Whereas coma and seizures are well-recognized neurological sequelae of hypoglycaemia, much interest is currently focused on the potential for hypoglycaemia to cause dangerous and life-threatening cardiac complications, such as arrhythmias and myocardial ischaemia, and whether recurrent severe hypoglycaemia can cause permanent cognitive impairment or promote cognitive decline and accelerate the onset of dementia in middle-aged and elderly people with diabetes mellitus. (nature.com)
of symptoms, and common compli- the symptom interpretation and care- Fourteen patients were excluded be- cations include recurrent ischaemia, seeking behaviour. (who.int)
Acute7
To evaluate the potential role of ASPECTS for acute endovascular treatment decisions, we studied the correlation between ASPECTS and CTP core, depending on the timing and the presence of large-vessel occlusion. (ajnr.org)
Therefore, an effective therapeutic strategy is required to prevent the onset of acute stroke and manage the chronic symptoms associated with neural ischemia, i.e., long-term neuroinflammation and localized necrosis [ 8 , 9 ]. (hindawi.com)
Graphical presentation of the various stages of cerebral ischemia stroke, i.e., acute phase, subacute phase, and chronic phase and their contributing factors. (hindawi.com)
A 10-year experience of managing acute limb ischaemia in India. (who.int)
Acute limb ischaemia is threatening to both limb and life. (who.int)
We did a retrospective analysis of the clinical profile of patients presenting with non-traumatic acute limb ischaemia to our department (a tertiary care centre in India) from January 1998 to December 2007. (who.int)
Acute limb ischaemia is a catastrophic event. (who.int)
Stroke4
6 hours) versus late (6-24 hours) times from stroke onset and in the presence versus absence of large-vessel occlusion. (ajnr.org)
However, this was stronger in patients with large-vessel occlusion and longer delay from stroke onset. (ajnr.org)
An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
Onset is sudden and the major symptoms of cerebellar stroke are occipital headache, vertigo, nausea and vomiting, and unsteady gait. (medlink.com)
Clinical3
Although the phenomenon of ischaemic preconditioning (IPC) is associated with the desired protective capacity, the necessity of its application before sustained ischaemia limits its clinical potential. (sun.ac.za)
This timing makes postconditioning relevant from the clinical perspective, in which limitation of irreversible myocardial damage following a coronary thrombosis and ST-elevation myocardial infarction remains a major objective [3]. (justia.com)
However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
Protective2
We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)
The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)
Reperfusion6
The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
The invention pertains to a polypeptide for the protection against heart ischemia-reperfusion injury. (justia.com)
Ischemia-reperfusion injury (IRI) is a syndrome affecting the myocardium upon blood flow restoration following a sufficiently long interruption, such as encountered in a coronary thrombosis or heart surgery [1,2]. (justia.com)
One object of the present invention is to provide a therapy of heart ischemia-reperfusion injury by applying GLP-1 analogues which can be administered as single component and avoiding administration of the drug with a second compound. (justia.com)
Postconditioning using N-Ac-GLP-1(7-34)amide N-terminally blocked and C-terminally truncated results in a limitation of ischemia-reperfusion injury in an isolated rat heart. (justia.com)
This figure outlines the time course for normoxic (A) and ischemia-reperfusion (B) experiments. (justia.com)
Dementia1
We observed a large amount of variation in the dementia incidence rates over time and that the hazard ratio increased every year. (preprints.org)
Dose2
The demography, risk factors, time taken to present to the emergency from the onset of symptoms, time taken to administer the first dose of heparin upon arrival to the emergency, primary interventions and outcomes in terms of amputation rates and in-hospital mortality were studied. (who.int)
The recommended dose is 100 mg ritonavir once or two times per day, depending on the concurrently used protease inhibitor. (who.int)
Application1
Prevention of hypoglycaemia is an important part of diabetes mellitus management and strategies include patient education, glucose monitoring, appropriate adjustment of diet and medications in relation to everyday circumstances including physical exercise, and the application of new technologies such as real-time continuous glucose monitoring, modified insulin pumps and the artificial pancreas. (nature.com)
Patients1
In a multivariate logistic regression analysis, the type of AMI was classified based on electrocardiography findings (odds ratio 5.18, 95% confidence interval: 1.69-15.91, P=0.004) and was independently associated with a long prehospital delay time, indicating that patients with ST segment elevation MI would seek early medical care. (who.int)
Hours2
Prehospital delay time ranged from 15 minutes to 10 days, with a median of 2 hours (interquartile range: 9.50). (who.int)
One hundred and twenty-six pa- within the first 2 hours after the onset tional variables (14,15,21) influenced tients were approached in the 2 months. (who.int)
Myocardial ischemia4
2) Cardiac death with symptoms suggestive of myocardial ischemia and presumed new ischemic EKG changes, or new LBBB, but death occurred before cardiac biomarkers were obtained or would be increased (type 3 MI). (aacc.org)
Indeed, serious episodes of cardiac ischemia (referred to herein as acute myocardial ischemia) typically result in either a subsequent AMI or VF, often within one to twenty-four four hours, sometimes within only a half an hour or less. (justia.com)
Accordingly, it would be highly desirable to provide a technique for reliably detecting acute myocardial ischemia so that the victim may be warned and medical attention sought. (justia.com)
Animal models of acute myocardial infarction include embolism of the coronary arteries, slow or rapid constriction of arteries, intimal sclerosis and narrowing by various techniques and, by dietary cholesterol, atherosclerosis leading to acute or subacute myocardial ischemia and infarction. (nih.gov)
Cardiac7
To evaluate the diffusion changes occurring in neonatal brain ischemia, we used a robust quantitative diffusion technique, line-scan diffusion imaging (LSDI), which has been shown previously to yield high-quality images in neonates, children, and adults without the use of head restraints, cardiac gating, or specialized hardware (13-17) . (ajnr.org)
No. 12/360,822, filed Jan. 27, 2009, titled "System and Method for Distinguishing Among Cardiac Ischemia, Hypoglycemia and Hyperglycemia Using an Implantable Medical Device," which is a division of U.S. patent application Ser. (justia.com)
No. 11/043,612, filed Jan. 25, 2005, titled "System and Method for Distinguishing Among Cardiac Ischemia, Hypoglycemia and Hyperglycemia Using an Implantable Medical Device," now U.S. Pat. (justia.com)
The invention generally relates to implantable medical devices such as pacemakers and implantable cardioverter/defibrillators (ICDs) and, in particular, to techniques for detecting cardiac ischemia, hypoglycemia and hyperglycemia using such devices. (justia.com)
Cardiac ischemia is a condition whereby heart tissue does not receive adequate amounts of oxygen and is usually caused by a blockage of an artery leading to heart tissue. (justia.com)
Often AMI is preceded by episodes of cardiac ischemia that are not sufficiently serious to cause actual permanent injury to the heart tissue. (justia.com)
Episodes of cardiac ischemia may also trigger certain types of arrhythmias that may prove fatal, particularly ventricular fibrillation (VF) wherein the ventricles of the heart beat chaotically, resulting in little or no net flow of blood from the heart to the brain and other organs. (justia.com)
Ischemic5
It is unlikely that canine strokes can be diagnosed within the same rapid time frame as human strokes, and therefore the opportunity for thrombolytic intervention in ischemic strokes is unattainable. (frontiersin.org)
Ischemic conditioning has been shown to ameliorate ischemia-reperfusion injury in small animal models. (wjgnet.com)
Ischemic preconditioning refers to that performed before the duration of ischemia of the target organ. (wjgnet.com)
Ischemic perconditioning is performed over the duration of ischemia of the target organ. (wjgnet.com)
Ischemic postconditioning applies brief episodes of ischemia at the onset of reperfusion following a prolonged ischemia. (wjgnet.com)
Infarction2
Recent studies have documented that diffusion-weighted imaging can show areas of infarction in perinatal brain ischemia before abnormalities are apparent on conventional MR images (7, 11, 12) . (ajnr.org)
Ischemia, with or without overt infarction, can disrupt this integration and alter rhythmic stimulation, causing bradycardia or asystole or, more commonly, aberrant foci of electrical activity and fibrillation. (nih.gov)
Coronary2
Since Ms. Minnesota presented with symptoms suggestive of ischemia, and had no previous medical history of stent placement, percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG), we'll use the diagnostic criteria for MI following the Universal Definition guideline (See Box, right). (aacc.org)
Since the major risk factors can be shown to enhance atherogenesis, it is usually implied that their association with heart attack is through the ischemia resulting from coronary atherosclerosis. (nih.gov)
Elevation3
In a multivariate logistic regression analysis, the type of AMI was classified based on electrocardiography findings (odds ratio 5.18, 95% confidence interval: 1.69-15.91, P=0.004) and was independently associated with a long prehospital delay time, indicating that patients with ST segment elevation MI would seek early medical care. (who.int)
Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. (justia.com)
By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia. (justia.com)
Symptoms2
Even with the widespread use of cTn assays worldwide, there remains some confusion among clinicians and laboratorians about the timing, frequency, and duration for measuring cTn after patients present with symptoms suggestive of ACS. (aacc.org)
of symptoms, and common compli- the symptom interpretation and care- Fourteen patients were excluded be- cations include recurrent ischaemia, seeking behaviour. (who.int)
Focal1
Differences in LSDI of symmetric/diffuse and focal/multifocal lesions may reflect differences in pathophysiology or timing of the injury. (ajnr.org)
Duration1
Despite equivalent glycemic control and shorter disease duration, the prevalence of albuminuria and less favorable cardiovascular risk factors were greater in the T2DM 15-30 cohort, even soon after diabetes onset. (diabetesjournals.org)
Differences3
This timing varies due to differences in analytical sensitivity of cTn assays, as well as differences in patients' physiology. (aacc.org)
and (3) differential contractility responses occurred preferentially at times when circadian rhythms also showed strain-specific differences. (biomedcentral.com)
These effects were not detected at 10:00 AM, i.e., at another time-point when circadian genes showed no strain-specific differences. (biomedcentral.com)
Circulation2
The process of necrosis is not immediate in response to ischemia, and once necrosis occurs, it usually takes 1-4 hours for cTn to increase in the circulation before becoming detectable in the blood. (aacc.org)
Hypoxia is not identical with ischemia since hypoxia can occur while the circulation maintains the local concentrations of other ions and substrates. (nih.gov)
Include1
The neurologic sequelae of perinatal brain ischemia include seizures, spasticity, behavioral disturbances, and developmental delay. (ajnr.org)
Effects2
Neuroprotective strategies, including the early use of pharmacologic agents and induced cerebral hypothermia, may help to decrease the deleterious effects of brain ischemia (3) . (ajnr.org)
All effects occurred preferentially at the same time of the day, but varied as a function of the genetic origin of MSY. (biomedcentral.com)
Brain2
mean age, 2.6 days) with perinatal brain ischemia were evaluated using LSDI (1520/62.5/1 [TR/TE/excitations]) ( b maximum = 750 s/mm 2 ) and T1- and T2-weighted spin-echo (conventional) MR imaging. (ajnr.org)
This suggests that diffusion imaging may be useful in the early detection of perinatal brain ischemia and likely is to become crucial in the effective and safe use of neuroprotective strategies (7, 11, 12) . (ajnr.org)
Sensitive1
Moreover, the mitochondria are sensitive to ischemia and rapidly lose their ability to synthesize adenosine triphosphate, and are unable to maintain the energy requirements of the cell to live and function. (nih.gov)
Techniques2
Additionally, investigation into new imaging techniques may increase the sensitivity and specificity of stroke diagnosis, as well as provide new ways to monitor strokes over time. (frontiersin.org)
Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. (justia.com)
Heart1
Hypertension increases the work and mass of the heart and creates a larger nutritional demand and relative ischemia. (nih.gov)
Change1
You can change these settings at any time, but that may impair functionality on our websites. (aacc.org)