• In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)
  • In the second one, fibrosis could be a result of local adipose tissue inflammation induced by tissue expansion. (springer.com)
  • Adipose tissue inflammation appears to be a risk factor for the progression of chronic kidney disease (CKD), but the effect of CKD on adipose tissue inflammation is poorly understood. (mdpi.com)
  • The purpose of this study was to clarify the involvement of uremic toxins (indoxyl sulfate (IS), 3-indoleacetic acid, p-cresyl sulfate and kynurenic acid) on CKD-induced adipose tissue inflammation. (mdpi.com)
  • Research progress on the mechanism of perivascular adipose tissue inflammation promoting atherosclerosis[J]. Basic & Clinical Medicine, 2023, 43(4): 685-689. (magtechjournal.com)
  • We previously reported that the gut microbiota is involved in high-fat diet-induced metabolic endotoxaemia, adipose tissue inflammation and metabolic disorders. (bmj.com)
  • In the past, numerous studies investigating WAT inflammation have shown that the release of pro-inflammatory cytokines, such as TNFα, IL-6 or gp130 cytokines, are implicated in insulin-resistance [ 9 , 10 ]. (springer.com)
  • However many more pro and anti-inflammatory mediators produced by the adipose tissue have been described since then. (springer.com)
  • As senior investigator Dr. Noyan Gokce told Reuters Health, "Our data demonstrate that obese subjects exhibit varying degrees of inflammation in their fat tissue, and increased inflammatory activity in fat was associated with systemic metabolic abnormalities including insulin resistance. (massagemag.com)
  • Type 2 immunity against pathogens is tightly regulated to ensure appropriate inflammatory responses that clear infection and prevent excessive tissue damage. (broadinstitute.org)
  • However, upon exposure to inflammatory stimuli, they also initiate and amplify type 2 inflammation by inducing mucus production, eosinophilia, and Th2 differentiation. (broadinstitute.org)
  • We hypothesize that the low-grade inflammatory state associated with obesity is present in human mammary tissue, stimulates Wnt activity, and thereby leads to the development of breast cancer. (umass.edu)
  • These macrophages were also highly imbued by known pro-inflammatory proteins, NLRP3 inflammasome and Caspase-1 which are associated with type 2 diabetes and insulin resistance in adipose tissue. (oulu.fi)
  • The inflammatory phase of any tissue injury is crucial and necessary for healing to take place as it is the initial phase in the repair process. (spriggschiropractic.co.uk)
  • Problems appear to only seriously arise when the inflammatory trigger is non-infectious inflammation. (drvincentjosephblog.com)
  • PVAT inflammation could induce various crucial stages of atherosclerosis by disturbing secretion of inflammatory and anti-inflammatory adipokines, inhibiting PVAT cell autophagy, and activating angiogenesis in arterial adventitia, thereby promoting the onset and progression of atherosclerosis. (magtechjournal.com)
  • Larvae can cause inflammatory reactions in organs and tissue damage. (cdc.gov)
  • Photobiomodulation reduces abdominal adipose tissue inflammatory infiltrate of diet-induced obese and hyperglycemic mice. (google.com)
  • The accumulation of sub-dermal adipose tissue and, consequently, increased pro-inflammatory cytokine release could affect the dermal fibroblast physiology. (buckingham.ac.uk)
  • Some specific SF1 neurons appear to regulate inflammatory response and thermogenesis differently in individual depots of fat through sympathetic nerves innervating the tissues. (polymerelektronik.org)
  • Misbah Rashid et al, Inhibition of high-fat diet-induced inflammatory responses in adipose tissue by SF1-expressing neurons of the ventromedial hypothalamus, Cell Reports (2023). (polymerelektronik.org)
  • Take scientific discoveries in inflammation biology through into new treatments for patients with inflammatory and autoimmune joint, muscle, gut and liver diseases. (birmingham.ac.uk)
  • BZK induced a significant increase in the severity of the clinical score, infiltration of inflammatory cells, local expression of inflammatory cytokines in subcutaneous tissue, and total serum immunoglobulin (Ig) E. PVP-I increased the clinical score, number of mast cells, and production of inflammatory cytokines, and total serum IgE. (medsci.org)
  • The accumulation in adipose tissue of macrophages in an inflammatory state is a hallmark of obesity-induced insulin resistance. (edu.au)
  • In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper. (frontiersin.org)
  • Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. (wjgnet.com)
  • We assessed changes in the gut microbiota, intestinal permeability, gut peptides, intestinal epithelial tight-junction proteins ZO-1 and occludin (qPCR and immunohistochemistry), hepatic and systemic inflammation. (bmj.com)
  • Obesity is associated with adipose and vascular remodelling, an inadequate blood supply leading to hypoxia and systemic inflammation. (buckingham.ac.uk)
  • Centre for Inflammation and Tissue Repair (CITR) conducts world leading fundamental and translational research in the field of inflammation and tissue repair within the setting of respiratory disease and tissue fibrosis. (ucl.ac.uk)
  • Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)
  • In this review, we aim to describe two hypotheses trying to explain the sequence of events linking fibrosis, inflammation and obesity complications. (springer.com)
  • Whether fibrosis is a cause or consequence of inflammation is presently unknown but will be discussed further. (springer.com)
  • Using animals with a DNA repair, the IMBB researchers provide a novel mechanism by which DNA damage leads to cellular senescence, fibrosis, loss of tissue architecture and chronic pancreatitis in mice. (forth.gr)
  • Some interpret this type of response to mean that (in a world prior to the availability of antibiotics, inflammation, with reactive walling-off fibrosis to contain pathogens) it is desirable because it increases survivability of the host. (drvincentjosephblog.com)
  • As explained by three vaunted researchers Cyriax, Boyd, and Guyton above, the trigger to the walling-off fibrosis response of the body is inflammation. (drvincentjosephblog.com)
  • In such cases, excessive tissue fibrosis creates local impairments in biomechanical function. (drvincentjosephblog.com)
  • Once established, abnormal tissue fibrosis can be improved with the use of a variety of motion applications. (drvincentjosephblog.com)
  • The chronic nature of this scar tissue or fibrosis is expressed in the 1998 article by Thomas Melham and associates (6). (drvincentjosephblog.com)
  • Many athletes develop excessive connective tissue fibrosis (scar tissue) or poorly organized scar tissue in and around muscles, tendons, ligaments, joints, and myofascial planes as a result of acute trauma, recurrent microtrauma, immobilization, or as a complication of surgical intervention. (drvincentjosephblog.com)
  • However, persistent inflammation prevents proper tissue regeneration and instead results in fibrosis, the accumulation of connective tissue. (forbes.com)
  • Hematoxylin-eosin and Masson's trichrome stained sections showed absence of necrosis, fibrosis, inflammation, cyst formation, and increased vascularization of both inner and outer zones of the grafts in Group IV. (google.com)
  • Application of PBM to the recipient site before and after fat transfer improved outcomes in rats at 56 day after fat grafting by means of volume retention, increased neovascularization and adipocyte viability and reduced necrosis, fibrosis and inflammation. (google.com)
  • Alcohol-mediated activation of inflammation signaling pathways can increase tumorigenesis in mice[ 3 ]. (wjgnet.com)
  • Mice lacking the Vanin-1 isoform lack cysteamine and show increased resistance to inflammation-triggered gut damage. (univ-mrs.fr)
  • Mice lacking Vanin-1 are protected from acute inflammation triggered by toxic or infectious insults in gut. (univ-mrs.fr)
  • Although Tmem45b-knockout mice showed normal responses to noxious heat and noxious mechanical stimuli under normal conditions, mechanical pain hypersensitivity was selectively impaired after inflammation and tissue incision, reproducing the pain phenotype of IB4 sensory neuron-ablated mice. (iasp-pain.org)
  • Results from bone marrow chimeric and knockout mice show that B7-H1 expressed on intestinal parenchyma, but not on hematopoietic cells, controls intestinal inflammation in an adaptive immunity-independent fashion. (johnshopkins.edu)
  • Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism[J]. Vascul Pharmacol, 2019, 115:55-63. (magtechjournal.com)
  • When challenged with a high-fat diet, mice that received β1-/- bone marrow displayed enhanced adipose tissue macrophage inflammation and liver insulin resistance compared with animals that received WT bone marrow. (edu.au)
  • Neutrophils and activated macrophages (CD11c+ CD11bhi) persisted after recovery in lung tissues of anti-AREG-treated mice. (cdc.gov)
  • Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. (frontiersin.org)
  • Circulating cytokines can act on the brain to induce local inflammation and production of cytokines which can contribute to cognitive decline and dementia. (buckingham.ac.uk)
  • Macrophages participate in all the different phases of tissue repair: they can promote phagocytosis of cellular debris and apoptotic neutrophils and produce cytokines that may help orchestrate the healing response. (hindawi.com)
  • However, due to the release of proinflammatory cytokines and cytotoxic radical species, uncontrolled activity of macrophages may also be detrimental to tissue repair. (hindawi.com)
  • Macrophages play a significant role in many processes, such as the human immune function, parasite infection, and tissue remodeling by secreting cytokines and producing reactive oxygen and nitrogen intermediates. (frontiersin.org)
  • Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)
  • This mechanism might account for the extent of tissue damage upon stress but also contributes to normal chondrogenesis by regulating chondroblast expansion. (univ-mrs.fr)
  • Excessive scar tissue contributes to chronic soft tissue dysfunction that cause significant disabilities and time lost from work or training activities, and these problems are often difficult to successfully treat. (drvincentjosephblog.com)
  • Results In the live birth subjects with chronic placental inflammation we observed an increased proportion of RORγt+ cells in Foxp3+ cells, regardless of the presence of acute inflammation, compared to subjects with neither acute nor chronic inflammation. (figshare.com)
  • Macrophage activation has been described as a dynamic process: the same cell may initially induce proinflammatory and cytotoxic reactions and later may take part in the resolution of inflammation and wound healing [ 9 ]. (hindawi.com)
  • The hyphal form, constituted by filamentous cells, has the ability to invade tissue and induce inflammation. (lu.se)
  • Phenotypic changes in T cell and macrophage subtypes in perivasuclar adipose tissue precede high-fat diet-induced hypertension [J]. Front Physiol, 2021, 12:616055. (magtechjournal.com)
  • The researchers found that 50 of the subjects had an inflamed adipose phenotype characterized by tissue macrophage accumulation in crown-like structures. (massagemag.com)
  • In addition, macrophage retention in fat was associated with upregulated tissue CD68 and tumor necrosis factor mRNA expression and with increased plasma high sensitivity C-reactive protein. (massagemag.com)
  • In this thesis, two behaviorally distinct macrophage pools are identified in subcutaneous adipose tissue of subjects with obesity. (oulu.fi)
  • Inflammation increased both MCP-1 and TNF-α expression and macrophage infiltration in radial arteries. (medsci.org)
  • Therefore, in the last years characterization of macrophage phenotype in vivo during tissue repair has been a matter of active investigation. (hindawi.com)
  • On microscopic level, this associates with the infiltration of immune cells, particularly macrophages, into adipose tissue. (oulu.fi)
  • Of these, only the macrophages associated with pyroptotic adipocyte deaths decreased after laparoscopic Roux-en-Y gastric bypass for obesity. (oulu.fi)
  • IMBB researchers reveal that DNA damage in tissue-infiltrating macrophages triggers an exosome-based metabolic reprogramming leading to chronic inflammation. (forth.gr)
  • Beyond their role in innate immunity, macrophages play increasingly defined roles in orchestrating the healing of various injured tissues. (hindawi.com)
  • A lot of evidence demonstrated that after acute injury M1 macrophages infiltrate early to promote the clearance of necrotic debris, whereas M2 macrophages appear later to sustain tissue healing. (hindawi.com)
  • In this paper, we discuss the current available information about the role that different phenotypes of macrophages plays after injury and during the remodelling phase in different tissue types, with particular attention to the skeletal muscle. (hindawi.com)
  • Macrophages are essential for the efficient healing of numerous tissues. (hindawi.com)
  • Heterogeneity and plasticity of macrophages could explain these apparently contrasting roles in tissue healing. (hindawi.com)
  • A common scenario is emerging, in which soon after injury infiltrating macrophages are mainly proinflammatory M1 macrophages, whereas M2 macrophages are the primary effectors of later stages of tissue repair or remodelling phases [ 10 - 12 ]. (hindawi.com)
  • Here, we reveal a role for AMPK β1 in protecting macrophages from inflammation under high lipid exposure. (edu.au)
  • β1-/- macrophages displayed increased levels of diacylglycerol and markers of inflammation, effects that were reproduced in WT macrophages by inhibiting fatty acid oxidation and, conversely, prevented by pharmacological activation of AMPK β1-containing complexes. (edu.au)
  • Macrophages are phagocytes found in tissues and maintain tissue homeostasis, regulate inflammation, and play a significant role in host protection. (frontiersin.org)
  • From a cohort of 19 live birth infants, we collected cord blood and placenta samples to evaluate for signs of acute and chronic histologic inflammation and cell phenotype characterization. (figshare.com)
  • One of the research areas at the MDC is immunology and inflammation, which covers tumor immunology, DNA repair in B lymphocytes, the role of tumor stroma-immune cell interaction in cancers, the role of innate immune cells in gliomas and neurodegenerative diseases, and the development of immunotherapy strategies. (mdc-berlin.de)
  • Finally, we demonstrate that B7-H1 dampened intestinal inflammation by inhibiting tumor necrosis factor α (TNF-α) production and by stimulating interleukin 22 secretion from CD11c + CD11b + lamina propria cells. (johnshopkins.edu)
  • Tumor Microenvironment: Tissue cytometry is heavily used in research to characterize the tumor microenvironment including e.g. identification of the immune landscape or tumor-vascularization, within IHC/IF-processed tissue sections. (wikipedia.org)
  • Accumulation of neutral lipids, such as triglycerides, in key insulin target tissues, has been postulated to inhibit metabolic functions, however, they are less likely to be deleterious. (frontiersin.org)
  • Notably, recent studies suggest that the accumulation of sphingolipids, namely ceramides and it's metabolites, play essential roles in the development of insulin resistance in tissues such as skeletal muscle, liver and, adipose tissue in obese rodents, and humans ( 6 - 20 ). (frontiersin.org)
  • However, very few studies of the possible effects of insulin in cerebral tissues of septic patients have been reported. (biomedcentral.com)
  • Understanding the tissue-specific pathways that regulate ILC2 diversity and function is a critical step in the development of potential therapies for allergic diseases. (broadinstitute.org)
  • 2006). By using some of these compounds found in certain foods, the healing process can be supported, allowing for both optimal healing and stopping/inhibiting some pathways that trigger chronic or recurring inflammation. (spriggschiropractic.co.uk)
  • We used linear regression analysis determine the association of retinoic acid-related orphan receptor gamma t positive (RORγt+) and Treg cell frequency with different types of inflammation seen in the live cohort subjects. (figshare.com)
  • The presence of various types of adipocytes (white, brown, and beige) characterized by the number/size of lipid droplets, mitochondrial density, and thermogenic capacity, further highlights how intricate is the communication of these cell-types with other metabolic tissues to sense nutrients. (frontiersin.org)
  • In obesity the inherent capacity of adipose tissue to store and sense nutrients is compromised, causing spillover of the intermediate lipid metabolites into circulation and resulting in their ectopic deposition in tissues not suitable for lipid storage, a phenomenon known as lipotoxicity. (frontiersin.org)
  • In this review, we aim to describe the relationships and discussed sequence of events associated with hypoxia, ECM remodeling and inflammation in the development of obesity and associated complications. (springer.com)
  • This failed tissue regeneration is key to osteoarthritis. (forbes.com)
  • Persistent mechanical pain hypersensitivity associated with peripheral inflammation, surgery, trauma, and nerve injury impairs patients' quality of life and daily activity. (iasp-pain.org)
  • Following any trauma or tissue insult, the first thing that happens in your body is the tissues become inflamed (Hammar and Leahy, 1999). (spriggschiropractic.co.uk)
  • We propose that racial residential segregation and discrimination increases tissue inflammation and cytokine production, resulting in dysregulated immune signaling, which promotes plaque formation and cardiovascular disease. (frontiersin.org)
  • We expect to define a novel mechanism that obesity mediates the development of postmenopausal breast via inflammation-driven Wnt signaling. (umass.edu)
  • Thus, our data uncover a mechanism through which intestinal tissue-expressed B7-H1 functions as an essential ligand for innate immune cells to prevent gut inflammation. (johnshopkins.edu)
  • Here, we hypothesised that prebiotic modulation of gut microbiota lowers intestinal permeability, by a mechanism involving glucagon-like peptide-2 (GLP-2) thereby improving inflammation and metabolic disorders during obesity and diabetes. (bmj.com)
  • Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
  • Conclusions Signs of immune cell accumulation and activation are present both in the bronchial tissue and in BAL of untreated patients with early RA without concomitant lung disease, strengthening the role of the lung compartment as an important player in ACPA-positive RA. (bmj.com)
  • They participate in polarized Th2 reactions, parasite clearance, damping of inflammation, and promotion of angiogenesis and tissue remodelling [ 7 , 8 ]. (hindawi.com)
  • Research carried out at the Institute of Molecular Biology and Biotechnology (IMBB) of FORTH, provides evidence that persistent DNA damage triggers an exosome-based, metabolic reprogramming that leads to chronic inflammation and tissue pathology in DNA repair-deficient progeroid syndromes and likely also during aging. (forth.gr)
  • Examination of tissue biopsies and morphological identification of larvae may be helpful, but depending on the number of larva it may be problematic to acquire an effective sample (one with a cross-section of a larva). (cdc.gov)
  • Immunohistochemistry is used in clinical practice, where tissue biopsies from every potential cancer patient are collected, fixed in formalin and embedded on paraffin. (wikipedia.org)
  • Here, CFTR is downregulated in brain, heart, and lung tissue and associates with inflammation and degenerative processes. (lu.se)
  • By utilizing tissue cytometry multiple research groups were able to demonstrate the impact of various immune cell subpopulations (CD4, CD68, CD8, CD20, Foxp3, PD1) on patient survival in different cancer types (e.g. breast cancer, colon cancer, gastric cancer, melanoma, non-small cell lung cancer). (wikipedia.org)
  • The association of chorioamnionitis on human neonatal immune cells systemically and within tissues is not known. (figshare.com)
  • How is the tissue specificity of immune cells generated and how is it affected by environmental influences, plasticity and the tissue microenvironment? (mdc-berlin.de)
  • In this review, we intend to provide a perspective on ceramides and ceramide metabolites in the maintenance of adipose tissue homeostasis and how adipose tissue ceramides contribute to the development of metabolic diseases. (frontiersin.org)
  • There is now a growing appreciation that various metabolites released from adipose tissue serve as key signalling mediators, influencing this interaction with inflammation . (bvsalud.org)
  • The initiative entitled "Immunology & Inflammation" brings together immunology research - which is spread out over various Helmholtz Centers - in a common structure. (mdc-berlin.de)
  • In a new study published in Cell Reports , researchers led by the National Institute for Physiological Sciences (NIPS) employed a high fat diet-fed mouse model to demonstrate how neurons that express a protein called steroidogenic factor 1 (SF1) influence inflammation in different regions or "depots" of fat. (polymerelektronik.org)
  • This epithelial molecule senses tissue stress and licenses downstream activation of innate immune responses. (univ-mrs.fr)
  • B7-H1 deficiency during intestinal inflammation leads to high mortalityand morbidity, which are associated with severe pathological manifestations in the colon, including loss of epithelial integrity and overgrowth of commensal bacteria. (johnshopkins.edu)
  • Thus, our study demonstrates that Tmem45b is essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity and highlights Tmem45b as a therapeutic target for future treatment. (iasp-pain.org)
  • Thus, we tested ivacaftor as therapeutic strategy for MI-associated target tissue inflammation that is characterized by CFTR. (lu.se)
  • These findings led the team to propose a new therapeutic strategy, aimed at combating chronic inflammation and tissue damage with aging. (forth.gr)
  • The findings support the notion that the development of EV-based therapeutic regimens against DNA damage-driven cytoplasmic ssDNAs is a promising therapeutic strategy against chronic inflammation and tissue degeneration with aging. (forth.gr)
  • Diathermy is therapeutic heating of tissues using oscillating high-frequency electromagnetic fields, either short-wave or microwave. (msdmanuals.com)
  • They are not only responsible for innate immunity, but also participate in the development of intestinal inflammation. (frontiersin.org)
  • Different effects of high-fat and high-sucrose diets on the physiology of perivascular adipose tissues of the thoracic and abdominal aorta[J]. Adipocyte, 2021, 10:412-423. (magtechjournal.com)
  • Subcutaneous WAT manifests a lower extent of inflammation than that in abdominal WAT. (polymerelektronik.org)
  • The Centre for Inflammation and Tissue Repair (CITR) is part of the UCL Respiratory collaborative network with close links to The Lungs for Living Research Centre (L4L) and The Centre for Respiratory Biology . (ucl.ac.uk)
  • Inflammation contributed to foam cell formation in the radial arteries of ESRD patients via activation of the CXCL16/CXCR6 pathway, which may be regulated by P2X7R. (medsci.org)
  • Pathological conversion of mouse perivascular adipose tissue by Notch activation[J]. Arterioscler Thromb Vasc Biol, 2020, 40:2227-2243. (magtechjournal.com)
  • Through a series of experiments, they discovered that inflammation in the synovial fluid may be the proximate cause. (forbes.com)
  • Researchers have compiled a comprehensive reference of synovial tissue from patients with rheumatoid arthritis, which could inform new targeted therapies. (birmingham.ac.uk)
  • Tissue cytometry enables cellular analysis within thick tissues, retaining morphological and contextual information, including spatial information on defined cellular subpopulations. (wikipedia.org)
  • Although various deletions of the mitochondrial genome have been reported, the 4977 bp deletion is the most widespread and has been associated with ageing in tissues ( Kowald, 1999 ). (nature.com)
  • We therefore sequenced a small portion of the hypervariable D-loop region of mitochondria from individuals with HCC in matching tumour and nontumour liver tissue to determine the frequency of mitochondrial mutations. (nature.com)
  • about 66% is found in the skeleton, 16% in the liver, 8% in the kidneys and 10% in other tissues. (who.int)
  • Release of damaged cells and tissue debris occurs upon injury. (medscape.com)
  • Type 2 innate lymphoid cells in the induction and resolution of tissue inflammation. (broadinstitute.org)
  • Recent research has shown that type 2 innate lymphoid cells (ILC2s) contribute to steady-state tissue integrity and exert tissue-specific functions. (broadinstitute.org)
  • We also found an increased proportion of RORγt+ cells within Foxp3+ cells in subjects with acute high stage fetal and maternal inflammation compared to those without acute or chronic inflammation. (figshare.com)
  • Following an injury, the body releases a myriad of different cells and chemicals into the blood stream that cause vasodilation causing blood to pool around the injured tissue resulting in the swelling and redness (Stevens and Lowe, 2000). (spriggschiropractic.co.uk)
  • The fluid collection that causes the swelling allows blood, oxygen, glucose, salts, vitamins and minerals to enter the site and provide appropriate nutrition to the tissues and cells present. (spriggschiropractic.co.uk)
  • An increase of white blood cells indicates infection, inflammation, or bleeding into the cerebrospinal fluid. (medlineplus.gov)
  • However, the lower frequency of the large deletion in cancerous tissue suggests that there is selection against either mitochondria, which harbour large deletions, or against cells that contain these mitochondria during hepatocarcinogenesis. (nature.com)
  • In this process, a tissue sample, either formalin-fixed paraffin-embedded (FFPE) or frozen tissue section, also referred to as "cryocut", is labelled with either immunohistochemistry(IHC) or immunofluorescent markers, scanned with high-throughput slide scanners and the data gathered from virtual slides is processed and analyzed using software that is able to identify individual cells in tissue context automatically and distinguish between nucleus and cytoplasm for each cell. (wikipedia.org)
  • The advantage of tissue cytometry against flow cytometry is that tissue cytometry does not require the cells to be suspended in fluid, aiding in maintaining the integrity of the tissue structure, morphology, and contextual information, further assisting in precise and accurate contextual analysis that are not possible in flow cytometry. (wikipedia.org)
  • A more robust and automated system was designed to perform flow cytometry-like analyses on immunostained cells in a fixed tissue and termed tissue cytometry. (wikipedia.org)
  • Structure and function of the human body including cells, tissues and membranes. (bangor.ac.uk)
  • One reason is that by using this technology the complex tissue architecture stays intact and therefore also spatial relationships between cellular phenotypes and/or multicellular structures can be analyzed. (wikipedia.org)
  • NEW YORK (Reuters Health) - Certain obese people demonstrate potentially harmful proinflammatory changes in their adipose tissue, researchers report in the September issue of Arteriosclerosis, Thrombosis, and Vascular Biology. (massagemag.com)
  • Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling[J]. Nat Commun, 2022, 13:5117. (magtechjournal.com)
  • Multilevel Assessment of Stent-Induced Inflammation in the Adjacent Vascular Tissue. (illumina.com)
  • Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and consumption. (frontiersin.org)
  • The percentage of control subjects harbouring D-loop mutations was 11%, which was significantly lower than that observed in both the noncancerous (49%, P =0.033) and tumour tissue (59%, P =0.014) of patients with HCC. (nature.com)
  • We also review recent discoveries about ILC2 plasticity and heterogeneity in different tissues, as revealed partly through single-cell RNA sequencing of transcriptional responses to various stimuli. (broadinstitute.org)
  • Back in 1984, orthopedic surgeon Sir James Cyriax, MD, reviewed The Concept Of Motion in his Textbook of Orthopaedic Medicine, Diagnosis of Soft Tissue Lesions (1). (drvincentjosephblog.com)
  • When it comes to soft tissue injuries like sprains and strains, red light therapy may both promote healing and offer pain relief as well. (healthline.com)
  • Researchers are uncovering ever more details about the complex system of organs, tissues, and different cell types that make up the human immune system. (mdc-berlin.de)
  • Inflammation and tissue damage, I feel is an important topic for people to understand because if you understand the what happens during inflammation and tissue damage, you can take control over your health and healing from injuries. (spriggschiropractic.co.uk)
  • Another pantetehinase isoform exists in mouse and is encoded by the Vanin-3 gene showing distinct tissue specificity. (univ-mrs.fr)
  • Inflammation is one of the body's first reactions to injury. (medscape.com)
  • The needle itself may provide drainage and a release of pressure, and it may also mechanically disrupt the scar tissue in the muscle. (medscape.com)
  • These authors note that post-traumatic scar tissue can cause pain with activity, pain on palpation, decreased range of motion, and loss of function, and that these problems are resistant to surgery and to conventional physical. (drvincentjosephblog.com)