• the pyrimidine nucleotides are Thymidine (T) and Cytosine (C). In RNA, the pyrimidine nucleotide Uridine (U) is substituted for Cytosine. (agemed.org)
  • Nucleotides 1" By Boris (PNG), SVG by Sjef - en:Image:Nucleotides.png (Public Domain) via Commons Wikimedia, Lakna, a graduate in Molecular Biology & Biochemistry, is a Molecular Biologist and has a broad and keen interest in the discovery of nature related things, Difference Between Nucleotide and Nucleoside, 3. (paragonlockandsafe.com)
  • The existence of a functional, although inefficient, thymine salvage pathway was demonstrated and this pathway operated more effectively when de novo thymidine nucleotide biosynthesis was inhibited by trimethoprim or methotrexate. (microbiologyresearch.org)
  • However, delta9-THC administered daily for 10 days significantly inhibited Friend leukemia virus-induced splenomegaly by 71% at 200 mg/kg as compared to 90.2% for actinomycin D. Experiments with bone marrow and isolated Lewis lung cells incubated in vitro with delta9-THC and delta8-THC showed a dose-dependent (10(-4)-10(-7)) inhibition (80-20%, respectively) of tritiated thymidine and 14C-uridine uptake into these cells. (erowid.org)
  • Thymine and thymidine uptake by Haemophilus influenzae and the labelling of deoxyribonucleic acid. (microbiologyresearch.org)
  • Polyadenylated [poly(A)+] mRNA isolated from rabbit small-intestinal mucosa was injected into Xenopus laevis oocytes, and expression of the N2 Na+/nucleoside co-transporter was assayed by measuring Na+-dependent thymidine uptake. (kent.ac.uk)
  • Expression of Na+-dependent thymidine uptake steadily increased after mRNA injection and was on average increased 11-fold by day 6 over background. (kent.ac.uk)
  • We have investigated UP-substrate interactions by determining the crystal structures of native Escherichia coli UP (two forms), and complexes with 5-fluorouracil/ribose 1-phosphate, 2-deoxyuridine/phosphate and thymidine/phosphate. (rcsb.org)
  • Preformed nucleoside chloramines also induce plasmid cleavage, though this only occurs to a significant extent with unstable thymidine- and uridine-derived chloramines, where radical formation is rapid. (ku.dk)
  • We show here a novel molecular mechanism by which antiviral drugs of the nucleoside analog family could lead to impairments of the kidney, bone marrow, gastrointestinal, and neuronal functions, and how these side effects could possibly be restricted by the presence of TDP or uridine. (biomedcentral.com)
  • These properties of the expressed thymidine transport strongly suggest that the epithelial N2 Na+/nucleoside co-transporter can be expressed in X. laevis oocytes. (kent.ac.uk)
  • How does EdU labeling compare to BrdU or the 3H-thymidine incorporation assay? (baseclick.eu)
  • On the basis of thermodynamic data, the obtained contribution made by the 5-methyl group of thymidine to the structural characteristics of DNA and RNA is discussed. (elsevierpure.com)
  • Methyl transferase is related to folate and dihydrofolate, particularly with formation of methionine from homocysteine and thymidine from uridine. (aaaai.org)
  • [ 17 ] Genetic polymorphisms of the UGT1A1 promoter, specifically the T-3279G and the thymidine-adenine (TA)7 dinucleotide repeat TATAA box variants, were found to be commonly inherited in white individuals with high allele frequency. (medscape.com)
  • This immediate effect can be substantially reduced by the simultaneous incubation of the cells with thymidine-5′-diphosphate (TDP) or uridine, both of which are by themselves unable to affect I Cl . (biomedcentral.com)
  • Inhibiting liver UP in humans raises blood uridine levels and produces a protective effect ("uridine rescue") against the toxicity of the chemotherapeutic agent 5-fluorouracil without reducing its antitumour activity. (rcsb.org)
  • Decreased uridine diphosphate-glucuronyl transferase ( UGT1A1 ) activity may be associated with prolonged hyperbilirubinemia in breast milk jaundice. (medscape.com)
  • 3 PDGFRα Biological Activity H-thymidine, 3H-uridine and 14C-leucine have been applied. (bet-bromodomain.com)
  • After pyrimidine replacement the incorporation of H 3 -uridine, H 3 -adenosine, and H 3 -leucine was measured by the autoradiographic grain counting method. (rupress.org)
  • 1. Characterization and susceptibility to antiviral agents of herpes simplex virus type 1 containing a unique thymidine kinase gene with an amber codon between the first and the second initiation codons. (nih.gov)
  • 3. Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus. (nih.gov)
  • 4. Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay. (nih.gov)
  • 5. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene. (nih.gov)
  • 7. Substrate specificity of feline and canine herpesvirus thymidine kinase. (nih.gov)
  • 11. Genital herpes due to acyclovir-sensitive herpes simplex virus caused secondary and recurrent herpetic whitlows due to thymidine kinase-deficient/temperature-sensitive virus. (nih.gov)
  • 13. Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1. (nih.gov)
  • 14. Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine. (nih.gov)
  • 15. Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes. (nih.gov)
  • 16. Comparison of HSV-1 thymidine kinase-dependent and -independent inhibition of replication-competent adenoviral vectors by a panel of drugs. (nih.gov)
  • Inhibitors of human and viral uracil-DNA glycosylase, dUTPase and thymidine kinase. (neidos.it)
  • First, the mouse promoter lacks the highly polymorphic thymidine/adenine repeat occurring in the human promoter, which has been associated with some forms of hyperbilirubinemia. (aspetjournals.org)
  • For example, in pyrimidine nucleoside phosphorylase (PYNP, ) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP, ) ( PUBMED:9817849 ). (embl-heidelberg.de)
  • Frentizole (62.5 ng/mL) can effectively inhibit uridine incorporation and the inhibition of uridine incorporation is independent of the phytochemical used[1]. (peptidedb.com)
  • Thymidine diphosphate was prepared by the method of Hail and Khorana as described for the uridine nucleotides (10). (nih.gov)
  • Following the exposures the cells were then cultured at 37 degrees-C. The cellular processes followed to examine the effects of exposure included viability, morphological change, and DNA/RNA synthesis monitored by tritiated uridine and thymidine uptake. (cdc.gov)
  • It is also involved in the synthesis of thymidine from deoxy uridine thus promoting nucleic acid protein synthesis. (avenzor.ae)
  • Derivado antiviral de la TIMIDINA, utilizado principalmente en el tratamiento de la queratoconjuntivitis primaria y de la queratitis epitelial recurrente producida por el virus del herpes simple. (bvsalud.org)
  • An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (bvsalud.org)
  • In human partially hepatectomized liver microsomes, the highest rate of trans -resveratrol glucuronidation (up to 1 mM [228 µg/mL] resveratrol and 1 mM uridine 5´-diphosphoglucuronic acid [UDPGA] in incubation mixture) occurred at neutral pH, and the resveratrol-glucuronide amount increased linearly with time up to 40 minutes. (nih.gov)
  • Primary-structure analysis of the mouse Thymidine Adevice promoter revealed marked differences with its human homolog. (aspetjournals.org)