Tissue epithelial cells. Medical search. Frequent questions

On the one hand, similar to endothelial cells, parenchymal epithelia must guide leukocytes to traverse them in order to reach a localized inflammatory focus, for example, in the lung or intestinal mucosa. (hindawi.com)
One of the first lines of defense in the GI tract is the physical barrier provided by a single layer of intestinal epithelial cells. (sciencedaily.com)
However, in previous studies, NIAID scientists had observed that some Salmonella replicate rapidly in the cytosol -- the fluid portion -- of intestinal epithelial cells. (sciencedaily.com)
Then they infected laboratory mice with the self-destructing Salmonella bacteria and found that replication in the cytosol of mouse intestinal epithelial cells is important for colonization of the GI tract and fuels fecal shedding. (sciencedaily.com)
We treated non-transformed intestinal epithelial cells with LTD4 and found that this led to increased expression of COX-2. (lu.se)

Case-control studies have shown that the E1A DNA from group C adenoviruses is present in greater amounts in the lungs of patients with COPD than in controls with normal lung function matched for age, sex and smoking history 5 , and that the excess inflammation in the lungs of smokers with severe emphysema is associated with increased numbers of alveolar epithelial cells expressing E1A 6 . (ersjournals.com)
Discussion: In conclusion, our data indicate that bronchial and alveolar epithelial cells respond differently to hypoxia and profibrotic stimuli. (lu.se)
Lung epithelial cells form a barrier that lines airway and alveolar surfaces and constitute an air-liquid interface. (springer.com)
some is secondarily produced by alveolar macrophages and epithelial cells. (msdmanuals.com)

Reports from several laboratories suggest that a phenomenon termed epithelial-mesenchymal transformation, in which epithelial cells transform into fibroblasts capable of producing connective tissue matrix, is an important feature of tissue remodelling 10 , 11 . (ersjournals.com)
Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
Introduction to basic histology of cells, epithelial tissue and connective tissue. (up.ac.za)
Anatomy of the musculo-skeletal system integrated, the histology of connective tissue and muscles. (up.ac.za)
Fibroblasts are the main connective tissue cells present in the body. (news-medical.net)
The primary function of fibroblasts is the maintenance of structural integrity within the connective tissue. (news-medical.net)
They achieve this by secreting extracellular matrix precursors required for formation of the connective tissue and various fibres. (news-medical.net)

Endothelial and epithelial barriers determine the different stages of leukocyte migration in its journey towards the inflammatory focus in complex tissues. (hindawi.com)
This cytokine was previously named NF-HEV 'nuclear factor (NF) in high endothelial venules' (HEVs) since it was originally identified in these specialized cells. (wikipedia.org)
Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
In endothelial and epithelial cells the tight junctional complex safeguards barrier function. (meduniwien.ac.at)

Glandular cells produce mucus in your cervix and uterus. (familydoctor.org)
An advanced lesion was found in the glandular tissue. (familydoctor.org)

Pathologic examination of a bronchoalveolar lavage (BAL) sample showed scattered cells, primarily columnar bronchial cells, with cytomorphologic changes reminiscent of BK polyomavirus (BKPyV)-infected decoy cells. (cdc.gov)
Using RNA-Seq, we identified a total of 163 and 568 differentially expressed genes in primary normal human bronchial epithelial (NHBE) cells that were exposed to diacetyl and 2,3-pentanedione, respectively. (nature.com)
In this study, we utilized primary normal human bronchial epithelial (NHBE) cells that are cultured at an air-liquid interface (ALI) to mimic the in vivo airway characteristics 30 . (nature.com)
Pathology showed benign bronchial-type epithelial cells with focal adrenal tissue. (sages.org)
Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. (springer.com)

Spatiotemporal localization of periostin and its potential role in epithelial-mesenchymal transition during palatal fusion. (bvsalud.org)
Cellular mechanisms underlying the degradation of MES have been proposed, such as apoptosis , epithelial-mesenchymal transition (EMT) and migration of medial edge epithelia (MEE). (bvsalud.org)
TG2 expression correlated with tumour advancement and expression of markers of epithelial-mesenchymal transition (EMT). (oncotarget.com)
It is believed that TGF-β1 signalling is involved in controlling epithelial cell proliferation, to drive epithelial-mesenchymal transition (EMT) and it plays a major role in lung fibrosis and emphysema. (springer.com)
This not only enables efficient numerical implementation, but provides a natural description of the T1 transition events responsible for local tissue rearrangements. (cam.ac.uk)
In some cases, epithelial cells may also produce fibroblasts, a process which is referred to as epithelial-mesenchymal transition (EMT). (news-medical.net)
Conversely, fibroblasts sometimes undergo mesenchymal-epithelial transition (MET) to produce epithelia, a process that is seen in development, tissue repair and tumor growth. (news-medical.net)

Guinea pig primary peripheral lung epithelial cells (PLECs) transfected with adenovirus E1A (E1A-PLECs) were compared to guinea pig normal lung fibroblasts (NLFs) transfected with E1A (E1A-NLFs). (ersjournals.com)
E1A transfection results in the transformation of peripheral lung epithelial cells and normal lung fibroblasts to a phenotype intermediate between that of the two primary cells. (ersjournals.com)
The changes that occur during adenoviral E1A transformation of primary guinea pig PLECs were also compared with those occurring during the transformation of the fibroblasts that frequently contaminate primary epithelial cultures, and evidence is presented that both cell types are transformed to an intermediate phenotype. (ersjournals.com)
We hypothesize that iPSC reprogrammed from ocular epithelial cells will be more efficient in differentiating into ocular lineages and exhibit higher functionality than non-ocular sources such as fibroblasts or blood. (stanford.edu)
Other lung cell types: Assistance with the isolation of lung fibroblasts and other cell types may be obtained with special planning through the core. (wustl.edu)
In the liver, this regulation requires the constant integration of signals by epithelial cells from non-epithelial, niche cells, which includes inflammatory cells and fibroblasts. (ed.ac.uk)
As well as being present as fibroblasts, these cells exist in an alternative state, as fibrocytes. (news-medical.net)

A germ is had by them cell cluster that's encircled with a somatic epithelium called the follicle cells. (brain-tumor-cancer-information.com)
The compound can also be used in protocols for the chemical reprogramming of somatic cells to iPSCs.Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition. (tocris.com)

TGF-β1 is a major mediator of airway tissue remodelling during atopic asthma and affects tight junctions (TJs) of airway epithelia. (springer.com)
In summary, we demonstrate a role of motile cilia in TGF-β1 sensing and showed that TGF-β1 disturbs TJ permeability of conductive airway epithelia by redistributing CLDN3 from TJs into cell nuclei. (springer.com)
During embryonic stages of lung organogenesis, TGF-β1 is pivotal in epithelial-mesenchymal interaction, during alveolarization and for airway branching morphology. (springer.com)
The goal of the core is to provide primary cells and cultured airway epithelial cell preparations from human, mouse and other species for the study of epithelial cells, lung biology and lung diseases. (wustl.edu)
Core procedures and capabilities: The airway epithelial cell core provides investigators with primary culture preparations of mouse and human airway epithelial cells differentiated at air-liquid interface to provide a model of normal airways including ciliated and secretory cells. (wustl.edu)
The core can also culture airway cells obtained by lung biopsies, brushings, as well as nasal and sinus biopsy, brush, scrape or polyps. (wustl.edu)
Normal human airway epithelial cells can be obtained as de-identified tissues and exempted from specific human research. (wustl.edu)
The core also has experience with the culture of airway epithelial cells from rats and pigs. (wustl.edu)
Manipulation and genetic modification of primary cells: The core has extensive experience with the manipulation of airway cells using growth factors, cytokines and specific culture conditions, as well as genetic manipulation using recombinant viral vectors. (wustl.edu)
These findings suggest that CI2 exposure causes oxidative and nitrosative stress in association with leading to airway epithelial damage. (cdc.gov)

Cells Tissues Organs;193(1-2): 53-63, 2011. (bvsalud.org)
Epithelial tubes are the infrastructure for organs and tissues and tube morphogenesis requires exact orchestration of cell signaling shape migration and adhesion. (ecologicalsgardens.com)
Your peritoneum is a tissue lining that covers the organs in the abdomen (belly). (medlineplus.gov)
Basic anatomy of tissues, organs, systems and joints. (up.ac.za)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
We are particularly interested in the role of the Wnt pathway in these processes and are currently working on both canonical and non-canonical Wnt signalling to define how these pathways regulate tissue architecture, using the adult liver and cancers of the adult liver as a models for these studies. (ed.ac.uk)

Expression of Lgr5 is controlled by Wnt signaling, which plays a critical role for stem cell turnover in the gastrointestinal tract 2 . (nature.com)
We demonstrate that while Rspo3 from myofibroblasts maintains colonic Lgr5 + cells during homeostasis, during injury its main function is not to maintain Lgr5 + cells but to interact with more differentiated cells that express Lgr4 but not Lgr5 and are able to regain expression of Wnt target genes and generate new crypts. (nature.com)
Consistent with this, qRT-PCR confirmed that the expression of multiple genes involved in cilia biogenesis was significantly downregulated by diacetyl and 2,3-pentanedione in NHBE cells. (nature.com)
The metastatic cell line SW620 showed high TG2 expression compared to the primary tumour cell lines SW480 and RKO and could form tumour spheroids under non- adherent conditions. (oncotarget.com)
TGFβ1 expression in CRC cells, and its level in the cell medium and extracellular matrix was increased in primary tumour CRCs overexpressing TG2 and could regulate TG2 expression and EMT by both canonical (RKO) and non-canonical (RKO and SW480) signalling. (oncotarget.com)
To define TTK69's regulatory part during epithelial tubulogenesis and to determine novel effectors we exploited the unique allele expression profiles via microarrays to identify direct and indirect focuses on of TTK69 evaluated the energy of TTK69-binding motifs as predictive tools and ascertained which TTK69-controlled genes are required for DA-tube development through hybridization (ISH) and tissue-specific RNAi. (ecologicalsgardens.com)
In addition, mTEC screen thymocytes for their expression of high affinity αβ-TCRs, with negative selection limiting the release of these reactive T-cells into the peripheral pool ( 4 ). (frontiersin.org)
These two cell types differed, however, in their NF-κB and AP-1 binding after lipopolysaccharide stimulation, possibly due to differences in the expression of the subunits that comprise these transcriptional complexes. (ersjournals.com)
In the present study, the hypothesis that adenoviral infection followed by persistent expression of its E1A gene is capable of producing epithelial-mesenchymal transformation was examined by investigating guinea pig PLECs that express adenoviral E1A. (ersjournals.com)
During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. (gu.se)
Cell function and gene expression analysis: Protocols and assistance with routine collection for protein and RNA are available. (wustl.edu)
Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution. (lu.se)

Periostin (also known as osteoblast -specific factor-2) is a secreted mesenchymal extracellular matrix component that affects the ability of cells to migrate and/or facilitates EMT during both embryonic development and pathologic conditions. (bvsalud.org)
The result is that select MEE establish interactions with periostin in the mesenchymal extracellular matrix , and these new cell -matrix interactions may regulate MEE transdifferentiation during palatal fusion. (bvsalud.org)
In early experiments, physical separation of mesenchymal and epithelial stroma from embryonic murine thymus resulted in defective thymus development when epithelium was cultured in vitro in the absence of mesenchyme ( 7 ). (frontiersin.org)
Epithelial-mesenchymal transformation is now recognised as an important feature of tissue remodelling. (ersjournals.com)

This has been studied mainly in the small intestine, where different cell types such as enterocyte progenitors 4 , more differentiated secretory Bmi1 + cells 3 , or even fully differentiated Paneth cells can repopulate crypts upon injury. (nature.com)

We have shown that in the stomach, stem cell homeostasis is regulated by Wnt and Rspo secreted by stromal myofibroblasts 11 . (nature.com)
Vascular barrier function is critical for the maintenance of blood flow and tissue homeostasis. (meduniwien.ac.at)
The goal of the cornea ageing and rejuvenation project is to analyze the difference between a young adult versus an old adult in terms of their markers involved in ageing, senescence, inflammation, mitochrondria dysfunction and epithelial homeostasis. (stanford.edu)
The perturbances in cellular redox homeostasis leads to high free radical burden thereby causing oxidative stress in the cells. (stanford.edu)
During tissue homeostasis and regeneration epithelial cells must balance proliferation, cell death and differentiation to maintain a functional organ. (ed.ac.uk)

2010 recognized broad classes of TTK69-regulated genes: protein folding mRNA splicing cell proliferation phagocytosis tracheal development and axon guidance. (ecologicalsgardens.com)

Regeneration requires stromal Rspo3, which is present at increased levels upon injury and reprograms Lgr5 − but Lgr4 + differentiated cells. (nature.com)
This Rspo3-driven regeneration program is supported by injury-induced stromal remodeling, and is essential for epithelial recovery. (nature.com)
Leukocyte recruitment into the inflamed parenchyma requires successive interactions with cellular and stromal barriers that establish mechanical, chemotactic and haptotactic gradients to guide immune cells towards the inflammatory focus. (hindawi.com)
These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)
While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
Ovaries are mostly made of three kinds of cells: epithelial, germ, and stromal. (webmd.com)
There's some evidence that Black women are a little more likely to have germ-cell and stromal tumors, compared to other groups. (webmd.com)
Some other rarer types of ovarian cancer are malignant germ cell tumors and stromal tumors. (medlineplus.gov)

Different pathologists have their own interpretations and opinions of the histopathological definitions of dysplastic epithelial lesions. (techscience.com)
This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)

From the proper period an egg chamber forms until stage 8 of oogenesis, the follicle cells collectively migrate along their cellar membrane (Cetera et al. (brain-tumor-cancer-information.com)

Co-staining for an epithelial cell marker identified most WUPyV viral protein 1-positive cells as respiratory epithelial cells. (cdc.gov)
This protein is one of many that acts as a cytokine and signals inflammation in the body by acting upon macrophages, neutrophils, B cells, Th2 cells, eosinophils, basophils and mast cells. (wikipedia.org)
Furthermore, E1A DNA and protein persisted in epithelial cells in the lungs of these animals 9 . (ersjournals.com)
Total internal reflection (TIRF) micrograph of MDCK cells stably transfected with the apical membrane protein P75-GFP (green) and stained for acetylated tubulin of the primary cilium (red) by immunofluorescence. (ucsd.edu)
See http://www.leica-microsystems.com/science-lab/protein-transport-processes-at-the-apical-membrane-of-polarized-epithelial-cells-applications-for-tirf-microscopy/ for additional details. (ucsd.edu)
Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. (tocris.com)
Of particular interest is NO2 that reacts with HOCI to form 3-nitrotyrosine (3NT) and 3-chlorotyrosine, markers of inflammation-mediated protein modification and tissue injury. (cdc.gov)
We furthermore detected a novel LTD4-induced association between Bcl-2 and the multifacetted protein b-catenin that may encompass a new mode of influencing cell survival. (lu.se)
These effects of LTD4 were shown to be mediated through the G-protein coupled receptor, CysLT1 and this strongly indicates that inflammatory mediators such as LTD4 may have large impacts on the state of cell survival regulation. (lu.se)

Particular attention has been paid to elucidating how leukocytes can migrate through the stroma, the way these cells remodel their morphology and sense cues that guide them towards dysfunctional tissue areas. (hindawi.com)

These specific localizations make it improbable that known PCP systems organize specific cell migratory behaviors on the basal surface area. (brain-tumor-cancer-information.com)
On the other hand, these barriers contain damaged or infected cells that are part of the inflammatory focus and the endpoint of the leukocyte migratory journey, so some sort of footprint, which is not completely understood, must exist in these cells to promote a preferential adhesion with infiltrated leukocytes. (hindawi.com)
We believe that successfully combining our current knowledge about leukocyte extravasation, three-dimensional migration through the stroma and the sequential interactions with parenchymal cell barriers, which include adopting unified experimental models, will help shed light on the entire migratory route of each immune cell type and on the specificity of the innate inflammatory responses in each type of tissue. (hindawi.com)

The AVMs combine the Vertex Model for confluent epithelial tissues with active matter dynamics. (cam.ac.uk)

This constant replacement of the epithelium is driven by cells located in the base of colonic crypts, which constantly divide and give rise to the various differentiated cell types. (nature.com)
Crypt abscesses develop in the epithelial glands, and ulceration of the mucosal epithelium occurs. (medscape.com)
Dysplasia, in BO, is characterised by morphological transitions in oesophagus lining where mucus-secreting goblet cells and glands start to form in the epithelium and lamina propria. (techscience.com)

IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. (wikipedia.org)

Thymic epithelial cells (TEC) effect crucial roles in thymopoiesis including the control of negative thymocyte selection. (ox.ac.uk)
Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)

Human colon cancer cell lines (CRCs) RKO, SW480 and SW620 were investigated for TG2 involvement in tumour advancement and aggression. (oncotarget.com)
2. The aim of this work was to investigate how hypoxia affects human lung epithelial cells in combination with profibrotic stimuli and its correlation to pathogenesis. (lu.se)
Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
Our aim is to establish phenotypically and transcriptionally characterized different subsets of primary human ocular cells. (stanford.edu)
The core utilizes a system in collaboration with the Thoracic Surgery Division for the routine procurement of human tissues from lung transplantation donors and explanted lungs and surgical tissues. (wustl.edu)
Non-human preparations: The core has special expertise in the culture and differentiation of mouse tracheal epithelial cells (mTEC). (wustl.edu)
Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells , the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε -carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. (rsc.org)
T47-D cell lysate, colon cancer lysate, Human breast carcinoma tissue, Human normal breast tissue. (abcam.com)
Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. (lu.se)

At the top of the picture, below the epithelial layer, there is a large volume of foamy macrophages laden with cholesterol. (cellimagelibrary.org)

Much of the chromatin architecture found in mature mTEC was found to be present already over earlier stages of mTEC lineage differentiation as well as in non-TEC tissues. (ox.ac.uk)
Medullary epithelial cells (mTEC), in conjunction with dendritic cells, then take over control of developing thymocytes. (frontiersin.org)

4 ] in 1951 cell culturing has become one of the most widely used methods with exceptional contribution to the advances in almost all fields of contemporary biology - cell biology, genetics, cell biochemistry, physiology etc. (intechopen.com)

Polarized epithelial cells compartmentalize tissue cavities and are often exposed to inflammatory challenges such as toxics or infections in non-lymphoid tissues. (hindawi.com)
Thymoma originates within the epithelial cells of the thymus, a lymphoid organ located in the anterior mediastinum. (medscape.com)

And these domes had a structure, a completely different appearance from the other cells, therefore it was clearly a phenomenon of differentiation. (webofstories.com)
The AF form of SALSA had a more intact structure and contained peptides from the zona pellucida domain, which is involved in cell differentiation and oligomerization. (researchgate.net)
Protocols and training: Protocols for cell isolation, culture and differentiation are available. (wustl.edu)

Rspo proteins are secreted and can stabilize the effects of Wnt ligands by preventing ubiquitination and turnover of the Wnt receptor frizzled 9 , thereby dictating the size of the Lgr5 + stem cell pool by regulating self-renewal of Lgr5 + cells 10 . (nature.com)
In these operational systems, specific models of transmembrane proteins localize to opposing sides from the same cell and mediate intercellular conversation by getting together with each other across cell-cell limitations. (brain-tumor-cancer-information.com)
2009). However, previous work recognized two transmembrane proteins that are excellent candidates to mediate planar signaling at the basal surface and thus promote migration of this tissue: the atypical cadherin Excess fat2 and the receptor tyrosine phosphatase Leukocyte antigen related (Lar) (Bateman et al. (brain-tumor-cancer-information.com)
Taken at face value, senile cataract is intimately associated with the increased risk of oxidative stress, which levies irrevocable changes in the lenticular proteins that impel the lens epithelial cells to the apoptotic phase. (molvis.org)
In lung tissue, oxidation of component proteins rich in carbonyl groups was examined by Western blotting for DNPH (2,4-dinitrophenylhydrazone-hydrazone). (cdc.gov)

Lgr5 is a well-established marker of these basal stem cells in the gastrointestinal tract 1 and lineage tracing experiments have demonstrated that Lgr5 + cells give rise to clonal cell populations establishing entire colonic crypts 2 . (nature.com)
Confocal microscopic analysis using an EMT marker, twist1, and an epithelial marker, cytokeratin 14 , provided evidence that select MEE were undergoing EMT in association with periostin. (bvsalud.org)
β-Catenin and TG2 was also upregulated in SW620 spheroid cells enriched with cancer stem cell marker CD44 and TG2 inhibition/knockdown reduced the spheroid forming potential of SW620 cells. (oncotarget.com)

The goal of the project is to develop new strategies for the synthetic morphogenesis of epithelial tissues. (ibecbarcelona.eu)

The colonic epithelial turnover is driven by crypt-base stem cells that express the R-spondin receptor Lgr5. (nature.com)
Upon Lgr5 + cell depletion, these cells are recruited to contribute to crypt regeneration. (nature.com)
During this process, the cells migrate along the crypt wall towards the surface where they are shed into the lumen. (nature.com)
Thus, we find that endogenous Rspo3 signaling is a critical determinant of cellular fate within the crypt and stimulates rapid recruitment of differentiated cells for epithelial wound healing and crypt regeneration through induction of Wnt signaling. (nature.com)

The micro changes will gradually be seen in oesophagus lining, as the smooth surface of the squamous epithelial layer begins to form a fingerlike cellular pattern, also known as villiform. (techscience.com)
Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
In an effort to advance the treatment strategies for the ocular surface diseases, I am focused on a regenerative medicine and single cell RNA sequencing based approaches to better comprehend the cellular biomarkers and molecular mechanisms involved in corneal tissue development and diseases. (stanford.edu)
Some researchers use the term fibroblast for both cellular states but the term "blast" usually refers to a stem cell or a cell's activated state. (news-medical.net)

We report WUPyV cell tropism in lungs transplanted into a recipient with Job syndrome. (cdc.gov)
These areas are often made up of polarized parenchymal epithelial cells that form barriers to compartmentalize functions in cavities of the liver, intestine or lungs (Figure 1 ). (hindawi.com)
Alpha-1 antitrypsin is a neutrophil elastase inhibitor (an antiprotease), the major function of which is to protect the lungs from protease-mediated tissue destruction. (msdmanuals.com)
In the lungs, alpha-1 antitrypsin deficiency increases neutrophil elastase activity, which facilitates tissue destruction leading to emphysema (especially in smokers, because cigarette smoke also increases protease activity). (msdmanuals.com)

Squamous cells form the surface of your cervix. (familydoctor.org)
This result means the squamous cells don't look normal. (familydoctor.org)
These cell changes are usually more serious than ASC (atypical squamous cells). (familydoctor.org)

These specialized cells absorb nutrients and are a critical barrier that prevent pathogens from spreading to deeper tissues. (sciencedaily.com)
1000 volts) exposure may, in regulating body temperature, fluid and however, cause damage to deeper tissues electrolytes. (who.int)

Black women with epithelial ovarian cancer are diagnosed most often with high-grade serous tumors, the most aggressive kind. (webmd.com)
Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. (medlineplus.gov)
Often the only way to know for sure that you have ovarian cancer is by having a biopsy of the tissue. (medlineplus.gov)

C jejuni is attracted to mucus and fucose in bile, and the flagella may be important in both chemotaxis and adherence to epithelial cells or mucus. (medscape.com)

The majority of epithelial cells are therefore short-lived, in contrast to a limited number of long-lived stem cells in the base of the crypts. (nature.com)
While Lgr5 + cells are long-lived and act as stem cells during homeostatic conditions, experimental models have demonstrated that Lgr5 + stem cells per se are not essential for maintaining epithelial integrity 3 . (nature.com)
Stem Cells Dev. (tocris.com)
Cornea is constantly regenerated from a small population of limbal epithelial stem cells via transiently amplifying cell (TAC) states. (stanford.edu)

1995 TTK69 also regulates varied processes during take flight development from cell-cycle rules to tracheal tubulogenesis (Baonza Isoacteoside et al. (ecologicalsgardens.com)

Tissue was prepared by standard histological methods for pathology. (cellimagelibrary.org)
Boundary effect in digital pathology is a phenomenon where the tissue shapes of biopsy samples get distorted during the sampling process. (techscience.com)

Throughout their migration (arrow), the follicular epithelial cells crawl along the cellar membrane, which continues to be fixed. (brain-tumor-cancer-information.com)
Axelrod and Matis, 2013), whereas the cell migration equipment reaches the basal surface AR-C69931 tyrosianse inhibitor area. (brain-tumor-cancer-information.com)
The egg chamber offers a effective model to research the mechanisms managing epithelial AR-C69931 tyrosianse inhibitor migration (Statistics 1CC1G). (brain-tumor-cancer-information.com)
So far, most of the in vivo and in vitro approaches to study leukocyte migration across the tissue parenchyma have addressed the role of each single tissue barrier that immune cells encounter in their journey to the inflammatory focus. (hindawi.com)

Precursor cells migrate to the thymus and differentiate into lymphocytes. (medscape.com)

In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)

Just like migrating cells separately, each epithelial cell stretches actin-rich protrusions at its industry leading that form fresh adhesions towards the extracellular matrix (ECM). (brain-tumor-cancer-information.com)
A fibroblast is a type of cell that is responsible for making the extracellular matrix and collagen. (news-medical.net)
Together, this extracellular matrix and collagen form the structural framework of tissues in animals and plays an important role in tissue repair. (news-medical.net)

We also include cell alignment, cell-specific mechanical properties, cell growth, division and apoptosis as well as a flexible, dynamically changing boundary of the epithelial sheet. (cam.ac.uk)

The Integrative Cell and Tissue Dynamics Group is looking for Postdoctoral Researcher to work on engineering organoid systems. (ibecbarcelona.eu)
One way that leading and trailing edge dynamics could possibly be coordinated between migrating epithelial cells is certainly by using a planar signaling program. (brain-tumor-cancer-information.com)
Ongoing work applied to the early chick embryo focuses on a model where contractile junctions with myosin feedback are responsible for tissue dynamics and mechanics, and I will present preliminary results. (cam.ac.uk)

During the inflammatory response, immune cells egress from the circulation and follow a chemotactic and haptotactic gradient within the tissue, interacting with matrix components in the stroma and with parenchymal cells, which guide them towards the sites of inflammation. (hindawi.com)

We also discuss recent findings showing that the loss of apicobasal polarity increases leukocyte adhesion to epithelial cells and the consequences that this could have for the inflammatory response towards damaged, infected or transformed epithelial cells. (hindawi.com)
The inflammatory infiltrate consists of neutrophils, mononuclear cells, and eosinophils. (medscape.com)

A serious concern for IBD patients is the increased risk of developing colorectal cancer and since there seems to be a general connection between inflammation and cancer we hypothesised that LTD4 induced signalling events could be involved in increasing the tumourgenic potential of cells. (lu.se)

Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. (nature.com)

These genes displayed enriched manifestation in DA-tube cells except mutants and exhibited RNAi phenotypes that were enhanced inside a genetic interactions. (ecologicalsgardens.com)

We conclude that the observed effects contribute to loss of epithelial integrity during atopic asthma. (springer.com)

They can also take a sample of tissue (biopsy) to test for cancer. (familydoctor.org)

Indeed, a common feature of epithelial dysfunction is the loss of polarity. (hindawi.com)

Chemical injury induced by DSS leads to a loss of both Lgr5 + cells and Axin2 + cells and epithelial regeneration is driven by Axin2 − cells, including differentiated Krt20 + surface enterocytes. (nature.com)

Hs 578T are epithelial cells isolated from breast tissue derived from a 74-year-old, White, female breast cancer patient. (atcc.org)
Axillary PD can arise from underlying axillary accessory breast tissue. (medscape.com)
Patient developed infiltrating ductal carcinoma of underlying breast tissue with axillary lymph metastasis. (medscape.com)

The duct (clear zone at center) is lined by highly polarized epithelial cells with dark nuclei at the base. (cellimagelibrary.org)
Spatial scale is approximate based on known size of cell nuclei. (cellimagelibrary.org)
Then, the condition may progress into low-grade dysplasia where size, shape, and other cytological features in the cells and nuclei, starts to morph. (techscience.com)
TGF-β1 activated accumulation of phosphorylated SMAD2 (pSMAD2-C) at centrioles of motile cilia and at cell nuclei. (springer.com)

Title : Tissue cultures of KB epithelial cells for poliomyelitis virus tests Personal Author(s) : Luoto, Lauri;Pickens, Edgar G. (cdc.gov)
So, we embarked upon it, we also decided to continue to study the development in a simpler system, and the simpler system was provided by tissue cultures. (webofstories.com)
And, observing the cultures of these epithelial cells, I noted that when the cells grew in the cultures, on glass plates, the cells always became more numerous, they started to develop what we call domes, therefore they broke away from the substrate and grew forming this dome. (webofstories.com)

The most common renal cell carcinoma that develops in patients with end-stage renal disease and acquired cystic disease. (cismef.org)

Adenoviral DNA is retained by peripheral epithelial cells of the lung (PLECs) in humans in whom the viral E1A gene is expressed 4 without replication of a complete virus 5 . (ersjournals.com)

The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. (frontiersin.org)
However, experimental evidence suggests these cells are important for thymus function by either directly influencing T-cell development, or by indirectly regulating TEC development and/or function. (frontiersin.org)
In early life, the thymus is responsible for the development and maturation of cell-mediated immunologic functions. (medscape.com)
The thymus is composed predominantly of epithelial cells and lymphocytes. (medscape.com)

The RPE is a monolayer of cells between the neural retina and choroidal blood supply, and is critically important for photoreceptor function. (arvojournals.org)

In cancer, these interactions become deregulated and epithelial cells can either be regulated independent of their microenvironment or the niche becomes permissive to tumour formation. (ed.ac.uk)
Our lab is interested in how the signals, which come from the regenerative microenvironment drive tissue repair following injury and how these signals are co-opted by the tumour to support cancer growth. (ed.ac.uk)
Inhibition of this enzyme reduces cancer risk and it is highly elevated in tumour tissue. (lu.se)

The Pap test checks for cell changes on a woman's cervix that could turn into cancer if they are not treated. (familydoctor.org)
The virus can cause cell changes that lead to cervical cancer. (familydoctor.org)
Pap tests can detect cancer cells, but it is rare. (familydoctor.org)
Cells of the cervix go through many changes before they turn into cancer. (familydoctor.org)
Abnormal or precancerous cells are often found before cancer develops. (familydoctor.org)
Use these cells in breast cancer research. (atcc.org)
Each of these cells can cause a different kind of cancer. (webmd.com)
Cancer is a disease in which abnormal cells in the body grow out of control and form a tumor. (medlineplus.gov)
The most common type is epithelial cancer. (medlineplus.gov)
Fallopian tube cancer forms in the tissue lining a fallopian tube. (medlineplus.gov)
Primary peritoneal cancer forms in the tissue lining the peritoneum. (medlineplus.gov)
one, the cells were truly epithelial, are the cancer cells, the cells from the breast ducts, and the other, however, with the cells that seemed fusiform, not therefore epithelial, that had to be a type. (webofstories.com)
New Therapeutic Procedure To Eliminate Cancer Cells Infiltrated In Brain. (usherbrooke.ca)
HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells. (lu.se)

Anatomy74

Organisms13

Diseases9

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes49

Disciplines and Occupations2

Information Science3

Intestinal5

Alveolar4

Connective tissue7

Endothelial5

Glandular2

Bronchial5

Transition7

Fibroblasts7

Somatic2

Airway10

Organs4

Pathways2

Expression12

Mesenchymal4

Small intestine1

Homeostasis5

Proliferation1

Stromal10

Lesions2

Follicle cells1

Protein9

Morphology1

Migratory3

Vertex Model1

Epithelium3

Induces1

Thymic3

Human9

Macrophages1

MTEC2

Biology1

Lymphoid2

Differentiation3

Proteins5

Marker3

Morphogenesis1

Crypt4

Cellular4

Lungs4

Squamous3

Deeper tissues2

Ovarian3

Mucus1

Stem cells4

Tracheal1

Pathology2

Migration4

Migrate1

Medullary1

Extracellular matrix3

Apoptosis1

Dynamics3

Stroma1

Inflammatory2

Colorectal1

Regulate1

Phenotypes1

Integrity1

Biopsy1

Dysfunction1

Regeneration1

Breast tissue3

Nuclei4

Cultures3

Carcinoma1

Peripheral1

Thymus4

Retina1

Tumour3

Cancer14