• Thymine is a part of one of the most common mutations of DNA, which involves two adjacent thymines or cytosines. (wikibooks.org)
  • Ever since the first thymine-requiring (so-called thymineless) strain of Escherichia coli was isolated in 1947 (described in reference 94 ), thyA mutants have been employed to follow DNA synthesis in vivo ( 60 ). (asm.org)
  • Since thymine is a precursor of DNA only, radioactive isotope-labeled thymine and scintillation counters are used to track synthesis in bacteria and their viruses. (asm.org)
  • Thymine glycol (5,6-dihydroxy-5,6-dihydrothymine) is one of the principal DNA lesions that can be induced by oxidation and ionizing radiation. (wikipedia.org)
  • The rate of repair of thymine glycol damage in human fibroblasts was found to decrease with age. (wikipedia.org)
  • Brain samples from humans who died of stroke were found to be deficient in base excision repair of thymine glycol as well as other types of oxidative damages. (wikipedia.org)
  • In enzymology, a thymine dioxygenase (EC 1.14.11.6) is an enzyme that catalyzes the chemical reaction thymine + 2-oxoglutarate + O2 ⇌ {\displaystyle \rightleftharpoons } 5-hydroxymethyluracil + succinate + CO2 The 3 substrates of this enzyme are thymine, 2-oxoglutarate, and O2, whereas its 3 products are 5-hydroxymethyluracil, succinate, and CO2. (wikipedia.org)
  • The systematic name of this enzyme class is thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating). (wikipedia.org)
  • 2 ) presents an excellent account of the metabolic pathways involving thymine for both prokaryotes and eukaryotes (see the summary in Fig. 1 ). (asm.org)
  • Before the semiconservative nature of replication predicted by the double-helix model was demonstrated, running density gradients of DNA labeled with the heavy thymine analogue 5′-bromodeoxyuridine had been considered ( 43 ). (asm.org)
  • These were resolved by systematic investigations of pool sizes of thymine metabolites and of the rate of chromosome replication in relation to the external concentrations of thymine (for example, see reference 85 ). (asm.org)
  • Thymine limitation is used as a means to dissociate the rate of DNA replication from the culture growth rate, i.e., to change the relative schedule of the replication and division cycles. (asm.org)
  • A microwave-assisted hydrothermal method was employed to prepare thymine-modified graphitic carbon nitride quantum dots (T-gCNQDs) which are shown to be a novel fluorescent nanoprobe for Hg(II). (springer.com)
  • A microwave-assisted hydrothermal route was employed to prepare thymine-functionalized graphitic carbon nitride QDs (T-gCNQDs). (springer.com)
  • The effect of three sensitizers, misonidazole, p-nitroacetophenone and 4-hydroxy-2,2,6,6-tetramethylpiperidino-1-oxy (TMPN), on formation of thymine damage of the 5,6-dihydroxydihydrothymine type by irradiation with gamma rays was characterized in HeLa cells. (springer.com)
  • Oligos synthesized with cis-syn thymine dimer are stable for greater than 6 month when stored frozen, protected from light and preferably in an ethanol precipitated dried state. (genelink.com)
  • Therefore, the mechanism by which they sensitize under hypoxic conditions, such as found in solid tumors, is not by an increase in thymine base damage. (springer.com)
  • Remsen J.F. (1986) Radiosensitizers and Thymine Base Damage. (springer.com)
  • 2017. https://www.tabers.com/tabersonline/view/Tabers-Dictionary/759064/all/thymine. (tabers.com)
  • Wild-type species of bacteria are unable to pump thymine into the cells ( 92 ) and to incorporate it into DNA. (asm.org)
  • To the best of our knowledge, this was the first report applying statistical experimental designs to optimize the crosslinking of thymine-based polymers. (hindawi.com)
  • To understand this method, one must know the unique modes by which thymine is metabolized. (asm.org)
  • This minireview revisits an old technique (thymine limitation) in a new light and illustrates how one can use this technique to manipulate some of the parameters of the cell cycle under balanced growth conditions, which should be helpful in addressing some of the above questions. (asm.org)
  • Water soluble, environmentally benign photopolymers of 1-(4-vinylbenzyl) thymine (VBT) and vinylphenyl sufonate (VPS) undergo a photodimerization reaction when exposed to low levels of ultraviolet irradiation leading to an immobilization of the copolymer on a variety of substrates. (hindawi.com)
  • Other names in common use include thymine 7-hydroxylase, 5-hydroxy-methyluracil dioxygenase, and 5-hydroxymethyluracil oxygenase. (wikipedia.org)
  • The study shows small discrepancies between CASSCF and CASPT2 PEHs, displaying a shallow planar or twisted 1 (ππ*) minimum, respectively, and thus featuring a qualitatively similar scenario for supporting the ultrafast bi-exponential deactivation registered in thymine upon UV-light exposure. (mdpi.com)