• Biomaterials Science and Tissue Engineering - The application of materials engineering and cell biology principles to achieve improved repair of injured and damaged body tissues and organs. (sheffield.ac.uk)
  • It is an age old dream of medicine: if arbitrary kinds of tissue could be produced artificially from stem cells, then injuries could be healed with the body's own cells, and one day it might even be possible to produce artificial organs. (eurekalert.org)
  • My PhD focussed on investigating the distributions and possible functions of nitric oxide/nitric oxide synthases in the physiology and pathology of a variety of tissues and organs and I was fortunate enough to publish some of the first papers on the involvement of these molecules in human diseases, notably in the cardiovascular system. (nottingham.ac.uk)
  • Cells Tissues Organs (2016) 202 (1-2): 85-101. (karger.com)
  • This cell-mediated immune response is ultimately responsible for the widespread tissue injury, in addition to the fibrosis of the skin and the connective tissue that pervades muscles, nerves, and other organs. (medscape.com)
  • This is helping accelerate the growth of engineered biological systems that span from one single cell all the way to multicellular systems, like engineered organs. (medlineplus.gov)
  • In general, researchers are developing these approaches to replace or repair tissues and organs, as well as provide 'organ simulators' for testing drugs and understanding how the body works. (medlineplus.gov)
  • 3) biomimetic in vitro culture environments, designed to replicate the in vivo milieu by using biologically inspired requirements, influence and drive cells to differentiate towards the desired phenotype and to express their functions, promoting extracellular matrix formation and tissue maturation. (polito.it)
  • This study covers the whole production cycle, from biodegradable polymer processing to an in vivo tissue engineered construct. (researchgate.net)
  • In the case of the in vivo samples, the mechanical properties were restored again, stepwise, by the presence of growing/maturing tissue between weeks 3 and 12. (researchgate.net)
  • The approach is to combine numerical simulations with tissue explant ex vivo experiments in bioreactors where the physical environment can be controlled. (tue.nl)
  • This review summarizes the technical aspects of engineered human myocardium generation, lessons learned from preclinical in vitro and in vivo studies and the current state of this approach on its way to clinical translation. (nih.gov)
  • Hair follicle germs (HFGs), identified during in vivo development, are considered effective tissue grafts for hair regenerative. (researchgate.net)
  • Thus, the strategy of functionalization of nanofibers by nanoreservoirs of BMP-2 or BMP-7 showed a great efficiency for bone regeneration and increased the differentiation of MSCs (mesenchymal stem cells), accelerating the tissue regeneration in vivo [ 9 , 10 , 13 , 14 ]. (hindawi.com)
  • Implantation of the printed cortical tissues into ex vivo mouse brain explants results in substantial structural implant-host integration across the tissue boundaries as demonstrated by the projection of processes and the migration of neurons, and leads to the appearance of correlated Ca2+ oscillations across the interface. (bvsalud.org)
  • Relating in vitro to in vivo exposures with physiologically-based tissue dosimetry and tissue response models. (cdc.gov)
  • To date, much progress has been made in improving in silico, in vitro, and ex vivo model systems with increased complexity and with promising predictivity of tissue-level responses. (cdc.gov)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • Biomaterials can be used to restore or replace tissue function by filling defects, providing physical stability, and allowing cells to infiltrate, expand in number, and form tissue. (healthylongevitychallenge.org)
  • In the last decade, a great deal of progress was made in this field due to new advances in interdisciplinary areas such as biology, genetic engineering, biomaterials, polymer science, bioreactor engineering, and stem cell biology. (polito.it)
  • Various biomaterials, whether they are biological, synthetic, or a combination of both, can be used to create scaffolds, which when implanted in a human body can promote host tissue regeneration. (wikipedia.org)
  • His work is focused on biomaterials and scaffold development, tissue engineering and regenerative therapies, mostly for musculoskeletal tissues. (selectbiosciences.com)
  • The 'smartest' biomaterials are the natural tissues in our bodies. (tue.nl)
  • If only we could unlock their secrets and bioengineer smart biomimetic biomaterials that help our tissues to heal, responding to their cues. (tue.nl)
  • To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. (routledge.com)
  • The regrowth of myelinating oligodendrocytes from neural stem cells through a biomaterials approach may prove to be a beneficial strategy following the onset of demyelination. (karger.com)
  • Dr. Lavik's lab used biomaterials, drug delivery, and tissue engineering approaches to protect and regrow neural tissue. (fescenter.org)
  • Therefore, the innovative field of cardiac tissue engineering (TE) could represent an effective alternative to overcome the limitations of the current clinical therapies. (polito.it)
  • This strategy, in fact, has shown the potential to generate both functional cardiac tissue substitutes for use in the failing heart, and biological in vitro model systems to investigate the cardiac tissue-specific development and diseases, allowing to perform accurate and controlled in vitro tests for cell and tissue-based therapies, drug screening, predictive toxicology and target validation. (polito.it)
  • What are the challenges of translating such research findings into applicable approaches for regenerative bone therapies? (youris.com)
  • Tissue bioengineering and stem/progenitor cell treatments have both been individually pursued for stroke neural repair therapies, with some benefit in tissue recovery. (researchgate.net)
  • Emerging directions in stroke neural repair approaches combine these two therapies to use biopolymers with stem/progenitor transplants to promote greater cell survival in the transplant and directed delivery of bioactive molecules to the transplanted cells and the adjacent injured tissue. (researchgate.net)
  • Her current research is focused on a UGA collaboration to establish a new approach of corneal organoid generation for a new strategy of future clinical therapies, such as aniridia. (nih.gov)
  • Current approaches of regenerative therapies constitute strategies for bone tissue reparation and engineering, especially in the context of genetical diseases with skeletal defects. (hindawi.com)
  • Both are effective at depleting B cells in blood, but these engineered CD19-targeted T cells can reach B cells sitting in tissues in a way that antibody therapies cannot, Konig explained. (medscape.com)
  • Engineering therapies in the CNS: what works and what can be translated. (fescenter.org)
  • The course covers complications from dysfunctional stem cells in connection with stem cell therapies and tissue engineering, and highlights the legal and ethical issues surrounding stem cell research. (lu.se)
  • In this context, tissue engineering becomes relevant for the treatment of large bone defects, where cells or growth factors are incorporated into a three-dimensional scaffold to mimic native tissue architecture and function in terms of osteoconduction, osteoinduction and osteointegration. (amrita.edu)
  • One of the goals of tissue engineered biomaterial approaches is to design the degradation of the biomaterial to: 1) initially support cells constructing the tissue, and 2) gradually degrade as new tissue replaces the scaffold. (healthylongevitychallenge.org)
  • In this way, paired tissue in-growth and scaffold degradation can maintain the properties of the tissue through the healing process. (healthylongevitychallenge.org)
  • The initial implantation of the foreign scaffold triggers various signaling pathways guided by the foreign body response for cell recruitment from neighboring tissues. (wikipedia.org)
  • The scaffold designed for tissue engineering is one of the most crucial components because it guides tissue construction, viability, and functionality long after implantation and degradation. (wikipedia.org)
  • The methods that have existed so far can be divided into two fundamentally different categories: Either one first creates small tissue building blocks, such as round cell agglomerates or flat cell sheets, and then assembles them, or one initially creates a fine, porous scaffold that is then cultivated with cells. (eurekalert.org)
  • The scaffold-based approaches that have been developed so far have great advantages: If you first make a porous scaffold, you can precisely define its mechanical properties,' says Dr Olivier Guillaume, lead author of the current study, who is researching at TU Wien in the team of Prof Aleksandr Ovsianikov at the Institute of Materials Science and Technology. (eurekalert.org)
  • We were able to show that the cells from neighbouring scaffold units do indeed merge and actually form a single tissue. (eurekalert.org)
  • The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
  • I work on various biochemical and biophysical approaches to investigate and control cell-cell, cell-scaffold interactions. (nottingham.ac.uk)
  • Approaches of bioengineering and regenerative medicine aim to create different types of materials, implants, or scaffold mimicking structure of extracellular matrix, functionalized with bioactive molecules or living cells. (hindawi.com)
  • The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
  • In cases of failure, the CS may be affected by severe fibrosis due to previous intervention and these patients may benefit from our innovative casting approach to engineer a three-layered tubular construct to mimic the organisation of the native CS. (emjreviews.com)
  • The two types of esophageal tissue derived-decellularized extracellular matrix bioinks can mimic the inherent components and composition of original tissues with layer specificity. (nature.com)
  • A nanoscale modular design strategy was employed to synthesize six engineered, recombinant proteins intended to mimic aspects of the extracellular matrix proteins fibronectin, laminin, and elastin as well as the cell-cell adhesive protein neural cell adhesion molecule. (frontiersin.org)
  • With 4D printing, engineers have created tiny needles that mimic parasites that attach to tissues and could replace hypodermic needles, according to a new study. (sciencedaily.com)
  • The electrospun randomized nanofiber network and the created micropores (diameter 100 μ m) mimic the pattern of the connective tissue matrix [ 4 , 5 ]. (hindawi.com)
  • In particular, during the PhD as engineering approach two different bioreactor prototypes for cardiac TE have been developed (Chapter II and III), while as biological and applicative approach the work dealt with the generation of a contractile cardiac patch by using a perfusion-based bioreactor culture system (Chapter IV). (polito.it)
  • Thus, in situ (in its original position or place) tissue engineering of heart valves serves as a novel approach that explores the use creating a living heart valve composed of the host's own cells that is capable of growing, adapting, and interacting within the human body's biological system. (wikipedia.org)
  • There are also current approaches that are manufacturing scaffolds and coupling them with biological cues. (wikipedia.org)
  • Tissue engineering can perhaps be best defined as the use of a combination of cells, engineering materials, and suitable biochemical factors to improve or replace biological functions. (sciencedaily.com)
  • This work of thesis aims to investigate the role of biophysical signals expressed by material surfaces on the assembly and structuring of biological tissues in vitro. (unina.it)
  • Then, we reported the studies on the use of nano-topography to control tissue assembly, which are limited and the possibility to exploit this control to biological applications. (unina.it)
  • This is being addressed through multiple biological and biomechanical approaches. (ucdavis.edu)
  • Jan. 6, 2022 Protein assembly is essential for the formation of ordered biological structures, but imagine engineering one! (sciencedaily.com)
  • Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. (routledge.com)
  • However, it is essential to provide each engineered tissue with its own environment so that the specific tissue phenotypes can be maintained for weeks to months, as required for biological and biomedical studies. (columbia.edu)
  • Langer and Vacanti 19 defined tissue engineering as an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. (bvsalud.org)
  • The purpose of this article is to review the biological principles of tissue engineering and the hurdles that must be overcome to develop regenerative endodontic procedures. (bvsalud.org)
  • Standard bone tissue engineering approaches require isolation and propagation of autologous cells, followed by seeding about a variety of scaffolds. (bioskinrevive.com)
  • Furthermore, BMP-9 appears to be a more powerful osteogenic inducer for cells within fats tissues than BMP-2 or -7. (bioskinrevive.com)
  • In this case, we use a combination of a granulate material and cells as therapeutic approach. (youris.com)
  • At TU Wien (Vienna), a third approach has now been developed: Using a special laser-based 3D printing technique, micro-scaffolds with a diameter of less than a third of a millimetre can be produced, which can accommodate thousands of cells. (eurekalert.org)
  • We used stem cells for our experiments, which can be induced to produce either cartilage or bone tissue. (eurekalert.org)
  • In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
  • As confirmation that ligand density in these engineered systems impacts neuronal cell behavior, we demonstrate that increasing the density of fibronectin-derived RGD ligands on coated surfaces while maintaining uniform protein surface coverage results in enhanced neurite extension of PC-12 cells. (frontiersin.org)
  • Hair regeneration using hair follicle stem cells (HFSCs) and dermal papilla cells is a promising approach for the treatment of alopecia. (researchgate.net)
  • The article, Electric-field facilitated rapid and efficient dissociation of tissues Into viable single cells shares the science behind the researcher's U.S. patent, wherein they invent and characterize a novel method and device to dissociate tissues with electric fields. (olin.edu)
  • Here, a new approach for dissociating tissues into constituent cells is described. (olin.edu)
  • Placing a tissue biopsy core within a liquid-filled cavity and applying an electric field between two parallel plate electrodes facilitates rapid dissociation of complex tissues into single cells. (olin.edu)
  • In recent years, the lab has identified stem and progenitor cells in articular cartilage, muscle and synovial tissues. (ucdavis.edu)
  • Tissue engineering performs the culture of cells on scaffolds, aiming at the restoration of damaged tissue. (springer.com)
  • Some approaches involve the use of stem cells, progenitor cells, and novel materials. (nih.gov)
  • I was also affiliated with the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), part of the Centre for Biomolecular Sciences, which is now the Biodiscovery Institute. (nottingham.ac.uk)
  • My research interests focus mainly on stem cells (embryonic, 'adult' and fetal origins) and their applications in tissue engineering, particularly the osteoblast and bone tissue. (nottingham.ac.uk)
  • Different sources of living cells are described, as mesenchymal stem cells (MSCs), adipose-tissue derived stem cells, skin derived multipotent stem cells, or oral cavity MSCs, presenting compatible immunophenotype or morphology [ 2 , 3 ]. (hindawi.com)
  • If you have a patient with myositis, for example, where autoreactive B cells are sitting in the inflamed muscle, or a patient with rheumatoid arthritis , where you have disease-relevant B cells in hard-to-reach tissues like the synovium, those cells are much harder to deplete with an antibody, compared to a T cell that evolved to surveil and effectively kill in all tissues," he explained. (medscape.com)
  • In this process, T cells are collected from patients via leukapheresis and then re-engineered to express chimeric antigen receptors. (medscape.com)
  • Today, a team of researchers from Columbia Engineering and Columbia University Irving Medical Center reports that they have developed a model of human physiology in the form of a multi-organ chip consisting of engineered human heart, bone, liver, and skin that are linked by vascular flow with circulating immune cells, to allow recapitulation of interdependent organ functions. (columbia.edu)
  • Human induced pluripotent stem cells are differentiated into upper- and deep-layer neural progenitors, which are then printed to form cerebral cortical tissues with a two-layer organization. (bvsalud.org)
  • Importantly, our methodology offers a technical reservoir for future personalized implantation treatments that use 3D tissues derived from a patient's own induced pluripotent stem cells. (bvsalud.org)
  • All tissues originate from stem cells. (bvsalud.org)
  • A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
  • Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
  • These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)
  • Our objective is to identify the cells and factors that are essential in the engineering process. (lu.se)
  • of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
  • Keita Ito chairs the research group Orthopaedic Biomechanics, where engineering and biology are combined to expand our understanding of the biomechanical function of musculoskeletal tissues as well as their adaptive developmental and physiological nature. (tue.nl)
  • The UC Davis Center for Tissue Regeneration and Repair focuses on regeneration for the musculoskeletal system to restore function to tissue diseased or damaged from cancer, trauma, and arthritis. (ucdavis.edu)
  • Several approaches were considered to fabricate tubular constructs for esophageal tissueengineering. (nature.com)
  • Combining two or more materials in a layered fashion leads to complex constructs suitable for the treatment of defects at tissue interfaces. (selectbiosciences.com)
  • When many of them are brought into direct contact, it is possible to create large tissue constructs with a high initial cell density in a short time. (eurekalert.org)
  • Recently, this field has made tremendous advances regarding in vitro optimization of tissue-engineered constructs, and valuable data have been generated in small animal models. (nih.gov)
  • Bone morphogenetic protein (BMPs) are referred to as bone tissue forming growth elements. (bioskinrevive.com)
  • Dr. A. Champa Jayasuriya has a Tissue Engineering/Regenerative Medicine background and is currently investigating biomimetic strategies for bone tissue engineering. (utoledo.edu)
  • Bone regeneration using electrospun nanofibers' implant has the following objectives: bone neoformation induction with rapid healing, reduced postoperative complications, and improvement of bone tissue quality. (hindawi.com)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
  • Therefore, this engineered protein adsorption approach allows for the facile preparation of tunable, quantifiable, and reproducible surfaces for in vitro studies of cell-ligand interactions and for potential application as coatings on neural implants. (frontiersin.org)
  • Here we present a new approach to create enhanced neural implant bio-interfaces that offers nanoscale precision and is reproducible, simple to apply, quantifiable, and customizable. (frontiersin.org)
  • Aurand, E.R., K.J. Lampe, K.B. Bjugstad (2012) Defining and designing polymers and hydrogels for neural tissue engineering. (karger.com)
  • Their work spanned from basic work engineering a neural stem cell niche to translatable work delivering off patent drugs in ways that protect and repair the nervous system. (fescenter.org)
  • Journal of Neural Engineering , 14 (3), Article 036026. (lu.se)
  • In this work, we present a novel approach to fabricate such coatings, which specifically involves the use of surface-adsorbed, nanoscale-designed protein polymers to prepare reproducible, customized surfaces. (frontiersin.org)
  • Here, we use a droplet printing technique to fabricate tissues comprising simplified cerebral cortical columns. (bvsalud.org)
  • Based on this suggested technique, we developed a bioprinted 3D esophageal structure with multi-layered features and converged with biochemical microenvironmental cues of esophageal tissue by using decellularizedbioinks from mucosal and muscular layers of native esophageal tissues. (nature.com)
  • Katholieke Universiteit Leuven, Faculty of Engineering, Department of Chemical Engineering, Chemical and Biochemical Process Technology and Control Laboratory: PhD candidate. (imperial.ac.uk)
  • You'll learn about biology, physiology and anatomy, and begin to understand how traditional engineering principles can be applied to the human body. (sheffield.ac.uk)
  • Biomanufacturing - The application of chemical engineering and cell biology principles to improve the manufacture of pharmaceuticals and other biologically active substances. (sheffield.ac.uk)
  • The ideas involved are important not only from the point of view of modelling real electronic circuits but also because many complicated processes in biology, medicine and mechanical engineering are themselves modelled by electric circuits. (sheffield.ac.uk)
  • I returned full time to Imperial College in 1999 to take up a lectureship in cell biology and tissue engineering and was also actively involved in establishing the Tissue Engineering Centre. (nottingham.ac.uk)
  • From 1999 onwards my research has been focused primarily on osteoblast biology and approaches to tissue engineer and model bone biology, pathology and repair. (nottingham.ac.uk)
  • We need to continue to nurture the growth of the engineering and physical science community in biology and medicine. (medlineplus.gov)
  • Starting from a wide and in-depth review of the state of the art of bioreactors for cardiac TE (Chapter I), two bioreactor prototypes were developed (Chapter II and III), firstly, as model systems to investigate in vitro the effects of biophysical stimuli on cardiac cell culture and cardiac tissue formation and maturation. (polito.it)
  • In conclusion, our approach enables construction of tubular structures with distinct composition in the different cell layers. (emjreviews.com)
  • He'd just co-authored, with his M.S. student Ayelet Levy and ROHO Inc. collaborator Kara Kopplin, an article in the Journal of Tissue Viability: "An Air-Cell-Based Cushion for Pressure Ulcer Protection Remarkably Reduces Tissue Stresses in the Seated Buttocks with Respect to Foams: Finite Element Studies. (mobilitymgmt.com)
  • For example, it can happen that the cell spheres change their size or shape and the tissue ends up with different properties than desired. (eurekalert.org)
  • In the first part of the thesis an introduction on the importance of cell−material interaction in tissue engineering is presented, focusing on cell−topography crosstalk and mechanics. (unina.it)
  • Here, patterned PDMS substrates are used as cell culture supports to promote organized tissue assemblies. (unina.it)
  • Therefore, we hypothesized that topographic signal could indirectly regulate tissue structure via cell ordering. (unina.it)
  • Tissue Engineering schemes usually require long term cultures in which cell-cell contacts may over-rule cell-material interactions. (unina.it)
  • Yet, material signals can affect tissue morphology and this can indirectly influence cell fate. (unina.it)
  • This stated, we investigated to what extent the signals provided by the endogenous matrix affected stem cell behavior and if a relation between different assemblies of the endogenous tissue and stem cell fate existed. (unina.it)
  • The Integrative Cell and Tissue Dynamics Group is looking for Postdoctoral Researcher to work on engineering organoid systems. (ibecbarcelona.eu)
  • Chimeric antigen receptor (CAR) T-cell therapy has offered a novel approach to treating hematologic cancers since 2017, but there are early signs that these cellular immunotherapies could be repurposed for B-cell mediated autoimmune diseases. (medscape.com)
  • Tissue engineering the retinal ganglion cell nerve fiber layer. (fescenter.org)
  • Engineering human tissue with diverse cell types and architectures remains challenging. (bvsalud.org)
  • However, one of the challenges in AAV-mediated gene therapy is achieving efficient targeting of specific cell types and tissues. (lu.se)
  • By introducing peptide insert modifications into the AAV capsid, the viral vectors can be engineered to target specific cell types and tissues. (lu.se)
  • However, a systematic approach is needed to identify the most efficient AAV variants for different cell types, tissue types, and specific targets while avoiding off-target effects, particularly in non-target tissues such as the liver. (lu.se)
  • The experimental part involves the use of diverse AAV libraries with peptide insert modifications, designed to enhance AAV tropism and enable specific targeting of neuronal and non-neuronal populations in the central nervous system (CNS) and other tissue and cell types. (lu.se)
  • Statistical analysis, visualization, and comparative studies will be performed to evaluate the performance of different AAV variants across various cell types and tissue types. (lu.se)
  • This will be coupled with next generation sequencing based approaches to understanding the consequences of perturbing immune cell function. (lu.se)
  • In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. (cdc.gov)
  • Some types of fabricated scaffolds include solid 3-D porous scaffolds that have a large pore network that permits the flow through of cellular debris, allowing further tissue and vascular growth. (wikipedia.org)
  • and 3) rich in vascular spaces and microvessels (3 μm tissue section, elastin staining in purple). (emjreviews.com)
  • Tissues cultured in the multi-organ chip (from left to right: skin, heart, bone, liver, and endothelial barrier) maintained their tissue-specific structure and function after being linked by vascular flow. (columbia.edu)
  • The biocompatibility of surgically implanted foreign biomaterial refers to the interactions between the biomaterial and the host body tissue. (wikipedia.org)
  • Biomaterial approaches for sustainable tissue engineering. (ukm.my)
  • In vitro models of human hair follicle-like tissue could be fundamental tools to better understand hair follicle morphogenesis and hair drug screening. (researchgate.net)
  • The goal of the project is to develop new strategies for the synthetic morphogenesis of epithelial tissues. (ibecbarcelona.eu)
  • In addition to silicosis, scientific evidence indicates that occupational exposure to crystalline silica puts workers at increased risk for other serious health conditions: chronic obstructive lung disease, lung cancer, kidney and connective tissue disease, and tuberculosis. (cdc.gov)
  • So I decided I would focus on that and try to bring the tools that mechanical engineers use, like computational modeling. (mobilitymgmt.com)
  • Mechanical engineers use a lot of computational tools, computer tools, to try to describe how complex structures behave. (mobilitymgmt.com)
  • Gefen explains that he applied the sort of computer simulations used by mechanical engineers "to look at how loads develop in tissues, not only on the surface of tissues, but also internally, where you can't look. (mobilitymgmt.com)
  • Mechanical engineering helps me to look at loads inside the tissue, but that's not enough, really," he notes. (mobilitymgmt.com)
  • Keita Ito studied Mechanical Engineering at the Massachusetts Institute of Technology (MIT, Cambridge, MA, USA) where he received his MSc degree in 1987. (tue.nl)
  • The method is compared with standard chemical and mechanical approaches for tissue dissociation. (olin.edu)
  • We think our 4D-printed microneedle array will allow for more robust and sustained use of minimally invasive, pain-free and easy-to-use microneedles for delivering drugs, healing wounds, biosensing and other soft tissue applications," said senior author Howon Lee, an assistant professor in the Department of Mechanical and Aerospace Engineering in the School of Engineering at Rutgers University-New Brunswick. (sciencedaily.com)
  • Lijie Grace Zhang is assistant professor in the Department of Mechanical and Aerospace Engineering and the Department of Medicine at the George Washington University, USA. (routledge.com)
  • Bone grafts are among the most sought after tissue transplants in clinical practice. (youris.com)
  • 1 In a series of presentations at European Association of Urology (EAU) Congress 2018, the use of tissue-engineered oral mucosa grafts (TEOMG) for urethral reconstruction was discussed. (emjreviews.com)
  • Hair regenerative medicine must involve practical procedures, such as cryopreservation of tissue grafts. (researchgate.net)
  • Nov. 9, 2023 Scientists demonstrate a novel approach for creating high-performance ultrafast lasers on nanophotonic chips. (sciencedaily.com)
  • One novel approach to restore tooth structure is based on regenerative endodontic procedures by application of tissue engineering. (bvsalud.org)
  • Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost tissue. (researchgate.net)
  • Most of the research in the BME program is highly interdisciplinary, and our students form strong research collaborations with scientists, engineers, and clinicians from Johns Hopkins University and leading academic institutions from around the world. (jhu.edu)
  • Engineers and physical scientists have been developing methods to mathematically represent complex cellular processes. (medlineplus.gov)
  • Dr. Sarit Bhaduri is pursuing several externally funded research projects in this area, like the innovative approaches to the treatment of osteoporotic bone. (utoledo.edu)
  • As alternative models improve their predictivity of tissue-level responses, organ-level and systemic responses remain a long-term goal and will require novel integration of a number of innovative approaches to get there. (cdc.gov)
  • The mesenchymal tissue separating the 2 systems is known as the tracheoesophageal septum. (medscape.com)
  • Physical adsorption isotherms were experimentally determined for these engineered proteins, allowing for direct calculation of the available ligand density present on coated surfaces. (frontiersin.org)
  • The proteins are synthesized using recombinant, genetic engineering techniques, allowing for the creation of biocompatible polymers with nanoscale precision that impart highly specific protein functionalities. (frontiersin.org)
  • Autologous platelets as a source of proteins for healing and tissue regeneration. (springer.com)
  • This scenario greatly motivates research into effective therapeutic interventions, since complete native regeneration is unlikely for fully differentiated, loadbearing cardiac tissues. (polito.it)
  • Secondly, once optimal culture conditions have been identified, bioreactors can be used as production systems for in vitro generation of functional engineered cardiac tissues. (polito.it)
  • Currently, numerous alternative treatment approaches aiming at cardiac regeneration are under investigation. (nih.gov)
  • The compressive modulus of the construct was comparable to that of the native tissue. (emjreviews.com)
  • This strategy will ensure that all patients regenerate stable, functional tissue leading to a reduction of repeat surgeries and an improvement in pain, function, and aesthetics over the lifetime of the patient. (healthylongevitychallenge.org)
  • Could companies eventually print functional cancerous tissue in the lab to hasten the development of oncology drugs? (advfn.com)
  • Preclinical studies, showing that implantation of excess fat or muscle tissue fragments transduced with an adenoviral BMP-2 vector induces structural and practical healing of large segmental bone defects, were recently reported20,21,22,23. (bioskinrevive.com)
  • Using chicken muscle tissue as a model, the researchers showed that tissue adhesion with their microneedle is 18 times stronger than with a barbless microneedle. (sciencedaily.com)
  • You'll join a community of outstanding researchers and skilled professionals devoted to conduct excellent interdisciplinary research at the frontiers of engineering and life sciences. (ibecbarcelona.eu)
  • A major challenge for researchers has been how to model body functions and systemic diseases with multiple engineered tissues that can physiologically communicate-just like they do in the body. (columbia.edu)
  • Harness the power of the immune system to treat diseases such as cancer and promote tissue regeneration for improved healing and repair. (jhu.edu)
  • In the future, will humans be able to bioprint living tissue to repair and replace ailing or diseased tissue? (advfn.com)
  • Orth, P., *Eldracher, M., Cucchiarini, M., Madry, H. Small diameter subchondral drilling improves DNA and proteoglycan contents of the cartilaginous repair tissue in a large animal model of a full-thickness chondral defect Journal of Clinical Medicine , 2020, 18;9(6):E1903. (uniklinikum-saarland.de)
  • Walles talks to youris.com about the content of the project's toolbox and the challenges of translating research into applicable approaches. (youris.com)
  • Research Engineer in the Laboratory of Food Chemistry and Technology of the School of Chemical Engineering, National Technical University of Athens, Greece. (imperial.ac.uk)
  • While studying chronic wounds, Gefen says he noticed a comparative lack of research in the field, "which is really almost neglected in terms of the research resources that we biomedical engineers see in fields like orthopaedics, cardiovascular, cancer. (mobilitymgmt.com)
  • Motivated by those statistics - that spinal cord injuries generally happen to younger people, and that too many are succumbing to pressure ulcers - Gefen borrowed engineering tools for his research. (mobilitymgmt.com)
  • His research is focused on microfluidic/continuous-flow and plasma-chemistry based engineering, and space-resource research. (wiley-vch.de)
  • A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
  • President Barabino Co-Authors New Research on Dissociation of Tissues. (olin.edu)
  • Olin College of Engineering President Gilda A. Barabino has co-authored new research published in the leading multidisciplinary science journal, Nature Scientific Reports . (olin.edu)
  • P30 CA013696 to the Confocal and Specialized Microscopy Shared Resource), NSF (Engineering Research Center EEC-1647837 to C.S.C. and G.V.-N., Graduate Research Fellowship DGE1644869 to D.N.T.), and F.C.T. (PD/BD/105819/2014 to D.T. (columbia.edu)
  • While no reported cases of silicosis in the U.S. have been linked to quartz surfacing materials, recent research indicates that exposures to silica-containing dust while working with these materials may approach or exceed the Occupational Safety and Health Administration (OSHA) current Permissible Exposure Limit (PEL) (Phillips et al. (cdc.gov)
  • They can even be equipped with special biomolecules that promote tissue formation. (eurekalert.org)
  • The presented approach might be used for the evaluation of drugs and nutrients that promote tissue integration. (bvsalud.org)
  • It's designed to develop you as a professional engineer and get you thinking about sustainable solutions. (sheffield.ac.uk)
  • Develop and translate advanced technologies to enhance and restore function at the molecular, cellular, and tissue levels. (jhu.edu)
  • The tissues show layer-specific biomarker expression and develop a structurally integrated network of processes. (bvsalud.org)
  • Our tissue-engineered CS can be combined with future applications of TEOMG, and this approach towards tissue engineering of multilayered tubular structures may be applicable to the urological field, as well as in other fields of soft tissue engineering. (emjreviews.com)
  • Myocardial tissue engineering strategies follow the idea of in vitro generation of myocardium-like structures for epicardial transplantation. (nih.gov)
  • However, current tissue engineering approaches cannot produce such structures. (bvsalud.org)
  • This approach involves the intramolecular cross-linking of 5′ amine- and 3′ disulfide-modified MO oligonucleotides using appropriately functionalized tethers, generating macrocyclic structures that conformationally resist RNA hybridization. (cdc.gov)
  • National Technical University of Athens, School of Chemical Engineering. (imperial.ac.uk)
  • Master Thesis: (September 2005-June 2006) Laboratory of Food Chemistry and Technology, Division IV, School of Chemical engineering, Thesis title: Kinetic study and validation of new enzymatic, photochemical and physicochemical Time Temperature Integrators (TTI) for the Chill Chain Management of foods. (imperial.ac.uk)
  • Volker Hessel is Professor at the University of Adelaide (Australia) in the School of Chemical Engineering and Advanced Materials. (wiley-vch.de)
  • Tissues with complex three-dimensional morphology, significant depth, or rapid movement are challenging to selectively target by optical techniques. (cdc.gov)