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  • Mechanism
  • The processing mechanism and gelatinolytic activity of the membrane-type matrix metalloproteinase 1 (MT-MMP-1) were examined by expressing in COS-1 cells a deletion mutant of MT-MMP-1 lacking the trans-membrane domain (delta MT1) and its site-directed mutant with a furin-resistant sequence in the propeptide domain (mutant delta MT1). (semanticscholar.org)
  • vascular
  • Adipose tissue secretes various bioactive molecules, termed adipocytokines, that directly contribute to obesity-linked metabolic and vascular diseases. (ahajournals.org)
  • Human
  • It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. (labome.org)
  • Adiponectin is an adipocyte-specific plasma protein that we identified in a human adipose tissue cDNA library. (ahajournals.org)
  • 7 Moreover, we recently found that C-reactive protein levels are negatively correlated with adiponectin levels in both human plasma and adipose tissue. (ahajournals.org)
  • enzyme
  • Complexes of enzyme and inhibitor are not re-activated by aminophenylmercuric acetate and only partially so by high levels of trypsin. (biochemj.org)
  • cell
  • Cell cycle inhibitors such as p21 and p27 are crucial in promoting the exit of cardiomyocytes from the cell cycle ( 6 ). (physiology.org)
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • Type
  • Hepatocyte growth factor (HGF/scatter factor) signaling regulates a multitude of downstream prometastatic effector molecules, such as urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), plasminogen activator inhibitor-1 (PAI-1), and MMPs ( 15 - 17 ). (aacrjournals.org)