Tissue in vivo tissue scaffolds. Medical search. Frequent questions

Dr. Yang has extensive expertise in developing novel biomaterials and stem cell-based therapeutics for musculoskeletal tissue engineering, or engineering 3D in vitro cancer models for drug screening and mechanistic discovery. (stanford.edu)
Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)
Her research is focused on developing biomaterials and harnessing their potential for tissue regeneration. (southampton.ac.uk)
She has worked on designs and chemical modification of scaffold/hydrogel and assessment of them by in vitro and in vivo studies, and published in journals such as Nature Communications, Biomaterials, Biofabrication, and Advanced Healthcare Materials. (southampton.ac.uk)
Researchers have explored combinations of biomaterials, cells, and bioactive factors, using them to generate new cartilage and bone tissue in vitro and in vivo . (corning.com)
Osteochondral tissue engineering is the additive technology that 'makes it possible to spatially pattern cells, bioactive factors, and biomaterials in 3D,' Advanced Healthcare Materials asserts. (corning.com)
To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. (routledge.com)
The development of new biomaterials for tissue engineering provides a scientific basis for the creation of scaffolds that could provide appropriate regeneration and tissue repair 14 . (bvsalud.org)

A biodegradable scaffold allows the replacement of biological tissues via physiological extracellular components without leaving toxic degradation products. (hindawi.com)
For this purpose, we developed a fibrous scaffold resembling the bone/bone marrow extracellular matrix (ECM) based on protein without addition of synthetic polymers. (nature.com)
Interaction of MSCs with bone morphogenic proteins (BMPs) in an alginate scaffold mimicking the extracellular matrix (ECM) in vivo enhances their differentiation into bone cells 9 . (nature.com)
Current Challenges and Future Promise for Use of Extracellular Matrix Scaffold to Achieve the Whole Organ Tissue Engineering Moonshot. (mayo.edu)
Basement Membrane of Tissue Engineered Extracellular Matrix Scaffolds Modulates Rapid Human Endothelial Cell Recellularization and Promote Quiescent Behavior After Monolayer Formation. (mayo.edu)
Tissue engineered bovine saphenous vein extracellular matrix scaffolds produced via antigen removal achieve high in vivo patency rates. (mayo.edu)
Basement membrane proteins modulate cell migration on bovine pericardium extracellular matrix scaffold. (mayo.edu)
Small Diameter Xenogeneic Extracellular Matrix Scaffolds for Vascular Applications. (mayo.edu)
Biological tissues are ensembles of various types of cells and extracellular molecules. (materialstoday.com)
Functionality in tissues arises from their components (cells and extracellular molecules) as well as from the location of those components relative to each other. (materialstoday.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
My lab focuses on understanding the role of the extracellular environment for endogenous and exogenous lung tissue regeneration in healthy and diseased lung. (lu.se)

Sufficient porosity is needed to accommodate cell proliferation and differentiation, which will eventually enhance tissue formation [ 2 , 3 ]. (hindawi.com)
Although graphene/stem cell-based tissue engineering has recently emerged and has promisingly and progressively been utilized for developing one of the most effective regenerative nanomedicines, it suffers from low differentiation efficiency, low hybridization after transplantation and lack of appropriate scaffolds required in implantations without any degrading in functionality of the cells. (rsc.org)
Among various stem cells, neural stem cells (NSCs) and their neural differentiation on graphene have attracted a lot of interest, because graphene-based neuronal tissue engineering can promisingly realize the regenerative therapy of various incurable neurological diseases/disorders and the fabrication of neuronal networks. (rsc.org)
Since there has been no in vivo application of graphene in neuronal regenerative medicine, we hope that this review can excite further and concentrated investigations on in vivo (and even in vitro ) neural proliferation, stimulation and differentiation of stem cells on biocompatible graphene scaffolds having the potential of degradability for the generation of implantable neuronal networks. (rsc.org)
The challenge for existing stem cell-based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo , because stem cells are rather sensitive to even minute changes in their environment. (routledge.com)
Platelet-rich fibrin (PRF), commonly known as a second-generation PC, was shown to have a high capacity to improve wound healing and tissue repair owing to the gradual release of growth factors during its slow degradation along with its intrinsic fibrin scaffolding, which offers a unique three-dimensional (3-D) microstructure for promoting proliferation and differentiation of recruited cells ( 12 , 13 ). (spandidos-publications.com)
Melinda is highly proficient in the use of in vitro and in vivo assays for normal and malignant hematopoietic stem and progenitor cells, determination of self-renewal, expansion and lineage specific differentiation capabilities, and the use of induced pluripotent stem cells for the investigation of hematopoietic disorders and leukemic progression and the testing of targeted therapeutics. (edu.au)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)

26 ] has shown that osteoblast survival and growth were significantly enhanced in the PLLA/HA composite scaffolds compared to the plain PLLA scaffolds. (hindawi.com)
in the HA pure scaffolds was negative for cell viability and proliferation, while in the 50HA/50β-TCP composite scaffolds it resulted more biocompatible. (maastrichtuniversity.nl)
The FDM-printed PLA/nano ß-TCP composite scaffolds exhibited good personalized porosity and shape, and their osteogenic ability , biocompatibility, and bone repair ability in vivo were superior to those of pure PLA. (bvsalud.org)

We also present the construction of a correlation between changes in the expression of the EGFP-HIF-1alpha fusion protein and gradients in oxygen concentration through the volume of hydrogel scaffold. (aiche.org)
Engineering cartilage has typically involved 'encapsulating chondrocytes, or stem cells which can be differentiated along a chondrogenic linage, in a supportive matrix such as a hydrogel or scaffold,' Advanced Healthcare Materials explains. (corning.com)
Results: To increase the viability of stem cells, techniques like scaffolds of stem cells with hydrogel or alginate, pre-conditioning, different routes of administration and encapsulation, are implemented. (benthamscience.com)

Specifically, as they mimic important properties of tissues such as bone and cartilage they are ideal for orthopaedic tissue engineering. (edu.au)
MSCs have the ability to differentiate into adipocytes and chondrocytes forming fat tissue and cartilage as well as into bone cells - called osteocytes. (nature.com)
Now, potential engineered-tissue cartilage products are beginning to be formed through biofabrication. (corning.com)
Thereafter, these bioactive scaffolds were implanted into osteochondral defects surgically created in rabbits to assess their effects on tissue repair using micro‑CT scanning, histological observations and the evaluation scoring method for cartilage repair established by the International Cartilage Repair Society (ICRS). (spandidos-publications.com)
At 16 weeks after implantation surgery, full‑thickness osteochondral defects with a diameter of 5 mm and a depth of 4 mm were well‑filled with newly regenerated tissues, exhibiting the simultaneous regeneration of avascular articular cartilage and well‑vascularized subchondral bone, as proven through macroscopic and microscopic observations in PRF‑treated groups compared with that in the untreated group. (spandidos-publications.com)
The application of L‑PRF and F‑PRF for osteochondral defects in rabbits contributed to massive host remodeling and reconstruction of osteochondral tissues, thus offering a prospective bioactive scaffold for the simultaneous reconstruction of articular cartilage and subchondral bone tissue. (spandidos-publications.com)
Moreover, to produce acceptable structural and functional repair, all three kinds of tissues involved in osteochondral lesions, including subchondral bone, the osteochondral interface and articular cartilage, need to be reconstructed simultaneously ( 3 ). (spandidos-publications.com)
Collagen refers to a collection of proteins found in the tendon and ligament, as well as the connective tissue layer of the skin dermis, dentin, and cartilage, that are composed of white, fairly inelastic fibres with high tensile strength. (vedantu.com)
Chondrocyte sheet in vivo cartilage regeneration technique using miR-193b-3p to target MMP16. (antibodies-online.com)

Polymers have been widely chosen as tissue scaffolding material having a good combination of biodegradability, biocompatibility, and porous structure. (hindawi.com)
Biodegradable polymers have been widely used and accepted as the most suitable materials for scaffolds due to their degradability, biocompatibility, and ease of processability [ 9 - 11 ]. (hindawi.com)
The biocompatibility of graphene scaffolds and their probable toxicities (especially after the disintegration of graphene scaffolds and distribution of its platelets in the body), which is still an important challenge, were reviewed and discussed. (rsc.org)
The physical and chemical properties , biocompatibility, and in vitro osteogenic capacity of the scaffolds were investigated, and their bone repair capacity was evaluated using an in vivo animal model of rabbit femur bone defects. (bvsalud.org)
The FDM-printed PLA/nano-ß-TCP composite scaffold with a ratio of 73 exhibited good personalized porosity and shape, as well as good osteogenic ability , biocompatibility, and bone repair ability . (bvsalud.org)
Currently, work has been focused on the synthesis and physicochemical characterization of poly lactic acid scaffolds, a synthetic polyester that has been extensively study for its excellent biocompatibility and biodegradability. (bvsalud.org)

Li C, Alfonso-Garcia A, McMasters J, Bec J, Weyers B, Uyesaka L, Griffiths L , Panitch A, Marcu L. Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor. (mayo.edu)
Advances in 3D printing also offer exciting new opportunities for regenerative medicine, including incorporation of vascular scaffolds into bioengineered tissues and organs. (genomeweb.com)
He is also designing a small diameter tissue engineered vascular graft to treat cardiovascular diseases. (pitt.edu)
These can be divided into autologous tissue grafts, allografts, xenografts, alloplastic prostheses/artificial grafts, and tissue-engineered vascular grafts. (medscape.com)

With further optimization in topologically ordered porosity design exploiting material property and fabrication technique, porous biodegradable metals could be the potential materials for making hard tissue scaffolds. (hindawi.com)
One of the most attractive subjects in tissue engineering is the development of a scaffold, a three-dimensional porous solid structure that plays a key role in assisting tissue regeneration [ 1 ]. (hindawi.com)
Ideally, a scaffold must be porous, bioactive, and biodegradable and possess adequate mechanical properties suited to the biological site. (hindawi.com)
Zhang and Ma have developed [ 25 ] a highly porous biodegradable polymer/apatite composite scaffold (95% porosity) through a thermally induced phase separation technique, which resulted in significant improvement in mechanical properties compared to polymer-only scaffold. (hindawi.com)
Given their native-like biological properties, high growth factor retention capacity and porous nature, sulfated-polysaccharide-based scaffolds hold great promise for a number of tissue engineering applications. (edu.au)
In this in vivo examination, porous cylindrical hydroxyapatite scaffolds with a hollow center were immersed in 100 m g/ml laminin solution and air-dried. (scirp.org)

In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)
Much research focuses on increasing the porosity and pore interconnectivity of ceramic scaffolds to increase osteoconductivity, cell migration and cell-cell interaction. (maastrichtuniversity.nl)
Nanoparticles and scaffolds were characterized regarding morphology, chemical and mineral composition, porosity and mechanical properties. (maastrichtuniversity.nl)
Scaffolds with total porosity of 71%-87%, pores in the range of 280-550 µm and connectivity density up to 43 mm-3 were obtained. (maastrichtuniversity.nl)

The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)

Pioneering tissue engineering studies used traditional 2D substrates, but in recent years, research has focused on the development of biomimetic 3D scaffolds and cell culture platforms to repair and regenerate osteoarthritis' osteochondral defects, according to Bio-Design and Manufacturing . (corning.com)
Many different osteochondral scaffolds have been developed by researchers, and some are commercially available. (corning.com)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)

Even so, scientists in the field have just recently begun to utilise them as building blocks for tissue engineering scaffolds. (edu.au)
Fused Deposition Modeling Printed PLA/Nano ß-TCP Composite Bone Tissue Engineering Scaffolds for Promoting Osteogenic Induction Function. (bvsalud.org)
Three-dimensional (3D)-printed bone tissue engineering scaffolds exhibit promising application potential. (bvsalud.org)
FDM- 3D printing technology was used to prepare polylactic acid (PLA)/nano ß-tricalcium phosphate (TCP) composite bone tissue engineering scaffolds in this study. (bvsalud.org)
PLA/nano-TCP composite bone tissue engineering scaffolds were prepared using FDM- 3D printing technology . (bvsalud.org)

We are investigating the use of novel shape-memory polymer scaffolds and electrospun shape-memory polymer sleeves as methods of rapidly stabilizing bone defects, reconstructing comminuted fractures, and delivering antimicrobial and osteoinductive agents to facilitate autologous repair long-term. (upstate.edu)
Inspired by the native tendon-bone interface, we have designed and evaluated a biomimetic bilayer scaffold, comprised of electrospun poly (lactide-co-glycolide) (PLGA) nanofibers seamlessly integrated with PLGA-hydroxyapatite (HA) fibers, in order to engineer tendon-bone integration. (columbia.edu)

Cell-based bone tissue engineering has the potential to address this shortage of bone graft material, as it employs a biomaterial scaffold carrying progenitor cells that will regenerate new bone at the site of injury. (uconn.edu)
Tissue bioengineering and stem/progenitor cell treatments have both been individually pursued for stroke neural repair therapies, with some benefit in tissue recovery. (researchgate.net)
Emerging directions in stroke neural repair approaches combine these two therapies to use biopolymers with stem/progenitor transplants to promote greater cell survival in the transplant and directed delivery of bioactive molecules to the transplanted cells and the adjacent injured tissue. (researchgate.net)
and reprogramming progenitor cells in vivo to treat disease. (genomeweb.com)
Until now, several progenitor cells derived from dental tissues have been isolated and characterized ( table I ). (bvsalud.org)

For this purpose, we have developed oxygen-sensing microparticles that are suspendable through the volume of any transparent biomaterial scaffold used in cell culture and tissue engineering. (aiche.org)

It is concluded that laminin is useful for bone formation, as in an in vitro culture study using bone marrow cells, in hydroxyapatite scaffolds in vivo . (scirp.org)
Pluripotent cells are implanted in a hydroxyapatite-coated poly- L -lactic acid scaffold that releases bone morphogenic protein 2. (nature.com)

Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. (hindawi.com)
The research in Dr. Vorp's lab focuses on the biomechanics, "mechanopathobiology," regenerative medicine, and tissue engineering of tubular tissues and organs, predominantly the vasculature. (pitt.edu)
Tissue engineering is the science that combines the principles of biology and engineering techniques in order to obtain biological substitutes for regenerating, replacing, modifying, repairing or restoring the function of organs and tissues. (bvsalud.org)

Thus, here we propose to validate the efficacy of µRB-like hydrogels with tunable stiffness and macroporosity as cell-delivery matrices that enhance the engraftment and survival of stem cells for both soft and hard tissue reconstruction using relevant animal models in vivo. (ca.gov)
Tissue engineering and function reconstruction through host remodeling and autologous cell recruitment effectively was shown to overcome the aforementioned limitations and represent a fundamental shift from cell-based approaches ( 6-8 ). (spandidos-publications.com)
Large bone defects caused by congenital defects , infections , degenerative diseases , trauma , and tumors often require personalized shapes and rapid reconstruction of the bone tissue . (bvsalud.org)

Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues. (routledge.com)

Here we will review methods for replicating in vitro the 3D histoarchitecture of live tissues, focusing on those approaches that use (or are compatible with) tissue-harvested scaffolds. (materialstoday.com)

This methodology should deepen our understanding of this process, ultimately leading to safer and more effective tissue engineering therapies. (uconn.edu)
Our lab's mission is to develop therapies for regenerating human tissues lost due to diseases or aging, and to build tissue engineered 3D models for understanding disease progression and informing drug discovery. (stanford.edu)
Stem cell-based therapies hold great promise for treating tissue loss and enhancing tissue regeneration, often via direct injection of cells at the target site. (ca.gov)
Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)
In recent years, tissue engineering has evolved considerably, due to the problems in the biomedical area concerning tissue regeneration therapies. (bvsalud.org)

Conversely, synthetic scaffolds3,4 provide tailored, defined, repeatable ECM but lack the chemical signaling completeness provided by biological scaffolds. (materialstoday.com)
ideally, the scaffold eventually is replaced by biological tissue. (corning.com)
Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. (routledge.com)

Metals that can degrade in physiological environment, namely, biodegradable metals, are proposed as potential materials for hard tissue scaffolding where biodegradable polymers are often considered as having poor mechanical properties. (hindawi.com)
But developing these scaffolds requires creating multiple layers that are able to withstand the physiological load on the joint without failure or fatigue. (corning.com)

The multidisciplinary journal features innovative research and applications of tissue growth and regeneration, uniting the principles of engineering and life sciences within the realm of tissue development and regenerative medicine. (uconn.edu)
International Fellow of Tissue Engineering and Regenerative Medicine (FTERM, elected in 2023). (forth.gr)
She joined the Bone and Joint Research Group at the Centre for Human Development, Stem cells, and Regenerative Medicine in 2016 and focused on developing clay nanoparticles for stem cell-driven tissue regeneration funded by Dr Dawson's EPSRC fellowship ( Nanoclay group ). (southampton.ac.uk)
Huang, G.T., Gronthos, S. and Shi, S. (2009) Mesenchymal stem cells derived from dental tissues vs. those from other sources: Their biology and role in regenerative medicine. (scirp.org)
Ramalingam, M. Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine. (benthamscience.com)
The use of patient-specific induced pluripotent stem cells (iPSCs) in combination with bioengineering advances and genome editing offers unique opportunities for developing personalized disease models and tissues for regenerative medicine," the NIH said. (genomeweb.com)

Biodegradable metal scaffolds have showed interesting mechanical property that was close to that of human bone with tailored degradation behaviour. (hindawi.com)
Its degradation rate should match the rate of new tissue regeneration in order to maintain the structural integrity and to provide a smooth transition of the load transfer from the scaffold to the tissue [ 3 ]. (hindawi.com)
Mechanically, the major challenge is to achieve adequate initial strength and stiffness and to maintain them during the stage of healing or neotissues generation throughout the scaffold degradation process [ 3 , 7 , 8 ]. (hindawi.com)
For instance, PLA could be combined with PGA to form poly(lactic- co -glycolic acid) (PLGA), which has degradation rate tailored with the tissue healing period and has been shown to support osteoblast cells attachment and growth in vitro and in vivo [ 22 - 24 ]. (hindawi.com)
Faster degradation was observed with in vitro scaffolds compared to in vivo scaffolds during the one-year follow up. (researchgate.net)
The possibility of degradation of graphene scaffolds (NIR-assisted photodegradation of three-dimensional graphene nanomesh scaffolds) was also discussed based on the latest achievements. (rsc.org)
The aim of the present study was designed to analyze the effects of different sterilization techniques, i.e. ethylene oxide (ETO), gamma radiation (GR) and hydrogen peroxide- based plasma (H2O2) in biodegradable PLA scaffolds, and to determine the best sterilization technique to render a sterile product with minimal degradation and deformation, and good tissue response. (bvsalud.org)

We aimed to fabricate biocompatible 3D-scaffolds featuring macro- and microporous calcium phosphates with high pore interconnection. (maastrichtuniversity.nl)
Moreover, the histological response showed that the scaffolds are biocompatible and those sterilized by GR showed a more severe inflammatory response, accompanied with the presence of giant foreign body cells. (bvsalud.org)

Scaffolds harvested from tissues replicate precisely the in vivo ECM but they may be limited by its biologic variability2. (materialstoday.com)
In particular, our work focuses on the design and use of biologic and synthetic scaffolds to bioengineer new lung tissue for transplantation. (lu.se)

Therefore, understanding the cellular response to changes in soluble cues through their biomaterial microenvironment, such as oxygen concentration, is crucial for engineering materials that can more closely mimic conditions in vivo and that can potentially lead for improving methods for control over cell behavior in tissue engineering. (aiche.org)
Alvetex 3D cell culture enables cells maintain their in vivo morphology, behavior and responsiveness within an in vitro model system. (reprocell.com)

The characterization data of the scaffolds were obtained using relevant detection methods . (bvsalud.org)

Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)

This study covers the whole production cycle, from biodegradable polymer processing to an in vivo tissue engineered construct. (researchgate.net)

The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
We have conducted extensive in vitro studies to confirm its efficacy in supporting stem cell viability, proliferation and new tissue deposition. (ca.gov)

Meanwhile, we will also start assessing the efficacy of µRB-based scaffolds for supporting stem cell engraftment and bone regeneration in a murine cranial defect model. (ca.gov)
In vivo engraftment of stem cell-derived cells into damaged or diseased tissue has many challenges. (nature.com)
For one, if pluripotent stem cells are introduced in numbers large enough for tissue regeneration, there is a high risk of teratomas in an immunodeficient mouse (a standard research model for studying engraftment). (nature.com)

After bone fractures mesenchymal stromal cells (MSCs) take on a key role in the in vivo bone repair process 1 . (nature.com)
Here he also utilizes mesenchymal stem cells or their products incorporated in a biodegradable scaffold that undergoes substantial in vivo remodeling to develop a native-like blood vessel. (pitt.edu)
Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)

Biologically, the supraspinatus tendon inserts into bone via a biphasic fibrocartilaginous transition, exhibiting region-dependent changes in its compositional, structural and mechanical properties, which enables efficient load transfer from tendon to bone as well as multi-tissue homeostasis. (columbia.edu)
The objective of this thesis is to explore the key design parameters that are critical for integrative tendon-bone repair using this biphasic scaffold as a model. (columbia.edu)
It was observed that the biphasic scaffold exhibited a stable long term response, as the mechanical properties of rat shoulders repaired by this scaffold remained comparable to that of the control at 20 weeks post-surgery. (columbia.edu)
This scaffold was also evaluated in a large animal model (sheep), in which a clinically-relevant rotator cuff repair procedure was implemented with the biphasic scaffold. (columbia.edu)

Calcified Tissue International, 83, 139-145. (scirp.org)
Calcified Tissue International epub ahead of print. (upstate.edu)

Three types (Ø 12, 15 and 19 mm) of cylindrical scaffolds were manufactured from the knit, and the properties of those were studied in vitro for 48 weeks. (researchgate.net)

It is also desirable for a scaffold to have high interconnectivities between pores for uniform cell seeding and distribution, and for the nutrients and metabolites exchange at the cell/scaffold construct [ 4 - 6 ]. (hindawi.com)
The research project and paper focus on cell-based bone tissue engineering. (uconn.edu)
However, numerous obstacles currently prevent the application of cell-based bone tissue engineering. (uconn.edu)
For the group, combining this labeling approach with their model allows the 3D tracking of any protein or cell of interest within a live animal and in a cell-biomaterial construct for tissue engineering. (uconn.edu)
Positive charge was introduced via cationization that additionally supported the stability of the scaffold in cell culture, and acted as nucleation point for mineralization during osteogenesis. (nature.com)
As cell culture reaches beyond flat, rigid surfaces, several approaches have been published that attempt to re-create in vitro the three-dimensional (3D) histoarchitecture found in vivo. (materialstoday.com)
To overcome this major bottleneck, the goal of this proposal is to validate the efficacy of novel microribbon (µRB)-based scaffolds for cell delivery. (ca.gov)
These scaffolds combine the injectability and cell encapsulation of conventional hydrogels with macroporosity, which facilitates nutrient transfer, cell survival, proliferation, and tissue formation. (ca.gov)
Recent research has shown that pieces of fetal nigral tissue placed in the striatum of 6-OHDA lesioned rats offer greater cell survival and predictability of graft function (in comparison to dissociated nigral cells) in the animal model of Parkinson's disease [ 20 ]. (hindawi.com)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
As a result of being capable of differentiating into a variety of cell types, it can be presumed that stem cell therapy has an advantage when compared to other tissue repair methods. (bvsalud.org)
The high regeneration potential has aroused a great interest in the scientific community 3 , due to its many clinical applications in cell therapy or tissue engineering. (bvsalud.org)
Cell therapy is a therapy where cellular material is injected systemically or directly into the injured tissue, to promote local repair or to restore systemic health. (bvsalud.org)

Analysis of surface morphology showed that ETO and GR modified the PLA scaffolds without any change in its chemical composition. (bvsalud.org)

Moreover, sterilization strategies of scaffold are a crucial step for its application in tissue regeneration, however, the sterilization process have to maintain the structural and biochemical properties of the scaffold. (bvsalud.org)

During her PhD, she focused on enhancing macrophage recruitment to defects and modulating the macrophage phenotype by drug delivery to accelerate the tissue regeneration process. (southampton.ac.uk)
Though research is proceeding quickly, especially in scaffold biotechnology, there is still a big gap between treating these small defects and joint replacement. (corning.com)
Our results validate these scaffolds are injectable and can be delivered into defects in a minimally-invasive manner. (ca.gov)
Tissue loss and organ failure represents a substantial socioeconomic burden to the State of California, with increasing medical costs for treating patients suffering from various degenerative disease, trauma and congenital defects. (ca.gov)
2016) Self-deploying shape memory polymer scaffolds for grafting and stabilizing complex bone defects: a mouse femoral segmental defect study. (upstate.edu)
The ability of the bone - tissue -engineered scaffold to repair bone defects was evaluated in vivo and in vitro . (bvsalud.org)

Functional integration of bone with soft tissues such as tendon is essential for joint motion and musculoskeletal function. (columbia.edu)

Finally, as a mechanical support, a scaffold must possess adequate mechanical stability to withstand both the implantation procedure and the mechanical forces that are typically experienced at the scaffold-tissue interface and does not collapse during patient's normal activities [ 3 ]. (hindawi.com)
For the Ø 15 mm scaffold type, mechanical properties were also studied in a one-year in vivo experiment. (researchgate.net)
The in vitro and in vivo scaffolds lost their mechanical properties after 1 week. (researchgate.net)
In the case of the in vivo samples, the mechanical properties were restored again, stepwise, by the presence of growing/maturing tissue between weeks 3 and 12. (researchgate.net)
Scaffolds 50HA/50β-TCP featured superior interconnectivity and mechanical properties. (maastrichtuniversity.nl)

The scaffolds were implanted in the rat subcutis. (researchgate.net)
The scaffolds were implanted into the dorsal subcutis of 7-week-old male Fischer 344 rats for 6 weeks. (scirp.org)

The effect of laminin on hard tissue formation using rat bone marrow cells was assessed. (scirp.org)
In vitro examinations showed the effectiveness of laminin for hard tissue formation from the results of biochemical and immunochemical analysis. (scirp.org)
From the in vivo examination, laminin coating of the scaffolds induced hard tissue in the pores with the cells. (scirp.org)
Yoshikawa, M. , Kakigi, H. , Yabuuchi, T. and Hayashi, H. (2014) Effects of laminin on hard tissue formation by bone marrow cells in vivo and in vitro . (scirp.org)
More importantly, the design principles elucidated here are anticipated to have a broader impact in the field of tissue engineering, as they can be readily applied towards the regeneration of other soft-hard tissue interfaces. (columbia.edu)

The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)

Anatomy1

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes3

Technology, Industry, Agriculture8

Health Care1

Biomaterials8

Extracellular12

Differentiation9

Composite scaffolds3

Hydrogel3

Cartilage9

Biocompatibility6

Vascular4

Porous6

Porosity5

Materials for scaffolds1

Osteochondral3

Engineering Scaffolds5

Electrospun2

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Biomaterial scaffold1

Hydroxyapatite2

Organs3

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Therapies5

Biological3

Physiological2

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Biocompatible2

Biologic2

Behavior2

Characterization1

Derived from dental tissues1

Biodegradable polymer1

Viability2

Engraftment3

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Calcified Tissue International2

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