• 177 Lu-J591 is currently undergoing a Phase IIb trial in men with castration-resistant prostate cancer (MCRPC) who demonstrate rising prostate-specific antigen levels, but no detectable metastases. (genengnews.com)
  • The first is entitled "Concurrent Versus Sequential Treatment with Sipuleucel-T (Provenge) and Abiraterone (Zytiga) in Men With Metastatic, Castration-Resistant Prostate Cancer (mCRPC). (godandprostate.net)
  • The team found certain types of tumors in mice were more vulnerable to radiation after being given a drug that blocks p53 levels from declining and oscillating. (sciencedaily.com)
  • Tumors treated this way shrunk significantly more than when given either radiation alone or the drug alone. (sciencedaily.com)
  • We were able to connect differences in temporal p53 expression with radiation response, and these insights allowed us to 'coax' radioresistant tumors into more radiosensitive ones," said co-corresponding author Ralph Weissleder, the Thrall Family Professor of Radiology and HMS professor of systems biology at Mass General. (sciencedaily.com)
  • BET inhibitors (BETi especially JQ1) gained a lot of interest in last decade due to its promising anticancer efficacy in number of preclinical cancer models including hematologic malig- nancies and solid tumors (Delmore et al. (nadph-oxidasesignaling.com)
  • This amazing food has shown powerful immune-boosting and anticancer activity-including blocking the formation of tumors. (depkewellness.com)
  • This drug is showing promise as an adjuvant treatment for colon cancer and brain tumors, in combination with other antiprotozoal agents. (anticancer.news)
  • The first preclinical study of the anti-cancer technology "quadrapeutics" found it to be 17 times more efficient than conventional chemoradiation therapy against aggressive, drug-resistant head and neck tumors. (medicalxpress.com)
  • The research, which is available online this week Nature Medicine , reports that Rice's "quadrapeutics" technology was 17 times more efficient than conventional chemoradiation therapy against aggressive, drug-resistant head and neck tumors. (medicalxpress.com)
  • Chemotherapy and radiation are commonly used to treat the residual portions of these tumors, but some tumors become resistant to chemoradiation. (medicalxpress.com)
  • Recurrent tumors are highly aggressive, potentially cross-drug resistant, highly metastatic, and have a poor prognosis. (hindawi.com)
  • Neuroblastoma prognosis differs widely from those who bears tumors with higher frequency of spontaneous relapse and involve no intervention and those with metastatic and therapy resistant tumors (Shimada et al. (springeropen.com)
  • Because these tumors are rare it is not known which is the best combination of drugs, but chemotherapy can often control the tumor for long periods. (diagnose-me.com)
  • Additional treatments, such as radiation therapy or chemotherapy, may be recommended for more aggressive tumors or tumors that cannot be completely removed with surgery. (reportsanddata.com)
  • Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
  • In the present study, we attempt to establish a resistant gastric cancer cell to CDDP, and to overcome the resistant mechanism by radiation, which will be one of potent therapies for gastric cancer. (aacrjournals.org)
  • We literally bring surgery, chemotherapies and radiation therapies inside cancer cells. (medicalxpress.com)
  • Participants who have adverse event (AEs) due to previous anticancer therapies must have recovered to =Grade 1 or baseline. (who.int)
  • Resistance to anticancer agents and apoptosis results in cancer relapse and is associated with cancer mortality. (oaepublish.com)
  • Substantial data have provided convincing evidence establishing that human cancers emerge from cancer stem cells (CSCs), which display self-renewal and are resistant to anticancer drugs, radiation, and apoptosis, and express enhanced epithelial to mesenchymal progression. (oaepublish.com)
  • Several mechanisms participate in the drug and apoptosis resistance phenotype in CSCs in various cancers. (oaepublish.com)
  • This article will review the CSCs drug and apoptosis resistance mechanisms and how to target CSCs. (oaepublish.com)
  • As the drug blocked cell cycle progression, it increased p53 protein stability and induced apoptosis of the cancer cells. (anticancer.news)
  • The drug induced oxidative stress on the cancer cells, making them more vulnerable to apoptosis. (anticancer.news)
  • The drug triggers apoptosis without affecting p53 expression. (anticancer.news)
  • Natural product anticancer agents enhance intracellular levels of ceramide, a sphingolipid that promotes cell apoptosis. (sphingolipidclub.com)
  • A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
  • The candidate has successfully completed a Phase II trial in castrate-resistant metastatic prostate cancer patients. (genengnews.com)
  • France-based Atlab says the 177 Lu radioisotope emits radiation over a very short range, which is ideal for eradicating small-volume lesions commonly found in the bone marrow and lymph nodes of prostate cancer patients, including premetastatic or micrometastatic lesions that can't be detected through imaging studies. (genengnews.com)
  • Metformin, a widely used oral anti-diabetic drug, enhanced the anti-prostate cancer activity of abiraterone and enzalutamide. (renalandurologynews.com)
  • Metformin, a widely used oral anti-diabetic drug, enhanced the anti-prostate cancer activity of abiraterone and enzalutamide, a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2016 has shown. (renalandurologynews.com)
  • On the other hand, clinically, acquired chemo-resistant cell against an anticancer drug after therapy will be a critical problem to be solved, urgently. (aacrjournals.org)
  • In the end, the drug decreased cell proliferation of both chemo-sensitive and chemo-resistant ovarian cancer cells. (anticancer.news)
  • In a 2022 study, fenbendazole was tested against chemo-resistant colorectal cancer cells . (anticancer.news)
  • With our recent discovery of the molecule HB-EGF in resistance pathways, we worked with collaborators in Japan to bring a new drug to the clinic that targets this specific pathway. (massgeneral.org)
  • Radiation will overcome acquired chemo-resistance with cisplatin in gastric cancer cell. (aacrjournals.org)
  • We established CDDP-resistant gastric cancer cell lines using TMK-1 and MKN-74 with long-term exposure (several months) with low concentration of CDDP (TMK-1/D and MKN-74/D). Evaluation of each cell resistance was performed with MTT method. (aacrjournals.org)
  • Radiation might have potent possibilities to re-control and overcome acquired resistance to CDDP after exposure with CDDP in gastric cancer cell lines. (aacrjournals.org)
  • The recurrence and drug resistance of breast cancer are intractable due to the presence of breast cancer stem cells (BCSCs), which are adequate to initiate tumor formation and refractory to conventional remedies. (spandidos-publications.com)
  • State‑of‑the‑art research has indicated the retention of RUNX2 expression in a more invasive subtype of breast cancer, and in particular, triple‑negative breast cancer development and drug resistance are associated with estrogen receptor signaling pathways. (spandidos-publications.com)
  • The present review mainly focused on the latest updates on RUNX2 in BCSCs and their roles in breast cancer progression and drug resistance, providing insight that may aid the development of RUNX2‑based diagnostics and treatments for breast cancer in clinical practice. (spandidos-publications.com)
  • Taken together, these studies indicated the involvement of RUNX2 in BCSCs and its roles in breast cancer diagnosis and drug resistance, revealing its promising prospective clinical application and utility as an antitumor drug target in the future. (spandidos-publications.com)
  • Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)
  • For example, over-expression of survivin has been shown to induce drug resistance against anti-mitotic compounds by stabilizing microtubule network in vincristine/colchicine-resistant oral cancer cells and down-regulation of it restores drug sensitivity to those compounds in the same cell line [ 9 ]. (biomedcentral.com)
  • These emerging strategies may help target CSC-associated drug resistance and metastasis in clinical settings. (oaepublish.com)
  • Furthermore, by adding various kinase inhibitors, we confirmed that the phosphorylation status of rpS3 was regulated by both Lyn and doxorubicin, and the phosphorylation of rpS3 by Lyn increased drug resistance in cells by upregulating p-glycoprotein translation. (bmbreports.org)
  • Therefore, in this study, we investigated the possible role of rpS3 as a key target of anti-cancer drug resistance. (bmbreports.org)
  • From previous our studies, to control tumor microenvironment is expected to be necessary for reducing cancer resistance for tumor therapy, We deliberately changed and designed an experimental design to establish a therapeutic method in which the effects of conventional anticancer drugs, radio sensitizers and radiotherapy reproduce the most promising environment and lead to higher antitumor effects. (nii.ac.jp)
  • Nevertheless, BC might acquire drug resistance and sometimes relapse. (wjgnet.com)
  • This amazing food has the ability to complement chemotherapy and radiation therapy by countering several of the side effects of these modalities, including nausea, bone marrow suppression, anemia, and lowered resistance. (depkewellness.com)
  • is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
  • systematic analysis of patterns of cross resistance between anticancer agents and treating drug resistant malignancy. (novapublishers.com)
  • Researchers have uncovered a novel pathway that explains how cancer cells become resistant to chemotherapies, which in turn offers a potential solution for preventing chemo-resistance. (technologynetworks.com)
  • DNA-PKcs has been known for its role in DNA repair related to immune system antibody generation and resistance to radiation. (technologynetworks.com)
  • Four wild-type (drug-sensitive) human breast cancer cell lines (MCF-7, T47D,MDA-MB-231, MDA-MB-435) were used to evaluate the influence of acute and chronic exposure to ceramide and ceramide metabolites on MDR1 mRNA,P-gp, and resistance to chemotherapeutic agents. (sphingolipidclub.com)
  • Some cancers can become resistant to radiation therapy. (sciencedaily.com)
  • These viruses have the potential to treat many cancers that are resistant to currently available therapeutics. (news-medical.net)
  • This inexpensive and efficacious anti-parasitic drug could be useful in treating various cancers, but just like the anti-parasitic drug ivermectin, it too remains suppressed by the Food and Drug Administration and is relegated to being just some "horse dewormer" for veterinary use only. (anticancer.news)
  • In December 2013, Hoffmann-La Roche, manufacturer of capecitabine (Xeloda), an oral agent for the treatment of breast and colorectal cancers, reported that in rare cases, patients using the drug may develop potentially fatal cutaneous disease, such as Stevens-Johnson syndrome or toxic epidermal necrolysis. (medscape.com)
  • Radiation Oncology. (wikipedia.org)
  • Conventionally, Hodgkin's disease is treated by a team of specialists that may include a medical oncologist , oncology nurse, and/or radiation oncologist. (diagnose-me.com)
  • Lab principal investigator James C. Cusack, MD , is co-inventor of the patent "Use of NF-kappaB inhibition in combination therapy for cancer," (United States patent 6,831,057), which describes the therapeutic strategy noted above and is now licensed to two pharmaceutical companies for novel drug development. (massgeneral.org)
  • Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
  • CDDP will be one of key drugs for combination with newly developed anticancer drug like taxanes. (aacrjournals.org)
  • The collaboration will also evaluate Beactica's compounds in combination with multiple other anticancer agents. (drugdiscoverynews.com)
  • One of most promising novel therapeutic approach to cancer therapy is the combination of anti-cancer drugs with calorie restriction. (unisalento.it)
  • Since June 2021, Bristol-Myers Squibb has been conducting a Phase II clinical trial study in collaboration with Nektar Therapeutics to assess the safety, tolerability, and drug levels of Bempegaldesleukin (BEMPEG) in combination with nivolumab, and is also estimating its preliminary efficacy in children, adolescents, and young adults with recurrent or treatment-resistant cancer. (reportsanddata.com)
  • Secondly, the drug induces oxidative stress that disrupts cell metabolic processes. (anticancer.news)
  • Exposure to radiation can wreak indiscriminate havoc on cells, tissues, and organs. (sciencedaily.com)
  • When cells are exposed to ionizing radiation, high-energy atomic particles haphazardly assault the delicate molecular machinery inside. (sciencedaily.com)
  • They found that by blocking MDM2 activity after radiation exposure, p53 could be forced to remain elevated in cells where it would otherwise decline. (sciencedaily.com)
  • This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)
  • Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
  • And, radiation may be modifying some acquired resistant mechanism to CDDP in gastric cancer cells. (aacrjournals.org)
  • Most importantly, ARV showed promising cytotoXicity, anti-migration and apoptotic activity against vemurafenib-resistant melanoma cells. (nadph-oxidasesignaling.com)
  • Interestingly, a recent report suggests that over-expression of survivin may also enhance DNA double-strand breaks (DBD) repair capability in radiation-treated oral cancer cells by up-regulating the molecular sensor of DNA damage, Ku70 [ 11 ]. (biomedcentral.com)
  • Studying such mechanisms not only provides mechanistic insights into these cells that are unresponsive to drugs, but may lead to the development of targeted and effective therapeutics to eradicate CSCs. (oaepublish.com)
  • Segerman wrote in an article entitled "Therapy response in brain tumor cells is linked to disease prognosis" that: "The new results from Uppsala University show that a single tumor contained GICs in different states are differently resistant to therapy. (drugdiscoverynews.com)
  • These engineered viruses kill cancer cells through a mechanism that is completely different from chemotherapy or radiation," said Dr. William Wold, chair of the department of molecular microbiology and immunology at Saint Louis University School of Medicine. (news-medical.net)
  • Dr. Wold and his colleagues Karoly Toth, Konstantin Doronin, Ann E. Tollefson, Mohan Kuppuswamy, Baoling Ying, Jacqueline Spencer, and Maria Thomas have been researching for many years ways to convert the relatively benign "adenovirus" that causes symptoms similar to the common cold in children into an anti-cancer drug that attacks and destroys cancerous cells. (news-medical.net)
  • Most drugs are made to target "bulk" cancer cells, but not the root cause: the cancer stem cell. (theconversation.com)
  • Now that we have found them and we know how they behave, it should be relatively simple to find drugs to target cancer stem cells. (theconversation.com)
  • As a consequence, "big pharma" drug screening should actually focus on cancer stem cells and their relevant targets. (theconversation.com)
  • In the study, " Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics (2023)," researchers found that Fenbendazole has two primary mechanisms of action against cancer cells. (anticancer.news)
  • First, the drug displays anti-mitotic activity, which means it inhibits tubulin polymerization by binding to tubulin sites of rapidly dividing cells. (anticancer.news)
  • There is also evidence that benzimidazole drugs sensitize tumor cells so they can become more susceptible to radiation therapy. (anticancer.news)
  • In the study, " Redox-mediated Anticancer Activity of Anti-parasitic Drug Fenbendazole in Triple-negative Breast Cancer Cells," researchers tested fenbendazole on triple negative breast cancer cells, including a highly metastatic type. (anticancer.news)
  • In another 2023 study , the drug was tested on mouse lymphoma and spleen cells to see if there was differentiation between killing cancer cells and preserving healthy spleen cells. (anticancer.news)
  • The drug proves to be less toxic to healthy cells than traditional chemotherapy agents, yet similarly lethal to the cancer cells. (anticancer.news)
  • In addition, the drug causes autophagy, necroptosis and ferroptosis, killing off even the most resistant cancer cells. (anticancer.news)
  • Additionally, the drug inhibited cell migration, preventing further invasion of GBM cells. (anticancer.news)
  • Lapotko said quadrapeutics differs from other developmental cancer treatments in that it radically amplifies the intracellular effect of drugs and radiation only in cancer cells . (medicalxpress.com)
  • Plasmonic nanobubbles act as a "mechanical drug" against cancer cells that cannot be surgically removed and are otherwise resistant to radiation and chemotherapy. (medicalxpress.com)
  • In cancer cells that survive the initial explosions, the bursting nanobubbles greatly magnify the local doses of both chemotherapy drugs and radiation. (medicalxpress.com)
  • All three effects-mechanical cell destruction, intracellular drug ejection and radiation amplification-occur only in cancer cells and do not harm vital healthy cells nearby. (medicalxpress.com)
  • Quadrapeutics shifts the therapeutic paradigm for cancer from materials-drugs or nanoparticles-to mechanical events that are triggered on demand only inside cancer cells," Lapotko said. (medicalxpress.com)
  • In each case, the scientists used encapsulated versions of the drug that were tagged with antibodies designed to target cancer cells. (medicalxpress.com)
  • Thanks to the magnifying effect of the plasmonic nanobubbles, the intracellular dose-the amount of the drug that is active inside cancer cells-is very high even when the patient receives only a few percent of the typical clinical dose. (medicalxpress.com)
  • The gold nanoclusters amplify the deadly effects of radiation only inside cancer cells, even when the overall dose to the patient is just a few percent of the typical clinical dose. (medicalxpress.com)
  • What kills the most-resistant cancer cells is the intracellular synergy of these components and the events we trigger in cells," Lapotko said. (medicalxpress.com)
  • BCNU-treated UWR2 and UWR3 cells showed a significant BCNU dose-dependent increase in radiation-induced DNA-SSBs at 6 hrs post-drug treatment, and at 100 microM BCNU DNA-ISC was completely masked in UWR2 cells. (duke.edu)
  • We provide evidence that the synergism between BCNU and radiation in the generation of DNA-SSBs is the result of low DNA-SSB repair capacity of the cells, and is further potentiated by the carbamoylating action of BCNU. (duke.edu)
  • benzimidazole drugs are also found to prevent the radiation-induced transformation of cancer cells into radiation-resistant cells, and furthermore sensitize some drug-resistant cells. (cures.news)
  • Here we show that nutrient deprivation can consistently enhance the sensitivity of tumor cells to cell death induction by CDDP, also of those malignancies particularly resistant to any treatment, such as oncogenic BRAF melanomas. (unisalento.it)
  • Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
  • Conventional medicine uses harmful chemicals and radiation to stop the partying of cancer cells. (healthblogs.org)
  • Cancer cells eventually become resistant to these chemical attacks, with obvious consequences. (healthblogs.org)
  • The research describes for the first time how a type of enzyme - previously known for its roles in DNA repair - prevents DNA damage in cancer cells, making them tolerant to chemotherapy drugs. (technologynetworks.com)
  • Many anti-cancer drugs work by creating blocks on the DNA of cancer cells as they replicate. (technologynetworks.com)
  • But cancer cells have a way of slowing down these forks, which allows them to avoid such collisions and protect their DNA, leading to drug tolerance. (technologynetworks.com)
  • However, multidrug-resistant (MDR) cancer cells may avoid the cytotoxic effects of chemotherapy by glycosylating ceramide. (sphingolipidclub.com)
  • Chemotherapy is a drug treatment that uses powerful chemical substances to kill fast-growing cells in the body. (diagnose-me.com)
  • Anticancer drugs generally affect cells that divide rapidly. (diagnose-me.com)
  • Using these targets, the drug disables the cancer cells so they cannot spread. (medlineplus.gov)
  • Cancer cells can become resistant to these drugs. (medlineplus.gov)
  • Although establishment of a radiation resistant in vitro condition has been difficult, we find out inhibitor of Carbonic anhydrase 9, which could control hypoxic condition, and it showed the effect of suppressing metastasis and tumor invasion, itself. (nii.ac.jp)
  • Moreover, the new agent combined with conventional anticancer agents, radiation therapy or photodynamic therapy exerted a high antitumor effect. (nii.ac.jp)
  • However, Hsp90 interferes with a number of molecules that up-regulate the intracellular level of survivin, raising the question that clinical use of Hsp90 inhibitors may indirectly induce survivin expression and subsequently enhance cancer anti-drug responses. (biomedcentral.com)
  • Adjuvant treatment for breast cancer involves radiation therapy and a variety of chemotherapeutic and biologic agents. (medscape.com)
  • On February 15th, 2012, the U.S. Food and Drug Administration (FDA) approved a urine-based molecular diagnostic test that aids clinical decision-making for repeat prostate biopsies in men who have had a previous negative biopsy. (godandprostate.net)
  • Approximately 95%-98% of new anti-cancer drugs actually fail phase III clinical trials , the phase in which new treatments are compared with existing therapy options. (theconversation.com)
  • The researchers did however find that benzimidazole drugs have low water solubility, making them hard to apply in clinical applications. (anticancer.news)
  • There are currently no clinical trials for Fenbendazole, yet there are clinical trials for a similar drug in this class, called Mebendazole. (anticancer.news)
  • Clinical trials are ongoing for cancer therapy with benzimidazole drugs. (cures.news)
  • You may receive these drugs as part of your regular treatment, or as part of a clinical trial . (medlineplus.gov)
  • For instance, as reviewed by Li et al ( 3 ), triple-negative breast cancer (TNBC) may have worse cause-specific survival and overall survival than the non-TNBC counterpart in all stages and substages, regardless of influencing factors from univariate and multivariate analyses (e.g., tumor grade, age, ethnicity, surgery and radiation treatments). (spandidos-publications.com)
  • Multiple peer-reviewed papers suggest that anti-parasite benzimidazole drugs could be useful in cancer treatment protocols . (anticancer.news)
  • benzimidazole drugs are also being combined with other chemotherapeutics, such as paclitaxel, trametinib, gemcitabine and methoxyestradiol, to enhance the anti-cancer treatment efficacy. (cures.news)
  • The Beactica/Uppsala research will be conducted at the In Vitro and Systems Pharmacology Facility of the SciLifeLab Drug Discovery and Development Platform. (drugdiscoverynews.com)
  • The first component of quadrapeutics is a low dose of a clinically validated chemotherapy drug. (medicalxpress.com)
  • To administer quadrapeutics, the team uses four clinically approved components: chemotherapy drugs, radiation, near-infrared laser pulses of low energy and colloidal gold. (medicalxpress.com)
  • An increasingly popular strategy is pharmaconutrition, which combines a tailored pharmacological treatment with a diet designed to synergize the effects of drugs. (frontiersin.org)
  • Numerous phytochemicals and their determined analogs have been recognized as possible contender for anticancer treatment and the present review article sheds light on few of these phytocompounds. (researchsquare.com)
  • This is the very first paper investigating a PROTAC class of molecule for the treatment of drug resistant cancer, preformulation and formulation studies. (nadph-oxidasesignaling.com)
  • This may open a door leading to the development of new treatment strategies designed to reverse therapy-resistant cell states. (drugdiscoverynews.com)
  • There was no enhancement of radiation-induced DNA-SSBs in both cell lines after treatment with cis-DDP, CHZ, or MNU. (duke.edu)
  • The treatment modalities available include topical treatment, surgery (main treatment), radiation therapy and chemotherapy. (medthical.com)
  • All have increasing, resistant disease, unlikely to respond to treatment. (sunriserounds.com)
  • Treatment usually involves radiation therapy or chemotherapy . (diagnose-me.com)
  • Instead, targeting Hsp90 with small molecule inhibitors will induce the over-expression of survivin in certain cancer cell lines and subsequently enhances the ability of cell survival in drug-treated situations. (biomedcentral.com)
  • It has been reported to show immense pharmacological and biological importance including anticancer property. (springeropen.com)
  • SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)
  • The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)
  • To probe the effects of p53 behavior, the team used an experimental anti-cancer drug to inhibit MDM2, a protein that degrades p53. (sciencedaily.com)
  • In the study, " Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer ," researchers found that fenbendazole's anti-cancer effects were not realized in mouse models until it was prepared using nanoparticles for efficient drug delivery. (anticancer.news)
  • increase the murderous anti-cancer effect of chemo drugs. (healthblogs.org)
  • They demand IV hydration and nutrition, minimal pain control, physical therapy, transfusions, frequent lab tests and they intend to begin anti-cancer drugs, as soon as she is ready. (sunriserounds.com)
  • L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)
  • We are basically trying to make cold-resistant Asian elephants to save that species and save the carbon that's locked in the tundra. (medscape.com)
  • Phytochemicals are viewed as appropriate possibility for anticancer medication advancements due to their pleiotropic activities on track occasions with numerous habits. (researchsquare.com)
  • At the functional level, down-regulation of survivin by siRNA further increased the drug sensitivity to 17-AAG in the tested cancer cell lines. (biomedcentral.com)
  • If a single-agent drug regimen fails in low-risk patients, they may continue to be eligible for an alternative single-agent regimen. (medscape.com)
  • Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)
  • BZL's license covers the development of PSMA-targeting antibody-drug conjugates, radiolabeled antibodies, naked antibodies, and related diagnostic and therapeutic methods, as well as rights to key issued patents for the targeting of PSMA expressed on solid tumor neovasculature. (genengnews.com)
  • In a study published Dec. 13, 2016, in the journal Cell Reports , scientists from Uppsala University indicate that a type of stem cell in the tumor is present in different states, with different responses to drugs and radiation. (drugdiscoverynews.com)
  • The toxic side effects of chemotherapy and radiation make the cure often seem as bad as the ailment, and there is also the threat of recurrence and tumour spread. (theconversation.com)
  • The production of DNA interstrand crosslinks (ISC) by BCNU and other bifunctional alkylators and the effects of these drugs on the repair of radiation-induced DNA-single strand breaks (SSB) were studied in two human glioblastoma used to assess both DNA-ISCs and DNA-SSBs. (duke.edu)
  • Unfortunately, renal cell carcinoma (RCC) has proven to be particularly resistant to chemotherapy . (diagnose-me.com)
  • Optimized ARV- SNEP spontaneously formed nanoglobules of 45.02 nm with zeta potential of −3.78 mV and significantly en- hanced solubility of ARV in various aqueous and bio-relevant media. (nadph-oxidasesignaling.com)
  • This research was initiated to explore the anticancer potential of maslinic acid against human neuroblastoma. (springeropen.com)
  • Results evidenced remarkable anticancer potential of maslinic acid against human neuroblastoma. (springeropen.com)
  • A new study now finds that cellular survival after radiation exposure depends on behavior of the tumor-suppressor protein p53 over time. (sciencedaily.com)
  • Reporting in Nature Communications on Feb. 9, they describe how cellular survival after radiation exposure depends on behavior of p53 over time. (sciencedaily.com)
  • In the intestine, which is normally more resistant to radiation, the addition of the drug reduced cell viability and survival. (sciencedaily.com)
  • 2)Interestingly, radiation sensitivity (in 8 Gy alone without chemotherapy) will be decreasing in each resistant cell, as each survival ratio of TMK-1 and TMK-1/D with 8Gy radiation is 44.6%, 55.5%,respectively, and that of MKN-74 and MKN-74/D is 33.5 and 59.6%, respectively. (aacrjournals.org)
  • Previously, Lahav and colleagues revealed the dynamic behavior of p53 over time and how it affects cancer drug efficacy, cell fate, and more. (sciencedaily.com)
  • After radiation exposure, all four tissues expressed elevated p53 along with other markers of DNA and cellular damage as expected. (sciencedaily.com)
  • Our data suggest caution in the use of the standard alkaline elution technique (with 6 hrs between drug exposure and irradiation) to measure BCNU-induced DNA-ISC induction in highly BCNU-resistant cell lines. (duke.edu)
  • A resistant cell state of the GICs was linked to characteristics associated with poor prognosis, and a sensitive cell state was linked to characteristics associated with better outcome. (drugdiscoverynews.com)
  • Yet, levels of this sentinel protein are often similar in tissues with vastly different sensitivities to radiation, posing the question: How is p53 involved? (sciencedaily.com)
  • 95, 679-84, 2004), Thus, several reports mentioned that chemosensitivity to an anticancer drug in a kind of cancer cell will be enhanced by another drug after molecular modification in some mechanism inside the cell. (aacrjournals.org)
  • It is most often used to treat cancer, by means of cytotoxic and other drugs. (diagnose-me.com)