AggregationRBCsOsmoticNeutrophil adhesionMalaria parasiteFibrinogenBiconcaveHematocritBloodShearOxidativeParametersMembraneIntracellularSignificantlyVascularPentoxifyllineLipidAntioxidant effectsPassagePlasmaOxygenEffectsDiseaseEnzymesCellsIncidenceEffectPropertiesResultsHighIntakeDependentAntioxidantsStudyFlowAnalysisNext time

Aggregation10

• The hemorheological parameters, erythrocyte aggregation and deformability are determined in jaundice patients and are compared with that of healthy subjects. (iospress.com)
• The analysed data is represented by aggregation parameters-aggregate size index, aggregate sedimentation time index, total number of fluctuations, time required for completion of process, effective number of cells and effective cellular sedimentation duration. (iospress.com)
• The observations show that the aggregation process in jaundice starts earlier, form compact structures which move faster initially and thus reducing the effective number of cells in the observation volume at all time intervals compared to that of normal suspensions. (iospress.com)
• Surface tension driven flow of blood in a rectangular microfluidic channel: effect of erythrocyte aggregation. (cut.ac.cy)
• Effects of erythrocyte aggregation, haematocrit and deformability in the flow characteristics of blood, flowing in a TiO2 coated microfluidic channel. (cut.ac.cy)
• Erythrocyte aggregation: basic aspects and clinical importance. (hemorheology.com)
• As a first step, we correlated a number of deformability and aggregation parameters in red blood cells from healthy donors, which we obtained in the course of our studies on red blood cell homeostasis in health and disease. (frontiersin.org)
• The observations suggest that deformability and aggregation share at least one common, membrane-related molecular mechanism. (frontiersin.org)
• Together with data obtained after treatment with various agents known to affect membrane organization in vitro , our findings suggest that a phosphorylation-controlled interaction between the cytoskeleton and the integral membrane protein band 3 is part of the membrane-centered mechanism that plays a role in deformability as well as aggregation. (frontiersin.org)
• Tissue oxygenation depends on hemoglobin as much as on red blood cell (RBC) characteristics such as metabolism, communication with the immune system, deformability and aggregation behavior. (frontiersin.org)

RBCs7

• To study the microrheological characteristics of RBCs during erythrocyte senescence in vivo, an anemia model of rabbit induced by phenylhydrazine injection was developed. (semcs.net)
• We tested the deformability of RBCs using a high-throughput microfluidic device which mimics blood flow through microcapillaries. (cfidsresearch.com)
• Membrane lipids of RBCs are believed to be the foundation of these cells' exquisite stability and deformability [ 21 ]. (biomedcentral.com)
• Anemia is accompanied by a reduced number of RBCs RBCs Erythrocytes, or red blood cells (RBCs), are the most abundant cells in the blood. (lecturio.com)
• Subtypes are classified by the size of RBCs RBCs Erythrocytes, or red blood cells (RBCs), are the most abundant cells in the blood. (lecturio.com)
• Red blood cells (RBCs) deformability can be defined as the ability of the cells to deform when subjected to certain flow conditions. (webmedcentral.com)
• Hence, the main objective of the present paper is to measure RBCs deformability index (DI) in a hyperbolic microchannel and examine the effect of both diamide and glutaraldehyde on the cell deformation of human and ovine RBC. (webmedcentral.com)

Osmotic5

• The effects of eleven flavonoids on lipid peroxidation, protein degradation, deformability and osmotic fragility of human erythrocytes exposed in vitro to 10 mM H 2 O 2 for 60 min at 37˚C have been studied. (scirp.org)
• Quercetin and 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside significantly protected erythrocytes against loss of deformability and increased osmotic fragility, indicating that the loss of erythrocyte deformability and the increase in osmotic fragility of erythrocytes exposed to H 2 O 2 are related to protein degradation rather than to lipid peroxidation. (scirp.org)
• In vitro exposure of erythrocytes to oxygen radical generating systems (such as H 2 O 2 , ascorbate/Fe 3+ , cumene hydroperoxide, tert-butyl hydroperoxide, etc.) was shown to induce lipid peroxidation, protein degradation, loss of deformability, an increase in osmotic fragility, membrane lipid bilayer perturbation, inhibition of enzymes and hemolysis [5-12]. (scirp.org)
• Erythrocytes have intracellular hemoglobin, 2-3,diphosphoglycerate (2,3-DPG), and ATP, which all exert osmotic pressure across the semipermeable cell membrane. (medscape.com)
• The resulting hydrocytosis leads to increased osmotic fragility and decreased deformability, with consequent hemolysis. (medscape.com)

Neutrophil adhesion1

• Pentoxifylline has been shown to increase leukocyte deformability and to inhibit neutrophil adhesion and activation. (drugs.com)

Malaria parasite1

• Her research is focused on understanding how host factors from the human erythrocyte influence the biology and pathogenesis of the malaria parasite Plasmodium falciparum. (stanford.edu)

Fibrinogen1

• Blood coagulation functions were evaluated according to activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time, and fibrinogen preoperatively and on postoperative days 1, 3, 7, and 14. (biomedcentral.com)

Biconcave1

• The shape of erythrocytes change from biconcave discoid to an ellipsoid due shear flow in microcapillaries that provides a larger specific surface area-to-volume ratio for optimal microvascular perfusion and tissue oxygenation establishing the importance not only of total hematocrit but also of the capacity for large deformations in physiology. (cfidsresearch.com)

Hematocrit1

• The erythrocyte deformability is determined by measurement of passage time (reciprocal of deformability) of erythrocyte suspension in phosphate buffered saline at hematocrit 6% through cellulose … membranes. (iospress.com)

Blood13

• We use continuous wavelet analysis (WA) of Laser Doppler Flux (LDF) time series measured in basal cell carcinomas (BCC) and plaque psoriasis (PP) in order to investigate the rhythmical behavior of blood flow in tumor or inflammatory associated neoangiogenesis. (iospress.com)
• Pentoxifylline administration has been shown to produce dose-related hemorrheologic effects, lowering blood viscosity, and improving erythrocyte flexibility. (drugs.com)
• Following oral administration of aqueous solutions containing 100 to 400 mg of pentoxifylline, the pharmacokinetics of the parent compound and Metabolite l are dose-related and not proportional (non-linear), with half-life and area under the blood-level time curve (AUC) increasing with dose. (drugs.com)
• Cinnarizine manufactures erythrocyte deformability and decreases blood consistency in vitro. (medicinesmexico.com.mx)
• A computer algorithm can then analyze the size and stiffness of the blood cells in real-time. (elifesciences.org)
• Population genetic studies dating back to the mid-20th century first proposed that erythrocytes (red blood cells), the host cell for P. falciparum, have been under natural selection due to malaria. (stanford.edu)
• Here the lipid profiles of red blood cells infected with the five different sexual stages of Plasmodium falciparum were analysed by mass spectrometry and compared to those from uninfected and asexual trophozoite infected erythrocytes. (biomedcentral.com)
• Ebrahimi S, Bagchi P. A computational study of red blood cell deformability effect on hemodynamic alteration in capillary vessel networks. (hemorheology.com)
• The rheologic properties of blood - aggregability , deformability and elasticity - significantly impact vascular flow resistance, particularly in the microcirculation. (hemorheology.com)
• 1 There are a number of conditions associated with poor RBC deformability, such as poor circulatory health, diabetes, cardiovascular disease, sepsis, sickle cell disease, and various other blood disorders. (hemorheology.com)
• MIZAR uses syllectometry to provide a set of measurements conveying information about the deformability, elasticity and aggregability of the blood sample. (hemorheology.com)
• Rodrigues RO, Faustino V, Pinto E, Pinho D, Lima R. Red Blood Cells deformability index assessment in a hyperbolic microchannel: the diamide and glutaraldehyde effect. (webmedcentral.com)
• Notably, it has been recently shown that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is underlined by changes in the mechanical properties of blood cells, including decreased erythrocyte deformability and decreased lymphocyte and neutrophil stiffness as compared to blood cells from SARS-CoV-2-naïve individuals 6 . (jove.com)

Shear3

• We also observed reduced erythrocyte deformability at high shear rates. (annaly-nevrologii.com)
• Erythrocytes must be able to rapidly deform while also maintaining membrane stability when exposed to varying shear stresses. (hemorheology.com)
• The sample is exposed to light while the shear stress is removed, and light transmission through the sample is monitored over time as the cells react to the removal of the shear stress and interact with each other. (hemorheology.com)

Oxidative6

• The other flavonoids (chrysin, 2-carboxy ethyl dihydroxy flavone, apigenin, cirsimaritin, α-naphto flavone and flavanone) failed to protect erythrocytes against the observed oxidative damages. (scirp.org)
• Erythrocytes are susceptible to oxidative damage as a result of the high polyunsaturated fatty acid content of their membranes and the high cellular concentrations of oxygen and haemoglobin [1]. (scirp.org)
• In healthy erythrocytes, significant oxidative damage is prevented by a very efficient antioxidant system, consisting of a number of antioxidant compounds and enzymes [2]. (scirp.org)
• However, when free radicals overwhelm the capacity of antioxidant system in the erythrocyte, oxidative damages may occur endangering the integrity of the erythrocytes [3,4]. (scirp.org)
• Erythrocytes are potent scavengers of oxidative stress, and their shape changes appreciably in response to oxidative stress and certain inflammatory conditions including obesity and diabetes. (cfidsresearch.com)
• 2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)

Parameters2

• Over 3 early magnetic resonance imagings, the same parameters were assessed in 2 subgroups, the only 2 that had sufficient patients continuing on 1 regimen and for a significant period of time, 1 on deferrioxamine (low iron load patients nâ =â 41, Group A) and 1 on deferoxamine-deferiprone (iron overloaded nâ =â 60, Group B). Finally, 28 deaths and causes were compared to those of an earlier period. (bvsalud.org)
• We recorded the movement of the cells at high speed (4000 fps), followed by image analysis to assess the following parameters: entry time (time required by the cells to completely enter the test channels), average transit velocity (velocity of the cells inside the test channels) and elongation index (ratio of the major diameter before and after deformation in the test channel). (cfidsresearch.com)

Membrane2

• Defects in such disparate systems (ie, basal ganglia and erythrocytes) have led to the suggestion that a common neurohematological membrane defect is involved. (medscape.com)
• Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)

Intracellular1

• Acute exposure causes marked depletion of antioxidants in plasma 13 , 14 , intracellular GSH in erythrocytes 15 and GSH in ELF 10 , 12 . (ersjournals.com)

Significantly2

• quercetin, 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside and 3-hydroxy flavone significantly protected erythrocytes against protein degradation. (scirp.org)
• Before bedtime and can was a significantly greater reduction in energy intake in the oxymetholone-treated patients compared period of time to accomplish a specific goal, but bodybuilders may use steroids for long periods of time. (afip.org)

Vascular1

• The complex retains and slows down the elimination of proteolytic enzymes of the drug from the body, increases the time of their circulation in the vascular bed and, accordingly, the therapeutic effect. (pillbuys.com)

Pentoxifylline1

• The major metabolites are Metabolite l (1-[5-hydroxyhexyl]-3,7-dimethylxanthine) and Metabolite V (1-[3-carboxypropyl]-3,7-dimethylxanthine), and plasma levels of these metabolites are 5 and 8 times greater, respectively, than pentoxifylline. (drugs.com)

Lipid1

• The lipid profiles of infected erythrocytes are characteristic for the particular parasite life cycle and maturity stages of gametocytes. (biomedcentral.com)

Antioxidant effects1

• These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats. (scialert.net)

Passage2

• Deformability represents intrinsic property of erythrocytes to undergo deformation that is crucial for their passage through the narrow capillaries. (acva.sk)
• Deformability is a critical determinant of RBC function, because of the extensive change in cell shape required for efficient passage through the capillaries and the spleen. (frontiersin.org)

Plasma1

• After administration of the 400 mg extended-release TRENTAL tablet, plasma levels of the parent compound and its metabolites reach their maximum within 2 to 4 hours and remain constant over an extended period of time. (drugs.com)

Oxygen4

• Anemia is a condition in which individuals have low Hb Hb The oxygen-carrying proteins of erythrocytes. (lecturio.com)
• Management is aimed at improving Hb Hb The oxygen-carrying proteins of erythrocytes. (lecturio.com)
• Anemia is a quantitative deficiency of Hb Hb The oxygen-carrying proteins of erythrocytes. (lecturio.com)
• Anemia is noted when Hb Hb The oxygen-carrying proteins of erythrocytes. (lecturio.com)

Effects5

• These effects are dependent on the time course of exposure to tobacco smoke. (ersjournals.com)
• Comentarios desactivados en Effects of a competitive wrestling season on body composition, endocrine markers, and anaerobic exercise performance in NCAA collegiate wrestlers. (ulpgc.es)
• Comentarios desactivados en Effects of carbohydrate-hydration strategies on glucose metabolism, sprint performance and hydration during a soccer match simulation in recreational players. (ulpgc.es)
• Adult: PO Extended release 400 mg 3 times/day (normally for at least 8 wk), may reduce to 400 mg twice daily if adverse effects occur. (medicscientist.com)
• l Trilinolein, isolated from the traditional Chinese herb Sanchi (Panax notoginseng), has been shown to have various beneficial effects including reducing thrombogenicity, erythrocyte deformability and arrhythmias. (bfsumastore.com)

Disease2

• Although each test helps to narrow down the final diagnosis they become increasingly expensive and time-consuming to perform, and rapid action is often important when treating a disease. (elifesciences.org)
• Prevalence Prevalence The total number of cases of a given disease in a specified population at a designated time. (lecturio.com)

Enzymes1

• At the same time, proteolytic enzymes stimulate the healing and repair processes, reduce the risk of thromboembolic complications during prolonged immobilization, and prevent the development of trophic disorders and purulent complications. (pillbuys.com)

Cells3

• We measure hundreds of cells from each patient, so, because of this, even though the number of patients is low, we get a very statistically significant distinction between patient and healthy cells' deformability. (cfidsresearch.com)
• Although the notion that malaria has helped shape the human genome is well- accepted, the lack of a nucleus in human erythrocytes has hindered our ability to study genetic interactions between these unusual host cells and P. falciparum parasites. (stanford.edu)
• Recently, we developed a hematopoietic stem cell-based approach to tackle this issue, in which we can genetically alter nucleated hematopoietic precursor cells and differentiate them ex-vivo to mature erythrocytes that can be infected by P. falciparum. (stanford.edu)

Incidence1

• It is differentiated from incidence, which refers to the number of new cases in the population at a given time. (lecturio.com)

Effect3

• With immediate effect, and kidney problems or failure, and damage to the reproductive system interestingly, erythrocyte deformability was. (afip.org)
• Comentarios desactivados en Effect of exercise-induced dehydration on endurance performance: evaluating the impact of exercise protocols on outcomes using a meta-analytic procedure. (ulpgc.es)
• Evaluation of erythrocyte deformability in subjects with sickle cell trait during a soccer game: effect of hydration ad libitum. (ulpgc.es)

Properties2

• For samples of known optical properties, Fraunhofer theory should only be applied for particles of an expected diameter at least 10 times larger than the light source's wavelength, and/or to opaque particles. (wikipedia.org)
• Therefore, the pathological changes in elastic properties of the erythrocyte membranes in stroke are not corrected by ongoing standard therapy. (annaly-nevrologii.com)

Results2

• When erythrocytes are cooled to room temperature or lower (eg, after phlebotomy), the net K + leak is greater than expected and results in factitious hyperkalemia. (medscape.com)
• Monitoring the light transmission results in a time-dependent light intensity plot called a syllectogram . (hemorheology.com)

High1

• At present time, the experts focus mostly on excessive calorie intake, due to high obesity prevalence in children. (acva.sk)

Intake1

• Timing of nutrient intake is as important as composition. (ulpgc.es)

Dependent1

• The time dependent behaviour of the relevant data are further analyzed to produce relevant indices. (cut.ac.cy)

Antioxidants1

• The increased levels of oxidants and decreased levels of enzymatic, nonenzymatic antioxidants, glycoproteins and ATPases were observed in erythrocytes of aged rats. (scialert.net)

Study1

• This study compared erythrocyte changes between a group of subjects with sickle cell trait (SCT) and controls (subjects without hemoglobinopathy) during a soccer game in two conditions: with and without hydration. (ulpgc.es)

Flow1

• This particle size analysis process does not depend on volumetric flow rate, the amount of particles that passes through a surface over time. (wikipedia.org)

Analysis1

• Wavelet analysis of laser Doppler flux time series of tumor and inflammatory associated neoangiogenesis. (iospress.com)

Next time2

• If you log out, you will be required to enter your username and password the next time you visit. (medscape.com)
• Save my name, email, and website in this browser for the next time I comment. (medicscientist.com)