Filter...

AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science

Select a category...

Tight JunctionsNephronsOccludinTight Junction ProteinsZonula Occludens-1 ProteinIntercellular JunctionsClaudinsClaudin-1Gap JunctionsAdherens JunctionsZonula Occludens-2 ProteinMembrane ProteinsClaudin-3Claudin-4Claudin-5Freeze FracturingEpithelial CellsElectric ImpedancePermeabilityNeuromuscular JunctionKidney Tubules, DistalJunctional Adhesion MoleculesMARVEL Domain Containing 2 ProteinCell Membrane PermeabilityPhosphoproteinsCaco-2 CellsZonula Occludens ProteinsKidneyDogsEpitheliumKidney TubulesCadherinsInulinLoop of HenleCell PolarityMicroscopy, ElectronConnexinsBlood-Brain BarrierBlood-Testis BarrierKidney Tubules, ProximalKidney Tubules, CollectingCell LineConnexin 43Claudin-2Intestinal MucosaKidney GlomerulusMannitolCell CommunicationEsophagogastric JunctionMicroscopy, FluorescenceBlood-Retinal BarrierUreterCells, CulturedCell Adhesion MoleculesMicroscopy, ConfocalFluorescent Antibody TechniqueAbsorptionImmunohistochemistryMolecular Sequence DataActinsSertoli CellsKidney MedullaKidney CortexSodiumDesmosomesHolliday Junction ResolvasesRats, Sprague-DawleyLanthanumCell MembraneModels, Biologicalalpha CateninGlomerular Filtration RateRNA, MessengerNucleoside-Phosphate KinaseFerrocyanidesCell AdhesionPuncturesSignal TransductionMadin Darby Canine Kidney CellsCapillary PermeabilityBase Sequencebeta CateninCytoskeletal ProteinsBlotting, WesternMicroscopy, ImmunoelectronBiological TransportDesmoplakinsMyosin-Light-Chain KinaseOrganogenesisImmunoblottingProtein TransportCytoskeletonEnterocytesAmino Acid SequenceSodium-Potassium-Exchanging ATPaseCalciumEndothelial CellsMice, Inbred C57BLSeminiferous EpitheliumMicroscopy, Electron, Transmission

Approximately one million nephronsPortion of the nephronMetanephric nephronEpithelial cellsCollecting ductKidneyAdherensClaudinRenalClaudinsProteinCardiacFunctionalFiltrationCell-cellPartsActsOrganoidsProgenitor cellsZonula adherensReabsorptionProgenitorsEpitheliumProximalCortexKidneysSodium transportMembraneCapillariesFunctional unitStrandsPathwaysAdherens junctionTubularParacellularBowman'sOxidativeStructuresMyosinStructuralGlomerularTissueHumanMillionTransportPerformCellsFormationFunctions

Approximately one million nephrons2

• The human kidney contains approximately one million nephrons, each composed of at least 20 different cell types. (j-organoid.org)
• There are approximately one million nephrons in the kidneys of the adult human. (drprincetta.com)

Portion of the nephron2

• In the kidney, the first portion of the nephron, called the proximal tubule (PT), performs the majority of solute reabsorption including about two-thirds of calcium. (ku.edu)
• The S3 segment of the proximal tubule, which maintains the delicate balance between high O 2 demand and low basal O 2 tension in the corticomedullary region, is the portion of the nephron most vulnerable to ischemia (Parker et al. (cellphysiolbiochem.com)

Metanephric nephron2

• These renal vesicles connect the collecting duct and ureter, developing into metanephric nephron progenitors ( Fig. 1 ) [ 8 , 9 ]. (j-organoid.org)
• The interstitial stroma, another subcompartment of the metanephric nephron, is characterized by the expression of the transcription factor forkhead box D1 ( Foxd1 ). (j-organoid.org)

Epithelial cells1

• Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. (planteome.org)

Collecting duct1

• The primary manifestations of ADPKD come in the kidney, with the forming of several epithelial-lined cysts that develop through the entire nephron and mainly in collecting duct cells. (biotech2012.org)

Kidney5

• Excessive activation of the vasopressin type 2 (V2) receptor in the kidney leads to glomerular hyperfiltration and nephron loss, whereas stimulation of vasopressin V1a or V1b receptors in the liver, pancreas, and adrenal glands promotes catabolic metabolism for energy mobilization, enhancing glucose production and aggravating DKD. (bvsalud.org)
• In contrast to earlier models that featured nephron-like structures, these advances have improved the differentiation efficiency and similarity to the human kidney. (j-organoid.org)
• Presently, kidney organoids contain not only nephrons and ureteric buds but also stromal cells. (j-organoid.org)
• One functional component of the kidney, the nephron, carries out tasks such as filtration and reabsorption. (j-organoid.org)
• The nephron acts as the functional unit of the kidney. (vedantu.com)

Adherens1

• Adherens junctions (AJs) allow cell contact to inhibit epithelial migration yet also permit epithelia to move as coherent sheets. (ibecbarcelona.eu)

Claudin3

• First, I examined the patterns of claudin expression in the proximal nephron and found that claudins-2 and -10a are expressed throughout the PT, in both convoluted and straight segments. (ku.edu)
• In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. (thermofisher.com)
• as well as the tight junction protein claudin-1 and occludin. (biotech2012.org)

Renal3

• Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. (mdpi.com)
• The renal blood flow is under tight regulation to achieve proper filtration and excretion of the waste. (vedantu.com)
• To understand the peculiarities of renal circulation it is important to understand the basic anatomy of the nephron. (vedantu.com)

Claudins1

• Claudins are a group of transmembrane tight junction (TJ) proteins that are vital to the regulation of paracellular transport. (ku.edu)

Protein1

• ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)

Cardiac1

• ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)

Functional1

• The nephron can be defined as the basic functional unit. (vedantu.com)

Filtration1

• Nephron receives the incoming blood, performs its filtration, and then sends back the purified blood. (vedantu.com)

Cell-cell1

• ZO-1 may be involved in signal transduction at cell-cell junctions. (thermofisher.com)

Parts1

• The nephron has the following vital parts: Bowman's capsule, tubule-like region, the loop of Henle. (vedantu.com)

Acts1

• more specifically a carbonic anhydrase (CA) inhibitor, acetazolamide predominantly acts within the proximal convoluted tubule of the nephron (De Marchi and Cecchin 1990). (ukessays.com)

Organoids4

• In both two- and three-dimensional culture, NPCs form kidney organoids containing epithelial nephron-like structures expressing markers of podocytes, proximal tubules, loops of Henle and distal tubules in an organized, continuous arrangement that resembles the nephron in vivo. (nih.gov)
• GSK3β inhibition differentiates spheroids into segmented, nephron-like kidney organoids containing cell populations with characteristics of proximal tubules, podocytes and endothelium. (nature.com)
• Presently, kidney organoids contain not only nephrons and ureteric buds but also stromal cells. (j-organoid.org)
• These organoids have tight junctions and a structured pseudostratified epithelium, strikingly similar to in vivo airways. (newcellsbiotech.co.uk)

Progenitor cells3

• We report an efficient, chemically defined protocol for differentiating hPSCs into multipotent nephron progenitor cells (NPCs) that can form nephron-like structures. (nih.gov)
• Branching ureteric tips are surrounded by nephron progenitor cells on the peripheral face and nascent nephrons are developing on the central face. (silverchair.com)
• WT1 acts to maintain nephron progenitor cells throughout kidney development, in part by activating Gas1 transcription. (silverchair.com)

Zonula adherens1

• These consist of a tight junction (zonula occludens) and an intermediate junction (zonula adherens). (pediagenosis.com)

Reabsorption4

• One functional component of the kidney, the nephron, carries out tasks such as filtration and reabsorption. (j-organoid.org)
• The proximal convoluted tubule (PCT) is the major site of solute reabsorption in the nephron. (pediagenosis.com)
• Tight junctions play a key role in mediating paracellular ion reabsorption in the kidney. (nih.gov)
• In the renal collecting duct, which is a typical absorptive tight epithelium, coordination between transcellular sodium reabsorption and paracellular permeability may prevent the backflow of reabsorbed sodium to the tubular lumen along a steep electrochemical gradient. (nih.gov)

Progenitors2

• Although classically thought to restrain proliferation, p53 promotes self-renewal in nephron progenitors of the mouse kidney and also regulates their metabolic profile. (silverchair.com)
• Wilms' tumor suppressor 1 (WT1) controls nephron numbers by regulating fibroblast growth factor signaling in nephron progenitors via Gas1 , a novel WT1 target gene. (silverchair.com)

Epithelium3

• From capillaries to alveoli in the lungs, and nephrons in the kidneys, simple squamous epithelium can be found in a variety of places. (wisewaystostudy.com)
• The epithelium of proximal convoluted tubule (PCT) of nephron in the kidney has microvilli. (biologyease.com)
• Three types of cell Junction are found in the epithelium and other issues. (biologyease.com)

Proximal1

• Dominant features of a nephron in the cortex of rat kidney showing f-actin localization in the glomerulus, a blood vessel, and proximal tubules. (ucsd.edu)

Cortex1

• There are two types of nephrons, according to their relative position in the cortex. (golifescience.com)

Kidneys2

• Kidneys are made up of many functional microscopic units called "nephrons. (golifescience.com)
• This is commonly found in ducts of glands and tubular parts of nephrons in kidneys and its main functions are secretion and absorption. (biologyease.com)

Sodium transport1

• To investigate whether transcellular sodium transport controls tight-junction composition and paracellular permeability via modulating expression of the transmembrane protein claudin-8, we used cultured mouse cortical collecting duct cells to see how overexpression or silencing of epithelial sodium channel (ENaC) subunits and claudin-8 affect paracellular permeability. (nih.gov)

Membrane1

• Tight junctions are formed by membrane proteins to ensure that ions, gases, small molecules, and water are transported only through the cell and not through the interstitial spaces. (wisewaystostudy.com)

Capillaries2

• At the blind end of the nephron, the capillaries are supplied by an "afferent arteriole" and drained by a smaller "efferent arteriole. (golifescience.com)
• Each nephron begins with a tuft of 6-8 renal blood capillaries that are probed into the end of a tubule. (golifescience.com)

Functional unit1

• A nephron is the functional unit of the kidney. (golifescience.com)

Strands1

• Nagarajan SK , Klein S , Fadakar BS , Piontek J (2023) Claudin-10b cation channels in tight junction strands: Octameric-interlocked pore barrels constitute paracellular channels with low water permeability. (charite.de)

Pathways1

• 2007 . Maternal nutrition, low nephron number, and hypertension in later life: pathways of nutritional programming. (nih.gov)

Adherens junction1

• Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. (thermofisher.cn)

Tubular1

• Although tight junctions are critical for maintaining the barrier between the tubular lumen and interstitium, a small number of discontinuities permits some molecules to be reabsorbed through a paracellular route. (pediagenosis.com)

Paracellular1

• The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). (nih.gov)

Bowman's1

• It is the Bowman's capsule at the end of a nephron that interacts closely with a glomerulus. (wisewaystostudy.com)

Oxidative1

• The distribution of oxidative and hydrolytic enzyme activities along the nephron of Necturus maculosus Rafinesque was studied histochemically. (rupress.org)

Structures1

• In contrast to earlier models that featured nephron-like structures, these advances have improved the differentiation efficiency and similarity to the human kidney. (j-organoid.org)

Myosin1

• In the neuroepithelium, apical cofilin 1 activates actomyosin contractility to promote neural tube closure, while basally it prevents ectopic myosin activation and tight junction formation. (silverchair.com)

Structural1

• Transmission electron microscopy showed extensive mitochondrial structural abnormalities in whole nephron. (bvsalud.org)

Glomerular1

• Through a series of secretions, absorptions and reabsorptions, urine is eventually formed and expelled from the body from the glomerular filtrate at the start of the nephron. (wisewaystostudy.com)

Tissue1

• Tight Junctions help to stop substances from leaking across a tissue. (biologyease.com)

Human3

• They perform excretory and homeostatic functions, and there are 1.3 million nephrons in each human kidney. (golifescience.com)
• There are 1.3 million nephrons in each human kidney. (golifescience.com)
• The human kidney contains approximately one million nephrons, each composed of at least 20 different cell types. (j-organoid.org)

Million1

• There are one million functional subunits called nephrons in the kidney. (wisewaystostudy.com)

Transport1

• Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). (nih.gov)

Perform1

• Adhering Junctions perform cementing to keep neighbouring cells together. (biologyease.com)

Cells2

• These are all made up of a single layer of cells that interdigitate with one another and are united by apical tight junctions. (golifescience.com)
• Gap junctions facilitate the cells to communicate with each other by connecting the cytoplasm of adjoining cells, for rapid transfer of ions, small molecules and sometimes big molecules. (biologyease.com)

Formation1

• These changes include formation of interdigitating foot processes, replacement of tight junctions with slit diaphragms, and the concomitant opening of intercellular urinary spaces. (embl-heidelberg.de)

Functions1

• Nephron: What is the Structure and its Functions of Nephron? (golifescience.com)