Tissue development or differentiation tissues mammalian embryonic. Medical search. Frequent questions

The fertilized oocyte is totipotent, with resultant blastomeres capable of generating all three primary germ layers, ectoderm, mesoderm, and endoderm, in addition to the extra embryonic tissues. (conditionmed.org)

The development of the rodent lung starts from the specification and proliferation of tracheal and lung cell progenitors from the foregut endoderm at embryonic day 9.5. (biomedcentral.com)
The study of the new dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. (biomedcentral.com)
We have used conditional gene deletion of mouse β-catenin in Sox17-positive embryonic and extra-embryonic endoderm as well as vascular endothelial progenitors to address the function of canonical Wnt signalling in cell lineage formation and patterning. (biologists.com)

For 3D culture methods using embryonic stem cells (ESCs) or adult stem cells, ECMs including Matrigel and laminin were widely used for in vitro organogenesis,including the development of the brain 1 , stomach 2 , kidney 3 , and intestinal tissues 4 . (researchsquare.com)
Bonus has been implicated in embryonic development and organogenesis and shown to regulate several signaling pathways, however, its targets and mechanism of action remained poorly understood. (elifesciences.org)

The generated heart organoids possess structural and functional capacity similar to atrial and ventricular parts of in vivo embryonic heart. (researchsquare.com)
While these populations have been extensively studied in non-human model systems, their identification and study in vivo human tissues have been limited due to the ethical and technical limitations of accessing gastrulation stage human embryos. (stanford.edu)
To further clarify the in vivo roles of Dab2 in development and physiology, we designed a new floxed allele to delete dab2 gene. (biomedcentral.com)
DTHHS) has developed and coordinated a mixtures program that includes trend analysis to identify the mixtures most often found in environmental media, in vivo and in vitro toxicological testing of mixtures, quantitative modeling of joint action, and methodological development for assessment of joint toxicity. (cdc.gov)
In vitro differentiation of small intestinal epithelium that nausea, vomiting, and watery diarrhea within 12-24 hours approaches physiologic functionality of the in vivo host of exposure and typically remain symptomatic for 1-2 may allow for the development of a pathogenesis model days ( 5 ). (cdc.gov)
Cell Culture Infectivity Assay for Norovirus cally resemble in vivo tissues and organs ( 25 ). (cdc.gov)

Given the successful development of non-mammalian embryos in microgravity, these findings were surprising, and Wakayama and colleagues intend to pursue further gravity-manipulation studies to zoom in on the source of the developmental problem. (medgadget.com)
My laboratory has developed new technologies and applied them towards understanding the molecular biology and enzymology of DNA replication in animal cells and viruses (SV40, polyomavirus, papillomavirus, and herpes simplex virus), and at the beginning of animal development (mouse preimplantation embryos and frog eggs). (nih.gov)
The embryos of larger arthropods and deuterostomes with well-provisioned eggs or viviparity, on the other hand, exhibit regulative development, while their larval "set-aside" or adult stem cells function in the growth, maintenance, and regulation of organ size coupled to constrained proliferation and cell turnover. (iospress.com)
Recording and contextualizing the science of embryos, development, and reproduction. (asu.edu)
In mouse development, transcription is first detected in late 1-cell embryos, but translation of newly synthesized transcripts does not begin until the 2-cell stage. (embl-heidelberg.de)
According to our findings, apoptosis seems to be the most frequently observed type of PCD, but it is not the exclusive type of morphological cell death during the development of axial structures in human embryos. (karger.com)

The cellular products of embryonic stem cells routinely come under global influences and give rise to the cells of germ layers and organ rudiments. (iospress.com)
Human induced pluripotent stem cells (hiPSCs) present an exciting alternative for modeling early human embryogenesis due to their well-established ability to differentiate into all embryonic germ layers. (stanford.edu)
The blastocyst comprises the inner cell mass (ICM), which gives rise to the three primary germ layers and consequently the fetus, and the trophectoderm (TE), which gives rise to the extraembryonic and placental tissue. (conditionmed.org)

In preeclampsia placental tissue, PEG10 has been shown to be downregulated and upregulated implicating it as a possible causal role in the occurrence of preeclampsia. (wikipedia.org)

Ty3/Gypsy retrotransposon fossils in mammalian genomes: did they evolve into new cellular functions? (wikipedia.org)
not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)
Our knowledge about the genome-wide distribution of DNA methylation, how it changes during cellular differentiation and how it relates to histone methylation and other chromatin modifications in mammals remains limited. (gsea-msigdb.org)
Second, methylation of CpGs are dynamic epigenetic marks that undergo extensive changes during cellular differentiation, particularly in regulatory regions outside of core promoters. (gsea-msigdb.org)
This noroviruses has been limited by our inability to propagate level of cellular differentiation was achieved by growing the these viruses in vitro ( 12 ). (cdc.gov)

Microgravity led to an overall reduction in the rate of blastocyst formation after 96 hours of culture, and closer examination of these blastocysts revealed that the differentiation of embryonic cells into trophectoderm-the tissue that nourishes the embryo and ultimately contributes to placenta formation-was markedly impaired. (medgadget.com)
Our current research now focuses on two basic, interrelated questions: (1) How do mammalian cells decide where and when to initiate DNA replication? (nih.gov)
Failure of mammalian cells to regulate their proliferation cycle leads to cancer. (nih.gov)
and virtually all mammalian cells possess a specific TGF receptor. (caslab.com)
Generation of functional heart organoids from mouse embryonic stem cells. (researchsquare.com)
Mammalian heart development involves differentiation of diverse cell types, including atrial and ventricular muscle cells known as cardiomyocytes (CMs), specific myocytes constituting conducting tissue such as Purkinje fibers, smooth muscle (SM) cells, and non-muscle cells including endothelial cells (ECs) and neuronal cells. (researchsquare.com)
Profoundly different patterns of potency and division are exhibited by mammalian embryonic and adult stem cells. (iospress.com)
Mystification may have been introduced historically with the concepts of determinate and regulative development, but, hopefully, the muddle can be resolved by tracing the evolution of stem cells in Metazoa. (iospress.com)
Mammalian embryonic stem cells would seem adapted to rapid proliferation, functioning in part to enclose yolk or to acquire access to maternal resources. (iospress.com)
Mammalian adult stem cells resemble the blastomeres of planktonic and benthic organisms with small eggs and may have evolved in mature organisms as an adaptation to the growth and maintenance of tissues via proliferation and the regulation of organ size via cell loss (e.g., terminal differentiation). (iospress.com)
Strategies for regenerative therapies in adult mammals, therefore, might be based on stimulating growth of adult stem cells or their surrogates in specific tissues rather than on introducing embryonic stem cells into adults. (iospress.com)
Somites are blocks of cells that contain distinct sections that diverge into specific types (axial or limb) of musculature and are an essential part of early vertebrate development. (asu.edu)
Gurdon's first experiment in 1958 showed that the nuclei of Xenopus cells maintained their ability to direct normal development when transplanted. (asu.edu)
To fulfill the promise of pluripotent stem cells, both embryonic and induced pluripotent stem cells, it is essential to fully understand their properties and how those properties can be manipulated to make any cell in the human body. (ca.gov)
Therefore, we use a combination of the mouse model and human cells to dissect the molecular basis of stem cell function and differentiation toward adult tissues. (ca.gov)
We have found these small RNAs are essential for normal mammalian development and growth and differentiation of stem cells. (ca.gov)
We have also been studying how microRNAs are used shortly after fertilization first to maintain pluripotency (the ability to make all cells of the body) and then to promote differentiation into what eventually will become all the adult tissues. (ca.gov)
This research is expected to enable to us to more easily manipulate cell fates to produce high quality cells that could be used to study diseases of many types as well as reintroduce healthy tissue into patients with degenerative diseases. (ca.gov)
We propose that quantitative experimental embryology offers essential ways to explore the reaction of cells and tissues to targeted cell addition, removal, and confinement. (mdpi.com)
To establish protocols for the safe and efficient differentiation of healthy cells for therapies, we must develop a better understanding of the dynamic continuum of metabolic states that span pluripotency and differentiation, and how to influence them. (conditionmed.org)
The developing embryo, from which pluripotent stem cells originate, undergoes a series of dynamic metabolic transitions synchronized to its molecular development. (conditionmed.org)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
L-type Ca 2+ channels (LTCCs) drive the bulk of voltage-gated Ca 2+ entry in vertebrate inner ear hair cells (HCs) and are essential for mammalian auditory processing. (jneurosci.org)
Mesenchymal cells derived from the dermomyotome condense within connective tissue (mesenchymal) scaffolds to form 2 common muscle masses. (medscape.com)
Postnatal alveolar development is characterized by the expansion of epithelial cells lining primitive saccules and the formation of secondary septa by alveolar myofibroblasts (MYFs). (biomedcentral.com)
Conditional deletion indicates that Dab2 is dispensable for organ development, when the vast majority of the embryonic cells are dab2 null. (biomedcentral.com)
Cells Tissues Organs (2001) 169 (4): 347-354. (karger.com)
In most cases, dying cells during development exhibit generalized morphological features typical of apoptosis. (karger.com)
Here we report the generation and analysis of genome-scale DNA methylation profiles at nucleotide resolution in mammalian cells. (gsea-msigdb.org)
Using high-throughput reduced representation bisulphite sequencing and single-molecule-based sequencing, we generated DNA methylation maps covering most CpG islands, and a representative sampling of conserved non-coding elements, transposons and other genomic features, for mouse embryonic stem cells, embryonic-stem-cell-derived and primary neural cells, and eight other primary tissues. (gsea-msigdb.org)
Third, analysis of embryonic-stem-cell-derived and primary cells reveals that 'weak' CpG islands associated with a specific set of developmentally regulated genes undergo aberrant hypermethylation during extended proliferation in vitro, in a pattern reminiscent of that reported in some primary tumours. (gsea-msigdb.org)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)

This protocol introduces how to generate heart organoids from mouse embryonic stem cell-derived embryoid bodies (EB) in the presence of the laminin-entactin (LN/ET) complex and fibroblast growth factor 4 (FGF4) by three consecutive steps, 1) the culture of ESCs, 2) in vitro differentiation of ESCs into EBs and 3) in vitro culture of EBs for the generation of heart organoids. (researchsquare.com)
It is only through understanding embryonic metabolism and development that we can derive and maintain different in vitro stem cell states for disease modeling and therapies. (conditionmed.org)

Also, these heart organoids exhibited the ultrastructural, histochemical and gene expression profile similarities to embryonic hearts via consecutive morphological changes like self-organization and, therefore, without the requirement of complex differentiation protocols. (researchsquare.com)
Fluoxetine, at the doses administered during pregnancy in this study, did not alter the morphological development of the coronal dentin-pulp complex in their offspring. (bvsalud.org)

So when I was recently contacted by an earnest and amiable member of a local school board who was concerned about the questionable manner in which the issue of "stem cell" research - both human embryonic and adult - was presented to the high school students in his district in a currently-used science textbook, I agreed to evaluate that section in the text for him. (lifeissues.net)
In my opinion there is no question but that the scientific information on stem cell research included in this science text book being used in Illinois schools incorporates some inaccurate scientific facts, and seems to be very partial to the use of human embryonic "stem cell" research. (lifeissues.net)
Here, we consider the metabolism of the early embryo through development, and look at the nutrient milieu within the developing stem cell niche. (conditionmed.org)

Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
The primary interest of my laboratory is to understand the role of signaling molecules in regulating embryonic development and adult tissue homeostasis. (sejinlee.org)

In the past, our research focused on viral genomes as models for DNA replication in mammalian cell nuclei. (nih.gov)

The HGF‑Met signaling pathway contributes in a paracrine manner to the development of epithelial organs, exerts regenerative effects on the epithelium, and promotes the regression of fibrosis in numerous organs. (spandidos-publications.com)

Here, we describe the development of a TBX5/MYL2 lineage tracing reporter system that allows for the identification of FHF- progenitors and their descendants including left ventricular cardiomyocytes. (stanford.edu)

Because CPEB2-knockout (KO) mice showed emphysematous phenotypes, we investigated how CPEB2-controlled translation affects pulmonary development and function. (biomedcentral.com)
Previously, two independent gene knockout studies have been reported, with some discrepancies in the observed embryonic phenotypes. (biomedcentral.com)

Ovotestes are usually compartmentalized, with connective tissue separating the ovarian components from the testicular components. (medscape.com)

One report describes a 46,XX/46,XY infertile chimeric male who fathered a child with sperm obtained from his testicular tissue through intracytoplasmic sperm injection. (medscape.com)
Spermatogenesis has been reported in only 12% of these cases, and tubular atrophy with hypoplastic testicular tissue is the norm. (medscape.com)
A diagnosis of OT-DSD is based solely on the presence of ovarian and testicular tissue in the gonad and not on the characteristics of the internal and external genitalia, even if ambiguous. (medscape.com)
People with ovotesticular disorder of sexual development are individuals who have both ovarian and testicular tissue. (medscape.com)
Müllerian duct structures typically develop on the gonad side(s) not containing testicular tissue. (medscape.com)
Wolffian duct structures tend to be observed on the gonad side(s) containing functioning testicular tissue. (medscape.com)

Aside from the physical and emotional consequences associated with genital ambiguity, patients with ovotesticular disorder of sexual development usually do not possess other developmental malformations. (medscape.com)
Fertility potential does exist in people with ovotesticular disorder of sexual development who are given a female sexual assignment. (medscape.com)
People with ovotesticular disorder of sexual development who are given a male sex assignment rarely reproduce. (medscape.com)
Many patients with ovotesticular disorder of sexual development are sexually active with a small portion being sexually dissatisfied. (medscape.com)
Ovotesticular disorder of sexual development due to 47,XYY/46,XY/45,X mixed gonadal dysgenesis in a phenotypic male presenting as cyclical haematuria: clinical presentation and assessment of long-term outcomes. (medscape.com)
Such gonads are found exclusively in people with ovotesticular disorder of sexual development (OT-DSD), formerly known as true hermaphroditism. (medscape.com)
Many patients with ovotesticular disorder of sexual development have a uterus. (medscape.com)
Ovotesticular disorder of sexual development is a rare condition. (medscape.com)
Genital ambiguity occurs in 1 in 4,500 births, and ovotesticular disorder of sexual development occurs in fewer than 10% of all disorders of sexual development. (medscape.com)

2020). This places metabolism at the forefront of development and cell state decisions. (conditionmed.org)
The 5-HT neurotransmitter regulates important pathways of mammalian metabolism and is synthesized from the phenylalanine, tyrosine and tryptophan amino acids 5 . (bvsalud.org)
The metabolism of mineralized tissues can be influenced by the central nervous system (CNS) 9 . (bvsalud.org)

Subsequently, coordinated branching morphogenesis and vascular development result in a tree-like structure of epithelial tubules with differentiated airways and saccules. (biomedcentral.com)
Activation of PDGFRα in response to epithelial cell-secreted PDGF-A is crucial for the proliferation, differentiation and migration of MYFs [ 6 ]. (biomedcentral.com)

In doing so, it is an essential methodology to uncover principles of development that remain elusive such as pattern regulation, scaling, and self-organisation. (mdpi.com)
Regulation of gene expression at the beginning of mammalian development and the TEAD family of transcription factors. (embl-heidelberg.de)
A rapid overview of this morphologic scheme provides the framework for further studying the processes and regulation involved in development. (medscape.com)
The actual regulation of the process of outgrowth is discussed in Positioning, Regulation, and Patterning of Limb Development. (medscape.com)
This important study advances our understanding of the functions and regulation of the Drosophila transcriptional regulator Bonus, an ortholog of mammalian TIF1 family members. (elifesciences.org)
Epigenetic regulation of gene expression is an essential mechanism that guides cell differentiation during development. (elifesciences.org)

This gene has been reported to play a role in cell proliferation, differentiation and apoptosis. (wikipedia.org)

Transforming growth factor (TGF) betas are involved in many cell-to-cell interactions that occur during embryonic development. (caslab.com)
These phenomena are cyto- and histo-differentiation steps that occur during odontogenesis and give rise to teeth 11-12 . (bvsalud.org)

Drawing upon a history of using tissue interactions to understand differentiation, Kollar and Baird designed their experiments to understand how differentiated structures become specified. (asu.edu)
We are using reporters, genetic manipulation, and rescue strategies to discover the first examples of endogenous siRNA-gene interactions in mammals, once again focusing on early embryonic development. (ca.gov)

DNA methylation is essential for normal development and has been implicated in many pathologies including cancer. (gsea-msigdb.org)

Degeneration and hyalinization of the seminiferous tubules with poor germ cell development is frequently observed. (medscape.com)

virtually every tissue expresses at least one family member, consistent with a critical role for TEAD proteins in either cell proliferation or differentiation. (embl-heidelberg.de)

Inspired by the combination of this approach with advanced techniques to uncover core principles of neural crest development by the laboratory of Roberto Mayor, we review key quantitative examples of experimental embryology from recent work in a broad range of developmental biology questions. (mdpi.com)
A developmental process is a morphologically observable event such as limb bud formation or the development of digits. (medscape.com)

Serotonergic neurotransmission modulates cell proliferation in several tissues, but is involved mainly in the morphogenesis of the craniofacial region 8 . (bvsalud.org)

Several drugs cross the placental barrier and some have teratogenic effects on the fetus, which may cause dysfunction and disorders during embryonic development, particularly during the first three months of intrauterine life 2 . (bvsalud.org)
Traditionally, complications from the surgical treatment of patients with disorders of sexual development were related to stenosis after vaginal reconstruction procedures and urinary tract problems associated with correction of severe hypospadias. (medscape.com)
Josso N, Audi L, Shaw G. Regional variations in the management of testicular or ovotesticular disorders of sex development. (medscape.com)
Those diagnosed with this rare condition represent a small fraction of patients within the diagnostic category of the disorders of sexual development (DSD), formerly known as intersex. (medscape.com)

In the past year, we have been looking more deeply into the mechanism by which the mammalian egg suppresses one of these classes of small RNAs, the microRNAs, but not the other, the endogenous siRNAs. (ca.gov)

5-HT also has a stimulatory role in tooth germ development by inducing the formation of enamel and dental papilla to form the bell and crown stages. (bvsalud.org)

Together, our work identified Bonus as a regulator of tissue-specific gene expression and revealed the importance of SUMOylation as a regulator of complex formation in the context of transcriptional repression. (elifesciences.org)

Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. (wikipedia.org)
During mammalian development, the left and right ventricles arise from early populations of cardiac progenitors known as the first and second heart fields, respectively. (stanford.edu)
Together these results are giving new and important insights into the role of small RNAs in early embryonic development. (ca.gov)
We found that knockdown of Bonus in early oogenesis results in severe defects in ovarian development and in ectopic expression of genes that are normally repressed in the germline, demonstrating its essential function in the ovary. (elifesciences.org)
2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)

The alveolar structure in CPEB2-deficient lungs appeared normal at birth but became simplified through the alveolar stage of lung development. (biomedcentral.com)
However, the mice were grossly normal when dab2 deletion was restricted to the embryo proper and the gene was retained in extraembryonic tissues using Meox2-Cre and Sox2-Cre. (biomedcentral.com)
Tissue samples were taken from the cervicothoracic region of normal human conceptuses. (karger.com)
Apoptotic death occurred during the 5th week of normal development in all the axial structures. (karger.com)
However, because of functioning normal ovarian tissue, most people experience breast development at puberty, and approximately two-thirds of those with a 46,XX peripheral karyotype menstruate. (medscape.com)

Sexual and gender minority relevant policies in Canadian and U.S. organ and tissue donation and transplantation systems: An opportunity to improve equity and safety. (stanford.edu)
Current policies in organ and tissue donation and transplantation (OTDT) systems in Canada and the United States unnecessarily restrict access to donation for sexual and gender minorities (SGM) and pose safety risks to transplant recipients. (stanford.edu)
Policy domains include the risk assessment of living and deceased organ and tissue donors, physical examination considerations, viral testing recommendations, and informed consent and communication. (stanford.edu)

capable of influencing cell proliferation, differentiation and other functions in a wide range of cell types. (caslab.com)
TGF beta 2 is produced by many cell types and has been found at the highest concentration in porcine platelets and mammalian bone. (caslab.com)
In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. (cdc.gov)

Paul M. Brakefield and his research team in Leiden, the Netherlands, examined the development, plasticity, and evolution of butterfly eyespot patterns, and published their findings in Nature in 1996. (asu.edu)

Additionally, testicular and ovarian tissue may develop on the same side of the pelvis as a separate ovary and testis. (medscape.com)
The presence of estradiol in developing ovarian follicles usually inhibits spermatogonia development in adjacent or contralateral seminiferous tubules. (medscape.com)

In this paper Viktor Hamburger and Rita Levi-Montalcini collaborated to examine the effects of limb transplantation and explantation on neural development. (asu.edu)

This heart organoid model system using the laminin-entactin (LN/ET) complex 5 in the ECM and FGF4 6 generates heart organoids with atrium- and ventricle-like structures containing CM, conducting tissues, SM and ECs that exhibited myocardial contraction and action potentials. (researchsquare.com)

Platelet-derived growth factor receptor α (PDGFRα) signaling is crucial for alveolar myofibroblast (MYF) proliferation and its deficiency is associated with risk of BPD, but posttranscriptional mechanisms regulating PDGFRα synthesis during lung development remain largely unexplored. (biomedcentral.com)
1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)

Development, Plasticity and Evolution of Butterfly Eyespot Patterns' (1996), by Paul M. Brakefield et al. (asu.edu)

Theses heart organoids can be used to study mouse heart development and can also provide an effective tool with applications, such as drug safety testing for hearts. (researchsquare.com)
Since mTEAD-2 is the only one expressed during the first 7 days of mouse development, it is most likely responsible for the TEAD transcription factor activity that first appears at the beginning of ZGE. (embl-heidelberg.de)

Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation. (stanford.edu)
Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)

Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. (biomedcentral.com)
CPEB2-controlled translation, in part through promoting PDGFRα expression, is indispensable for lung development and function. (biomedcentral.com)

Anatomy61

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