• RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about changes that occur in DNA and identify biomarkers related t. (bioportfolio.com)
  • RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. (bioportfolio.com)
  • Amplification and overexpression of these two genes in four ovarian cancer cell lines were confirmed by Southern and Northern blot analyses. (aacrjournals.org)
  • CRC tissues and adjacent normal tissues were collected and CRC SW620 cells line and normal human intestinal epithelial cells (HIECs) were incubated. (cancerindex.org)
  • Specifically, the monoclonal nuclear pore complex antibody 414 shows that NCSs are present in about half of all human endometrial epithelial cells but not in any other cell type, tissue or species. (biologists.org)
  • These temporal changes of the endometrium are evident at the tissue and epithelial cell level. (biologists.org)
  • 97. Piotrowski-Daspit A.S. & Nelson C.M. (2016) Engineering three-dimensional epithelial tissues embedded within extracellular matrix. (princeton.edu)
  • AQP3 was strongly expressed in many of the human tissues examined particularly in basolateral membranes of the distal nephron (medullary collecting ducts), distal colon, upper airway epithelia, transitional epithelium of the urinary bladder, tracheal, bronchial and nasopharyngeal epithelium, stratified squamous epithelial cells of the esophagus, and anus. (surrey.ac.uk)
  • Through DNA microarray analysis and other techniques for looking at genetic and molecular characteristics, a more detailed knowledge of the malignant transformation process, and alterations with therapy, in these patients may be obtained. (clinicaltrials.gov)
  • Vibrational spectroscopy has proven to be useful for cell and tissue characterization based on the intrinsic molecular information. (rsc.org)
  • and 2) the molecular analysis of growth factor receptors and signaling. (yale.edu)
  • Group 1: translational studies using tissue microarray technology and AQUA (automated quantitative analysis) applying basic molecular observations and tools to diagnostic problems in pathology. (yale.edu)
  • In a subgroup analysis, Wnt-5a was significantly associated with better prognosis in patients with Luminal A tumors (p = 0.04). (nih.gov)
  • Our objective was to investigate whether the presence of a tumor increases hyaluronan (HA) levels in surrounding prostate tissues and whether this extratumoral HA influences tumor growth and outcome. (diva-portal.org)
  • These findings provide new mechanistic insight into how the host commandeers proinflammatory cytokines for tissue repair and highlight the potential for manipulating the IL-36/IL-23/IL-22/AMP network in treating acute intestinal damage. (pnas.org)
  • Enzymes that are responsible for the remodeling of the ECM, including matrix metalloproteinases (MMPs) and tissue inhibitor of metallopreoteinase (TIMP) families, and a wide variety of cytokines and signaling molecules, are important to homeostasis of the sclera [ 2 , 3 ]. (medsci.org)
  • The aromatase then acts in conjunction with other steroid biosynthetic enzymes present in the decidual tissue to support de novo synthesis of E. This locally produced E is able to support the advancement of the stromal differentiation program even in the absence ovarian E in an ovariectomized, progesterone-supplemented pregnant mouse model. (pnas.org)
  • 2013). Control of somatic tissue differentiation by the long non-coding RNA TINCR. (springer.com)
  • In multicellular organisms, patterning is a process that generates axes in the primary body plan, creates domains upon organ formation, and finally leads to differentiation into tissues and cell types. (plantcell.org)
  • In small mammals brown adipose tissue (BAT) plays a predominant role in regulating energy expenditure (EE) via adaptive thermogenesis. (biomedcentral.com)
  • To achieve this we firstly established a mouse BAT enriched-miRNA profile by comparing miRNAs expressed in mouse BAT, white adipose tissue and skeletal muscle. (biomedcentral.com)
  • We investigated the role of GLUT4 in adipose tissue and muscle in whole-body insulin sensitivity, making tissue-specific GLUT4-overexpressing and GLUT4 knockout mice. (diabetesjournals.org)
  • Overall, these studies have expanded our understanding of the multifaceted role of adipose tissue in metabolic health and how adipose dysfunction increases the risk for type 2 diabetes. (diabetesjournals.org)
  • We knew that adipose tissue was a storage depot, but we did not even completely appreciate that this storage function prevented ectopic lipid deposition in muscle, liver, heart, and other tissues, which can cause insulin resistance and other metabolic problems including hepatic steatohepatitis. (diabetesjournals.org)
  • In patients with ER-positive tumors, Wnt-5a was an independent positive prognostic marker (HR 0.51 95% CI: 0.33-0.78 p = 0.002) and HER2 a negative prognostic marker (HR 2.84 95% CI: 1.51-5.31, p = 0.001) in a Cox multivariate analysis adjusted for standard prognostic markers and tamoxifen treatment. (nih.gov)
  • We performed a systematic review and meta-analysis to synthesize the available evidence regarding to the prognostic value of STAS in NSCLCs.MethodsStudies were identified by searching databases including PubMed, EMBASE. (medworm.com)
  • 102. Pang M.F., Siedlik M.J., Han S., Stallings-Mann M., Radisky D.C., & Nelson C.M. (2016) Tissue stiffness and hypoxia modulate the integrin-linked kinase (ILK) to control breast cancer stem-like cells. (princeton.edu)
  • 100. Nelson C.M. (2016) Collective migration in tissues. (princeton.edu)
  • 98. Navis A. & Nelson C.M. (2016) Pulling together: Tissue-generated forces that drive lumen morphogenesis. (princeton.edu)
  • Scientists who have been developing antibodies for therapeutic purpose all need their preliminary results from frozen tissues to get approval from FDA. (wikipedia.org)
  • This study demonstrates the potential of vibrational spectroscopy and imaging to discriminate between non-IBC and IBC at both cell and tissue levels. (rsc.org)