These include the inability of fibrinolysis to restore normal TIMI flow grade 3 in 50-60% of patients, the occurrence of intracerebral hemorrhage in 0.9% of cases [3] and recurrent ischemia and reinfarction in 3-5% cases. (wikidoc.org)
of symptoms, and common compli- the symptom interpretation and care- Fourteen patients were excluded be- cations include recurrent ischaemia, seeking behaviour. (who.int)
Cerebral4
Graphical presentation of the various stages of cerebral ischemia stroke, i.e., acute phase, subacute phase, and chronic phase and their contributing factors. (hindawi.com)
Background and Objective: In hyperacute ischaemic stroke, T2 of cerebral water increases with time. (ox.ac.uk)
Our objective was to develop a user-unbiased method to measure the effect of cerebral ischaemia on T2 to study stroke onset time-dependency in human acute stroke lesions. (ox.ac.uk)
Methods: Six rats were subjected to permanent middle cerebral occlusion to induce focal ischaemia, and a consecutive cohort of acute stroke patients (n = 38) were recruited within 9 hours from symptom onset. (ox.ac.uk)
Acute stroke1
Therefore, an effective therapeutic strategy is required to prevent the onset of acute stroke and manage the chronic symptoms associated with neural ischemia, i.e., long-term neuroinflammation and localized necrosis [ 8 , 9 ]. (hindawi.com)
Lesion2
The subacute or secondary phase continues its deleterious events up to 6 months after the onset of the lesion. (hindawi.com)
Conclusions: Data from the spherical reference method showed that the median T2 increase in the ischaemic lesion is correlated with stroke onset time in a rat as well as in a human patient cohort, opening the possibility of using the approach as a timing tool in clinics. (ox.ac.uk)
Interpretation1
ABSTRACT This cross-sectional study aimed to assess interpretation of symptoms as a cause of delays in patients with acute myocardial infarction (AMI). (who.int)
Clinical4
However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
We did a retrospective analysis of the clinical profile of patients presenting with non-traumatic acute limb ischaemia to our department (a tertiary care centre in India) from January 1998 to December 2007. (who.int)
If there are clinical signs and symptoms of failure of the fibrinolytic agent to achieve reperfusion, then rescue PCI is performed to open the totally occluded artery. (wikidoc.org)
If there are clinical signs and symptoms of incomplete reperfusion, then adjunctive PCI is performed to further open a patent artery (one with TIMI grade 2 or 3 flow). (wikidoc.org)
Reperfusion1
The strategy differs from facilitated PCI, a strategy in which the intent is to administer a fibrinolytic agent, and routinely perform PCI in the majority of patients even in the presence of or irrespective of signs and symptoms of successful fibrinolytic reperfusion. (wikidoc.org)
Patients3
Most patients attributed AMI-related symptoms to a reason other than heart disease. (who.int)
In a multivariate logistic regression analysis, the type of AMI was classified based on electrocardiography findings (odds ratio 5.18, 95% confidence interval: 1.69-15.91, P=0.004) and was independently associated with a long prehospital delay time, indicating that patients with ST segment elevation MI would seek early medical care. (who.int)
For patients who present within 2 hours of symptom onset, a previous study demonstrated that there was no significant difference in the in-hospital mortality between fibrinolysis and PPCI treatment groups (5.1% vs. 7.8%, p=0.37) [1] . (wikidoc.org)
Hours4
Prehospital delay time ranged from 15 minutes to 10 days, with a median of 2 hours (interquartile range: 9.50). (who.int)
Results: ΔT2 increases linearly in rat brain ischaemia by 1.9 ± 0.8 ms/h during the first 6 hours, as determined by the spherical reference method. (ox.ac.uk)
Another study demonstrated a trend towards reduction in 30-day mortality with fibrinolysis when initiated within 2 hours of symptom onset compared to PPCI (2.2% vs. 5.7%, P=0.058) [2] . (wikidoc.org)
One hundred and twenty-six pa- within the first 2 hours after the onset tional variables (14,15,21) influenced tients were approached in the 2 months. (who.int)
Dose2
The demography, risk factors, time taken to present to the emergency from the onset of symptoms, time taken to administer the first dose of heparin upon arrival to the emergency, primary interventions and outcomes in terms of amputation rates and in-hospital mortality were studied. (who.int)
The recommended dose is 100 mg ritonavir once or two times per day, depending on the concurrently used protease inhibitor. (who.int)
Include1
Symptoms include chest discomfort with or without dyspnea, nausea, and/or diaphoresis. (msdmanuals.com)
Medical1
Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)