• For example, the secondary agent may be Loteprednol (loteprednol etabonate) and/or Timolol (Timolol maleate). (justia.com)
  • Dorzolamide/timolol maleate is a medication used to reduce high pressure in the eye due to glaucoma or ocular hypertension. (optionrx.com)
  • Dorzolamide/timolol maleate works by reducing the fluid in your eye. (optionrx.com)
  • Dorzolamide/timolol maleate is a generic medication also sold under the brand name Cosopt. (optionrx.com)
  • For the treatment of high eye pressure, dorzolamide/timolol maleate use is common. (optionrx.com)
  • The combination of dorzolamide and timolol is used to treat eye conditions, including glaucoma and ocular hypertension, in which increased pressure can lead to a gradual loss of vision. (optionrx.com)
  • Dorzolamide and timolol is used for patients whose eye condition has not responded to another medication. (optionrx.com)
  • Dorzolamide and timolol lowers pressure in the eye by decreasing the production of natural fluids in the eye. (optionrx.com)
  • This drug contains a beta blocker (timolol) and a carbonic anhydrase inhibitor (dorzolamide). (optionrx.com)
  • What Form(s) Does Dorzolamide Hcl-Timolol Mal Come In? (optionrx.com)
  • Timolol is in a class of medications called topical beta blockers. (optionrx.com)
  • A 32-year-old woman was using ophthalmic drops containing 0.5% timolol and 0.2% brimonidine twice daily in the right eye for 6 months. (nih.gov)
  • A Cochrane review compared the effect of timolol versus brimonidine in slowing the progression of open angle glaucoma in adults but found insufficient evidence to come to conclusions. (cloudfront.net)
  • Ophthalmic use of timolol by the mother should pose little risk to the breastfed infant, although some guidelines state that gel formulations are preferred over solutions. (nih.gov)
  • Timolol was measured in milk during the use of ophthalmic drops twice daily in one eye. (nih.gov)
  • No side effects were reported in one case report of a 9-week-old breastfed infant whose mother was using 0.5% ophthalmic timolol drops twice daily in one eye. (nih.gov)
  • The aim of the present study was to investigate the effect of carteolol hydrochloride, an adrenergic β-blocker, on the production of reactive oxygen species (ROS) and the viable cell number after ultraviolet irradiation of cultured lens epithelial cells (LECs). (openophthalmologyjournal.com)
  • Cultured LECs were exposed to 0, 10 -5 , 10 -4 , and 10 -3 M carteolol hydrochloride for 30 min followed by ultraviolet B (UVB) irradiation at intensity of 100, 200, or 400 mJ/cm 2 . (openophthalmologyjournal.com)
  • Exposure to 10 -3 M carteolol hydrochloride significantly decreased the amount of ROS after exposure to UVB at intensities of 100, 200, and 400 mJ/cm 2 . (openophthalmologyjournal.com)
  • In addition, 10 -3 M carteolol hydrochloride significantly increased the viable cell number after exposure to UVB at 400 mJ/cm 2 . (openophthalmologyjournal.com)
  • However, 10 -4 and 10 -5 M carteolol hydrochloride had no significant effect on ROS or the viable cell number in LECs. (openophthalmologyjournal.com)
  • Carteolol hydrochloride protects LECs against UVB irradiation by inhibiting the intracellular production of ROS. (openophthalmologyjournal.com)
  • The reported antioxidant properties of carteolol hydrochloride have, however, differed among the previous studies. (openophthalmologyjournal.com)
  • A mother who was taking 2 drops of timolol 0.5% eye drops daily as well as using pilocarpine eye drops twice daily and acetazolamide 250 mg orally twice daily and delivered a preterm infant at 36 weeks of gestation. (nih.gov)
  • Because of the variability in excretion of timolol into breastmilk and minimal reported experience during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant. (nih.gov)
  • With less than 10% protein binding, 20% renal excretion and a relatively short half-life, timolol presents a moderate risk for accumulation in infants, especially neonates. (nih.gov)
  • Timolol is a beta blocker medication used either by mouth or as eye drops . (cloudfront.net)
  • LBN 0.024% QD in the evening was noninferior to timolol 0.5% BID over 3 months of treatment, with significantly greater IOP lowering in subjects with OAG or OHT at all but the earliest time point evaluated, and demonstrated a good safety profile. (entokey.com)
  • Another recent phase 3 trial with a similar design (the APOLLO study) found that LBN QD in the evening was significantly better than timolol 0.5% BID with regard to IOP lowering throughout the day. (entokey.com)
  • Timolol is marketed under many trade names worldwide. (cloudfront.net)
  • Nine women taking oral timolol 5 mg three times a day had a mean milk timolol level of 15.9 mcg/L (range 2 to 55 mcg/L). In 4 women taking 10 mg three times a day, the mean milk timolol levels was 41 mcg/L (range 7 to 88 mcg/L). The time after the dose when milk was sampled was not stated. (nih.gov)
  • Timolol was patented in 1968, and came into medical use in 1978. (cloudfront.net)
  • [22] Timolol can also lead to fainting , congestive heart failure , depression , confusion , worsening of Raynaud's syndrome and impotence . (cloudfront.net)
  • Milk timolol concentrations ranged from 0 to 0.37 mcg/L. The authors estimated that the maximum dose that a fully breastfed infant would obtain would be 123 ng/kg daily or 0.012% of the weight-adjusted maternal dosage. (nih.gov)