Tissue induce blastema cells. Medical search. Frequent questions

It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types. (wikipedia.org)
In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
In this research, we generate differentiated kidney cells (DKCs) from mouse pluripotent stem cells (mPSCs) analyzing their morphological, genetic, phenotypic, and spectroscopic characteristics along differentiation, highlighting that there are no reports of the use of Fourier transform infrared (FTIR) spectroscopy to characterize the directed differentiation of mPSCs to DKCs. (biomedcentral.com)
Moreover, FTIR spectroscopy resulted in a non-invasive, rapid and precise technic that together with principal component analysis allows to characterize chemical and structurally both kind of cells and also discriminate and determine different stages along the cell differentiation process. (biomedcentral.com)
Although not essential for initial WD formation, the later differentiation of this embryological structure relies on androgens derived from the Leydig cells. (esur2023.com)
In the presence of a Y chromosome and the SRY gene, müllerian‐inhibiting substance produced by Sertoli cells causes regression of the MD. Meanwhile, testosterone produced by the Leydig cells induces differentiation of the WD into the efferent ducts that communicate with the rete testis, followed by the epididymis, ductus deferens, seminal vesicle, and ejaculatory duct. (esur2023.com)
Neural control of growth and size in the axolotl limb regenerate [2] "Upon the completion of the developmental stages of regeneration, when the regenerative organ known as the blastema completes patterning and differentiation, the limb regenerate is proportionally small in size. (edu.au)
HIF-1α drives the transcription of NOG to inhibit osteogenic differentiation of periodontal ligament stem cells in response to hypoxia. (stembook.org)

We are currently investigating the regenerative capacity of specific cardiac cell populations and comparing the restorative programs of different fish species. (unifr.ch)
Objectives: Regenerative studies on model animals often require invasive techniques such as tissue sampling and histology for visualisation of regenerative processes. (au.dk)
The internalisation of very small super paramagnetic iron oxide particles (VSOP) in animal cells enable non invasive cell tracking using magnetic resonance imaging (MRI) and can prove useful, when visualising regenerative processes. (au.dk)
Interestingly, the neoblast mitotic response was increased around the amputation area but the regenerative blastema failed to form. (biomedcentral.com)
This organism is well known for its stem cell-based regenerative capability. (biomedcentral.com)
Their findings suggest that Fgf signals act directly on fin ray mesenchyme to form a blastema at the early pre-blastema stage and activate regenerative cell proliferation at the post-blastema stage. (titech.ac.jp)
In urodele amphibians such as axolotls and newts, the same injury is followed by scarless regenerative healing that can fully restore both the lost tissue and its function (reviewed in Tanaka, 2016 ). (frontiersin.org)
This volume is therefore essential reading for molecular, cell, and developmental biologists studying regeneration in animals, as well as for all interested in the development of regenerative therapies for clinical application. (cshlpress.com)
therefore, new researches focused on regenerative medicine have been developed, including the use of stem cells. (biomedcentral.com)
Consequently, because of the increased rate of RF in terminal stage and few alternative treatments, new investigations focused on regenerative medicine have been developed, including the use of stem cells (SCs) [ 7 ]. (biomedcentral.com)
This study demonstrates the importance of a stress response for stem cell activation and regeneration in a basal chordate, which may have implications for understanding the limited regenerative activities in other animals, including vertebrates. (biomedcentral.com)
Members of the free-living genus Planaria are widely interrogated in the realm of stem cell biology due to their remarkable regenerative abilities [ 8 ]. (biomedcentral.com)

Through gain-of-function analyses, they demonstrated that Fgf20a induces distal blastemal formation and Fgf3 promotes blastema cell proliferation. (titech.ac.jp)
The metanephric blastema forms glomeruli, proximal and distal tubules. (esur2023.com)
In this specific article, that Lgr5 is normally demonstrated by us is really a marker of neither the toe nail stem cells nor the toe nail epithelium, but rather marks a mesenchymal people of cells inside the proximal toe nail flip as well as the distal groove whose appearance isn't correlated with a regeneration-specific function. (informationalwebs.com)
Lgr5 is usually expressed in a mesenchymal populace of cells in the proximal fold and distal groove. (informationalwebs.com)
Unidirectional regeneration in the basal chordate Ciona intestinalis involves the proliferation of adult stem cells residing in the branchial sac vasculature and the migration of progenitor cells to the site of distal injury. (biomedcentral.com)
However, after the Ciona body is bisected, regeneration occurs in the proximal but not in the distal fragments, even if the latter include a part of the branchial sac with stem cells. (biomedcentral.com)
siRNA-mediated gene knockdown showed that hsp70 and dnaJb4, but not bag3, are required for progenitor cell targeting and distal regeneration. (biomedcentral.com)
Heat shock treatment of distal body fragments activated hsp70 and dnaJb4 expression indicative of a stress response, induced cell proliferation in branchial sac vasculature cells, and promoted distal regeneration. (biomedcentral.com)
The stress response is absent from distal fragments, but can be induced by a heat shock, which activates cell division in the branchial sac vasculature and promotes distal regeneration. (biomedcentral.com)

Our laboratory identified signalling pathways that orchestrate proliferation, migration and patterning of different tissues in the regenerating fin. (unifr.ch)
Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
In mammals, Akt is ubiquitously expressed and is associated with regulation of cellular proliferation, metabolism, cell growth and cell death. (biomedcentral.com)
Functional disruption of Smed-Akt alters the balance between cell proliferation and cell death leading to systemic impairment of adult tissue renewal. (biomedcentral.com)
The protein kinase Akt also known as PKB, regulates multiple cellular functions including proliferation, survival, and growth during embryonic development and adult tissue homeostasis [ 1 - 5 ]. (biomedcentral.com)
This study defined the role of Smed-Akt in abnormal cell proliferation triggered by the abrogation of the phosphatase PTEN, an upstream component of the Akt signaling pathway, which is highly mutated in human cancers. (biomedcentral.com)
At a later stage, Fgf3 up-regulated in the blastema functions as a mitogen and promotes cell proliferation. (titech.ac.jp)
Many challenges remain, however, such as determining what makes Fgf20 activate in wounded epidermis, and how cell proliferation leads to complete recovery of tissue shape and function. (titech.ac.jp)
In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
RESULTS: Human ASCs exhibited decreased cell proliferation and migration with enhanced senescence when cultured in HG condition in vitro. (bvsalud.org)

The zebrafish fin is a multi-tissue appendage, the correct pattern and size of which can be restablished within 3 weeks after amputation. (unifr.ch)
First, the fin margin is covered by a wound epithelium, and next a proliferative blastema arises by dedifferentiation of stump tissues near the amputation. (unifr.ch)
However, in response to amputation, levels of cell death were decreased and failed to localize near the injury site. (biomedcentral.com)
This process relies on the formation of a blastema, a pool of progenitor cells that is formed in response to amputation. (lu.se)
After amputation, granular hemocytes infiltrate the blastema of regenerating cephalic tentacles of the freshwater snail Pomacea canaliculata. (unimore.it)
Histological studies focusing on the early cephalic tentacle regeneration in P. canaliculata, have demonstrated that wound closure and blastema formation took place within 24 h post amputation (hpa). (unimore.it)
Loss or amputation of the axolotl limb leads to the regeneration of the lost limb from trunk tissue, thereby repeating a developmental sequence as a repair process. (edu.au)

Kosir R, Acimovic J, Golicnik M, Perse M, Majdic G , Fink M, Rozman D Determination of reference genes for circadian studies in different tissues and mouse strains. (arnes.si)
One of our research interests is to understand mitochondrial heterogeneity and diversity of structure, function and expression dynamics across different tissues, but also in different disease conditions. (univ-amu.fr)

We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)

Our experiments revealed that the myocardium adjacent to the injury undergoes dedifferentiation, during which embryonic cardiac programs become reactivated to give rise to new tissue. (unifr.ch)
Dedifferentiation Dedifferentiation happens in conjunction with the libera tion of cells from their tissue matrix by protease induced histolysis. (atpasesignaling.com)
Hence it can be possible that LIN28 may perform a part from the selleckchem transcriptional regulation of nuclear reprogramming dur ing limb cell dedifferentiation. (atpasesignaling.com)
The molecular characteri zation of blastema cell surface antigens and study of the regulation of dedifferentiation by transcription variables, microRNAs, polycomb proteins and chromatin modify ing enzymes is going to be essential for comprehending the mecha nism of dedifferentiation in regenerating amphibian limbs. (atpasesignaling.com)

The formation of new cells, tissues, and organs enables animals to recover from day-to-day wear and tear, injury, and disease. (cshlpress.com)
Much current attention is focused on the axolotl's amazing ability to regenerate tissues and whole organs after injury. (edu.au)
This pathological end stage of tissue repair is characterised by excess extracellular matrix (ECM) deposition due to increased production and/or an imbalance in turnover often resulting in functional damage in tissues and organs [ 3 , 4 ]. (biomedcentral.com)

BMP7 induces the phosphorylation of SMAD1 and SMAD5, which in turn induce transcription of numerous osteogenic genes. (wikipedia.org)

Unlike mammals, certain species of amphibians and fish have the remarkable ability to regenerate tissue. (titech.ac.jp)

mitotically active cells of intact segments do not significantly contribute to the blastemal cellular sources. (mdpi.com)

This study examines the possibility of labelling limited numbers of axolotl blastema cells (aBC) and pig endothelial progenitor cells (pEPC) with VSOP and detecting these in vitro and in vivo using a traditional clinical 1.5 T scanner. (au.dk)
This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)

The focus of her studies includes the coordination of wound repair and functional regeneration of tissues in fish. (unifr.ch)

Sec ondly, NO signaling inhibits apoptosis and induces ded ifferentiation of chondrocytes in vitro by means of p38 kinase and calveolin 1. (atpasesignaling.com)
In a microarray gene profiling research with blood PD tissue, it was demonstrated a panel of genes linked with PD danger, several of them concerned in patho biologically related sickness processes from the ubiquitin proteasome pathway system, mitochondrial function, and apoptosis. (fgfrinhibitors.com)

Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. (wikipedia.org)
To observe the role of Fgf signaling in regeneration, they transplanted Fgf signaling-deficient mesenchymal cells into wild-type zebrafish. (titech.ac.jp)
The early Fgf signal mediated by Fgf20 from the wound epidermis induces blastema formation by acting on the underlying mesenchymal cells. (titech.ac.jp)

Advances in molecular biological analyses have allowed researchers to identify specific molecules and signaling mechanisms involved in tissue regeneration. (titech.ac.jp)
The contributors discuss the dramatic molecular and cellular changes that occur when a regeneration program is initiated, the progenitor cells and morphogenic signals involved, the formation of a blastema, the roles of reprogramming and polyploidy, the diversity of cell fates, the integration of new structures with existing body parts, and our current understanding of why some structures are more resistant to regeneration than others. (cshlpress.com)
Because the nail is a constantly growing ectodermal appendage, we hypothesized that Wnt signaling was necessary to maintain the nail stem cell populace, which ultimately could induce secondary molecular signaling events facilitating digit tip regeneration. (informationalwebs.com)
With no recognized molecular marker specific to the nail stem cells, we turned to Lgr4/5/6, which have been described as markers of other adult stem cell populations within epithelia, including the hair follicle because it has been hypothesized to be an analogous keratinized ectodermal appendage (26). (informationalwebs.com)

reported the upregulation of two genes connected with combating cell strain in regenerating axolotl limbs at four dpa. (atpasesignaling.com)
Dedifferentiated cells express a number Resminostat price of genes related with all the dedifferentiated state, which include msx1, Nrad, rfrng and notch. (atpasesignaling.com)
Nevertheless, 3 on the four transcription component genes used to reprogram mammalian grownup somatic cells to pluripo tency are upregulated all through blastema forma tion in regenerating newt limbs, as well as all through lens regeneration. (atpasesignaling.com)
First of all, remedy of cultured insulin creating INS 1E cells with all the reversible ER stress inducer cyclopiazonic acid upregulated genes related to ER pressure when concurrently downregulating genes associated with differentiated cell functions. (atpasesignaling.com)
Far more recently, a genome wide pathway meta analysis with PD tissues has specifically recognized a set of genes controlling cellu lar bioenergetics and mitochondria biogenesis that have been selleck inhibitor shared by each brain and blood. (fgfrinhibitors.com)
Benefits Identification of the PD selleck chemical threat gene signature A 5 gene panel was discovered that optimally discriminates early PD from controls based on stepwise multivariate logistic regression examination of seven genes that had been uncovered substantially altered in sporadic PD SN tissue. (fgfrinhibitors.com)
These genes, acquired at conception or mutated during life, make the affected person prone to most cancers by altering or impairing several processes: & Production of nuclear transcription factors that control cell growth. (ehd.org)
Based on present research, Lgr5 seemed the most likely candidate of these genes to putatively mark the nail stem cells. (informationalwebs.com)
The upregulation of HSP70 chaperone genes was verified and their expression confirmed in BS vasculature cells previously identified as stem and progenitor cells. (biomedcentral.com)

One concentrate inside the mechanism of neuronal death in AD would be the aberrant expression of cell cycle related proteins, this kind of as cdc2, cdk4, cyclin B1, and cyclin D, which med iate cell cycle progression, in vulnerable neurons from the AD brain, these molecules perform important roles in neuronal death related with several paradigms of neuronal death. (fgfrinhibitors.com)

Kidney disease is characterized by derangement of the tubular architecture by both myofibroblast buildup and monocyte infiltration Because endogenous BMP-7 is an inhibitor of the TGF-β signaling cascade that induces fibrosis, the use of exogenous recombinant BMP-7 (rhBMP-7) could be a viable treatment of chronic kidney disease. (wikipedia.org)
It is also thought that BMP-7 reverses fibrosis and EMT through reduction in monocyte infiltration into inflamed tissue. (wikipedia.org)

Fgf20 and Fgf3 are present in all vertebrate species, and further study may lead to clues on inducing tissue regeneration in mammals, including humans. (titech.ac.jp)
But in mammals, including humans, some tissues (e.g., heart muscle) are more resistant to regeneration. (cshlpress.com)

The epithelial tissue emerging from this MET process eventually forms the tubules and glomeruli of the nephron. (wikipedia.org)
Eventually this restores the healthy epithelial cell population, and normal function of the kidneys in mice. (wikipedia.org)
Used together, the precedent for Lgr6 and Lgr5 to tag epithelial stem cell populations, in conjunction with the showed requirement of Wnt signaling for epimorphic regeneration, makes Lgr5 CIQ and Lgr6 reasonable applicants to interrogate for appearance and function in toe nail stem cells because they relate with digit suggestion regeneration. (informationalwebs.com)
Functional experiments and genetic lineage analyses have established that Lgr5 is a stem cell marker of both the intestinal epithelium and the hair follicle (17, 18), and recent experiments have shown it to mark epithelial stem cells in additional tissues, including the belly, mammary gland, tongue, and ovary (27C30). (informationalwebs.com)
These observations have led to a dogma that Lgr5 is a Wnt target gene, particularly in epithelial stem cell populations (23). (informationalwebs.com)
However, Lgr5 did not mark nail stem cells and, in fact, did not mark any cells within the nail epithelium, thus establishing the growth/maintenance of the nail apart from other epithelial stem cell pools and ectodermal appendages. (informationalwebs.com)

Despite significant technological advances, clinicians still lack tools to facilitate the recovery or reversal of tissue loss, while prosthetics offer only limited functional restoration of the patient's own limbs," the team continued. (genengnews.com)

Our fate mapping experiments demonstrated that the activated mesenchyme of the stump gives rise to the blastema. (unifr.ch)

In vivo, cells labelled at low concentration appeared bright with positive contrast, whereas cells labelled at higher concentration again appeared dark. (au.dk)
The pattern of depolarization matches that of the amputated limb and is correlated to the position and type of injury, revealing that information about damage is available to remote body tissues and is detectable non-invasively in vivo by monitoring the bioelectric state. (biologists.com)
In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)

Interestingly, in Xenopus limb buds rendered regeneration deficient by heat shock induced expression of transgenic noggin, chaperone gene expression is not really maintained since it is in wild style buds. (atpasesignaling.com)

Humans are capable of closing wounds with new tissue growth, and our livers have a remarkable, almost flatworm-like capability of regenerating to full size after a 50% loss. (genengnews.com)
In humans, injuries and diseases can result in irreversible tissue or organ loss. (unimore.it)

Lgr6, nevertheless, marks many cell populations inside the digit suggestion, including a little people of cells inside the toe nail epithelium specific towards the matrix. (informationalwebs.com)
This populace of cells likely represents the key to the necessity of canonical Wnt signaling in the epithelium during digit tip regeneration (10). (informationalwebs.com)

This paucity is likely due to the ubiquitous nature of this signaling pathway and the difficulty of analyzing stem cells in their natural environment during physiological cell turnover and regeneration in conventional animal models [ 15 - 17 ]. (biomedcentral.com)

Also to your human AD brain, the improved expression levels of cell cycle relevant proteins were also found in transgenic mouse models of AD. (fgfrinhibitors.com)

Planarians contain an abundant and accessible population of somatic adult stem cells called neoblasts [ 18 - 21 ]. (biomedcentral.com)
Genetic destiny mapping during both toe nail homeostasis and digit suggestion regeneration implies that the Lgr6-marked cells are adult stem cells giving rise to the nail. (informationalwebs.com)

This property involves activation of the remaining tissue at the site of injury to promote cell division, cell migration and replacement of the missing structures. (unifr.ch)
Embryonic GABAB Receptor Blockade Alters Cell Migration, Adult Hypothalamic Structure, and Anxiety- and Depression-Like Behaviors Sex Specifically in Mice. (arnes.si)

Regarding vibrational spectroscopy analysis by FTIR, bands related with biomolecules were shown on mPSCs and DKCs spectra, observing distinct differences between cell lineages and maturation stages. (biomedcentral.com)
However, not forgotten is the axolotl's equally amazing ability to thwart aspects of tissue maturation and retain juvenile morphology into the adult phase of life. (edu.au)

Regeneration in zebrafish predominantly relies on the intrinsic plasticity of mature tissues. (unifr.ch)

Which biological mechanisms guide the mature cells through the regeneration process? (unifr.ch)
We are currently investigating which adhesion mechanisms organize the different cells types during fin regeneration. (unifr.ch)
However, the mechanisms by which Akt signaling regulates stem cell behavior in the complexity of the whole body are poorly understood. (biomedcentral.com)
We also discuss the more elusive potential mechanisms that link wounding to tissue growth and patterning. (frontiersin.org)
Nevertheless, the mechanisms by which neuronal degeneration and death happen in AD and no matter whether they may be induced by Ab will not be wholly understood. (fgfrinhibitors.com)

Our findings abrogating Smed-Akt with RNA-interference in the planarian Schmidtea mediterranea led to a gradual decrease in stem cell (neoblasts) numbers. (biomedcentral.com)
This is a tool to help students find the right project for their Bachelor's and Master's thesis at Lund Stem Cell Center. (lu.se)
CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties. (stembook.org)
Leptin and NAP2 promote mesenchymal stem cell senescence through activation of PI3K/Akt pathway in patients with systemic lupus erythematosus. (stembook.org)

Advances in tissue engineering technology have led to the production of novel human skin equivalents and organoids that reproduce cell-cell interactions with tissue-scale tensional homeostasis, and enable us to evaluate skin tissue morphology, functionality, drug response and wound healing. (mdpi.com)

The neoblasts are the only dividing cells in planarians and constantly proliferate to repair tissues and support systemic cellular turnover [ 21 ]. (biomedcentral.com)

It is well-established that early embryonic signaling pathways are critical for growth and patterning of new tissue during regeneration. (frontiersin.org)
The regeneration of a tissue intuitively recapitulates aspects of its embryonic development. (frontiersin.org)
Embryonic or adult SCs by definition are characterized by their self-renewal and potentiality, peculiarities that allow them to give rise to more SCs and differentiate into various cell lineages under appropriate conditions. (biomedcentral.com)
According to their potentiality, embryonic stem cells (ESCs) are classified as totipotent and pluripotent, both of them can differentiate into the three germ lines. (biomedcentral.com)

Their study highlights the distinct functions of Fgfs in wound epidermis and blastemas, acting cooperatively to regulate fin regeneration (Figure). (titech.ac.jp)

Our results also reveal novel roles for Akt signaling during regeneration, specifically for the timely localization of cell death near the injury site. (biomedcentral.com)

The planarian ortholog Smed-Akt is molecularly conserved providing unique opportunities to analyze the function of Akt during cellular turnover and repair of adult tissues. (biomedcentral.com)
Nonetheless, there is limited understanding of how Akt signaling controls the response of stem cells during cellular turnover and tissue injury in the complexity of the whole organism. (biomedcentral.com)
Moreover, higher collagen density, more angiogenesis and cellular retention of applied ASCs were found in wound tissues treated with diabetic ASCs cultured in LG condition. (bvsalud.org)
On a cellular level, we look at the evolution of epithelia in the most primitive metazoan organisms (sea-water sponges) as an important structure to define organismal and tissue boundaries (in collaboration with Andre le Bivic and Carole Borchiellini). (univ-amu.fr)

Interestingly, we discovered that LIN28, a fourth transcription issue utilised to reprogram mammalian somatic cells to pluripotency, was upregulated on all dpa. (atpasesignaling.com)

Many conditions do not appear to be induced entirely by environmental factors and so genetic profiles have been studied to determine why some individuals are more susceptible to particular diseases. (biomedcentral.com)

The kidney is a complex organ composed of several cell types, and it is conformed approximately by 11,000 nephrons. (biomedcentral.com)

Injuries that sever tissues such as the limb or spinal cord are met with radically different outcomes among vertebrates. (frontiersin.org)
In fact, we tend to cover major injuries with an amorphous mass of scar tissue, protecting it from further blood loss and infection and preventing further growth. (genengnews.com)

Our recent work in adult Xenopus showed a significant degree of outgrowth induced by progesterone," they wrote. (genengnews.com)

Planarians are flatworms with large populations of stem cells capable of dividing to support adult tissue renewal and regeneration. (biomedcentral.com)
In the case of schistosomes, it is necessary to maintain active populations of freshwater snails as intermediate hosts, manage periodic shedding of the infective cercariae, induce transformation to schistosomula or allow for penetrance into a definitive host (usually mice). (biomedcentral.com)

Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells. (stembook.org)

Several years ago, our laboratory established a cryoinjury-induced myocardial infarction model in zebrafish, whereby a freezing-thawing procedure destroys approx. (unifr.ch)
Researchers at Tokyo Institute of Technology found that fibroblast growth factors (Fgfs) play an important role in regeneration of damaged fins in zebrafish, offering potential clues on tissue regeneration in other species. (titech.ac.jp)

ue shares considerable protein gene expression similarities to inaccess ible central nervous system tissues and so may present important surrogate markers for neuropsychiatric ailments. (fgfrinhibitors.com)

Implanted cells were easily distinguishable as dark spots with negative contrast relative to surrounding tissue. (au.dk)
Cells labelled at relatively high concentrations appear dark with less contrast, whereas labelling at low concentrations induces positive contrast. (au.dk)
In contrast, we found that Lgr6 is indeed expressed in the nail matrix, is a marker for nail stem cells, and moreover is necessary for nail regeneration. (informationalwebs.com)

These findings suggest that blood and brain neuronal cells could possess a frequent regulatory mecha nism for gene expression. (fgfrinhibitors.com)

Anatomy18

Organisms14

Diseases4

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes13

Disciplines and Occupations1

Information Science2

Differentiation8

Regenerative12

Distal9

Proliferation10

Amputation7

Different tissues2

Progenitor cell1

Dedifferentiation4

Organs3

Phosphorylation1

Ability to regenerate1

Blastemal1

Vitro and in vivo3

Regeneration of tissues1

Apoptosis2

Mesenchymal cells3

Molecular4

Genes9

Mechanism1

Fibrosis2

Mammals2

Epithelial6

Functional1

Mesenchyme1

Vivo3

Heat shock1

Humans2

Epithelium2

Signaling pathway1

Transgenic1

Adult stem2

Migration2

Maturation2

Predominantly1

Mechanisms5

Stem cell4

Advances1

Systemic1

Embryonic4

Distinct1

Roles1

Cellular4

Transcription1

Genetic1

Organ1

Injuries2

Xenopus1

Populations2

Acute myeloid1

Zebrafish2

Protein1

Contrast3

Findings1