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  • severe
  • Hypoxia-ischaemia around the time of birth is associated with approximately 1-3/1000 cases of moderate to severe encephalopathy and a high risk of death or disability [ 1 , 2 ]. (mdpi.com)
  • A physician should suspect this in any patient with rapid onset of severe abdominal pain, which is often out of proportion to the physical exam findings (lacking involuntary guarding or peritoneal signs although these may occur later in the course). (thecardiologyadvisor.com)
  • Severe ischemia results in depolarization of neural tissue. (asahq.org)
  • 18 Plausibly, this could enhance hyperpolarization, particularly in the context of the known massive release of γ-aminobutyric acid induced by severe forebrain ischemia. (asahq.org)
  • diagnosis
  • The diagnosis of acute mesenteric ischemia requires a high index of suspicion because the clinical manifestations vary greatly depending on the severity and chronicity of the process. (thecardiologyadvisor.com)
  • Many times this is a diagnosis of exclusion made after ruling out several possibilities. (thecardiologyadvisor.com)
  • The only diagnosis that causes optic nerve ischemia that has been proven to be amenable to steroid treatment is Giant Cell Arteritis , also called temporal Arteritis. (justanswer.com)
  • Otherwise, I would not expect steroids to help a diagnosis of optic nerve ischemia. (justanswer.com)
  • A useful method to formulate the differential diagnosis for inadequate perfusion to the extremities is to categorize by onset of symptoms. (clinicaladvisor.com)
  • Many times the diagnosis can be made through a careful history and physical and confirmed with a minimum number of tests. (clinicaladvisor.com)
  • outcome
  • [15,Although histologic outcome worsens as a function of the duration of ischemia, the effect of the duration of depolarization on outcome has not been studied closely. (asahq.org)
  • asymptomatic
  • Although some have reported a higher prevalence of asymptomatic ischemia in diabetic patients during ETT 12 13 14 15 and AECG monitoring, 15 others have shown a similar prevalence of asymptomatic ischemia in diabetic and nondiabetic patients during ETT. (ahajournals.org)
  • 24 The study results show that asymptomatic ischemia is frequent and can be suppressed in ≈50% of patients with medication or revascularization and that revascularization was the most effective treatment strategy to reduce ischemia. (ahajournals.org)
  • clinical
  • However, whether TKIs should be restarted in patients who receive successful intervention for cardiac ischemia remains uncertain, as such patients on clinical trials would have discontinued therapy. (hindawi.com)
  • insult
  • Hypoxia-ischaemia is characterized by progressive evolution of damage over days following the insult [ 3 , 4 ]. (mdpi.com)
  • To investigate whether time of day of an ischemic insult influences clinically relevant outcomes in mice. (ahajournals.org)
  • The unique delay in onset of ischemic cell change and the protracte increase in its incidence between 24 and 72 hours could reflect either delayed‐appearance of ischemic change in previously killed neurons or a delayed insult that continued to jeopardize compromised but otherwise viable neurons during the postischemic period. (deepdyve.com)
  • This timed, controlled, ischaemic insult to the brain provides an ideal model in which to investigate how rapidly purines are released into the blood following the onset of ischaemia, and how quickly they return to baseline following resolution of the ischemic insult. (springer.com)
  • oxygen
  • As a response to ischemia, collateral mesenteric circulation opens to make up the oxygen demand however it is able to do so only for up to 12 hours. (thecardiologyadvisor.com)
  • in those regions transfusion lowered abnormally high oxygen extraction fraction (OEF), indicating improved flow-metabolism coupling and reduced risk of ischemia. (crashingpatient.com)
  • Brain
  • 1 Although some of treatment regimens, primarily based on physical therapy, have partly improved the recovery of these patients, there are no drugs available that could effectively repair the brain tissue damage resulting from ischemia or mechanical injury. (asahq.org)
  • We performed a prospective observational study to test whether purine levels in arterial blood might correlate with brain ischaemia. (springer.com)
  • Although a few studies have examined whether purine levels in blood increase during stroke [ 20 ] and brain ischaemia [ 21 ], this has not been widely studied. (springer.com)
  • To address this issue, we have used a novel biosensor technology to examine the purine levels in sequential arterial blood samples taken before, during and after the mild and reversible brain ischaemia that is imposed during the cross-clamp phase of awake carotid endarterectomy. (springer.com)
  • thrombolysis
  • Stroke treatment has been limited to a strategy of rapid revascularisation, initiated within 4.5 h of onset, by inducing thrombolysis with recombinant tissue plasminogen activator (rtPA). (hindawi.com)
  • therefore, intra-arterial thrombolysis must be carried out within a strict time frame. (springeropen.com)
  • The GISSI and the LATE trial both established that late thrombolysis, up to 12 hours after onset of chest pain, is beneficial for STEMI. (blogspot.fr)
  • Time to thrombolysis and mortality reduction. (blogspot.fr)
  • chest pain
  • 1. The ECG is a better indicator of acuteness than the time since onset of chest pain. (blogspot.com)
  • There are many STEMI, however, which will benefit beyond 12 hours of chest pain: the time onset of chest pain is not necessarily the time of onset of irreversible ischemia. (blogspot.fr)
  • How long after onset of chest pain are thrombolytics effective (how long is the time window)? (blogspot.fr)
  • found in a subgroup of 432 first MI patients whose ECG was recorded within the first hour after onset of chest pain that pathologic Q-waves were already present, and this was particularly true for anterior MI patients. (blogspot.fr)
  • detrimental effects
  • However, whereas more recent studies have assessed the effect of meals of different composition on exercise tolerance and onset of ischemia ( [5, ), they did not assess the time course of any detrimental effects and furthermore used liquid meals rather than the warm solid foods that patients would usually consume. (onlinejacc.org)
  • carotid
  • We made real-time perioperative measurements, via microelectrode biosensors, of the purine levels in untreated arterial blood from 18 patients undergoing regional anaesthetic carotid endarterectomy. (springer.com)
  • results
  • Their results suggested that the DFT was determined not only by the presence or absence of regional ischemia but also by whether VF occurred spontaneously or was induced electrically. (ahajournals.org)
  • At the same time, quantitative analyses are used to explore and explain any observed dissimilarity (heterogeneity) in the results of the examined studies. (ahrq.gov)
  • These results might be relevant for the future treatment of retinal ischemia. (arvojournals.org)
  • profound
  • Multiple clock proteins appear to be regulated in a time-dependent manner in cardiomyocytes that may have profound effects on myocardial metabolism, function, and response to injury. (ahajournals.org)
  • We expose a profound time-of-day dependence for I/R tolerance, which is mediated by the cardiomyocyte circadian clock. (ahajournals.org)
  • tolerance
  • Given that the cardiomyocyte circadian clock influences myocardial physiology, 1,11 and that this mechanism becomes rapidly inactivated following an ischemic event, 12 we hypothesized that the cardiomyocyte circadian clock modulates I/R tolerance in a time-of-day-dependent manner. (ahajournals.org)