Thymus donor bone marrow transplantation. Medical search. Frequent questions

Another CFU, the colony-forming unit-spleen (CFU-S), was the basis of an in vivo clonal colony formation, which depends on the ability of infused bone marrow cells to give rise to clones of maturing hematopoietic cells in the spleens of irradiated mice after 8 to 12 days. (wikipedia.org)
A series of sublethal doses of radiation is directed at the patient's lymphoid tissue (spleen, thymus, and lymph nodes in the neck, chest, and abdomen), with bone marrow and other vital organs shielded from the exposure [ 387 ]. (nanomedicine.com)
Y-chromosome-specific sequence (Sry) of male SD rats could be detected in the bone marrow, spleen and thymus of female recipients at 15 d after bone marrow infusion . (zju.edu.cn)
MSCs were initially isolated from bone marrow but are now known to exist in a wide range of tissues in the human adult, including brain, thymus, lung, liver, spleen, kidney, and dental pulp [ 11 , 12 ]. (hindawi.com)
The lymph system includes organs such as the lymph nodes, spleen, and thymus, which fight infections and remove waste in the body. (vimfay.com)

GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
F(1 )transplantation models of acute and chronic GVHD, respectively, were studied. (ox.ac.uk)
In contrast, interleukin-4-driven chronic GVHD was not accompanied by a sustained thymic infiltration of donor T cells. (ox.ac.uk)
The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)

and Ly6d+ bone tissue marrow progenitors by intrathymic transplantation. (lavoixdesrroms.org)
Thymus function is usually considered to depend in a steady way to obtain T cell progenitors in the bone tissue marrow. (biongenex.com)
The thymus is definitely then colonized by developmentally caught T cell progenitors from your sponsor SCID or bone marrow and additional T cell production halts (Frey et al. (biongenex.com)
1996 It has consequently been assumed the thymus lacks self-renewing progenitors or long-term resident thymocytes and that thymus function is absolutely dependent on uninterrupted import of progenitors from your bone marrow. (biongenex.com)
2009 These mice have no endogenous T cell development because Tegafur of the lack of Kit and IL-7R function in their bone marrow progenitors. (biongenex.com)
To address the fate of a thymus in the complete absence of developmentally proficient bone marrow progenitors we have transplanted normal wild-type thymus into mice. (biongenex.com)
Our findings were subsequently tested by in vitro experiments, where putative early and later-stage DN1 progenitors from the thymus were purified and their pro- gression into DN2 was measured. (lu.se)
thymus from marrow-derived progenitors circulating in the blood. (lu.se)
In detail, thymus-settling progenitors enter the thymus and generate early T-cell progeni- tors (ETP/DN1 stage), which in turn give rise to DN2, DN3 and DN4 cells. (lu.se)

Transplantation is the transfer of living cells, tissues, or organs from one person, the donor, to another, the recipient (e.g., a blood transfusion), or from one part of the body to another (e.g., skin grafts) with the goal of restoring a missing function [ 361 ]. (nanomedicine.com)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
Within this study employing this stress as recipients for wild-type thymus grafts we observed thymus-autonomous T cell advancement lasting almost a year. (biongenex.com)
A varied T cell antigen receptor repertoire in progenitor-deprived thymus grafts implied that many thymocytes were capable of self-renewal. (biongenex.com)
The thymus grafts did not export HSC that could engraft in the bone marrow actually in probably the most HSC-deprived recipients. (biongenex.com)
2006 or HSC export from the thymus and to analyze the long-term fate of thymus grafts in the absence of progenitor competition from the bone Prp2 marrow we transplanted thymus lobes from newborn wild-type mice into adult recipients (see Materials and methods for donor and host MHC and congenic markers). (biongenex.com)
1996 Thus in hosts thymocyte development of thymus-resident cells was fully exhausted by this time and ～95% cells in the grafts were host-derived DN thymocytes blocked at the DN 3 stage. (biongenex.com)
In contrast even at later times in mice Tegafur a large proportion of cells were of donor thymus origin and overall donor cell numbers although heterogeneous between grafts were on average several orders of magnitude higher in compared with hosts (Fig. 1 B). Figure 1. (biongenex.com)
T cell development in thymus grafts in the absence of donor HSC engraftment. (biongenex.com)
One thymus … The fact that T cell development in the thymus grafts appeared to be ongoing after >2 mo as further demonstrated below raised. (biongenex.com)

Corneal Transplantation Corneal transplantations are done for several reasons: To reconstruct the cornea (eg, replacing a perforated cornea) To relieve intractable pain (eg, severe foreign body sensation due to recurrent. (msdmanuals.com)

Graft-versus-host disease is a potentially serious complication in a recipient of an allograft (usually a haematopoietic stem cell transplant) that arises from the attack of recipient tissues (such as the skin, liver or gut) by donor-derived T cells. (nature.com)
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. (lookformedical.com)
Bone Marrow Transplant. (stembook.org)
Duke's pediatric blood and bone marrow transplant specialists are internationally renowned experts in the emerging field of regenerative medicine. (duke.edu)
Our experienced pediatric kidney transplant team performs successful transplants in children using kidneys from deceased and living donors and provides your child with innovative, personalized transplant care. (duke.edu)
Duke's pediatric blood and bone marrow transplant program is internationally recognized for its innovative use of stem cells to treat childhood leukemia, lymphoma, inherited primary immunodeficiency disease, inherited metabolic diseases, and sickle cell disease. (duke.edu)
One hundred kidney transplant recipients were evaluated on the first and fifth days after transplantation by Tc-99m mononuclear cell scintigraphy. (shengsci.com)
Calcitriol started in the donor, expands the population of CD4+CD25+ T cells in renal transplant recipients. (shengsci.com)

We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)
Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
Nitric oxide-dependent immunosuppressive function of thymus-derived mesenchymal stromal/stem cells. (stembook.org)
This interdisciplinary project targets the interactions between leukemic and stromal cells in the thymus by single-molecule tracking. (centuri-livingsystems.org)
Analyzing and destabilizing leukemic stem cell adhesion to bone-marrow stromal cells by single molecule tracking nanoscopy. (centuri-livingsystems.org)

SCID is considered a pediatric emergency because survival depends on expeditious stem cell reconstitution, usually by bone marrow transplantation (BMT). (medscape.com)
Reconstitution of the peripheral T-cell compartment is a critical aspect for the success of bone marrow transplantation and is also dependent on the reestablishment of normal thymic structure and function. (ox.ac.uk)
Given the potential importance of MAIT cells in control of microbial infections and protection of epithelial surfaces, we investigated MAIT cell reconstitution in 43 children who underwent hematopoietic stem cell transplantation (HSCT) after myeloablative conditioning for the treatment of malignant hematological disease. (cryostem.org)

Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)

In due course, the stem cells in the bone marrow reconstitute the peripheral lymphoid system but the newly formed T cells seem to accept the graft as self [ 403 ]. (nanomedicine.com)
The thymus is a small butterly-shaped lymphoid organ located in the upper chest. (smart-immune.com)
Although the process was most efficient in hosts recipient mice the thymus exports a single wave of thymus-derived T cells that seed the peripheral lymphoid organs. (biongenex.com)

This rare immune disorder is characterized by the lack of a thymus, the small gland near the heart that generates infection-fighting T cells. (duke.edu)
T lymphocytes are specialized white blood cells that develop in an infant's thymus gland and then move into the bloodstream where they support the work of other immune cells. (health-secrets.net)

Once the graft has escaped the initial acute phase rejection reactions, a cumulative unresponsiveness to the graft develops as the recipient is continually exposed to donor MHC, a stable state that sometimes depends on the development of antigen-specific T-suppressor cells [ 371 , 5349 - 5354 ]. (nanomedicine.com)
establish a convolutional neural network-based model to predict acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation. (nature.com)
Infusion of nonmyeloablative bone marrow alleviates acute rejection reaction in liver allotransplantation[J]. Journal of Zhejiang University Science B, 2005, 6(12): 1188-1194. (zju.edu.cn)

HSCT is the transplantation of stem cells, usually derived from the bone marrow, peripheral blood, or umbilical cord blood, to produce additional normal healthy blood cells, including T-cells. (smart-immune.com)
IL-2 and IFN-γ level in peripheral blood and donor liver were detected respectively by Enzyme-Linked Immuno-Sorbent Assay (ELISA) and Western blot. (zju.edu.cn)
2. Making informed decisions regarding appropriate triaging of patient related samples (peripheral blood films and bone marrow aspirates as well as all other tests performed at the hematology laboratory). (gov.om)
A pilot study of HSV-TK gene transfer into donor peripheral blood lymphocytes for controlled GVL after allo-BMT. (unisr.it)

Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
For example, mice genetically deficient for adaptive immunity displayed accelerated bone healing. (hindawi.com)

MDMs from healthy donors were infected with a R5-tropic or Transmitted/Founder (T/F) HIV strain. (bvsalud.org)
We will extend our measurements to the simultaneous tracking of TCR, MHCII, RANK and RANKL, and then to primary normal or leukemic T cells, from healthy donors or patients. (centuri-livingsystems.org)
We will also analyze the peptides presented by dendritic cells from healthy donors expressing T1D-associated HLA alleles pulsed with b-cells protein extracts and/or soluble autoantigens. (uab.cat)

Recruitment of semiallogeneic dendritic cells to the thymus during post-cyclosporine thymic regeneration. (zju.edu.cn)

It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)

What is hematopoietic stem cell transplantation (HSCT)? (smart-immune.com)
HSCT may be autologous (the patient's stem cells are used) or allogeneic (the stem cells come from a donor). (smart-immune.com)

Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)

In vertebrates, the vast majority of hematopoiesis occurs in the bone marrow and is derived from a limited number of hematopoietic stem cells that are multipotent and capable of extensive self-renewal. (wikipedia.org)
Hematopoietic stem cells are found in the bone marrow of adults, especially in the pelvis, femur, and sternum. (wikipedia.org)
The cells can be removed as liquid (to perform a smear to look at the cell morphology) or they can be removed via a core biopsy (to maintain the architecture or relationship of the cells to each other and to the bone). (wikipedia.org)
Thymuses had been depleted of Thy1.1+ host cells to staining preceding, and the total amount of recovered T cells (DN1, DN2, DN3, DN4, DP, and SP) per thymus is proven in the column. (lavoixdesrroms.org)
All the values are detailed as a share of donor cells. (lavoixdesrroms.org)
In the thymus, cells proven are pregated as donor, and B220?CD19?Compact disc11c?Macintosh1?Gr1? (lavoixdesrroms.org)
Beliefs of every thymus inhabitants are detailed as a share of the full total thymic donor cells (not really proven). (lavoixdesrroms.org)
Around 65% of donor cells produced from ALPs had been from the T-cell lineage (Fig. 3A), and in 10-fold better numbers compared to the T cells made by either MPPs or BLPs (Fig. 3B). (lavoixdesrroms.org)
On the other hand, BLPs, like pre-pro-B cells, created nearly B cells solely, comprising almost 90% of donor-derived cells (Fig. 3A), and in amounts much larger than ALPs (Fig. 3B), recommending that BLPs are nearly fully focused on the B-cell destiny even when positioned straight into a highly T-cell-inducing environment in vivo. (lavoixdesrroms.org)
2005), and in keeping with the reduced result of B cells through the thymus (Akashi et al. (lavoixdesrroms.org)
bone tissue marrow had been stained to examine adjustments in the proportions of MPP, ALP, BLP, and pre-pro-B cells. (lavoixdesrroms.org)
Several lines of evidence support the hypothesis that gonadal steroids exert effects on the development of B cells in bone marrow. (jci.org)
The thymus ensures that T-cells do not attack the self and can recognize more than 200 million potential foreign particles such as viruses, bacteria, fungi and malignant cells. (smart-immune.com)
T-cell therapies can be manufactured from different materials (mature T-cells, stem cells, possibly induced pluripotent stem cells) and from different sources (the patient or a donor). (smart-immune.com)
chimerism of donor cells was measured by PCR for a male-specific marker (Y-chromosome-specific sequence, Sry). (zju.edu.cn)
Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
For infants who don't have HLA-identical marrow donors, parental bone marrow that has been depleted of mature T cells can be used instead. (health-secrets.net)
Since children with SCID don't possess their own T cells - thus eliminating the possibility of a rejection reaction - they do not need to go through chemotherapy prior to bone marrow transplantation. (health-secrets.net)
Simultaneously, mature donor-derived T cells expanded in the confines of the allogeneic thymic microenvironment, leading to local inflammation. (ox.ac.uk)
Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)
Come CELL Restorative STRATEGIES Autologous Versus Allogeneic Cells Cell transplantation can use either autologous (cells are returned to the donor's body) or allogeneic (cells are taken from a human being donor and reinfused to a human being recipient) donor sources. (cancer8.info)
Xenotransplant refers to transplantation of cells produced from a different donor varieties and is definitely not utilized in human being diseases. (cancer8.info)
In the case of allogeneic transplantation, one of the major complications is definitely the immune system mediated response to the foreign cells. (cancer8.info)
Respect to the recognition of proteins by T cells, our approach, following our previous experience with T1D and other autoinmune diseases, is to find T cell ligands that are present in the periphery but are not found in the thymus. (uab.cat)
We are aiming at the ex vivo identification of peptides presented by MHC class I and class II molecules from pancreatic b cells and thymus from donors matching relevant MHC class I and II alleles. (uab.cat)

Nevertheless we discovered no proof for export of donor HSCs from thymus to bone tissue marrow. (biongenex.com)
HSCs are discovered in bone fragments marrow niche categories and in umbilical cable bloodstream (UCB) and can also end up being made from peripheral bloodstream after bone fragments marrow enjoyment with granulocyte nest stimulating aspect (G-CSF) [42, 43]. (cancer8.info)

Conclusion: Mild preconditioning nonmyeloablative donor specific bone marrow infusion can enhance chimerism formation in recipients, alleviate the rejection of liver allotransplantation and prolong survival of liver allotransplantation. (zju.edu.cn)
A) Newborn wild-type thymi were transplanted into recipients (= 57) and analyzed 9-11 wk later. (biongenex.com)
Treatment with a new class of drugs, called senolytics, in donors improved the physical fitness of the recipients, a new study has shown. (medicaldaily.com)

Section 8.5.2.1 ) are closely matched to those of the donor, transplanted organs are usually rejected (beginning within minutes or hours of surgery [ 1832 ]) unless the recipient's immune system is carefully controlled. (nanomedicine.com)
00:00:27.07 So, the field of transplantation is limited by drug treatment-related complications, 00:00:33.20 chronic rejection, and the availability of organs. (ibiology.org)
00:00:37.15 So, one solution that would overcome all of these problems would be xenotransplantation, 00:00:43.22 meaning transplantation of organs from another species, with induction of tolerance to avoid 00:00:51.11 the drug treatment-related complications and chronic rejection. (ibiology.org)

Definitive management - one that cures up to 95% of children affected by SCID (if the disease is diagnosed before the age of three months) - involves the use of bone marrow stem cell transplantation. (health-secrets.net)
Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. (kyoto-u.ac.jp)
A comparative study of mesenchymal stem cell transplantation and NTG-101 molecular therapy to treat degenerative disc disease. (kyoto-u.ac.jp)
Striking progress has been observed in the number of volunteer donors for hematopoietic stem cell transplantation in the last years in Brazil. (shengsci.com)

Objective: To study the effect and implication of nonmyeloablative donor specific bone marrow (DSBM) infusion on the immunoreaction of liver allotransplantation. (zju.edu.cn)
Methods: Orthotopic liver transplantation model was used in this study. (zju.edu.cn)
Immunological tolerance and liver transplantation. (zju.edu.cn)

Antigen sampling on the Peyer's patches in a murine small bowel transplantation model. (shengsci.com)

Bone marrow taken from an HLA-identical sibling restores immunity in nearly all SCID sufferers. (health-secrets.net)

MSCs are made from the bone fragments marrow, epidermis adipose tissues, umbilical cable bloodstream, and in highest focus from Wharton's jello. (cancer8.info)

The first hand transplantation was done in 1998. (msdmanuals.com)
By the end of 1998, the number of donors barely reached 4200 but it has grown progressively. (shengsci.com)

Duke Children's Hospital is the only U.S. medical center offering thymus transplantation to infants born with complete DiGeorge syndrome. (duke.edu)

A new suicide system based on gene transfer of FAS into donor lymphocytes for controlled GVL. (unisr.it)

Transplantation and Cellular Therapy. (elsevierpure.com)

00:01:46.28 Most of the field feels that pigs would be the most desirable organ source for human transplantation 00:01:55.23 for a number of reasons, which I'll come back to. (ibiology.org)
00:04:13.00 And so they're actually a good size for organ transplantation to human, 00:04:19.26 because they're closer to our size, rather than the thousand pounds that a regular pig can grow to. (ibiology.org)

These agents also damage all tissues (e.g., gut epithelium, bone marrow) where rapid cell division is occurring, creating other undesirable side effects, thus often may not be suitable for use in medical nanorobotics. (nanomedicine.com)
Androgens also exert effects on B cell development in bone marrow. (jci.org)
Smart Immune is the first company to develop thymus-empowered allogeneic T-cell therapies and advance them into clinical testing through its T-cell progenitor platform, ProTcell. (smart-immune.com)
ProTcell is Smart Immune's thymus-empowered T-cell therapy platform to fully and rapidly re-arm the immune system, aimed at enabling next-generation allogeneic T-cell therapies for all. (smart-immune.com)
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
However we noticed thymus-autonomous T cell development in the absence of progenitor replenishment from your bone marrow. (biongenex.com)
Here we characterize this previously unrecognized capacity of the thymus to sustain productive T cell development under conditions of bone marrow progenitor deprivation and show that normal thymocyte turnover is not only regulated by cell-intrinsic life span but also by competitive progenitor replacement. (biongenex.com)
RESULTS AND DISCUSSION Thymus autonomy under conditions of T cell progenitor deprivation To search for signs of T cell progenitor (Lambolez et al. (biongenex.com)
Loss of IL-7R function leads to the loss of an antiapoptotic signal, resulting in a loss of T-cell selection in the thymus. (medscape.com)

Insight into this paradigm can provide valuable clues in identifying cellular and noncellular targets that can potentially be modulated to enhance both natural bone healing and bone repair augmented by the exogenous addition of MSCs. (hindawi.com)

Is there a differential peptide repertoire presented by MHC-II molecules in the cortex and the medulla of the thymus? (uab.cat)
Immunoproteomic analysis of the peptide repertoire participating in positive and negative selection in the thymus upon tissue microdissection. (uab.cat)

The suggested mechanism for this phenomenon is the possible inability of the thymus to delete these abnormal clones due to compromise of both central and peripheral tolerance mechanisms [ 5 ]. (hindawi.com)

Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)

Similarly, a reduction in tacrolimus dose and dosing rate of recurrence from 2?mg twice daily to 0.5?mg every 7 days is expected to maintain Ctrough levels within the range observed before initiation of 3D treatment at 12 months after transplantation. (informationalwebs.com)
Another group of short-term CsA treatment preoperatively without bone marrow infusion was also set as control. (zju.edu.cn)

Anatomy30

Organisms15

Diseases61

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment74

Psychiatry and Psychology2

Phenomena and Processes39

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Named Groups4

Health Care14

Spleen5

GvHD4

Progenitors9

Grafts10

Corneal Transplantation1

Transplant8

Stromal8

Reconstitution3

Inbred strains1

Lymphoid3

Gland2

Acute3

Peripheral blood4

Mice2

Healthy donors3

Dendritic cells1

Tissue Transplantation1

HSCT2

Graft-versus-1

Cells26

HSCs2

Recipients3

Organs3

Stem cell4

Liver3

Murine1

SCID1

Umbilical1

19982

Infants1

Lymphocytes1

Cellular Therapy1

Organ2

Cell9

MSCs1

Repertoire2

Tolerance1

Rejection1

Treatment2