Tissue in patients autologous. Medical search. Frequent questions

This is called autologous transplantation, and it reduces the risk of transplant rejection that can occur when tissues are transplanted between individuals. (jove.com)
In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
Thus, the availability of and access to human tissues for transplantation remains essential. (who.int)
In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. (haematologica.org)
High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
Current Research and Scholarly Interests My translational research focuses on using autologous stem cells to recreate a patient's ocular tissues for potential transplantation. (stanford.edu)
Cornea transplantation is at high risk of rejection when there is pre-existing vascularization of the cornea and in pediatric patients. (stanford.edu)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)

Clinical efficacy of pelvic autologous tissue reconstruction in treating pelvic organ prolapse in 36 patients. (urotoday.com)
Fat grafting is a technique in which harvested adipose tissue is injected underneath the skin for the reconstruction of traumatic, oncologic, or congenital defects. (nih.gov)
Background Following implant-based breast reconstruction (IBR) infection and explantation, autologous reconstruction is a common option for patients who desire further reconstruction. (thieme-connect.de)
However, few data exist about the outcomes of secondary autologous reconstruction (i.e., free flap breast reconstruction) in this population. (thieme-connect.de)
We hypothesized that autologous reconstruction following infected device explantation is safe and has comparable surgical outcomes to delayed-immediate reconstruction. (thieme-connect.de)
Methods We conducted a retrospective analysis of patients who underwent IBR explantation due to infection from 2006 through 2019, followed by secondary autologous reconstruction. (thieme-connect.de)
The control cohort comprised patients who underwent planned primary delayed-immediate reconstruction (tissue expander followed by autologous flap) in 2018. (thieme-connect.de)
Two flap losses were identified in the secondary autologous reconstruction group while no flap losses were reported in the delayed-immediate reconstruction group ( p = 0.18). (thieme-connect.de)
Conclusion Autologous reconstruction is a reasonable and safe option for patients who require explantation of an infected prosthetic device. (thieme-connect.de)
Failure of primary IBR did not confer significantly higher risk of complications after secondary autologous flap reconstruction compared with primary delayed-immediate reconstruction. (thieme-connect.de)
This information can help plastic surgeons with shared decision-making and counseling for patients who desire reconstruction after infected device removal. (thieme-connect.de)
5 Lagares-Borrego A, Gacto-Sanchez P, Infante-Cossio P, Barrera-Pulido F, Sicilia-Castro D, Gomez-Cia T. A comparison of long-term cost and clinical outcomes between the two-stage sequence expander/prosthesis and autologous deep inferior epigastric flap methods for breast reconstruction in a public hospital. (thieme-connect.de)
In a breast reconstruction procedure, a tissue expander (a temporary breast implant device) is sometimes put in place and inflated with saline to prepare (shape and enlarge) the recipient site (implant pocket) to receive and accommodate the breast implant prosthesis. (wikipedia.org)
Some patients choose to undergo breast reconstruction surgery either during or after a mastectomy. (moffitt.org)
When performing a reconstruction procedure, a surgeon creates a breast shape with an implant or flap of tissue derived from another area of the patient's body (autologous tissue transfer). (moffitt.org)
For more information about mastectomy and breast reconstruction, call 1-888-663-3488 or complete our online new patient registration form to schedule an appointment. (moffitt.org)
Few centres are currently able to offer their patients the full range of reconstruction methods. (pyramide.ch)
The Centre for Breast Cancer Surgery at the Pyramid Clinic specialises in autologous reconstruction, which uses the patient's own tissue. (pyramide.ch)
Dr. Freytes explained that bone reconstructions, such as craniofacial reconstruction, often involve "autologous tissue grafting, a method limited by harvesting difficulties, donor site morbidity, and the clinicians' ability to contour delicate 3-D shapes. (genengnews.com)

Stromal vascular fraction (SVF), containing large amount of stem cells and other regenerative cells, can be easily obtained from loose connective tissue that is associated with adipose tissue. (naturopathicstandards.org)
Massive adipose tissue depositions in the abdomen and thorax sufficient to interfere with respiration developed in a patient with multiple medical problems. (cdc.gov)
Biopsy of adipose tissue identified human adenovirus 36 (Adv 36) DNA. (cdc.gov)
Viral DNA was isolated from brain, lung, liver, muscle, and adipose tissue of monkeys 7 months after initial infection, long after the active virus has disappeared from blood and feces ( 3 ). (cdc.gov)
We postulate that these abnormal adipose tissue deposits were caused by Adv 36 infection. (cdc.gov)
Fat grafting is a technique in which harvested adipose tissue is injected underneath the skin to reconstruct traumatic, oncologic, or congenital defects. (nih.gov)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)

Here we evaluated safety and clinical efficacy of freshly isolated autologous SVF cells in a case control study in patients with grade 2-4 degenerative osteoarthritis (OA). (naturopathicstandards.org)
Purpose: To compare the clinical outcomes of MSC injection and arthroscopic marrow stimulation treatment with those of arthroscopic marrow stimulation treatment alone for the treatment of OLTs in older patients. (researchgate.net)
Patients were divided into 2 groups: 35 patients (37 ankles) treated with arthroscopic marrow stimulation treatment alone (group A) and 30 patients (31 ankles) who underwent MSC injection along with arthroscopic marrow stimulation treatment (group B). Clinical outcomes were evaluated according to the visual analog scale (VAS) for pain, the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale, and the Roles and Maudsley score. (researchgate.net)
This GINAKIT2 phase 1 clinical trial, the first to use of genetically engineered NKT cells in humans, will evaluate the anti-tumor activity of GD2 specific CAR and interleukin-15 expressing autologous NKT cells. (texaschildrens.org)
In this case, CARs include a part specific for the GD2 molecule, which is present at high levels in NB tumors and has already led to promising results in clinical trials of GD2-targeted T cells in NB patients. (texaschildrens.org)
The term "autologous fat grafting" refers to the same procedure when the fat is harvested from the person who will receive it, which is the most common clinical scenario. (nih.gov)
Also, I'm going to share some of my own experiences with patient cases in using this product in clinical use. (chiroeco.com)
Bioprocess considerations covering the cell isolation step starting from different tissue sources (i.e., stem/progenitor cells vs. more committed precursors), as well as the need for robust and cost-effective protocols featuring easy scalability envisioning clinical applications, which are approached herein. (mdpi.com)
This study helps further our understanding of the clinical presentation and pathogens in patients who present with a foot abscess and no accompanying wound. (medscape.com)
To identify study participants, Dr Schapiro and his team conducted clinical examinations of patients attending the sports and family medicine clinics at the University of Wisconsin. (medscape.com)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
14: Laurell H, Hansson LE, Gunnarsson U. Impact of clinical experience and diagnostic performance in patients with acute abdominal pain. (cancercentrum.se)

Complex reconstructive surgery, particularly with the patient's own tissue, requires extensive surgical expertise and many years of experience in the field of microsurgery. (pyramide.ch)

2 These cells either originate from the patient (autologous) or a donor (allogeneic). (pharmaceuticalcommerce.com)
An allogeneic bone marrow transplant uses marrow from a donor whose tissue type closely matches the patient's. (imaginis.com)
Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)

Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)
The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)

Outline interprofessional team strategies for improving care coordination and communication to optimize outcomes from autologous fat grafting. (nih.gov)
Also, how an exercise physiologist can assist in designing individualized fitness programs for patients to reach optimum outcomes. (agemed.org)
Therefore, patients with cardiovascular diseases would fail to achieve the desired outcomes by using these mitochondrial-targeted drugs ( 5 ). (frontiersin.org)
Dr Schapiro and his team used power Doppler ultrasound to gauge outcomes in a small group of patients treated with PRP or prolotherapy for chronic lateral epicondylosis, a noninflammatory degenerative condition of the common extensor tendon that can cause pain and decreased function. (medscape.com)

Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Tissue engineering is a multidisciplinary field that applies the principles of engineering and life-sciences for regeneration of damaged tissues. (wjgnet.com)
Today's webinar, "Breakthrough in Stem Cell Activation: The First Oral Protein Complex for Tissue Regeneration. (chiroeco.com)
Dr. Patterson, thank you for taking the time to participate in our webinar, and for sharing your expertise in stem cells, and helping our audience get a better understanding of stem cells and tissue regeneration. (chiroeco.com)
20% of the original mass invariably results in functional impairment with limited regeneration capacity, which requires reconstructive surgical procedures such as autologous muscle flap transfers 1 . (nature.com)
Being of autologous origin, platelet rich plasma (PRP) has gained popularity in tissue repair and regeneration as potential treatment for various acute and chronic disorders in human and veterinary medicine, including tendon and craniomaxillofacial applications. (aofoundation.org)
Regulation of pericyte function in angiogenesis and tissue regeneration: The role for T-cadherin. (aofoundation.org)
The main limitation seems to be the capacity for tracheal tissue regeneration. (ersjournals.com)
Biological scaffolding, either alone or in combination with cells for tissue regeneration, has the potential to revolutionize the repair of injured tissues and to replace tissues lost through disease and injury. (genengnews.com)

As director of the Wake Forest Institute for Regenerative Medicine, Dr. Atala leads a team of more than 400 researchers dedicated to developing cell therapies and engineering replacement tissues and organs for more than 40 different areas of the body. (wikipedia.org)
His work there involved growing human tissues and organs to replace those damaged by disease or defect. (wikipedia.org)
Atala continued his work in tissue engineering and printable organs after moving to Wake Forest Baptist Medical Center and the Wake Forest School of Medicine in 2004. (wikipedia.org)
It works by causing the body's immune system (a group of cells, tissues, and organs that protects the body from attack by bacteria, viruses, cancer cells, and other substances that cause disease) to fight the cancer cells. (medlineplus.gov)
Cells Tissues Organs. (cancercentrum.se)

These amniotic stem cells are pluripotent, meaning they can be manipulated to differentiate into various types of mature cells that make up nerve, muscle, bone, and other tissues, while avoiding the problem of tumor formation and the ethical concerns associated with embryonic stem cells. (wikipedia.org)
The project now has a consistent source of human dermis tissue from which stem cells can be isolated. (ca.gov)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
So one is to activate stem cells and the second is to regenerate tissue. (chiroeco.com)
We are generating tissue from induced pluripotent stem cells to treat limbal stem cell deficiency in patients who are bilaterally blind. (stanford.edu)
Approaches to scaffolding technology that were discussed at the meeting ranged in complexity from tissue repair products consisting of bovine type 1 collagen knee implants to the highly complex such as the use of whole acellular lung matrix (ACM) to support the development of engineered lung tissue from embryonic stem cells. (genengnews.com)
Tissue engineers working at the laboratory for stem cells and tissue engineering at Columbia University's Fu Foundation School of Engineering are applying a biomimetic approach to developing tissue replacements. (genengnews.com)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)

The retention rate was comparable in patients using ipsilateral autologous corneal tissue with allograft corneal tissue. (springer.com)
Currently, an autologous tissue composite, with or without a tracheal allograft, is the only long-term working solution for every aetiology, despite its technical complexity and setbacks. (ersjournals.com)

A total of 1128 patients underwent standard liposuction under local anesthesia and SVF cells were isolated and prepared for application into 1-4 large joints. (naturopathicstandards.org)
This was a retrospective cohort study of patients who underwent transvaginal mesh operation for anterior and apical vaginal prolapse at a single tertiary center from January 2007 to December 2013. (urotoday.com)
Following serial surgical debridement and negative pressure wound therapy with instillation and dwell time (NPWTi-d), the patient underwent meshed HR-ADM placement. (woundsource.com)
In total, 71 patients who underwent cosmetic rhinoplasty were included. (bvsalud.org)

Sipuleucel-T injection is in a class of medications called autologous cellular immunotherapy, a type of medication prepared using cells from the patient's own blood. (medlineplus.gov)
AGS-003 is an autologous immunotherapy prepared from fully matured and optimized monocyte-derived dendritic cells, which are co-electroporated with amplified tumor RNA plus synthetic CD40L RNA. (biomedcentral.com)

Mastectomy patients could choose to rebuild the breast with an implant or to have autologous tissue transfer, depending on their preference and individual case. (plasticsurgery.org)

Furthermore, with age, patients experience decreased facial volume secondary to a combination of dermal thinning, muscular atrophy, fat volume loss, and reduction in bone thickness. (nih.gov)
At the time of skin grafting, the meshed HRADM was completely incorporated into the host tissue with a reduction in wound depth with no bone or tendon exposed. (woundsource.com)
Autologous bone marrow transplant means that the patient's own bone marrow is used. (imaginis.com)
The patient is then given high doses of chemotherapy that kill the cancer cells but also destroy the remaining bone marrow, thus robbing the body of its natural ability to fight infection. (imaginis.com)

Review the potential complications of autologous fat grafting. (nih.gov)
Between secondary autologous and delayed-immediate reconstructions, there were no significant differences in overall complications (29 and 37%, respectively, p = 0.45), any breast-related complications (18 and 21%, respectively, p = 0.75), or any major breast-related complications (13 and10%, respectively, p = 0.74). (thieme-connect.de)
Careful patient selection appears to be important but is not essential for a successful outcome when this form of minimally invasive therapy is considered, especially in less active patients who are at a higher risk for the complications inherent to more invasive procedures. (medscape.com)

A transverse rectus abdominis myocutaneous flap harvests tissue from your lower abdomen, incorporating skin, fat and sometimes part of your abdominal muscle. (plasticsurgery.org)
The main difference is that DIEP flap surgery draws from the lower abdominal tissue but leaves the muscle untouched, minimizing abdominal weakness afterward. (plasticsurgery.org)

Niklason, professor of anesthesiology and biomedical engineering and a member of Yale Medical Group, was senior author of a study published this month in Science Translational Medicine that demonstrated the efficacy of tissue-engineered vascular grafts that are immediately available at the time of surgery, with decreased potential for infection, obstruction or clotting. (yale.edu)
How long do you think it will take before tissue-engineered grafts are a reality for vascular surgeons? (yale.edu)
the fat-graft transfer approach augments the size and corrects contour defects of the breast hemisphere with grafts of the adipocyte fat tissue , drawn from the person's body. (wikipedia.org)

Although autogenous fat transplants have been used for decades, the field of minimally invasive soft tissue augmentation expanded with the introduction of injectable bovine collagen in 1981. (medscape.com)
Dr. Atala is editor of 3 journals and 25 books including Principles of Regenerative Medicine, Foundations of Regenerative Medicine, Methods of Tissue Engineering and Minimally Invasive Urology. (wikipedia.org)
Autologous fat grafting is a minimally invasive method used for the removal of unwanted fat from one area of the body and re-injecting it into a desired area. (ukprwire.com)

With the latter, autologous tissue - another way to say your own tissue - is taken from a donor site on your abdomen, back, buttocks or thighs to reconstruct your breast. (plasticsurgery.org)
Additionally, there's the aesthetic concern of scars - not only will the breast area show surgical marks, but the tissue donor site will also have scars. (plasticsurgery.org)

Using your tissue instead of implants will give you more sensitivity in your breasts compared to getting implants. (plasticsurgery.org)
Implants may not necessarily last you an entire lifetime, whereas your own tissue should. (plasticsurgery.org)
The images below depict soft tissue implants. (medscape.com)
The ability to perform breast augmentation through autologous fat grafting is also driving the market as it can be performed on women who are either unsuitable for implants or not wanting implants. (ukprwire.com)

This activity reviews the utility of this procedure for facial rejuvenation and highlights the role of the interprofessional team in managing and improving care for patients who undergo autologous fat grafting. (nih.gov)
Additionally, a patient who has been identified as having a high risk of developing breast cancer may choose to undergo a prophylactic mastectomy as a preventive measure. (moffitt.org)
Despite many improvements in CPB technology and circuit design, patients still undergo an intense inflammatory response when their blood comes in contact with the nonendothelial surfaces involved in extracorporeal circulation. (medscape.com)
Overall, injections of urethral bulking agents can help the group of patients that is unfit or unwilling to undergo surgery for incontinence. (medscape.com)

Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
The development of 3D printing and 3-dimensional assembly of multi-cellular types technologies, parallel to the increasing need of patient-specific solutions has motivated the choice of layer-by-layer bioprinting for the fabrication of complex tissue engineered cellular scaffolds or tissues. (aofoundation.org)
At McGowan Institute's "Symposium on Biologic Scaffolds for Regenerative Medicine" held recently in Boulder, CO, academic and industry scientists discussed topics ranging from peptide-based scaffolds for nerve tissue to tissue engineering via self assembly. (genengnews.com)

1114 patients were followed for 12.1-54.3 months (median 17.2 months) for safety and efficacy. (naturopathicstandards.org)
6 , 9 The demonstrated efficacy, lack of myelosuppression, and overall tolerability of thalidomide provide a strong rationale for its incorporation in standard induction regimens for patients presenting with NDMM who may be eligible for ASCT. (haematologica.org)

Another option worth considering is autologous tissue transfer, a procedure in which a skilled plastic surgeon uses your own tissue to recreate the breasts. (plasticsurgery.org)
A procedure in which tissue samples are removed from the body for examination of their appearance under a microscope to find out whether cancer or other abnormal cells are present. (imaginis.com)

In patients with chronic lateral epicondylosis treated with platelet-rich plasma (PRP) or prolotherapy injections, power Doppler ultrasound has been used to detect treatment response, according to results from a new study. (medscape.com)

Patient prior to bovine collagen injection for lip augmentation. (medscape.com)
To investigate the potential role of 'a disintegrin-like and metalloproteinase with thrombospondin type motifs-2 (ADAMTS-2), collagen type-1, tissue inhibitor of metalloproteinases-3 (TIMP-3) and papilin' levels in the uterosacral ligament (USL) and cardinal ligament (CL) of the uterus on the etiopathogenesis of pelvic organ prolapse (POP) among postmenopausal women without stress urinary incontinence (SUI). (urotoday.com)
Stem and other cells gradually inhabit the tissue, regenerating collagen, blood vessels, and other components of a living tendon. (medscape.com)
The BEAR scaffold is made of extracellular matrix proteins, including collagen, obtained from bovine tissue. (medscape.com)
Injectable therapy using bulking agents composed of synthetic materials, bovine collagen, or autologous substances augment the urethral wall and increase urethral resistance to urinary flow. (medscape.com)
Urethral bulking agents reported in the literature include autologous fat, glutaraldehyde cross-linked bovine collagen, calcium hydroxylapatite, pyrolytic carbon-coated beads, polydimethylsiloxane, ethylene vinyl alcohol copolymer, dextranomer hyaluronic acid, and polytetrafluoroethylene. (medscape.com)

iPSCs are potentially valuable in medicine, because a patient who needs a particular cell type-for instance, someone with a damaged retina due to macular degeneration-could receive a transplant of the required cells, generated from another cell type in their own body. (jove.com)
Subjects who relapse =12 months after therapy should have progressed after autologous transplant or been ineligible for autologous transplant. (who.int)

This report describes four unusual cases of cutaneous squamous cell carcinoma resembling nonhealing wounds, highlighting the importance of tissue biopsy in these instances. (medscape.com)

This article reviews injectable soft tissue fillers. (medscape.com)
Injectable soft tissue fillers are generally injected into the dermal layer. (medscape.com)
These procedures involve injecting synthetic and autologous fillers into the wall of the urethra to aid in coaptation of the mucosa. (medscape.com)

The progressive hemifacial atrophy (Parry-Romberg syndrome) is a rare disease of unknown etiology characterized by unilateral facial atrophy that affects skin, subcutaneous tissue, muscle, and rarely osteocartilaginous structures. (bvsalud.org)
A new technique has been presented that results in an acceleration of delayed primary healing with full thickness skin and subcutaneous tissue coverage. (who.int)

Over the past 20 years, there has been a dramatic increase in the use of autologous fat grafting to treat volume and contour defects in aesthetic and reconstructive surgery. (nih.gov)
Soft tissue volume replacement with injectable materials has been a challenging problem for facial plastic and reconstructive surgeons. (medscape.com)

Ten patients had previously undergone failed penetrating keratoplasty. (springer.com)
Patients were excluded if they had received corticosteroid injections in the 3 months preceding study enrollment, were chronic users of nonsteroidal anti-inflammatory drugs, were pregnant, had undergone previous surgery, or had carpal tunnel syndrome , trauma, or some other elbow pathology. (medscape.com)
Subjects who have undergone autologous SCT with disease progression or relapse following SCT will be eligible if all other eligibility criteria are met. (who.int)

Results We identified 38 secondary autologous reconstructions after failed primary IBR and 52 primary delayed-immediate reconstructions. (thieme-connect.de)

Adv 36 DNA persists in multiple tissues of infected animals for long periods after initial infection ( 3 ). (cdc.gov)
Patients treated this way didn't have any significant inflammation or infection, and MRI images showed a continuous ACL. (medscape.com)
Based on its oral administration and the reduced incidence of infection and cytopenia, cyclophosphamide-thalidomide-dexa-methasone may be considered an effective induction therapy option for patients with newly diagnosed multiple myeloma. (haematologica.org)
Although patients receiving mechanically assisted ventilation do not represent a major proportion of patients who have nosocomial pneumonia, they are at highest risk for acquiring the infection. (cdc.gov)
Unique Presentation of Orf Virus Infection in a Thermal Burn Patient After Receiving an Autologous Skin Graft. (cdc.gov)

While the development of xenografts (products of animal origin) and bioengineered alternatives is advancing, to date they cannot fully mimic or replace all human-sourced tissues on an equivalent basis. (who.int)

Methods: Among 107 patients with OLTs treated arthroscopically, only the patients older than 50 years (65 patients) were included in this study. (researchgate.net)
Design and Methods Oral cyclophosphamide, thalidomide, and dexamethasone was compared with infusional cyclophosphamide, vincristine, doxorubicin, and dexamethasone in patients with newly diagnosed multiple myeloma. (haematologica.org)

The patient, a 62-year old man who was diagnosed with high-grade large cell lymphoma in 1999, received multidrug (cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy, central nervous system prophylaxis with cytarabine, and high-dose methotrexate. (cdc.gov)

Furthermore, the substitute should not involve the use of growth factors, which are contraindicated in patients with cancer. (ersjournals.com)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)

these are cartilage extracellular matrix component important in imparting mechanical function to the tissue. (ca.gov)

Atala served as the director of the Laboratory for Tissue Engineering and Cellular Therapeutics at Boston Children's Hospital. (wikipedia.org)
No long-term solutions exist for cartilage degeneration, but cellular therapies hold promise toward replacing degenerated cartilage with healthy tissue. (ca.gov)
Toward developing a long-term solution for this vexing problem, cellular therapies hold the promise of replacing degenerated cartilage with healthy tissue. (ca.gov)
1 By contrast, cellular therapy uses healthy transplanted human cells to grow, replace, or repair damaged tissue that causes disease. (pharmaceuticalcommerce.com)
These approaches have achieved bioengineered skeletal muscle tissue fabrication with cellular alignment in vitro, and some showed a degree of therapeutic potential in vivo. (nature.com)

He is also developing experimental technology that can 3D print human tissue on demand. (wikipedia.org)
Niklason oversaw all the research, which included scientists from Duke University, East Carolina University, Yale and Humacyte - a private company focused on human tissue engineering, of which Niklason is a founder. (yale.edu)

Patients with refractory symptoms may benefit from surgical intervention. (aafp.org)
Although these results were not statistically superior to partial meniscectomy which is one of the most successful orthopedic surgical procedures, Menaflex patients, DiChiara said, had the additional benefit of approximately 70% more tissue within the meniscus to potentially protect the articular surfaces from degradation. (genengnews.com)
Design Descriptive study of all patients with an aortic root abscess during 1987-97, identified by retrospective review of the echocardiographic and surgical registries. (bmj.com)
We identified five patients with aortic root abscess from the surgical and echocardiography registry between 1987 and 1997 (table 1 ), and reviewed their records retrospectively. (bmj.com)
The more than 6.5 million surgical records in this database have helped create surgical risk calculators and have led to improvements in perioperative care for cardiac surgery patients. (medscape.com)

Last year, she led a research team that successfully implanted tissue-engineered lungs, cultured in vitro, in adult rats. (yale.edu)

The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)

In conclusion, here we report a novel and promising treatment approach for patients with degenerative OA that is safe, cost-effective, and relying only on autologous cells. (naturopathicstandards.org)
Comparing animal skin and human skin showed notable differences, including morphology, response to enzymatic digestion, and the rate at which cells attach to tissue culture plastic. (ca.gov)
We are currently enrolling patients on a phase 1 trial , GINAKIT2, to find the highest and safe dose of GD2-CAR NKT cells (GINAKIT cells) for subsequent study of their anti-tumor activity. (texaschildrens.org)
In order to help NKT cells expressing the GD2-CAR (CAR.GD2 NKTs) last longer in patients, we included a mediator known as interleukin-15. (texaschildrens.org)
We hypothesize that CAR.GD2-IL15 NKTs will demonstrate anti-tumor activity in NB patients through a combination of directly killing NB cells and indirectly targeting supportive TAMs. (texaschildrens.org)
In a rat model of an ACL injury, ACL-derived CD34+ cells were isolated from remnant human ACL tissues. (medscape.com)
What we are finding in regenerative medicine, over and over, is that we need provide only the approximately correct cues for cell growth, and the cells will respond and recapitulate tissues having amazing complexity. (yale.edu)
For example, retinal cells that could be used to replace damaged retinal tissue. (jove.com)
To create iPSCs, mature cells, like skin fibroblasts, are taken from a patient and put into culture. (jove.com)
The new cells could then be transplanted back into the patient to treat damage or disease with minimal risk of rejection, because they originated from the patient's own cells. (jove.com)
Also, a vascularization strategy using co-culture with endothelial cells (ECs) and fibroblasts improved the survival of the bioengineered skeletal muscle tissues 20 , 21 . (nature.com)
In patients who had sequential samples available for immune monitoring, the magnitude of the increase in the absolute number of CD8 + CD28 + CD45RA − effector/memory T cells (CTLs) after 5 doses of AGS-003 relative to baseline, correlated with overall survival. (biomedcentral.com)
In addition, repair or replacement cells or tissues should not provoke immune reactions in the host. (genengnews.com)
While many types of matrices have been successfully applied in the clinic, fundamental questions remain about how to combine and manipulate cells with scaffolding to generate functional tissue constructs that avoid immunogenicity. (genengnews.com)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
The advent of iPSCs has opened up the possibility to graft patient-specific cells which most likely would circumvent the need for immunosuppression. (lu.se)
However, patient-derived cells may be more prone to develop disease-associated pathology after grafting. (lu.se)
Instead, for sporadic patient cells alternative strategies need to be evaluated. (lu.se)

This case report describes the use of processed microvascular tissue for the treatment of a complicated left leg wound in a sarcoma patient undergoing chemotherapy. (medscape.com)
A study by Salles et al determined that correlations between specific biomarkers and the international prognostic index (IPI) score demonstrate that IPI remains the best available index in patients with DLBCL treated with rituximab and chemotherapy. (medscape.com)

This important molecule promotes NKT cell survival and function within tumor tissues. (texaschildrens.org)

Starting materials most often originate from the patient, and the final therapy is infused back into the same patient. (pharmaceuticalcommerce.com)
Starting materials most often originate from the patient, are sent to a manufacturing site to create the therapy, delivered back to the same patient's bedside, and infused into the patient. (pharmaceuticalcommerce.com)
Bioscaffolding materials may originate from multiple animal, tissue, and cell sources, as well as from synthetic polymers. (genengnews.com)

However, the transfer of a large volume of fat is not advisable as the chances of the survival of the patient are lesser as compared to small transfer volumes. (ukprwire.com)
A trend toward an overall survival advantage for cyclophosphamide-thalidomide-dexamethasone over cyclophosphamide-vincristine-doxorubicin-dexamethasone was also observed in a subgroup of patients with favorable interphase fluorescence in situ hybridization. (haematologica.org)

KPro surgery can restore useful vision in patients suffering from severe chemical burns. (springer.com)
This type of surgery may be recommended in cases where the extent of the cancer exceeds the amount of tissue that can safely be removed with a lumpectomy or in cases of recurrent breast cancer. (moffitt.org)
Blood cultures grew Staphylococcus aureus (n = 3) and Streptococcus pneumoniae (n = 2), but valve and aortic root tissues obtained at surgery were all sterile on culture. (bmj.com)
Adequate planning for specific patient variables and predictable problems often encountered in cardiac surgery, though essential, cannot fully eliminate the necessity of intervening and even urgently returning to CPB. (medscape.com)
Anesthesiologists will continue to play primary roles in optimizing patients' medical condition and safely guiding them through cardiac surgery with CPB. (medscape.com)

Second, we used directly converted neurons from sporadic patient fibroblasts to study of age-related disease relevant pathology. (lu.se)

Increase in the demand of aesthetic treatments from younger patients is expected to boost the Autologous Fat Grafting Market . (ukprwire.com)
Before beginning the first treatment, it is important to create a plan that takes into account all oncological aspects as well as the aesthetic needs of the patient. (pyramide.ch)

For instance, some patients have a choice between a mastectomy and a breast-conserving approach, such as a lumpectomy . (moffitt.org)

Preoperative risk stratification can facilitate the identification of patients at increased risk for perioperative morbidity and mortality, but it does not take into account significant intraoperative factors. (medscape.com)

Currently, silicone oil is approved by the FDA for ophthalmic use only but is being used off label for facial soft tissue augmentation. (medscape.com)
Gravity causes descent of the facial soft tissues and creates unflattering folds and shadows (e.g., nasolabial folds, tear troughs, marionette lines, etc.), contributing to an aged appearance. (nih.gov)

He is a founding member of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) from which he received the Lifetime Achievement Award. (wikipedia.org)

At least 75% Score improvement was noticed in 63% of patients and at least 50% Score improvement was documented in 91% of patients 12 months after SVF cell therapy. (naturopathicstandards.org)
One delay or a temperature excursion that renders a therapy obsolete can mean life or death for a patient. (pharmaceuticalcommerce.com)
Combination vincristine, doxorubicin, and dexamethasone (VAD) is considered a standard infusional induction therapy for younger MM patients prior to HDT and ASCT. (haematologica.org)
Eligible patients were 18 to 65 years of age, had pain for at least 6 months, and had failed conservative therapy. (medscape.com)
and the nine patients (14 elbows) in the conservative-therapy group received counseling on the modification of risk in activities of daily living and work. (medscape.com)
Sections on the prevention of bacterial pneumonia in mechanically ventilated and/or critically ill patients, care of respiratory-therapy devices, prevention of cross-contamination, and prevention of viral lower respiratory tract infections (e.g., respiratory syncytial virus {RSV} and influenza infections) have been expanded and updated. (cdc.gov)
Traditional preventive measures for nosocomial pneumonia include decreasing aspiration by the patient, preventing cross-contamination or colonization via hands of personnel, appropriate disinfection or sterilization of respiratory-therapy devices, use of available vaccines to protect against particular infections, and education of hospital staff and patients. (cdc.gov)
If patient has received anti-CD19 targeted therapy (i.e. (who.int)
HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)

Identify the indications and contraindications for autologous fat grafting in the face. (nih.gov)

Click below to read the largest patient-based international study ever done using stem cell transplants. (naturopathicstandards.org)
More importantly, the bioprinted constructs with neural cell integration facilitate rapid innervation and mature into organized muscle tissue that restores normal muscle weight and function in a rodent model of muscle defect injury. (nature.com)
AGS-003 was evaluated in combination with sunitinib in an open label phase 2 study in intermediate and poor risk, treatment naïve patients with metastatic clear cell renal cell carcinoma (mRCC). (biomedcentral.com)
Overall, the ultimate goal would be to obtain clinically relevant cell numbers, while maintaining cell/tissue identity and functionality. (mdpi.com)
Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)

Silicone injection into facial tissues was popularized in the 1960s and 1970s with the introduction of medical grade silicone (MDX 4-4011) by Dow Corning. (medscape.com)
These correlations were not observed in group B. Conclusion: Injection of MSCs with marrow stimulation treatment was encouraging in patients older than 50 years compared with patients treated with marrow stimulation treatment alone, especially when the lesion size was larger than 109 mm(2) or a subchondral cyst existed. (researchgate.net)
PRP involves the injection of autologous platelets that have been concentrated, typically, to five times the normal plasma level. (medscape.com)
Prolotherapy involves the injection of an irritant that is thought to induce inflammation and connective tissue repair. (medscape.com)

Muscle tissue engineering aims to repair or regenerate defective muscle tissue lost by trauma or disease. (mdpi.com)
Only patient 5 (bicuspid aortic valve and mild aortic stenosis) was previously known to have congenital heart disease. (bmj.com)
Echocardiography showed that patient 3 had a bicuspid aortic valve, but none of the other three patients had evidence of previous structural heart disease. (bmj.com)
Facial deformities caused by the disease cause social and psychological problems to affected patients. (bvsalud.org)

Anatomy38

Organisms6

Diseases42

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment74

Phenomena and Processes26

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science3

Health Care12

Transplantation13

Reconstruction19

Adipose7

Clinical12

Patient's own tissue1

Allogeneic5

Potential of autologous2

Outcomes4

Regeneration9

Organs5

Stem cells8

Allograft2

Underwent4

Immunotherapy2

Implant1

Bone4

Complications3

Flap2

Grafts3

Minimally invasive3

Donor site2

Implants4

Undergo4

Scaffolds3

Efficacy2

Procedure2

Platelet rich1

Collagen6

Transplant2

Biopsy1

Fillers3

Subcutaneous tissue2

Reconstructive2

Undergone3

Reconstructions1

Infection5

Mimic1

Methods2

High-dose1

Involve1

Ischemic1

Extracellular matrix1

Cellular5

Human tissue2

Surgical5

Adult1

Optimize1

Cells18

Chemotherapy2

Tumor1

Originate3

Survival2

Surgery5

Fibroblasts1

Aesthetic2

Mastectomy1

Morbidity1

Facial soft2

Regenerative Medicine1

Therapy10

Indications1

Cell6

Injection4

Disease4