Tissue distribution and renal. Medical search. Frequent questions

The in vivo excretion via renal and fecal routes accounted for 5% and 9% of the doses. (cdc.gov)
Renal excretion of unchanged drug depends upon urine pH. (theodora.com)
The renal excretion, renal cleareance, and fractional renal clearance (CF) of fluoride were all consistently higher in the alkalotic animals. (fluoridealert.org)
This study aimed to evaluate the transporter-mediated renal excretion mechanism for cilostazol and to characterize the mechanism of drug-drug interaction (DDI) between cilostazol and aspirin or probenecid. (aspetjournals.org)
Coadministration with probenecid, benzylpenicillin, or aspirin decreased the cumulative urinary excretion of cilostazol and renal clearance. (aspetjournals.org)
Renal dysfunction slows excretion of vancomycin. (nih.gov)
Distribution and renal excretion appear to be enhanced by citrate. (qxmd.com)
Renal excretion appears the major path of reduction for veliparib with typical 70% (range 31 of dental dose being retrieved in the urine as the unchanged medication in sufferers with cancer finding a one dosage of 50 mg (4). (bio-biz-navi.com)
Several aspects of fluoride metabolism - including gastric absorption, distribution and renal excretion - are pH-dependent because the coefficient of permeability of lipid bilayer membranes to hydrogen fluoride (HF) is 1 million times higher than that of F(-). This means that fluoride readily crosses cell membranes as HF, in response to a pH gradient between adjacent body fluid compartments. (fluoridealert.org)
The levels start declining thereafter due to two main reasons: uptake in calcified tissues and excretion in urine. (fluoridealert.org)
Plasma fluoride levels are not homeostatically regulated and vary according to the levels of intake, deposition in hard tissues and excretion of fluoride. (fluoridealert.org)

Renal impairment does not significantly affect the protein binding of gemifloxacin. (nih.gov)
Dose adjustments are not required in patients with mild to moderate renal impairment. (medicines.org.uk)
For patients with severe renal impairment, 10 mg is the maximum recommended dose. (medicines.org.uk)
Once-a-day dosing of 2.5 or 5 mg tadalafil both for the treatment of erectile dysfunction or benign prostatic hyperplasia is not recommended in patients with severe renal impairment (see sections 4.4 and 5.2). (medicines.org.uk)
Average renal Baicalin impairment CYP2D6 poor metabolizer and co-administration of OCT2 inhibitor (cimetidine) elevated veliparib steady-state publicity by 80% 20 and 30% respectively. (bio-biz-navi.com)
Although an individual factor (i actually.e. renal impairment CYP2D6 insufficiency and decreased OCT2 activity) displays a moderate influence they collectively you could end up a substantial and potentially medically relevant upsurge in veliparib publicity. (bio-biz-navi.com)
Recognise the need for dose reductions of antimicrobials in patients with renal impairment. (pharmaceutical-journal.com)
AKI describes a spectrum of kidney injury ranging from mild impairment to renal failure, comprising both direct injury to the kidney and a reduction in functionality. (pharmaceutical-journal.com)

Recently the phosphate and vitamin D regulating hormone fibroblast growth factor 23 (FGF-23) has also been implicated in cardiovascular risk of patients with normal and impaired renal function [ 4 , 5 ]. (plos.org)
Both FGF-23-deficient and α-Klotho deficient animal models exhibit similar phenotypes as patients with impaired renal function, e.g., accelerated aging with the development of extensive arteriosclerosis and vascular calcification [ 4 , 11 ]. (plos.org)

It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. (abeomics.com)

The hepatic and renal handlings of EGF by isolated perfused organs were also analyzed to obtain the kinetic parameters with respect to RME. (go.jp)
The results reveal a significant alteration in the histoarchitecture of both hepatic and renal tissues induced by melamine. (chemrxiv.org)

Pharmacokinetic analysis of the tissue distribution of EGF in rats performed in vivo clarified that the uptake of EGF by the liver and kidney exhibited clear saturation with K m values of 7 nM and 0.4 nM, respectively, and that both tissues could account for more than 80% of the total plasma clearance of EGF in the distribution phase. (go.jp)
The highest normal tissue uptake is seen in renal cortex, liver, pancreas and salivary glands. (drugbank.com)

Aside from the glomerular purification energetic tubular secretion has an important function Mouse monoclonal to CD247 in the renal clearance of veliparib (8). (bio-biz-navi.com)
Liver mercury levels were significantly lower in individuals with portal bile duct proliferation/fibrosis (p = 0.007) and a similar trend was found for proximal convoluted tubular hyalinisation in renal tissue (p = 0.07). (biomedcentral.com)

Background: The interactions of adipose tissue with the kidney are hypothesized to affect kidney function. (tokushima-u.ac.jp)
Objectives: To elucidate levels of adiponectin expression in peri-renal and subcutaneous adipose tissue and its determinants in human biopsied samples. (tokushima-u.ac.jp)
Subcutaneous adipose tissue (SAT) area, visceral adipose tissue (VAT) area and peri-renal adipose tissue (RAT) volume were quantified on abdominal computed tomography. (tokushima-u.ac.jp)

The upregulation of epithelial cell adhesion molecule (EpCAM) expression, found in a substantial fraction of renal cell carcinomas (RCCs), renders it a potential molecular target for the treatment of disseminated RCC. (spandidos-publications.com)
The major subtypes of renal epithelial neoplasms display differential aberrant CDH1 , PTGS2 , and RASSF1A promoter methylation levels. (biomedcentral.com)
Renal cell tumors account for about 85 percent of all adult renal neoplasms, comprising a heterogeneous class of epithelial tumors that range in biological potential from entirely benign to highly malignant [ 4 ]. (biomedcentral.com)
MSC migration was initiated in response to AA-I-treated renal epithelial cells in an in vitro migration assay. (biomedcentral.com)

The objective of this study was to determine the renal clearance of flunixin and meloxicam in pigs and compare plasma and urine concentrations and tissue residues. (biomedcentral.com)
These data suggest that pigs given a single intramuscular dose of meloxicam at 0.4 mg/kg or flunixin at 2.2 mg/kg are likely to have detectable levels of the parent drug in urine up to 2 days and 5 days, respectively, after the first dose, but unlikely to have tissue residues above the US FDA tolerance or EU MRL following negative urine testing. (biomedcentral.com)
Of the two studies that examined flunixin in urine of pigs, only one of those attempted to establish a correlation with tissue concentrations. (biomedcentral.com)
However, that study used a single spot urine sample taken at necropsy to predict the residue depletion profile in edible tissues. (biomedcentral.com)
AKI is a broad clinical syndrome encompassing a range of etiologies including hypo-perfusion (pre-renal), urine outflow obstruction (post-renal) and intrinsic kidney damage owing to kidney disease or exposure to nephrotoxins. (pharmaceutical-journal.com)

Renal cell carcinoma (RCC) is the leading type of malignant tumor originating from the kidneys, and makes up about 90% of all malignant renal tumors ( 1 ). (spandidos-publications.com)
The identification of renal cell carcinoma subtypes is essential in clinics, because RCC constitutes a heterogeneous group of tumors with prognostic uncertainty ( 2 ). (spandidos-publications.com)
In this study we aimed at defining a quantitative gene promoter methylation panel that might identify the most prevalent types of renal cell tumors. (biomedcentral.com)
A panel of 18 gene promoters was assessed by quantitative methylation-specific PCR (QMSP) in 85 primarily resected renal tumors representing the four major histologic subtypes (52 clear cell (ccRCC), 13 papillary (pRCC), 10 chromophobe (chRCC), and 10 oncocytomas) and 62 paired normal tissue samples. (biomedcentral.com)
Significant differences in methylation levels among the four subtypes of renal tumors were found for CDH1 ( p = 0.0007), PTGS2 ( p = 0.002), and RASSF1A ( p = 0.0001). (biomedcentral.com)
This gene panel might contribute to a more accurate discrimination among common renal tumors, improving preoperative assessment and therapeutic decision-making in patients harboring suspicious renal masses. (biomedcentral.com)
The vast majority of renal cell tumors are sporadic as only 2% of cases are associated with inherited syndromes [ 3 ]. (biomedcentral.com)
Most renal cell tumors are clinically silent in their earlier stages and 20-30% are diagnosed when metastatic spread has already occurred [ 6 ]. (biomedcentral.com)
Thus, there is a need for the development of new strategies both for early detection and differential diagnosis of renal cell tumors. (biomedcentral.com)

Renal secretion of organic cations or anions is normally a process which involves an entrance step on the basolateral membrane and an leave step on the apical membrane of renal tubule cells. (bio-biz-navi.com)

No dosing adjustment is required in patients who have renal insufficiency. (msdmanuals.com)

The effects of benzo[a]pyrene-induced skin cytochrome P450 elevation on 3,3',4,4'-tetrachlorobiphenyl percutaneous absorption and tissue disposition. (cdc.gov)

Skin Cyt P450 induction also changed label penetration depth and distribution pattern in local cutaneous tissues, suggesting that the enhanced cutaneous TCB metabolism may change the toxicity profile ( cutaneous vs. systemic). (cdc.gov)

The pharmacokinetic-pharmacodynamic romantic relationship for veliparib continues to be demonstrated within a preclinical syngeneic melanoma model treated with a combined mix of veliparib and temozolomide where the PARP inhibition in tumor tissue and antitumor activity are correlated with veliparib plasma/tumor concentrations (12). (bio-biz-navi.com)

We examined virus distribution and associated inflammation within nasal and periocular tissues during the acute phase of H1N1 IAV infection in ferrets following intranasal or ocular inoculation. (cdc.gov)

Consequently, dermatologic manifestations of renal disease may be divided into 3 general categories including: (1) dermatologic manifestations of diseases associated with the development of ESRD, (2) dermatologic manifestations of uremia, and (3) dermatologic disorders associated with renal transplantation. (medscape.com)

At higher doses aspirin is an effective anti-inflammatory agent, partially due to inhibition of inflammatory mediators via cyclooxygenase inhibition in peripheral tissues. (theodora.com)
Nociceptors are axonal termini in the peripheral tissues that discharge in response to painful stimuli. (ivis.org)

The housekeeping functions of these prostaglandins include maintaining renal and gastrointestinal blood flow (cytoprotection), regulation of vascular homeostasis, renal function, intestinal mucosal proliferation, and platelet function. (theunitutor.com)

It is unknown whether these levels are toxic to liver and kidney tissue. (biomedcentral.com)
The inorganic form of mercury is toxic to liver and kidney tissues due to the co-enzyme inhibition via high affinity to various microsome and mitochondria SH-group enzymes [ 8 ]. (biomedcentral.com)

See also Chronic Kidney Disease and Chronic Renal Failure . (medscape.com)
Creatinine-based calculations assume steady-state conditions and should only be used for interpreting renal function in chronic renal diseases. (pharmaceutical-journal.com)

Becasue of the importance of fibrosis in clinical disease it is vital that we understand the mechanisms of renal fibrosis so that novel therapeutic targets can be identified and drugs developed. (ncl.ac.uk)
Work is also underway to identify new non-invasive biomarkers that identifypatients with progressive renal fibrosis. (ncl.ac.uk)
Mitigation of renal interstitial fibrosis was further confirmed by immunohistochemistry, qPCR, and western blotting after MSC treatment. (biomedcentral.com)
These findings suggested that administration of MSCs into the cavity formed by the injured kidney and the greater omentum under ultrasound guidance improved renal function, attenuated kidney injury, and mitigated renal interstitial fibrosis and inflammatory responses. (biomedcentral.com)

This study sought to determine whether the mammalian polycystins are expressed in primary cilia of renal epithelia and whether these proteins co-localize with polaris and cystin, the newly described, cilia-associated protein that is disrupted in the cpk mouse. (nih.gov)

Glucuronidation of various substrates in hepatic, intestinal and renal microsomes of control, phenobarbital (PB), 3-methylcholanthrene (3MC) and Aroclor-1254 (A1254) pretreated rats was investigated. (nih.gov)
UDPGT activity towards bilirubin, although induced by PB, can be detected in hepatic, intestinal and renal microsomes. (nih.gov)
Induction of both 54 and 56 kDa polypeptides in hepatitis, intestinal and renal microsomes by 3MC or A1254 was observed. (nih.gov)
The results indicate that 54 and 56 kDa UDPGT polypeptides are the major A1254 inducible isoenzymes in intestinal and renal microsomes. (nih.gov)

In addition, uremia and conditions associated with renal replacement therapy are fraught with numerous and, often, relatively unique cutaneous disorders. (medscape.com)
The purpose of this article is to integrate renal and cutaneous aspects of disease as well as highlight some important, although frequently underappreciated, clinical or laboratory findings that ally renal and skin diseases. (medscape.com)
Many cutaneous disorders experienced by patients undergoing dialysis have little to do with the uremic syndrome and are related to the same underlying pathologic process that caused the renal disease. (medscape.com)
These systemic disorders and the associated renal diseases and cutaneous manifestations are tabulated in Table 1, below. (medscape.com)

Conclusions Renal function (creatinine clearance) is normally a substantial predictor for veliparib publicity in sufferers with cancers. (bio-biz-navi.com)
Serum creatinine and blood urea levels were measured to assess renal function. (biomedcentral.com)
Renal function tests indicated that MSCs improved renal function to a great extent, as reflected by decreased blood urea nitrogen and serum creatinine levels. (biomedcentral.com)

Tissue-to-plasma fluoride concentration ratios for heart and skeletal muscle were lower in the alkalotic group, which suggested a smaller volume of distribution for fluoride in alkalosis. (fluoridealert.org)
The mechanism(s) by which alkalosis protects against fluoride toxicity involves an enhanced renal fluoride clearance rate. (fluoridealert.org)

No studies were located in humans or animals regarding the effects on the respiratory, hematological, musculoskeletal, hepatic, renal, and dermal/ocular systems after inhalation exposure to thallium. (cdc.gov)

Phenylephrine: A vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. (medscape.com)
Considering the anatomic proximity and connection between the nasopharynx and periocular tissues, there is a need to understand the dynamics of virus spread between these sites following both respiratory and nonrespiratory viral transmission. (cdc.gov)
This work underscores the importance of investigating extrapulmonary tissues following mammalian infection with respiratory pathogens, even after intranasal inoculation. (cdc.gov)
We characterized the pathological findings in 72 mink from US farms with SARS-CoV-2 outbreaks, localized SARS-CoV-2 and its host cellular receptor angiotensin-converting enzyme 2 (ACE2) in mink respiratory tissues, and evaluated the utility of various test methods and specimens for SARS-CoV-2 detection in necropsy tissues. (cdc.gov)

Distribution: Salicylic acid is widely distibuted to all tissues and fluids in the body including the central nervous system (CNS), breast milk, and fetal tissues. (theodora.com)

Lanoxin Tablets (digoxin) is a cardiac glycoside that has specific effects on the myocardial ( heart muscle ) tissue and is used to treat heart failure by increasing left ventricular ejection fractions and arrhythmias such as atrial fibrillation by controlling the ventricular response rate. (rxlist.com)

A man in his 70s with a complex medical history, including cadaveric renal transplant, presented with recurrent urinary tract infections. (cdc.gov)

In light of multiple pathways mixed up in disposition of veliparib complicated disease- gene- and medication- medication interactions could take place when several scientific factors can be found concomitantly such as for example renal or liver organ dysfunction and adjustments in fat burning capacity or transport actions caused by hereditary polymorphisms or connections with coadministered medications. (bio-biz-navi.com)

Furthermore, the accumulation of NETs was exhibited in fixed lung tissues, as well as Ansatrienin A in tracheal aspirates of COVID-19 patients on mechanical ventilation [20]. (exposed-skin-care.net)
Further studies are warranted to evaluate roles of peri-renal fat mass accumulation and its pathophysiological machineries. (tokushima-u.ac.jp)

Distribution of hypertension and renal disease in Oregon. (cdc.gov)

The growth rate of prostate tissue accelerates in middle-aged men leading to the diseases of benign prostatic hyperplasia and possibly prostate cancer that are so common in older men. (nih.gov)

In this contribution, the protective effects of the synthesized starch-stabilized selenium nanoparticles (Se-NPs@starch) on melamine-induced hepato-renal toxicity have been systematically investigated. (chemrxiv.org)

Because dialysis and transplant centers are required to report specific information regarding each patient diagnosed with end-stage renal disease (ESRD) to the United States Renal Data System (USRDS), data regarding the causes of ESRD are readily available in the Annual Data Report published by the USRDS. (medscape.com)

Gemifloxacin penetrates well into lung tissue and fluids. (nih.gov)
Added value of this study Here, we showed that activated FXII (FXIIa) is usually increased in lung tissue and plasma from COVID-19 patients, indicating elevated intrinsic coagulation. (exposed-skin-care.net)
Interestingly, FXIIa colocalized with NETs in COVID-19 lung tissues, suggesting NETs to provide a platform for FXII contact activation. (exposed-skin-care.net)

The mean elimination half-life of vancomycin from plasma is 4 to 6 hours in subjects with normal renal function. (nih.gov)

RESEARCH OBJECTIVES Background Many tissues, organs and organ systems show decrements in function with age. (nih.gov)
Most organs and tissues of the body exhibit some age-related decline in function or increase in disease incidence. (nih.gov)
These programs encompass most tissues and organs of the body, outside of the nervous system. (nih.gov)
Human tissue and ECs from various organs were used for immunohistochemistry and Western blot. (plos.org)

Projects are encouraged that significantly advance basic biology research to understand how and why changes take place in tissues with age and how those changes relate to altered tissue and organ function. (nih.gov)
The Biology of Aging Program, Neuroscience and Neuropsychology of Aging Program, and Geriatrics and Clinical Gerontology Program at the NIA encourage applications that will elucidate the basic biological causes and consequences of changes in tissue and organ function related to aging and identify commonalities, distinguishing features, and interactions between them. (nih.gov)
In selecting a LANOXIN dosing regimen, it is important to consider factors that affect digoxin blood levels (e.g., body weight, age, renal function, concomitant drugs) since toxic levels of digoxin are only slightly higher than therapeutic levels. (rxlist.com)
Analysis of gene expression plays a critical role in understanding the biological function of any cell, tissue, or organism. (nanostring.com)
Normal vascular function is critically dependent on physiological endothelial cell (EC) responses to altered tissue nutrient demand and an appropriate stress response. (plos.org)

10. Renal clearance, tissue distribution, and CA-125 responses in a phase I trial of suramin. (nih.gov)
A remarkable feature of the disposition of polypeptide hormones and their analogues is the contribution of specific binding sites (receptors) to the polypeptides distribution and clearance in the body. (go.jp)
Mean plasma clearance is about 0.058 L/kg/h, and mean renal clearance is about 0.048 L/kg/h. (nih.gov)
The renal clearance of flunixin and meloxicam was 4.72 ± 2.98 mL/h/kg and 0.16 ± 0.04 mL/h/kg, respectively. (biomedcentral.com)

Cilostazol was distributed in the kidney and liver, with tissue to plasma partition coefficient ( K p ) values of 8.4 ml/g and 16.3 ml/g, respectively. (aspetjournals.org)

Dermatologic manifestations of renal disease are not uncommon findings in patients with end-stage renal disease (ESRD). (medscape.com)
Review of the 2019 report reveals that diabetes mellitus remains the most common cause of ESRD, responsible for approximately 42% of all patients on renal replacement therapy. (medscape.com)
However, because of its extensive distribution into tissue, blood levels are low, so tigecycline is probably not a good choice for patients with bacteremia especially those with intravascular sources of infection. (msdmanuals.com)

The effects of synthetic glucocorticoids, such as methylprednisolone, is dependent on its association with intracellular glucocorticoid receptors (GRs), and to a lesser extent, mineralocorticoid receptors (MRs). GRs are widely distributed in contrast to MRs that show a restricted tissue distribution. (wikipedia.org)
The mean time required for the recovery of receptors after being down-regulated in the liver is approximately 30 min, and was much shorter than those in other tissues. (go.jp)

No tolerance has been established for meloxicam in pigs, and therefore detection of any tissue residue would be considered a violation by USDA Food Safety and Inspection Service (FSIS). (biomedcentral.com)

Tumour lysis syndrome in a patient with renal-cell carcinoma treated with sunitinib malate. (nih.gov)
Sunitinib as adjuvant therapy for renal cell carcinoma. (nih.gov)
Role of VEGFR-TKIs in the treatment of renal cell carcinoma]. (nih.gov)
Due to the low efficiency of existing treatments, it is necessary to develop new approaches for both the therapy and diagnosis of renal cell carcinoma. (spandidos-publications.com)
Histopathology and localization of SARS-CoV-2 and its host cell entry receptor ACE2 in tissues from naturally infected US-farmed mink (Neovison vison). (cdc.gov)
Single-cell sequencing is a method in which cells are dissociated from a tissue and isolated to obtain sequence information of their individual DNA or RNA. (nanostring.com)
Previously, sequence information for a tissue required tissue homogenization, effectively pooling the DNA or RNA from all cell types in the tissue. (nanostring.com)
However, individual cell types in a tissue express different RNAs, and, depending on the tissue, may also have DNA differences. (nanostring.com)
Gaining insight into cellular functions and cell-cell interactions in a tissue requires information about the responsible cell types. (nanostring.com)
However, the initial tissue dissociation step required for single-cell sequencing disrupts any three-dimensional spatial context, thus lacking any information about cell-cell interactions. (nanostring.com)
We have recently shown that transmembrane cell surface α-Klotho is expressed in numerous human tissues beyond the kidney and parathyroid gland, including the smooth muscle cell layer of the artery wall [ 9 , 10 ]. (plos.org)
Moreover, flow cytometry was applied to analyze the distribution of cell cycle. (bvsalud.org)

A randomly chosen single renal lobe and a tissue sample from the periphery of a right liver lobe was taken for histological examination and fixed in a phosphate buffered formaldehyde/alcohol solution (3.5% formaldehyde, 86% ETOH and 10.5% H 2 O) to avoid freeze damage. (biomedcentral.com)

On the basis divided into aliquots for direct use in pathotyping studies, of these mostly retrospective studies, the pathogenesis of and their titers were determined by standard plaque (sub- infl uenza-associated ARDS is widely viewed as being the type H1N1) or median tissue culture infective dose assays same whatever the infecting strain. (cdc.gov)

RASSF1A methylation levels were significantly higher in pRCC than in normal tissue ( p = 0.035). (biomedcentral.com)

Suppurative rhinitis, lymphocytic perivascular inflammation in the lungs, and lymphocytic infiltrates in other tissues were common in both SARS-CoV-2-positive and SARS-CoV-2-negative animals. (cdc.gov)

I lead the renal clinical research group at the Freeman. (ncl.ac.uk)

Anatomy48

Organisms29

Diseases5

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes52

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture4

Information Science4

Health Care1

Excretion11

Impairment8

Impaired renal function2

Clear cell renal cell carc1

Hepatic and renal2

Uptake2

Tubular2

Adipose tissue3

Epithelial4

Urine5

Tumors9

Secretion1

Insufficiency1

Absorption1

Metabolism1

Concentrations1

Acute1

Transplantation1

Peripheral tissues2

Proliferation1

Liver and kidney2

Chronic2

Fibrosis4

Protein1

Intestinal4

Cutaneous4

Creatinine3

Fluoride2

Musculoskeletal1

Respiratory4

Fetal1

Cardiac1

Urinary1

Adjustments1

Accumulation2

Hypertension1

Diseases1

Toxicity1

Dialysis1

Lung3

Vancomycin1

Organs4

Function5

Clearance4

Plasma1

Patients3

Receptors2

Detection1

Cell12

Histological1

Dose1

Normal tissue1

Lungs1

Clinical1