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  • immunoglobulin
  • Ronco P, Plaisier E, Mougenot B, Aucouturier P. Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy. (medscape.com)
  • Buxbaum JN, Chuba JV, Hellman GC, Solomon A, Gallo GR. Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis. (medscape.com)
  • Masai R, Wakui H, Togashi M, Maki N, Ohtani H, Komatsuda A. Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease. (medscape.com)
  • Rostagno A, Frizzera G, Ylagan L, Kumar A, Ghiso J, Gallo G. Tumoral non-amyloidotic monoclonal immunoglobulin light chain deposits ('aggregoma'): presenting feature of B-cell dyscrasia in three cases with immunohistochemical and biochemical analyses. (medscape.com)
  • disorders
  • Clinical and molecular characteristics of patients with non-amyloid light chain deposition disorders, and outcome following treatment with high-dose melphalan and autologous stem cell transplantation. (medscape.com)
  • adipose tissue
  • However, except for two negative reports ( 8 , 21 ), related to adipose tissue lipolysis, we are unaware of any studies examining whether there is any link between amylin and lipid metabolism. (physiology.org)
  • Many studies have demonstrated that consumption of a diet high in long-chain fatty acids (LCFAs) induces widespread insulin resistance in muscle, liver, and adipose tissue of both rats and mice ( 4 - 7 ). (diabetesjournals.org)
  • Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture. (harvard.edu)
  • Hammarstedt A, Syed I, Vijayakumar A, Eliasson B, Gogg S, Kahn BB, Smith U. Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids. (harvard.edu)
  • immunoglobulin light
  • AL amyloidosis is the consequence of clonal production of amyloidogenic immunoglobulin light chain (LC) proteins, often resulting in a rapidly progressive and fatal amyloid cardiomyopathy. (embopress.org)
  • Rostagno A, Frizzera G, Ylagan L, Kumar A, Ghiso J, Gallo G. Tumoral non-amyloidotic monoclonal immunoglobulin light chain deposits ('aggregoma'): presenting feature of B-cell dyscrasia in three cases with immunohistochemical and biochemical analyses. (medscape.com)
  • situ
  • By simultaneously achieving ∼20-fold signal amplification and diffraction-limited spatial resolution, smHCR offers a robust and versatile approach for detecting single mRNAs in situ , including in thick tissues where high background undermines the performance of unamplified smFISH. (biologists.org)
  • metabolic
  • Insulin resistance, defined as an impaired ability of insulin to regulate carbohydrate and lipid metabolism in target tissues, is one of the major metabolic defects of obesity and type 2 diabetes. (diabetesjournals.org)
  • cDNA
  • We used cells of human respiratory epithelium after in vitro ciliogenesis to clone cDNA fragments of nine dynein heavy chain genes, one of which had never been identified before. (kuleuven.be)
  • Dynein heavy chains are highly conserved from protozoa to human and the evolutionary ancestry of these dynein heavy chain cDNA fragments was deduced by phylogenetic analysis. (kuleuven.be)
  • 1976
  • [ 4 , 56 ] LCDD was first described in 1976 in two patients with end-stage renal disease as granular deposits of free light chains in multiple organs, including the kidneys, that did not stain with Congo red. (medscape.com)
  • long chain
  • The elongases of very long-chain fatty acids (Elovl) account for the rate-limiting condensation step of the elongation process in fatty acid (FA) biosynthesis in vertebrates. (stir.ac.uk)
  • One member of the Elovl family, Elovl4, has been regarded as a critical enzyme in vertebrates in the production of the so-called very long-chain fatty acids (VLC-FA), a group of compounds that have been scarcely explored in fish. (stir.ac.uk)
  • Overall, our results suggest that TBR, RBB, and BAF patterns were most consistent with protein binding mechanisms although partitioning to phospholipids may contribute to the accumulation of long-chain PFASs in specific tissues. (diva-portal.org)
  • probes
  • In addition, light scattering caused by deep tissue imaging necessitates probes with higher photon counts than for thin section imaging. (biologists.org)
  • heavy chain
  • The chromosomal assignment of these dynein heavy chain genes which was confirmed by GeneBridge 4 radiation hybrid screening, will be extremely useful for linkage analysis efforts in patients with primary ciliary dyskinesia (PCD). (kuleuven.be)
  • fatty acids
  • While high-fat diets containing most classes of LCFAs (e.g., saturated, monounsaturated, and omega-6) lead to obesity and insulin resistance ( 4 , 6 , 11 ), an interesting group of fatty acids that have been suggested to have antiobesity potential are medium-chain (C8-12) fatty acids (MCFAs) ( 12 , 13 ). (diabetesjournals.org)
  • dysfunction
  • Restoration of autophagic flux by pharmacological intervention using rapamycin protected against amyloidogenic light chain protein‐induced pathologies including contractile dysfunction and cell death at the cellular and organ level and also prolonged survival in an in vivo zebrafish model of amyloid cardiotoxicity. (embopress.org)
  • significantly
  • However, background due to sample autofluorescence is significantly higher in tissue samples than in cell culture, making it difficult to robustly detect smFISH signals in tissue. (biologists.org)
  • 2014) reported that the relative level of UCA1 was significantly higher in ESCC tissues compared to the adjacent non-tumor tissue, and remarkably higher expression of UCA1 was found in esophageal cancer cell lines compared with the immortalized esophageal epithelial cell line NE1 , and it was found to be deregulated in cisplatin-resistant cells compared with their parent cells . (termedia.pl)
  • light
  • The ROCK inhibitor Y27632 completely inhibited ET-1-promoted contraction and the phosphatase inhibitor calyculin elicited contraction in the absence of any other agonists, suggesting that activation of the Rho/ROCK/myosn light chain phosphatase pathway is critical in regulating in vivo myofibroblast contraction. (epfl.ch)
  • These results are consistent with inhibition of myosin light chain phosphatase by the Rho/ROCK signaling pathway, which would account for the long-duration contraction of myofibroblasts necessary for wound closure. (epfl.ch)
  • [ 6 ] A monoclonal population of plasma cells can be detected in the bone marrow, and an altered serum-free light chain ratio is present. (medscape.com)
  • activation
  • 2 3 Activation of tissue-infiltrating inflammatory cells, such as macrophages, T cells, and mast cells, 4 5 6 7 has been implicated to cause plaque vulnerability through the local production of tissue-digesting enzymes and procoagulant substances. (ahajournals.org)
  • substances
  • Understanding the bioaccumulation mechanisms of per- and polyfluoroalkyl substances (PFASs) across different chain-lengths, isomers and functional groups represents a monumental scientific challenge with implications for chemical regulation. (diva-portal.org)
  • expression
  • Imaging gene expression levels with single-cell resolution in intact tissues is essential for understanding the genetic programs in many systems, such as developing embryos and dynamic brain circuits. (biologists.org)
  • In multiple large-scale screening studies, the expression of over 100 lncRNAs in ESCC tissues has been found to be altered. (termedia.pl)
  • positive
  • IHC staining of corneal sections revealed the presence of FeLV gp70 in corneal tissues of nine (52.9%) ELISA positive cats. (vt.edu)
  • Whole body bioaccumulation factors (BAFs) for short-chain PFASs deviated from the positive relationship with hydrophobicity observed for longer-chain homologues. (diva-portal.org)
  • Distribution
  • 24) in Atlantic salmon: Cloning, functional characterisation, and tissue distribution of an Elovl4 elongase, Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 159 (2), pp. 122-129. (stir.ac.uk)
  • Here, we investigate how the differential tissue distribution and bioaccumulation behavior of 25 PFASs in crucian carp from two field sites impacted by point sources can provide information about the processes governing uptake, distribution and elimination of PFASs. (diva-portal.org)
  • 1 for all PFASs and tissues except bile which displayed a distinct distribution pattern and enrichment of several perfluoroalkyl sulfonic acids. (diva-portal.org)
  • Principal component analyses of TBRs and RBBs showed that the functional group was a relatively more important predictor of internal distribution than chain length for PFASs. (diva-portal.org)
  • Cell
  • Global Cell and Tissue Analysis Products Industry 2015 Market Research Report is a new market research publication announced by Reportstack. (pitchengine.com)
  • This report is a professional and in-depth study on the current state of the Cell and Tissue Analysis Products industry. (pitchengine.com)
  • The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure.The Cell and Tissue Analysis Products market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. (pitchengine.com)
  • Upstream raw materials and equipment and downstream demand analysis is also carried out.The Cell and Tissue Analysis Products industry development trends and marketing channels are analyzed. (pitchengine.com)
  • activity
  • These findings help explain the anomalous single-chain activity of tPA and may suggest strategies for design of new therapeutic plasminogen activators. (rcsb.org)