostasis of the whole body. (nature.com)
  • molecular
  • With state-of-the art molecular biology and protein biochemistry labs, we work with our clients to rapidly evaluate in parallel to identify the optimal expression system for candidate proteins. (abgent.com)
  • The protein appears to be expressed in two forms with different molecular masses, both of which are enzymatically active as determined by casein zymography. (biomedcentral.com)
  • capability
  • Process for the powerful measurement of adaptable passive tightness (APS) utilized to assess the capability of selective inhibitors to attenuate KCl-induced era of APS. (welbourneprimary.com)
  • PIAS3 do, however, not only operate as SUMO-E3, since its coregulator effects are often independent of its RING-finger like domain but dependent on its capability to interact with sumoylated proteins via its conserved SIM (SUMO-interacting motif) or SAP (scaffold attachment factor-A/B/acinus/PIAS) domain (figure 2). (atlasgeneticsoncology.org)
  • integrity
  • The expression of these adipokines is an integrated response to various signals received from many organs, which depends heavily on the integrity and physiological status of the adipose tissue. (nature.com)
  • This review underlines the importance of the functional integrity of the adipose tissue in maintaining health. (nature.com)
  • cell
  • In long-standing chronic congestion, hypoxia may lead to parenchymal cell death and secondary tissue fibrosis, and the elevated intravascular pressure may cause edema. (brainscape.com)
  • Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions. (nature.com)
  • Furthermore, analysis of the sympathetic and parasympathetic innervations of adipose tissue revealed that the autonomic nervous system modulates the fat cell number and other processes, such as adipokine expression levels, lipogenesis/lipolysis, fatty acid uptake, and glucose uptake. (nature.com)
  • Ceritinib is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. (drugbank.ca)
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • IAPs are commonly upregulated in cancer, and although initially thought to only regulate cell death, they are now known to be involved in many aspects of both normal tissue function and tumour development. (omicsonline.org)
  • We have developed a protein inhibitor that blocks HPV protein expression in cell culture, a first step toward a topically-applied treatment for this cancer-causing virus," said senior author James Baleja, PhD, associate professor of biochemistry at Tufts University School of Medicine (TUSM) and member of the biochemistry program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts. (infectioncontroltoday.com)
  • 0.05
  • Ramifications of Inhibitors on CCG-63802 KCl-Induced Contraction and APS Evaluated By Active Length-Tension Function Loops Muscle pieces were put through the process demonstrated in Fig. 1and function 0.05. (welbourneprimary.com)
  • Protein concentration is above or equal to 0.05 mg/ml. (abcam.com)
  • Different
  • This knowledge has contributed to a better understanding of the intense cross-talk between the different components of fat tissue, and has led to stimulating speculations about the initiation of pathological conditions. (nature.com)