Tissue inhibitor of metalloproteinases 2 levels. Medical search. Frequent questions

Tissue inhibitors of metalloproteinases (TIMPs) are specific endogenous protease inhibitors to the matrix metalloproteinases. (wikipedia.org)
Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form. (wikipedia.org)
Known elastolytic enzyme inhibitors include serine proteinase inhibitors (serpins) and tissue inhibitors of metalloproteinase (TIMPs). (medscape.com)
An imbalance in levels of MMPs and TIMPs altering the rate of elastin turnover has been suggested as one explanation of the pathophysiology of anetoderma. (medscape.com)
The expression and regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) in neuroectodermal precursor cells is undocumented. (uea.ac.uk)
We report the presence of MMP-2, but no MMP-9, and of all the four known TIMPs in neuroepithelial stem cells isolated from the human CNS. (uea.ac.uk)
Hence, regulation of selective MMPs and TIMPs occurs during differentiation of human neural precursors suggesting that MMP-2 and TIMP-4 in particular may perform regulatory roles in the developing CNS. (uea.ac.uk)
However, whether the determinants of ECM composition, such as the balance between ECM proteases (matrix metalloproteinases [MMPs]) and their tissue inhibitors [TIMPs]), are altered in hypertensive heart disease is unknown. (indexindex.com)
Since the invasion process involves a complex system of tightly regulated proteases, matrix metalloproteinases (MMPs) and their tissue-specific inhibitors (TIMPs), the effect of VPA on MMP and TIMP expressions was analysed. (iiarjournals.org)
The substances that hamper angiogenesis are tissue inhibitors of metalloproteinases (TIMPs). (biomedcentral.com)
Remodeling of atrial extracellular matrix (ECM) in atrial fibrillation (AF) involves changes in the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs). (unboundmedicine.com)
A reduction of MMPs in aqueous humor can alter the balance between MMPs and the tissue inhibitors of metalloproteinases (TIMPs). (molvis.org)
The aim of the study was to explore whether the serum level of interleukin 6 (IL-6) is correlated with matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), and with clinical markers of the disease activity in rheumatoid arthritis (RA). (termedia.pl)
Furthermore, serum IL-6, MMPs and TIMPs correlated with the erythrocyte sedimentation rate, C reactive protein level, the number of tender and swollen joints, and Ritchie articular index (RAI). (termedia.pl)
We conclude that analysis of the serum IL-6, MMPs and TIMPs levels may be useful in the assessment of the RA activity. (termedia.pl)
Under normal physiological conditions, the proteolytic activity of the MMPs is controlled primarily at any of the following three known stages: transcription, activation of the zymogens, and inhibition of the active forms by various tissue inhibitors of MMPs (TIMPs). (periobasics.com)
The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). (embl.de)
It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). (embl.de)

The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP. (wikipedia.org)
INTRODUCTION: This study was designed to investigate the levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and their respective tissue inhibitors, tissue matrix metalloproteinase inhibitor-1 (TIMP-1) and tissue matrix metalloproteinase inhibitor-2 (TIMP-2), in eclamptic and preeclamptic pregnant women. (eastjmed.org)
METHODS: In this study carried out in the Department of Obstetrics and Gynecology of the Y z nc Y l University Faculty of Medicine Health Practice and Research Hospital, eclamptic (n=28), preeclamptic, (n=28) and healthy pregnant women (n=24) were enrolled and their levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 were studied by micro enzyme-linked immunosorbent assay (ELISA) method. (eastjmed.org)
When the three groups were examined in terms of the ratio of MMP-2 to TIMP-2, no significant difference was found (p=0.788). (eastjmed.org)
To investigate matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) expressions in the cultured rat mesangial cells (MsC) transfected with Smad 7 vector and to elucidate the mechanism of Smad 7 in blocking tissue fibrosis. (eurekamag.com)
The expressions of MMP-2 and TIMP-2 were determined by Western blot, RT-PCR and zymography assay. (eurekamag.com)
The expressions of TIMP-2 protein and mRNA however were suppressed. (eurekamag.com)
It is possible that Smad 7 can alleviate the development of tissue fibrosis by upregulating the expression of MMP-2 and downregulating the expression of TIMP-2 in mesangial cells. (eurekamag.com)
Tissue inhibitor of metalloproteinase 1 (TIMP-1), a MMP-9 inhibitor, was markedly increased in particle-exposed groups. (cdc.gov)
LPS exposure did not significantly alter particles-induced MMP-9, but markedly enhanced TIMP-1 levels. (cdc.gov)
To investigate the potential role of 'a disintegrin-like and metalloproteinase with thrombospondin type motifs-2 (ADAMTS-2), collagen type-1, tissue inhibitor of metalloproteinases-3 (TIMP-3) and papilin' levels in the uterosacral ligament (USL) and cardinal ligament (CL) of the uterus on the etiopathogenesis of pelvic organ prolapse (POP) among postmenopausal women without stress urinary incontinence (SUI). (urotoday.com)
Hazard ratio (95% confidence interval) was for MMP-2 1.126 (1.011-1.255), perlecan 1.0099 (1.0004-1.0196), and TIMP-4 1.037 (1.003-1.071) in age and sex-adjusted Cox-regression model. (lu.se)
The present study indicates that high levels of MMP-2, perlecan, and TIMP-4 are associated with poor survival in PAH. (lu.se)
In human PTE, hypoxia (1%02, 24hrs) increased total collagen production, decreased MMP-2 actvity and increased Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) protein. (ucl.ac.uk)
Eucalyptol upregulated elastin and TIMP-1 levels, and reduced neutrophil elastase (NE) levels, when compared to the CS group. (greenmedinfo.com)
The expression of TIMP-1, TIMP-2 and TIMP-3 was unchanged following stem cells differentiation into neurons and glia. (uea.ac.uk)
In contrast, while MMP-2 and TIMP-4 were localized to both stem and mature CNS cells, their levels of expression were substantially reduced in the latter. (uea.ac.uk)
An increased TIMP-1 level predicted the presence of CHF. (indexindex.com)
The activities of matrix metalloproteinase (MMP)-2 and−9 were further inhibited and TIMP-1 and−2, and NM23-H1, the MMPs negative modulators, were further activated in the combined treatment. (frontiersin.org)
The effects of platelet-derived growth factor-BB (PDGF-BB: 10ng/ml) and/or transforming growth factor-beta1 (TGF-beta1: 10ng/ml) on the expression of hyaluronan synthase (HAS)1,2,3, matrix metalloproteinase (MMP)1,2,3, tissue inhibitor of metalloproteinase (TIMP) 1,2, collagen type 1 ,3. (arvojournals.org)
Duodenal biopsies from untreated, treated celiac patients and controls were used to quantify the expression of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12, MMP-14, their inhibitor TIMP-1, IFN-gamma and TNF-alpha by using real-time reverse transcription-polymerase chain reaction and the gelatin/casein/elastin activities by gel zymography, and to isolate lamina propria mononuclear cells (LPMCs). (nih.gov)
The aim of the study was to evaluate the concentration of proteolytic enzymes, MMP-2 and MMP-9, and their tissue inhibitors, TIMP-1 and TIMP-2, in the blood of patients with benign and malignant pancreatic tumors. (biomedcentral.com)
MMP-2, MMP-9, TIMP-1, and TIMP-2 were evaluated in the patients with benign and malignant pancreatic tumors before surgery and in the 30-day follow-up. (biomedcentral.com)
The highest level of TIMP-1 was noted in patients with inflammatory tumors. (biomedcentral.com)
In 1 month following the operation, the highest level of MMP-2 was also in patients with unresectable cancer and the highest level of TIMP-2 in patients with inflammatory tumors. (biomedcentral.com)
Western blot analysis was used to detect protein expression levels of MMP‑9, MMP‑13, TIMP‑1, TIMP‑3 and type II collagen in cartilage tissue and chondrocytes. (spandidos-publications.com)
Furthermore, silencing of lncRNA GAS5 expression in IL‑1β‑treated chondrocytes downregulated the protein expression of MMP-9 and MMP-13 whilst upregulating the expression of tissue inhibitor matrix metalloproteinase (TIMP)-1, TIMP-3 and type II collagen. (spandidos-publications.com)
This study evaluated the in situ activity and expression of gelatinases (MMP-2 and MMP-9) and their relationship with TIMP-1 or TIMP-3 in atria undergoing rapid atrial pacing for the induction of AF (4 weeks' pacing followed by 2 weeks of maintained AF) in pigs. (unboundmedicine.com)
The inhibitory activities of glycosylated TIMP-1 and TIMP-3, but not TIMP-2, in AF tissues were markedly elevated and also localized in the atrial interstitium. (unboundmedicine.com)
TIMP-1 was found to be mostly colocalized with gelatinase activity over the AF tissues, implying the coexistence of gelatinase activity and TIMP-1, but TIMP-3 appeared only partially colocalized and discontinued the gelatinase activity surrounding the cardiomyocytes. (unboundmedicine.com)
NOX1 and NOX4 protein expression and mRNA expression of NOX1, NOX4, IL-6, matrix metalloproteinase (MMP)-2, tissue inhibitors of matrix metalloproteinase (TIMP)-2, and type I and III collagens in the Achilles tendon were determined. (biomedcentral.com)
In the diabetic rat Achilles tendon, NOX1 protein expression and mRNA expression of NOX1, IL-6, MMP-2, TIMP-2, and type III collagen were significantly lower while type I collagen expression was significantly higher in the DHEA group than in the control group. (biomedcentral.com)
Although the pathogenesis of diabetic tendinopathy is still not fully understood, the potential mechanisms by which DM causes and exacerbates tendinopathy are - accumulation of advanced glycation end-products (AGEs), adipokine dysregulation, increased reactive oxygen species (ROS), cell death and inflammatory cytokines, imbalance in the matrix metalloproteinase (MMP)/tissue inhibitor (TIMP) ratio, and impaired angiogenesis and tendon sheath differentiation [ 6 ]. (biomedcentral.com)
To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
In situ hybridization (ISH) was used to investigate the presence of HPV-16, while immunohistochemistry (IHC) was used to estimate the expression level of TIMP-2. (bvsalud.org)
The TIMP-2 was expressed in 27 (81.8%) of OSCC sections with no significant difference between its expression level in HPV-16 positive and HPV-16 negative OSCC cases (p=0.058). (bvsalud.org)
TIMP-2 was found to be highly expressed in OSCC sections, and the presence of HPV was not related to its overexpression. (bvsalud.org)
The percentage of samples that appeared to accommodate detectable HPV-16 was high, but no significant difference was observed in relation to TIMP-2 expression level. (bvsalud.org)
Future studies with a larger number of patients are highly recommended to address the possible association between TIMp-2 and OSCC positive HPV-16. (bvsalud.org)
Concentrations of IL-6, interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), gelatinase B (MMP-9), TIMP-1 and TIMP-2 were measured with an ELISA technique in serum of 32 RA patients. (termedia.pl)
In vitro , a concentration-dependent anti-invasive action of either FAAH inhibitor was demonstrated, accompanied with upregulation of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). (oncotarget.com)
Using siRNA approaches, a causal link between the TIMP-1-upregulating and anti-invasive action of FAAH inhibitors was confirmed. (oncotarget.com)
Other studies have shown elevated serum levels of manganese superoxide dismutase and tissue inhibitor of metalloproteinase (TIMP-1). (medscape.com)
Objective: To analyse matrix metalloproteinases (MMPs) and tissue inhibitor-1 of MMPs (TIMP-1) levels in the systemic circulation and synovial fluid (SF) of patients with RA and to compare these levels with inflammatory and collagen degradation markers. (tno.nl)
10) Supriono, Pratomo B, Kriestian M. Effects of Curcumin Against Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor Metalloproteinase-2 (TIMP-2) Serum Level on Rat Model of Liver Fibrosis Resolution Process. (scholarpublishing.org)
These anti-invasive effects appear to be mediated through the downregulation of MMP-2 (matrix metalloproteinase) and the upregulation of TIMP-1 (tissue inhibitor of metalloproteinase), 2 common effector molecules that have been implicated in regulating tumor cell invasion. (compassionateacupuncture.com)
2 , 4 ] Balance of the remodeling process occurs with inhibition of the remodeling by tissue inhibitors of metalloproteinases (TIMP). (uw.edu)
Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2. (embl.de)
The binding properties of the newly described tissue inhibitor of metalloproteinases-4 (TIMP-4) to progelatinase A and to the COOH-terminal hemopexin-like domain (C domain) of the enzyme were examined. (embl.de)
We present evidence for the first time of a specific, high affinity interaction between TIMP-4 and the C domain of human gelatinase A and show that TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2. (embl.de)

Elastolytic enzymes such as matrix metalloproteinases (MMPs) may be directly responsible for elastin degradation in anetoderma. (medscape.com)
A significant increase in matrix metalloproteinase-9 (MMP-9) was seen in BAL from CNP- and CNP+DEP-exposed rats. (cdc.gov)
In general, the pathophysiology underlying eosinophilic fasciitis is postulated to involve an inflammatory response resulting in an activated inflammatory cell infiltrate of affected tissues and subsequent dysregulation of extracellular matrix production by lesional fibroblasts. (medscape.com)
Human orthopedic studies of failed hip implant sites have identified increased mRNA expression of several collagen-degrading matrix metalloproteinases (MMPs), while in vitro experiments have shown increases in MMP secretion after exposure to inflammatory mediators. (allenpress.com)
Our results suggest that in response to stretch, MMP-2 responds rapidly by inhibiting conversion of a MMP-2 to the active form, while a slower up-regulation of MMP-9 may play a role in the long-term remodeling of extracellular matrix in response to continuous mechanical loading. (allenpress.com)
Proteolytic activity and collagenolytic degradation of extracellular matrix at the bone-implant interface have been reported in conjunction with increased mRNA expression of metalloproteinases (MMPs) in otherwise healthy tissues. (allenpress.com)
These enzymes constitute a family of zinc-dependent endopeptidases, expressed at low levels in normal adult tissues, which regulate the turnover of the extracellular matrix in connective tissues. (allenpress.com)
2 The cooperative effects of collagenases, gelatinases, and stromelysins-in combination with mechanical forces-suggest a role in MMP-dependent degradation of the extracellular matrix as an important determinant of implant failure due to excess occlusal forces. (allenpress.com)
The metastasizing cells will proliferate in large numbers in situ and secrete proteolytic enzymes, such as the matrix metalloproteinases (MMPs), which degrade the extracellular matrix and blood vessel wall. (frontiersin.org)
Matrix metalloproteinases (MMPs) are a family of endopeptidases playing a key role in tissue remodelling in both physiological and pathological conditions. (nih.gov)
Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. (scirp.org)
Vitamin C attenuated AAA development in an elastase-induced rat model via crucial protective effect, which was mediated by an increased level of antioxidant in cooperation with preserving elastin lamellae, inhibiting matrix-degrading proteinases and suppressing inflammatory responses. (nih.gov)
Western blotting was performed to detect the protein levels of cyclin‑dependent kinase inhibitor P21 (P21), B‑cell lymphoma‑2 (Bcl‑2), matrix metalloproteinase 9 (MMP9) and E26 oncogene homolog 1 (ETS1). (spandidos-publications.com)
Peng and Zhang ( 8 ) indicated that propofol inhibited proliferation, but induced apoptosis of SGC-7901 cells by regulating matrix metalloproteinase (MMP)2 ( 8 ). (spandidos-publications.com)
OPUS at UTS: Prospective, randomized, double-blind trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques. (edu.au)
BACKGROUND AND PURPOSE: Elevated levels of matrix metalloproteinases (MMPs), particularly MMP-1 and MMP-9, have been implicated in plaque rupture. (edu.au)
There was no difference in any other MMP (MMP-2, -3, or -9) or tissue inhibitor of matrix metalloproteinases-1 or -2. (edu.au)
TY - JOUR T1 - Upregulation of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases in rapid atrial pacing-induced atrial fibrillation. (unboundmedicine.com)
Matrix-metalloproteinase upregulation in ischemia reperfusion can be imaged acutely in-vivo with NIRF using MMPSense750. (biomedcentral.com)
Also, following transplantation and migration to target tissue, they encounter a harsh milieu accompanied by death signals because of the lack of proper tensegrity structure between the cells and matrix. (biomedcentral.com)
We investigated the effect of HA on the expression of matrix metalloproteinases (MMP-2 and MMP-9) in cultured trabecular meshwork cells. (molvis.org)
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases. (molvis.org)
that indicates the imbalanced rate of increased matrix synthesis to decreased breakdown of connective tissue proteins. (openmicrobiologyjournal.com)
Matrix metalloproteinases (MMPs) play a crucial role in remodeling of extracellular matrix. (openmicrobiologyjournal.com)
Development of most solid tumors is characterized by an increase in secretion and activation of matrix metalloproteinases (MMPs) produced by either the tumor cells or tumor-associated fibroblasts. (bvsalud.org)
It inhibited lung cancer cell invasion and down-regulated matrix metalloproteinase-7 (MMP-7), which promoted lung cancer cell invasion. (aacrjournals.org)
A critical step in this process is degradation of the basement membrane, which contains extracellular matrix (ECM) proteins and functions as a barrier to surrounding tissues. (aacrjournals.org)
Background: Furin-like proprotein convertases (PCs) are proteolytic activators of proproteins, like membrane type 1-matrix metalloproteinase (MT1-MMP) and transforming growth factor beta (TGF-beta), that are described in the arterial response to injury. (tno.nl)
Background: The increased expression of matrix metalloproteinases (MMPs) is considered to be a key factor in the development of COPD. (tno.nl)
The matrix metalloproteinases (MMPs) are a family of structurally and functionally related endoproteinases that are collectively capable of degrading most of the components of the extracellular matrix (ECM) 1, 2 . (periobasics.com)
The generic structure of matrix metalloproteinases (MMPs). (periobasics.com)
Another type of MMPs are called as the MT-MMPs (Membrane Type Matrix Metalloproteinases) that are localized to the cell surface. (periobasics.com)
Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. (scholarpublishing.org)
Curcumin: A potential candidate for matrix metalloproteinase inhibitors. (scholarpublishing.org)
1 , 2 ] The hepatic stellate cells are the primary cells responsible for producing these extracellular matrix proteins. (uw.edu)
3 ] This dynamic process can also involve remodeling and regression of the fibrous tissue via breakdown of the matrix proteins by the protease enzymes matrix metalloproteinases (MMP). (uw.edu)
Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). (embl.de)
In fact, matrix metalloproteinase 2 (MMP-2) and integrin alphavbeta3 are functionally associated on the surface of angiogenic blood vessels. (embl.de)
There are, in addition, other cals that are able to provoke an immune response such that characteristics, such as the ability to increase matrix allergic sensitization of the respiratory tract will be metalloproteinase expression or to cause perturbation of acquired. (cdc.gov)

Plasma levels of 14 ECM-related proteins, with altered levels in PAH. (lu.se)
Plasma levels of 14 ECM-related proteins, with altered levels in PAH compared to healthy controls, were analyzed with proximity extension assays, and related to hemodynamics, transplant-free survival time, and ESC/ERS risk score. (lu.se)
The amount of any cystatin (that is, of any member of the cystatin superfamily of proteins, many of which act as cysteine protease inhibitors) found in a specified sample of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. (mcw.edu)
Levels of MMPs are determined by a balance between their expression and inhibition in tissues by specific proteins, known as tissue inhibitors of metalloproteinases. (allenpress.com)
Metalloproteinases are proteolytic enzymes responsible for the degradation of ECM proteins and the basal membrane of the vessels. (biomedcentral.com)
These proteins play a master role in diverse physiological processes and diseases such as the homeostatic tissue remodeling and cancer 17 . (bvsalud.org)
In Sierra Leone during 2015-2018, we assessed LF patients' day-of-admission plasma samples for levels of proteins necessary for coagulation, fibrinolysis, and platelet function. (cdc.gov)

The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
In the endometrium, angiogenesis is a physiological process, whereas in most adult tissues neovascularization is initiated only during tissue repair or pathological conditions. (tno.nl)
This study also demonstrates that curcumin inhibits the transcript levels of 2 major angiogenesis factors VEGF (vascular endothelial growth factor) and b-FGF (basic fibroblast growth factor) mainly in ER-negative MDA-MB-231. (compassionateacupuncture.com)
Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. (embl.de)
PEX blocks MMP-2 activity on the chick chorioallantoic membrane where it disrupts angiogenesis and tumor growth. (embl.de)

The evaluation of the level of the studied cytokines in the pancreatic tumor patients can be diagnostically significant in the differentiation of benign and malignant changes. (biomedcentral.com)
We are currently testing the hypothesis that Dermaval may affect blood levels of metalloproteinases, tissue inhibitors of metalloproteinases, pro-inflammatory cytokines, and chemikines under these experimental conditions. (nutraingredients-usa.com)

Collagen IV mRNA levels decreased while collagen [alpha]1(1) mRNA increased, suggesting induction of an atypical, interstitial collagen. (ucl.ac.uk)
Fibroblasts from lesional tissue of patients with eosinophilic fasciitis produce excess collagen in vitro and display elevated TGF-beta and type 1 collagen mRNA levels when examined via in situ hybridization with specific cDNA. (medscape.com)
In vitro fibroblasts from involved fascia produce increased levels of mRNA for collagen types I, III, and IV compared with adjacent dermal fibroblasts. (medscape.com)

MMPs play an important role in skeletal connective tissue degradation and remodeling. (allenpress.com)
A dose of a patent-pending, all-natural combination of fruit and vegetable concentrates may inhibit the action of an enzyme linked to degradation of elastin in the skin and other connective tissue, says a new study. (nutraingredients-usa.com)

Possible explanations for the loss of elastic tissue include defective elastin synthesis, uncontrolled production of elastolytic enzymes, loss of elastolytic enzyme inhibitors, elastophagocytosis, or degeneration of elastic fibers secondary to local ischemia induced by microthromboses in dermal vessels. (medscape.com)
The changes in the levels of the studied enzymes and their inhibitors can have a prognostic value in the clinical severity of pancreatic cancer. (biomedcentral.com)

CONCLUSIONS: Doxycycline penetrated atherosclerotic plaques with acceptable tissue levels. (edu.au)
CONCLUSIONS: Superior Bcl-6 inhibitor catabolic reputation is significantly connected with workout intolerance, ventilatory ineffectiveness, along with chronotropic incompetence throughout CHF individuals, suggesting a significant surrounding mechanism on their restricted useful position. (fakpathway.com)

They play a significant part in the development of many neoplastic diseases and diseases of the connective tissues [ 11 ]. (biomedcentral.com)

Alpha-1 Antitrypsin Deficiency Alpha-1 antitrypsin deficiency is congenital lack of a primary lung antiprotease, alpha-1 antitrypsin, which leads to increased protease-mediated tissue destruction and emphysema in adults. (msdmanuals.com)

Western blot and RT-PCR analyses were then used to detect Smad 7 protein and mRNA expression levels. (eurekamag.com)
The two clones showed an increased expression of MMP-2 protein and enhanced enzyme activity. (eurekamag.com)
Accordingly, the expression levels of PDGF (3-folds), Rac1 (1.6-folds), NF-κB (7-folds) and AngII (12-folds) significantly increased in the TAC group compared to the SHAM group, and these levels were also reduced by 25% to 64% with following drug intervention. (medsci.org)
The expression and activity of mRNA for several MMPs (2, 3, 9, and 10) was assessed. (allenpress.com)
3 Because this bone cell culture model demonstrates a capacity to respond to mechanical changes, we hypothesize that this model may also show differences in expression of metalloproteinases in response to cyclic mechanical stretch that can be used to model changes at the bone-implant interface. (allenpress.com)
PDGF-BB induced the expression level of MMP1, MMP3 and HAS2 at mRNA level. (arvojournals.org)
De- cidual cells promote hemostasis through enhanced expression of tissue factor (TF), the primary initiator of hemostasis via thrombin generation, and plasminogen activator inhibitor-1, which inactivates tissue type plasminogen activator, the primary fibrinolytic agent. (scirp.org)
2009) Progestin and thrombin regulate tissue factor expression in human term decidual cells. (scirp.org)
Firstly, VPA induced cell growth inhibition and apoptotic activity, as demonstrated by sulforhodamine B protein assay, annexin V assay and by Western blot analysis for Bcl2 and Bax expression levels, in all three cell lines. (iiarjournals.org)
Exposure to VPA resulted in a decrease of MMP2 and MMP9 activity and expression level, as assesssed by gelatin zymography and Western blot analysis. (iiarjournals.org)
Since the recruitment of HDAC leads to transcriptional repression, inhibitors of this enzymatic activity can reverse aberrant repression in cancer cells and lead to re-expression of epigenetically silenced genes involved in growth and differentiation processes. (iiarjournals.org)
Furthermore, reverse transcription‑quantitative PCR was used to examine the expression levels of circular RNA‑PVT1 (circ‑PVT1), micoRNA‑195‑5p (miR‑195‑5p) and ETS1 in GC tissues and cells. (spandidos-publications.com)
Propofol could inhibit Bcl‑2 and MMP9 expression, and increase P21 expression in GC cells. (spandidos-publications.com)
The expression levels of circ‑PVT1 and ETS1 were increased in GC tissues and cells, and miR‑195‑5p was decreased. (spandidos-publications.com)
Meanwhile, miR‑195‑5p inhibitor reversed the si‑circ‑PVT1‑induced low expression of ETS1. (spandidos-publications.com)
Rosuvastatin curtailed the expression of CCL4, IFN-ß, IL-2, IL-4, and IL-10 more effectively than fluvastatin in both types of tissue. (bvsalud.org)
Moreover, the relative expression level of lncRNA GAS5 in cartilage tissue and chondrocytes was detected using reverse transcription‑quantitative PCR. (spandidos-publications.com)
The mRNA expression of MMP-2 and MMP-9 was determined by reverse transcription-polymerase chain reaction, and the protein expression of MMP-2 and MMP-9 by gelatin zymography analysis and qualified by the gel electrophoresis image analysis in different HA concentrations. (molvis.org)
The expression of MMP-2 and MMP-9 by the two methods significantly increased with HA concentration in a dose-response manner. (molvis.org)
The expression levels of fibulin-5 and MMP-7 were inversely correlated in lung tumors. (aacrjournals.org)
The combination resulted in a decrease of cyclooxigenase-2, metalloproteinases-2 and -9 expression level and activity while PPARgamma, RXRgamma and tissue inhibitors of metalloproteinase-1 and -2 expression were increased. (aianmodena.org)

Data revealed that the MMP2, MMP9 and TNF-α levels showed a significant elevation in chronic HCV patients compared to control group (p= 0.001). (openmicrobiologyjournal.com)

The effectiveness of these enzyme inhibitors has been established by many in vitro and in vivo experiments on a variety of tumor types ( 7 - 9 ). (iiarjournals.org)
Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)

This study suggests that the regulation of metalloproteinases at both the mRNA and protein level are important in the response of bone to mechanical stress. (allenpress.com)
In patients with HAE caused by C1-inhibitor deficiency or dysfunction, normal regulation of plasma kallikrein activity is not present, which leads to uncontrolled increases in plasma kallikrein activity and results in angioedema attacks. (medscape.com)

Decidual cell-derived thrombin weakens the amniotic membrane and lowers decidual cell-expressed progesterone receptor levels by increasing phospho-ERK1/2 signaling. (scirp.org)

To investigate whether the administration of renin-angiotensin system (RAS) inhibitors and statins could alleviate atrial fibrosis via platelet-derived growth factor (PDGF)/Rac1 /nuclear factor-kappa B (NF-κB) axis. (medsci.org)
The effectiveness of HDAC inhibitors, expecially VPA, in neuroblastoma cells, prompted us to investigate the anticancer activity of VPA in other neural crest-derived malignancies, such as glioblastoma, melanoma and Askin tumor. (iiarjournals.org)
The aim of the study was to investigate the ability of doxycycline, a nonspecific MMP inhibitor, to reduce MMP concentration in carotid atheroma. (edu.au)

In athymic nude mice FAAH inhibitors were shown to elicit a dose-dependent antimetastatic action yielding a 67% and 62% inhibition of metastatic lung nodules following repeated administration of 15 mg/kg AA-5HT and 5 mg/kg URB597, respectively. (oncotarget.com)

However, messenger RNA of tissue inhibitors of metalloproteinase-1 and tissue inhibitors of metalloproteinase-2 were both significantly upregulated in Vitamin C group. (nih.gov)
However, serum levels were significantly higher with mild or severe pre-eclampsia compared with normal pregnancies and significantly higher with severe rather than with mild pre-eclampsia. (who.int)
Elevated levels significantly increased risk more than severity of pre-eclampsia. (who.int)

Previous studies have investigated the inhibitory effect of propofol on cancer cells in a variety of tumors, such as breast ( 2 ), lung ( 3 ) pancreatic ( 4 ), ovarian ( 5 ), hepatic ( 6 ) and gastric cancer (GC) ( 7 , 8 ). (spandidos-publications.com)
Tumor metastasis is characterized by cell detachment from primary tumors and invasion of recipient tissues ( 2 ). (aacrjournals.org)

Eucalyptol alsoreduced all inflammatory (MPO, TNF-α, IL-1β, IL-6, KC, and TGF-β1) and redox marker levels (MDA) when compared to the CS group (at least p (greenmedinfo.com)
Taken together, the findings of these studies suggest a mechanistic framework marked by a proinflammatory and fibrogenic cytokine response with resultant tissue inflammatory cell infiltration. (medscape.com)
MMPs are secreted by a variety of connective tissue and pro-inflammatory cells including fibroblasts, osteoblasts, endothelial cells, macrophages, neutrophils, and lymphocytes. (periobasics.com)

0.05), whereas TNF-alpha levels were suppressed (P=0.0001). (nih.gov)

Atrial fibrosis is one of the most fundamental mechanisms involved in the physiopathology of cardiovascular disease, which includes atrial fibrillation (AF) [ 1 , 2 ] and heart failure (HF) [ 3 ] . (medsci.org)
furthermore, serum levels of various biomarkers change, in addition to the appearance of new biomarkers in the serum during the different stages of fibrosis [ 7 , 8 , 15 ]. (hindawi.com)
2. Is the Liver Biopsy Really the Gold Standard and Reference Method for Evaluating Hepatic Fibrosis? (hindawi.com)
2) The process of hepatic fibrosis is not linear, and biopsies from different areas have shown different stages of fibrosis. (hindawi.com)
In the tissues, the end effector cell of fibrosis is the fibroblast. (medscape.com)
In addition, fascial fibroblasts express transforming growth factor-beta I and connective-tissue growth factor mRNA, which may account for the clinical fibrosis. (medscape.com)
This scar tissue can restrict blood flow due to contraction of the organ, leading to progressive liver damage and cirrhosis (the end stage of fibrosis), complicated by liver failure, portal hypertension and/or hepatocellular carcinoma [ 1 ]. (biomedcentral.com)
This review will focus on the contribution of high-throughput genomic and proteomic approaches to the study of fibrogenesis and fibrosis progression, concentrating on the most prevalent human chronic liver diseases and findings from animal models in liver tissue, isolated liver cells, cell lines and serum. (biomedcentral.com)

U87MG human glioblastoma and G361 human melanoma cells, obtained from Interlab Cell Line Collection (Genoa, Italy), and SKNMC Askin tumor cells, purchased from the American Type Culture Collection (Rockville, USA) were maintained in RPMI (Sigma, USA), supplemented with 10% fetal bovine serum (FBS), 2 mM glutamine, 50 U/ml penicillin and 50 μg/ml streptomycin and grown at 37°C in a humidified air with 5% CO 2 . (iiarjournals.org)

IFN-gamma activates tissue macrophages and T cells. (medscape.com)
During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
We demonstrated previously that valproic acid (VPA) and other short-chain fatty acids, as HDAC inhibitors, can arrest cell growth and induce differentiation in human neuroblastoma cells ( 10 ). (iiarjournals.org)
Additionally, the effects of transfection with circ‑PVT1 small interfering RNA (si‑circ‑PVT1) on HGC‑27 and AGS cells could be reversed by treatment with miR‑195‑5p inhibitor. (spandidos-publications.com)
In GC, Yang et al ( 7 ) reported that propofol suppressed the proliferation of SGC-7901 and MGC-803 cells by promoting inhibitor of growth 3 ( 7 ). (spandidos-publications.com)
However, natural MSCs in vivo survival and their biological effects on tissue recovery decrease with long-term cultivation called aging and also injected cells demonstrate poor targeted migration [ 21 ]. (biomedcentral.com)
Trabecular meshwork cells were cultured from trabecular tissues obtained from the POAG patients aged 23 to 45. (molvis.org)
In POAG trabecular meshwork cells, the level of HA concentration increases the activities of MMP-2 and MMP-9. (molvis.org)
We investigated the effects of different level of HA concentrations on mRNA and protein expressions of MMP-2 and MMP-9 in cultured trabecular meshwork cells using reverse transcription-polymerase chain reaction (RT-PCR) method and gelatin zymography analysis. (molvis.org)
LC-MS analyses revealed increased levels of FAAH substrates (AEA, 2-AG, OEA, PEA) in cells incubated with either FAAH inhibitor. (oncotarget.com)
T helper 2 cells many important characteristics of chemical allergens are common to both contact and respiratory sensitizers. (cdc.gov)
Tissues and Cells. (lu.se)

Specifically, the gelatinases MMP-2 and MMP-9 have previously been considered to specifically injure the important components of the basal lamina around the cerebral blood vessels that precede microvascular damage in cerebral ischemia [ 1 ]. (biomedcentral.com)
MMP-2 and MMP-9 (also known as gelatinases based on their substrate preference) contain fibronectin-like domain repeats which aid in substrate binding. (periobasics.com)

The significant increase of MMP-9 in its pro-form and mRNA level, but not MMP-2, was shown to be responsible for the increased gelatinase activity in atria with AF. (unboundmedicine.com)
Together with the survey of several MMPs transcripts and the level of transforming growth factor-beta1 (TGF-beta1), we proposed that the increased activity of gelatinase (i.e. (unboundmedicine.com)

The aortic dilatation ratio was measured, and aortic tissues were further examined using biochemical and histologic techniques. (nih.gov)
The CCL20 and CCR2 levels reduced more extensively with rosuvastatin treatment only in abdominal aortic tissue. (bvsalud.org)

P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)

Besides activating cannabinoid receptors by administering agonists exogenously, another tool for therapeutical intervention lies in the activation of these receptors by increasing the levels of endocannabinoids locally at pathological foci. (oncotarget.com)

Selection of laboratory and/or imaging studies to rule out conditions other than migraine headache is determined by the individual presentation (eg, erythrocyte sedimentation rate and C-reactive protein levels may be appropriate to exclude temporal/giant cell arteritis). (medscape.com)

It remains a leading endostatin as an angiogenic inhibitor in cause of maternal and neonatal mortality patients with pre-eclampsia. (who.int)

The flask was then placed in a 5% CO 2 incubator at 37 °C. After 10 min, a 20% concentration of fetal bovine serum (Hyclone, Logan, UT) was added and the flask was put back to the incubator. (molvis.org)
Also, levels of TNF-α in liver and serum are increased in chronic HCV patient. (openmicrobiologyjournal.com)
Serum levels of these factors in non-pregnant women were similar to those in healthy pregnant women. (who.int)

alpha-1 antiprotease inhibitor deficiency). (msdmanuals.com)

Neutrophils mode of action and their specialized functions can be directly linked to TB-specific lung tissue damage observed on patient chest X-rays at diagnosis and contribute to long-term pulmonary sequelae. (frontiersin.org)
This study addressed the impact of two FAAH inhibitors (arachidonoyl serotonin [AA-5HT], URB597) on A549 lung cancer cell metastasis and invasion. (oncotarget.com)
In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)

Levels of PEX in these vascularized tissues suggest that it interacts with endothelial cell alphavbeta3 where it serves as a natural inhibitor of MMP-2 activity, thereby regulating the invasive behavior of new blood vessels. (embl.de)

It is a microtubule inhibitor, although the mechanism by which it is effective for actinic dermatosis is unknown. (medscape.com)

The concentrations of MMPs and doxycycline were determined in the atherosclerotic tissue by enzyme-linked immunosorbent assay and high-performance liquid chromatography, respectively. (edu.au)

infection during pregnancy usually leads to spontaneous abortion ( 2 ). (cdc.gov)

The findings of Dziadzio et al support increased levels of IL-5 in eosinophilic fasciitis, in addition to increased levels of transforming growth factor (TGF)-beta, another fibrogenic cytokine. (medscape.com)

Bempedoic acid is a first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibiting cholesterol synthesis in the liver. (medscape.com)

The cor- provoke the preferential development of T helper 2-type ollary is that by definition we are considering here chemi- immune responses. (cdc.gov)

Anatomy38

Organisms13

Diseases20

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes36

Disciplines and Occupations1

Information Science3

Health Care1

TIMPs18

TIMP50

Matrix39

Proteins7

Angiogenesis5

Cytokines2

Collagen3

Degradation2

Enzymes2

Conclusions2

Connective tissues1

Protease1

Expression21

Mmp91

Vitro2

Regulation2

Membrane1

Investigate3

Inhibition1

Significantly3

Tumors2

Inflammatory3

0.051

Fibrosis8

Tumor1

Cells12

Gelatinases2

Gelatinase2

Aortic2

Plasminogen2

Pathological1

Protein levels1

Angiogenic1

Serum3

Deficiency1

Lung3

Endothelial1

Mechanism1

Enzyme-linke1

Pregnancy1

Fibrogenic1

Lowers1

Type1