• deposition
  • Deficient deposition of WR- 2721 in tumor tissue has recently been demonstrated and this is thought to be a major reason for the preferential protection of normal tissues by the drug. (unt.edu)
  • rats
  • To test this hypothesis an interspecies comparison of the tissue distribution of $sup 35$S-labeled WR-2721 was carried out in normal mice, rats, rabbits, and dogs at 15 and 30 minutes after intravenous administration. (unt.edu)
  • The objectives of the current study were to investigate the lacteal secretion and maternal/fetal distribution of [ 14 C]dasatinib in rats after p.o. administration. (aspetjournals.org)
  • In light of this, we investigated the influence of lifetime dietary VK exposure on the tissue distribution of phylloquinone (K 1 ) and menaquinone-4 (MK-4) vitamers in 3-, 12- and 22-month-old male and female rats fed different K 1 diets since weaning or subjected to a 40% calorie restricted diet (CR) since adulthood. (mdpi.com)
  • Despite lifelong higher K 1 intakes per unit body weight, tissue K 1 and MK-4 contents at 20 months were generally lower in CR rats compared to their ad libitum ( AL) counterparts. (mdpi.com)
  • The motivation of this study was to explore the pharmacokinetic profiles, tissue distribution, and plasma protein binding of 10-dehydroxyl-12-demethoxy-conophylline in Sprague Dawley rats. (mdpi.com)