Tissue and gene specificity. Medical search. Frequent questions

Given that the minor spliceosome is ubiquitously expressed, we hypothesized that these restricted phenotypes might be caused by the tissue-specific regulation of the minor spliceosome targets, i.e. minor intron-containing genes (MIGs). (biomedcentral.com)
An analysis of lncRNA conservation across species identified a set of conserved lncRNA with potential functions associated with chromatin structure and gene regulation. (usda.gov)
We also argue that the differences between humans and other animals can be adequately explained by differential regulation of 20,000 protein-coding genes. (blogspot.com)
Studies in mouse indicate the 80 aa SMAF1 protein is involved in adipocyte tissue function or regulation. (nih.gov)
The rat HMGCS2 gene contains elements that control its multihormonal regulation and tissue specificity ( 11 - 14 ). (aacrjournals.org)
MicroRNAs are short non-coding RNAs with important functions in the regulation of gene expression in healthy and diseased tissues. (lu.se)
Subsequent comparative transcriptomics identified a set of differentially expressed genes (DEGs) associated with the biosynthesis and regulation of flavonoids and BIAs in lotus. (bvsalud.org)

We downloaded the GSE75010 and GSE10588 datasets from the GEO database and performed weighted gene coexpression network analysis (WGCNA) as well as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. (hindawi.com)
Candidate target genes were identified through Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. (scirp.org)

Insights into gene tissue specificity and protein-protein interactions in the context of purifying selection in humans. (qxmd.com)
How much are natural selection and gene characteristics, such as the number of protein-protein interactions (PPIs), tissue specificity (𝞽), and expression level, connected? (qxmd.com)
Protein misfolding cyclic amplification (PMCA) of peripheral tissues from patients with variant Creutzfeldt-Jakob disease (vCJD). (cdc.gov)
The approach is based on affinity reagents raised toward bioinformatics-designed protein epitope signature tags corresponding to unique regions of individual gene loci. (nih.gov)
The genes of human chromosome 21 identified by the genome efforts were investigated, and the success rates for de novo cloning, protein production, and antibody generation were 85, 76, and 56%, respectively. (nih.gov)
Using human tissue arrays, a systematic profiling of protein expression and subcellular localization was undertaken for the putative gene products. (nih.gov)
Tissue-specific genes were defined by processing RNA-Seq data from the Human Protein Atlas (HPA) (Uhlén et al. (bioconductor.org)
These transcripts match previously known patterns of lncRNA, such as generally lower expression levels than protein-coding genes and higher tissue specificity. (usda.gov)
Additionally, protein-protein interaction network analysis identified 10 hub genes, six ( FLT1 , FLNB , FSTL3 , INHA , TREM1 , and SLCO4A1 ) of which were used to establish a logistic model for PE. (hindawi.com)
Among the various genetic metabolic disorders, Angelman syndrome (AS) has attracted considerable attention due to the abnormal expression of the ubiquitin-protein ligase E3A (UBE3A) gene ( 1 ). (spandidos-publications.com)
The human UBE3A gene encodes an E3 ubiquitin ligase, which exhibits three known protein subtypes ( 1 , 8 ). (spandidos-publications.com)
This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. (origene.com)
Proponents of massive alternative splicing argue that most human genes produce many different protein isoforms. (blogspot.com)
According to these scientists, this means that humans can make about 100,000 different proteins from only ~20,000 protein-coding genes. (blogspot.com)
The clearest finding from proteomics experiments is that most human genes have a single main protein isoform, while those alternative isoforms that are identified tend to be the most biologically plausible: those with the most cross-species conservation and those that do not compromise functional domains. (blogspot.com)
Deep RNA-DNA, RNA-protein interaction studies, and phenotype rescue analyses reveal that LETR1 is a nuclear trans-acting lncRNA modulating, via key epigenetic factors, the expression of essential target genes, including KLF4 and SEMA3C , governing the growth and migratory ability of LECs. (nature.com)
Together, our findings should motivate caution when interpreting conditional alleles, and suggest the exciting possibility of inter-tissue RNA or protein trafficking in modulation of reproductive biology. (elifesciences.org)
Their results showed that genes from the same Gene Ontology 'Biological Process' (GO-BP) category - which indicates the physiological function of their encoded protein, such as 'response to temperature' or 'amino acid metabolism' - are transcriptionally co-regulated, independent of the tissue in which they are expressed. (sciencedaily.com)
What does this gene/protein do? (cancerindex.org)
The MAP2K1 gene provides instructions for making a protein known as MEK1 protein kinase. (medlineplus.gov)
The mutations lead to the production of a version of the protein that is overactive, which increases RAS/MAPK signaling in bone tissue. (medlineplus.gov)
The identified MAP2K1 gene mutation is a germline mutation that replaces the amino acid glutamic acid with the amino acid glycine at position 102 (written as Glu102Gly or E102G) in MEK1 protein kinase. (medlineplus.gov)
Telomere length, DNA-methylation, gene expression of Trf1, Trf2, ATM, and APP, protein expression of p-Tau, a-synuclein, and presenilin 1 and 2 were assessed in whole brain tissue at 12 wk after WF exposure ended. (cdc.gov)
We aimed to evaluate quantitative real-time PCR (qPCR) targeting three protein-coding genes of Histoplasma capsulatum (100-kDa, H and M antigens) for detection of this fungus in formalin-fixed paraffin-embedded (FFPE) samples from patients with proven histoplasmosis. (cdc.gov)

To our knowledge, this is the first demonstration of the prominent cell-type specificity of PMDs across normal, precursor, and malignant states," the researchers write. (genomeweb.com)
The molecular contents of EVs largely reflect the cell of origin and thus show cell-type specificity. (selectbiosciences.com)

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (nih.gov)

Organ Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Organ Specificity" by people in Harvard Catalyst Profiles by year, and whether "Organ Specificity" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Organ Specificity" by people in Profiles. (harvard.edu)

The human ATP5F1C gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase. (wikipedia.org)
This gene encodes a subunit of mitochondrial ATP synthase. (wikipedia.org)
This gene encodes the gamma subunit of the catalytic core. (wikipedia.org)
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. (thermofisher.com)
In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans. (ed.ac.uk)
This gene encodes the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a factor implicated in cell cycle, senescence, and cancer. (ed.ac.uk)

This gene also has a pseudogene on chromosome 14. (wikipedia.org)
The Symposium Proceedings addresses 21st Century Genetics: Genes at Work, and provides a current synthesis of genetic mechanisms and genome/chromosome biology. (cshlpress.com)
The loss of the expression of the maternal allele of the UBE3A gene is typically associated with the four following mechanisms: Deletion at the 15q11.2-q13 locus, UBE3A functional loss variation, presence of paternal parthenogenetic double chromosome or genomic imprinting defect ( 4 ). (spandidos-publications.com)
The UBE3A gene is located on the 15q11-q13 locus of chromosome 15. (spandidos-publications.com)

For complete details and additional special case rules, see Guidelines for Nomenclature of Genes, Genetic Markers, Alleles, and Mutations in Mouse and Rat . (jax.org)
Mutations in minor spliceosome components such as U12 snRNA (cerebellar ataxia) and U4atac snRNA (microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1)) result in tissue-specific symptoms. (biomedcentral.com)
Relevant large fragments of mutations and methylation abnormalities were not found in the associated genes. (spandidos-publications.com)
The data further revealed absence of 25‑bp repeat mutations at the shear mutation site of exon 1 of the small nuclear ribonucleoprotein polypeptide N gene in the subjects examined. (spandidos-publications.com)
At least 13 mutations in the MAP2K1 gene have been identified in people with cardiofaciocutaneous syndrome. (medlineplus.gov)
The MAP2K1 gene mutations that cause cardiofaciocutaneous syndrome are germline mutations, which means that they are present in cells throughout the body. (medlineplus.gov)
It is unclear why the E102G mutation causes Noonan syndrome with multiple lentigines and other germline mutations in the MAP2K1 gene cause different disorders, such as cardiofaciocutaneous syndrome (described above). (medlineplus.gov)
Mutations in the MAP2K1 gene have also been found in several forms of cancer. (medlineplus.gov)
Like the mutations that cause melorheostosis (described above), cancer-associated mutations in this gene are somatic. (medlineplus.gov)
Somatic mutations in the MAP2K1 gene have been reported in several forms of blood cell cancer (leukemia and lymphoma), lung cancer , and a form of skin cancer called melanoma . (medlineplus.gov)

Tissue-restricted inhibition of mTOR using chemical genetics. (harvard.edu)

While the observation that NHR-67 forms punctae associated with transcriptional repressors in non-invasive cells is intriguing, the work does not yet established a clear link between the formation and dissolution of NHR-67 condensates with the activation of downstream genes that NHR-67 is actively repressing. (elifesciences.org)
This epithelial molecule senses tissue stress and licenses downstream activation of innate immune responses. (univ-mrs.fr)

Jan. 13, 2023 When genes are activated and expressed, they show patterns in cells that are similar in type and function across tissues and organs. (sciencedaily.com)

We calculated receiver operating characteristic curves to determine the specificity and sensitivity of miR-637 biomarkers. (scirp.org)
We calculated specificity and sensitivity for each pipeline by aligning three isolates with chromosomal level assemblies and found that the GATK-based pipelines were well balanced between these metrics. (cdc.gov)

Genes in this pathway have been shown to be involved in the activation of transforming growth factor (TGF)-beta1 and matrix metalloproteinases and are subject to inhibition by SERPINE2. (nih.gov)
The analysis of the Hif1α pathway in SDHD-ESR tissues and in two newly derived cell lines after complete SdhD loss -a requirement for hereditary paraganglioma type-1 tumor formation in humans- partially recapitulated the "pseudo-hypoxic" response and rendered inconsistent results. (ed.ac.uk)
Combination analysis of subcellular localization and gene co-expression analysis (GCN) illustrates that NnGGPPS1 is the main transcript related with methylerythritol phosphate (MEP) pathway, abscisic acid (ABA) biosynthesis, carotenoid and chlorophyll biosynthesis and degradation. (bvsalud.org)
The up-regulated expression of the key genes in MEP pathway, carotenoid biosynthesis and chlorophyll biosynthesis, result in the increase of metabolic flux in NnGGPPS1 transgenic lines. (bvsalud.org)

The results provide evidence that genes involved in tissue remodeling and repair are differentially regulated in the lungs of obstructed smokers and suggest that they are potential therapeutic targets. (nih.gov)
While previous studies in chickens, cattle, and pigs have identified lncRNAs in developmental stages or differentially expressed under specific conditions in a limited number of tissues, more comprehensive identification of lncRNAs in these species is needed. (usda.gov)
In recent years, bioinformatics analysis and the microarray technology have been used to identify transcriptomic alterations and differentially expressed genes (DEGs), as well as their physiological functions, in many diseases. (hindawi.com)

Human ATP5F1C genome location and ATP5F1C gene details page in the UCSC Genome Browser. (wikipedia.org)
While genome assemblies and the identification of coding genes greatly enhanced our ability to connect DNA sequence (genotype) to traits of interest (phenotype), it becoming clear that genomes need to be more comprehensively annotated, especially with respect to regulatory elements. (usda.gov)
They analyzed the whole-genome bisulfite sequencing profiles of 45 esophageal tumors, representing both the squamous cell carcinoma and adenocarcinoma subtypes, and matched nonmalignant tissue. (genomeweb.com)
In particular, the FANTOM (Functional Annotation of the Mammalian Genome) consortium pioneered the discovery of the noncoding RNA world by providing, through Cap Analysis of Gene Expression (CAGE-Seq), the first evidence that large portions of our genome are transcribed, producing a multitude of sense and antisense transcripts 12 . (nature.com)
The development of tools to manipulate the mouse genome, including knockout and transgenic technology, has revolutionized our ability to explore gene function in mammals. (elifesciences.org)

For example, the user can input the most highly expressed genes from RNA-Seq data, or gene co-expression modules to determine which tissue-specific genes are enriched in those datasets. (bioconductor.org)
package can also be used to define tissue-specific genes from expression datasets provided by the user, which can then be used to calculate tissue-specific gene enrichments. (bioconductor.org)
Given a gene list as input, this function calculates the tissue-specific gene enrichment using tissue-specific genes from either human or mouse RNA-Seq datasets. (bioconductor.org)
It uses tissue-specific genes defined by processing RNA-Seq datasets from human and mouse. (bioconductor.org)
More details about the RNA-Seq datasets and tissue-specific genes are discussed in the next sections. (bioconductor.org)
We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
Altogether there are four main datasets, namely 409 "SLCs" in 59 tissue types and 56 cell lines, and 48 ABCs in the same tissue types and cell lines. (biorxiv.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

They tend to believe humans are considerably more complex than other animals even though we have about the same number of genes. (blogspot.com)
This challenges the conventional view that tissue-specificity is the best predictor of function, and could speed up the quest to understand whole genomes, in humans and other mammals, by decades. (sciencedaily.com)

Gene function in mammals can be quickly and reliably predicted using a high-throughput analysis of patterns of RNA expression, according to an article published in Journal of Biology. (sciencedaily.com)

these often differ significantly from the 'housekeeping' genes commonly used for normalisation in transcriptomics and qPCR studies. (biorxiv.org)
While the standard method, qPCR, allows for quick and cheap microRNA quantification, specificity is limited due to the short lengths of microRNAs and the high similarity between closely related microRNA family members. (lu.se)
The specificity of 100-kDa qPCR was 93% when compared against samples from patients with other mycoses and other infections, and 100% when samples from patients with non-infectious diseases were used as controls. (cdc.gov)

The results suggest that this affinity proteomics strategy can be used to produce a proteome atlas, describing distribution and expression of proteins in normal tissues as well as in common cancers and other forms of diseased tissues. (nih.gov)
Bioinformatics analysis revealed that several of the AS events could result in the production of novel tissue-specific proteins. (biomedcentral.com)
For example, they hardly ever detect all of the peptides of most genes even when the proteins are present in high concentrations. (blogspot.com)
In addition, expression of different neurodegeneration markers, such as p-Tau, presenilin 1-2 and a-synuclein proteins, were increased in brain tissue from the WF-exposed rats as compared to control. (cdc.gov)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)

We then analyzed the RNAseq data from eleven different mouse tissues, which revealed tissue-specific MIG expression and minor intron retention. (biomedcentral.com)
RNA-Seq data across 17 mouse tissues (Shen et al. (bioconductor.org)

As one of the FAANG pilot projects, lncRNAs were identified across eight tissues in two adult male biological replicates from chickens, cattle, and pigs. (usda.gov)
Tissue-specific lncRNA were identified, and genes nearby tissue-specific lncRNAs were enriched for GO terms associated with those tissues. (usda.gov)
For example, lncRNAs specific to spleen were nearby genes enriched in immune system related GO terms such as leukocyte activation. (usda.gov)
Conclusions LncRNAs have been identified in three important farm animal species using eight tissues from adult individuals. (usda.gov)
LncRNAs can beclassified into tumor suppressor genes or oncogenes, depending on their function within the cellular context and the signalling pathways in which they are involved. (newswise.com)
Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. (nature.com)

Symbols should not include tissue specificity and molecular weight designations. (jax.org)
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function. (harvard.edu)
In addition to such coarse-grained signals of organismal physiology, it is increasingly understood that more detailed molecular signals can be communicated between distant tissues. (elifesciences.org)

In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)

Orthologous to several human genes including CCNB1 (cyclin B1). (nih.gov)

These findings may shed light on the mechanism underlying tissue-specific phenotypes in diseases associated with minor spliceosome inactivation. (biomedcentral.com)
One way to explain this paradox of systemic minor spliceosome inhibition resulting in tissue-specific phenotypes would be that the MIGs are expressed, spliced and/or alternatively spliced in a tissue-specific manner. (biomedcentral.com)

succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. (ed.ac.uk)

Results Comprehensive lncRNA annotations for the chicken, cattle, and pig genomes were generated by utilizing RNA-seq from unique tissue samples with the same eight tissues at the same development stage (mature) and two biological replicates in each species. (usda.gov)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)

to be used for the tissue-specific gene enrichment analysis. (bioconductor.org)

This route is minimally invasive and therefore clinically relevant for gene therapy targeting to peripheral nerve soma. (frontiersin.org)
In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
The blood and lymphatic vascular systems are essential for the efficient transport of oxygen, nutrients, signaling molecules, and leukocytes to and from peripheral tissues, the removal of waste products, and the preservation of fluid homeostasis. (nature.com)

Monocytes in the circulation are precursors to tissue macrophages. (msdmanuals.com)
Monocytes migrate into tissues, where over approximately 8 hours, they develop into macrophages. (msdmanuals.com)
Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)
He identified periodic acid-Schiff (PAS)-staining granules, most likely representing degenerating bacterial forms, within macrophages isolated from the small bowel as well as other tissue and fluid specimens (eg, pericardium, endocardium, lymph nodes, synovia, lung, brain, meninges) obtained from patients in whom Whipple disease was suspected. (medscape.com)

Transcriptome variation in human tissues revealed by long-read sequencing. (harvard.edu)
Transcriptome analysis, dual-luciferase, and yeast 1-hybrid assays showed that NnMYB5 could directly activate the anthocyanin transporter gene GLUTATHIONE S-TRANSFERASE2 (NnGST2). (bvsalud.org)

For orthologous genes in other vertebrate species, use the same symbol as in human, rat, and mouse, whenever possible. (jax.org)

In this study, we used bioinformatics analysis to identify hub genes, establish a logistic model, and study immune cell infiltration to clarify the physiopathogenesis of PE. (hindawi.com)
KEGG and GO analyses further indicated the involvement of these genes in bioprocesses, such as gonadotropin secretion, immune cell infiltration, and the SMAD and MAPK pathways. (hindawi.com)
This study identified 10 hub genes in PE and used 6 of them to establish a logistic model and also analyzed immune cell infiltration. (hindawi.com)
Interestingly, the disease progression rate can vary considerably between individuals (with time to AIDS ranging between months to decades), and the immune specificity against HIV infection has been suggested to only explain about 22% of the most reliable predictor of when AIDS will develop? (lu.se)

Investigators showed higher rates of infection in experimental mice deficient in the genes that control expression of these 2 agents. (medscape.com)

Methylation reprogramming was correlated with increased gene expression variability. (jneurosci.org)

The formalin-fixed, paraffin-embedded (FFPE) tissue sections with a 5-μm thickness were cut for subsequent miR-637 in situ hybridization (ISH). (scirp.org)
FFPE tissue sections, adhered to glass slides, were deparaffinized in xylene and rehydrated using gradient ethanol. (scirp.org)

This new, quick, high-throughput method for predicting mammalian gene function merely from the pattern of RNA expression could make tissue specificity based predictions a thing of the past and revolutionize the field of functional genomics. (sciencedaily.com)

Extracellular vesicles (EVs) are lipid membranous vesicles released from almost all cell types, and they provide a tremendous opportunity as sources of novel biomarkers from liquid biopsies, as well as agents for tissue repair and wound healing in regenerative medicine. (selectbiosciences.com)

Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)

Here, based on significant liver contribution to the catabolism of the branched chain amino acid leucine, we develop a liver-directed adeno-associated virus (AAV8) gene therapy for MSUD. (nature.com)

We reasoned that gene expression profiling of COPD lungs could reveal previously unidentified disease pathways. (nih.gov)

Another pantetehinase isoform exists in mouse and is encoded by the Vanin-3 gene showing distinct tissue specificity. (univ-mrs.fr)
These may be fimbrial or nonfimbrial, each with distinct receptor specificity. (medscape.com)

Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. (harvard.edu)
The use of expression levels of transcription factor-encoding genes according to hierarchical anatomical classifications covering different tissues and cell types makes it possible to filter out irrelevant binding site predictions and to identify candidates of potential functional importance for further experimental testing. (lu.se)

Mechanistically, EPB41L4A-AS2, acting at least in part as a tumor suppressor, upregulated tumor suppressor gene expression. (cancerindex.org)

RT-PCR analysis also confirmed that, except FSTL3 , these genes were upregulated in PE. (hindawi.com)
A number of predictions resulting from the SVM analysis were confirmed by results that are already in the literature, and in the case of one gene of unknown function, P1W1, by directed experimentation. (sciencedaily.com)
Therefore, we performed microarray analysis of adrenal medulla and kidney in order to identify other early gene expression changes elicited by SdhD deletion. (ed.ac.uk)
We have developed new tools to explore VNN1 expression in human tissues and completed a first global analysis of VNN expression and function in tissues from patients. (univ-mrs.fr)
We developed TS-REX, a database/software system that supports the analysis of tissue and cell type-specific transcription factor-gene networks based on expressed sequence tag abundance of transcription factor-encoding genes in UniGene EST libraries. (lu.se)

In order to make the tissue-specific gene calculations more robust, we only used tissues that had ≥2 biological replicates. (bioconductor.org)
Our results revealed that each mutant tissue displayed different variations in their gene expression profiles affecting to different biological processes. (ed.ac.uk)

The disparate functions of different cell types are coordinated by a wide array of mechanisms, including direct cell-cell contacts within a tissue, shared access to nutrient pools, and both local (paracrine) and longer-range trafficking of small molecule and peptide signals. (elifesciences.org)
Streptococcal pathogens continue to evade concerted efforts to decipher clear-cut virulence mechanisms, although numerous genes have been implicated in pathogenesis. (cdc.gov)

We discovered a positive correlation between genetic constraints, PPIs, and expression levels in all tissues. (qxmd.com)
Genes with an expression level greater than 1 (TPM or FPKM) that also have at least five-fold higher expression levels in a particular tissue compared to all other tissues. (bioconductor.org)
Genes with an expression level greater than 1 (TPM or FPKM) that also have at least five-fold higher expression levels in a group of 2-7 tissues compared to all other tissues, and that are not considered Tissue Enriched. (bioconductor.org)
The expression levels of UBE3A depend on the parental origin and exhibit tissue specificity. (spandidos-publications.com)
The expression levels of these genes are tissue-specific and depend on the origin of the parent. (spandidos-publications.com)
Gene expression levels, not alternative splicing, seem to be the key to tissue specificity. (blogspot.com)
The factors responsible for the postnatal and starvation-associated induction of HMGCS2 gene expression have been identified and shown to involve changes in circulating hormone and fatty acid levels. (aacrjournals.org)
Therefore, this complex regulatory network requires precise control of gene expression patterns at both transcriptional and post-transcriptional levels in order to ensure proper maturation, differentiation, and formation of blood and lymphatic vessels. (nature.com)
Firstly, the oxidized form of cysteamine inhibits glutathione synthesis therefore regulating glutathione levels in tissues. (univ-mrs.fr)
Notably, callus browning was coupled with significantly up-regulated expression of two polyphenol oxidase (PPO) and 17 peroxidase (POD) encoding genes, while the expression of ethylene associated genes remained at marginal levels. (bvsalud.org)

The tissues isolated from embryonic stages are prefixed with 'E' followed by the timepoint. (bioconductor.org)
For example in Mouse ENCODE data, the placenta tissue isolated from embryonic day 14.5 is named as E14.5-Placenta. (bioconductor.org)
TS-REX was applied to predict regulators of Polycomb group genes in six human tumor tissues and in human embryonic stem cells. (lu.se)

The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. (thermofisher.com)

TS-REX covers ESTs from H. sapiens and M. musculus, and allows the characterization of both presence and specificity of transcription factors in user-specified tissues or cell types. (lu.se)

Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)
The altered signaling interferes with the normal development of many organs and tissues, resulting in the characteristic features of cardiofaciocutaneous syndrome. (medlineplus.gov)
The increased signaling interferes with the normal development of many organs and tissues, resulting in the characteristic features of Noonan syndrome with multiple lentigines. (medlineplus.gov)

I've the idea that if I can get the EST data from GeneMap into a table I can sort that with the tissue specificity query results from dbEST using Access. (bio.net)
The results from large-scale proteomics experiments are in line with evidence from cross-species conservation, human population variation studies, and investigations into the relative effect of gene expression and alternative splicing. (blogspot.com)
These results indicate that whereas Vanin-1 is an essential regulator of inflammation following an acute stress, it also participates to tissue cytoprotection in more chronic diseases. (univ-mrs.fr)

GBM can extensively infiltrate normal brain tissue, making surgical resection almost impossible, and postoperative recurrence is common [2]. (scirp.org)
Here, we investigated the effect of WF inhalation on telomere length and markers of neurodegeneration in whole brain tissue in rats. (cdc.gov)

We examined the extent to which [transcriptional co-expression] is effective for our data, and we show that it yields almost universally superior predictions of gene function in comparison to using information regarding simple tissue specificity or tissue restriction" say the authors. (sciencedaily.com)
However, when applying this concept to genomes of multicellular organisms such as mammals, one has to deal with a large number of false positive predictions since many transcription factor genes are only expressed in specific tissues or cell types. (lu.se)

have presented the crystal structure of apo-ApcT, a proton-coupled broad-specificity amino acid transporter, at 2.35 Å resolution. (tcdb.org)

Anatomy16

Organisms11

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment71

Phenomena and Processes77

Disciplines and Occupations4

Information Science7

Health Care13

Regulation7

Kyoto Encyclo2

Protein24

Cell-type specificity2

Ontology1

Organ Specificity3

Encodes6

Chromosome4

Mutations10

Genetics1

Downstream2

20231

Sensitivity2

Pathway4

Differentially3

Genome5

Datasets8

Humans2

Function in mammals1

QPCR3

Proteins5

Mouse tissues2

LncRNAs6

Molecular3

Epithelial1

Human genes1

Phenotypes2

Tumors1

LncRNA1

Endogenous1

Enrichment analysis1

Peripheral3

Macrophages4

Transcriptome2

Orthologous1

Immune4

Mice1

Methylation1

FFPE2

Mammalian1

Biomarkers1

Lymph nodes1

Adeno-assoc1

Expression Profiling1

Distinct2

Hierarchical2

Tumor supp1

Analysis5

Biological2

Mechanisms2

Levels10

Embryonic3

Chromosomal1

Transcription factors1

Characteristic3

Results3

Brain tissue2

Predictions2

Amino1