• Uses of thymine include cancer treatment where it serves as a target for actions of 5-fluorouracil (5-FU). (wikibooks.org)
  • Synthesis de novo , acquisition by salvage and interconversion of purines and pyrimidines represent the fundamental requirements for their eventual assembly into nucleic acids as nucleotides and the deployment of their derivatives in other biochemical pathways. (pubmedcentralcanada.ca)
  • In principle, the above nucleotides and/or their nucleoside and nucleobase precursors can be obtained in several ways: synthesis de novo , direct acquisition by salvage or by subsequent interconversions to yield the appropriate repertoire of purines and pyrimidine derivatives found in the nucleic acids and other important molecular species. (pubmedcentralcanada.ca)
  • A small number of drugs targeted to nucleotide metabolism, by virtue of their effect on folate biosynthesis and recycling, have been successfully used against apicomplexan parasites such as Plasmodium and Toxoplasma for many years, although resistance is now a major problem in the prevention and treatment of malaria. (pubmedcentralcanada.ca)
  • Low- and high-throughput technologies based on SNPs (Single nucleotide polymorphism) are a booming sector in the field of plant genotyping. (biomedcentral.com)
  • Indeed, as more and more diseases are discovered to be associated with changes at the genetic level, most notably single nucleotide polymorphisms (SNPs), the need for methods of both screening for SNPs or other mutations or genetic changes (by sequencing representative genomic samples) and scoring SNPs (or other mutations/changes) grows. (google.com)
  • The ability to determine DNA nucleotide sequences has become increasingly important as efforts have proceeded to determine the sequences of the large genomes of humans and other organisms. (google.com)
  • Replication of DNA and its transcription to the various RNA species necessitate a constant and substantial supply of the constituent nucleotides, a particularly demanding requirement in the case of rapidly dividing cells or pathogens, for example cancer cells or malaria parasites. (pubmedcentralcanada.ca)
  • As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. (wikipedia.org)
  • Results from pulse-chase experiments indicate that a rapid turnover of dTTP to thymidine may be involved in limiting the level of thymine nucleotides in the cell. (rupress.org)
  • 33, 34) suggesting transfer of thymine nucleotides from small thymus lymphocytes to precursor cells, may or may not be related to the apparent transfer of DNA label between thymic cells. (rupress.org)