• To evaluate the potential role of ASPECTS for acute endovascular treatment decisions, we studied the correlation between ASPECTS and CTP core, depending on the timing and the presence of large-vessel occlusion. (ajnr.org)
  • The patient had severe cardiac dysfunction and atrial fibrillation and presented with acute ischemia in the right lower limb 24 h after receiving an inferior vena cava filter. (medscape.com)
  • 30%) with acute symptoms of right lower-extremity ischemia. (medscape.com)
  • Spinal ischemia underlies 6% of acute myelopathies [1]. (fortunejournals.com)
  • In 1974, Hossmann and Zimmermann demonstrated that ischemia induced in mammalian brains for up to an hour can be at least partially recovered. (wikipedia.org)
  • However, it is now generally accepted that the mammalian brain may be more resistant to ischemia than previously thought. (biomedcentral.com)
  • The sudden onset of pain is suggestive but not diagnostic for an embolism and gradual onset of pain is typical of venous thrombosis. (medneg.com.au)
  • Fibrocartilaginous emboli are described in up to 5.5% of cases for unexplained and sudden onset spinal ischemia [2]. (fortunejournals.com)
  • These data show that nimesulide protects against permanent focal cerebral ischemia, even with a 2 h post-treatment delay. (biomedcentral.com)
  • 6 hours) versus late (6-24 hours) times from stroke onset and in the presence versus absence of large-vessel occlusion. (ajnr.org)
  • However, this was stronger in patients with large-vessel occlusion and longer delay from stroke onset. (ajnr.org)
  • Ischemia was induced by permanent occlusion of the middle cerebral artery in rats, via surgical insertion of a nylon filament into the internal carotid artery. (biomedcentral.com)
  • The symptoms of brain ischemia range from mild to severe. (wikipedia.org)
  • Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
  • Whereas coma and seizures are well-recognized neurological sequelae of hypoglycaemia, much interest is currently focused on the potential for hypoglycaemia to cause dangerous and life-threatening cardiac complications, such as arrhythmias and myocardial ischaemia, and whether recurrent severe hypoglycaemia can cause permanent cognitive impairment or promote cognitive decline and accelerate the onset of dementia in middle-aged and elderly people with diabetes mellitus. (nature.com)
  • Signs and symptoms of mesenteric ischaemia include severe abdominal pain with a lack of obvious physical findings. (medneg.com.au)
  • The main symptoms of brain ischemia involve impairments in vision, body movement, and speaking. (wikipedia.org)
  • Symptoms of brain ischemia can include unconsciousness, blindness, problems with coordination, and weakness in the body. (wikipedia.org)
  • The symptoms of brain ischemia reflect the anatomical region undergoing blood and oxygen deprivation. (wikipedia.org)
  • Ischemia within the arteries branching from the internal carotid artery may result in symptoms such as blindness in one eye, weakness in one arm or leg, or weakness in one entire side of the body. (wikipedia.org)
  • Ischemia within the arteries branching from the vertebral arteries in the back of the brain may result in symptoms such as dizziness, vertigo, double vision, or weakness on both sides of the body[citation needed]. (wikipedia.org)
  • Further, symptoms can last from a few seconds to a few minutes or extended periods of time. (wikipedia.org)
  • This can happen within twelve hours after the onset of symptoms. (medneg.com.au)
  • The Ca 2+ -related activation of intracellular second messenger systems, the increase in reactive oxygen species formation, as well as hypoxia itself triggers the expression of a large number of pro-inflammatory genes following cerebral ischemia. (biomedcentral.com)
  • The cause of the intestinal ischaemia involves damage to the celiac trunk (a major artery), the superior mesenteric artery or the inferior mesenteric artery. (medneg.com.au)
  • The invention pertains to a polypeptide for the protection against heart ischemia-reperfusion injury. (justia.com)
  • Ischemia-reperfusion injury (IRI) is a syndrome affecting the myocardium upon blood flow restoration following a sufficiently long interruption, such as encountered in a coronary thrombosis or heart surgery [1,2]. (justia.com)
  • One object of the present invention is to provide a therapy of heart ischemia-reperfusion injury by applying GLP-1 analogues which can be administered as single component and avoiding administration of the drug with a second compound. (justia.com)
  • The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)
  • Postconditioning using N-Ac-GLP-1(7-34)amide N-terminally blocked and C-terminally truncated results in a limitation of ischemia-reperfusion injury in an isolated rat heart. (justia.com)
  • Yet, we couldnĀ“t find any reported case of a trauma patient, that describes a late onset complete paraplegia of the lower limbs caused by spinal chord ischaemia without a spinal (chord) injury. (fortunejournals.com)
  • Spinal ischemia in traumatized patients is rarely described, and when it occurs, it is usually associated with direct trauma to the spine and consecutive vascular injury. (fortunejournals.com)
  • To date, no case has been described in the literature in which traumatized patients developed vascular myelopathy with a time delay without the presence of direct spinal trauma or direct vertebral vascular injury. (fortunejournals.com)
  • Previous studies suggest that the cyclooxygenase-2 (COX-2) inhibitor nimesulide has a remarkable protective effect against different types of brain injury including ischemia. (biomedcentral.com)
  • It is estimated that 20-25 percent of cardiac output goes to the GI tract at any given period of time. (medneg.com.au)
  • The interplay between the central nervous system and cardiac electrophysiology is fundamental, and becomes obvious each time one's pulse quickens in response to stress. (aerjournal.com)
  • We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)
  • This figure outlines the time course for normoxic (A) and ischemia-reperfusion (B) experiments. (justia.com)
  • In later experiments we investigated the therapeutic time window of protection of nimesulide by delaying its first administration 0.5-4 h after the ischemic insult. (biomedcentral.com)
  • Treatment of mesenteric ischemia include having a surgical embolectomy, resection of dead tissue and revascularization of the mesenteric arteries. (medneg.com.au)
  • citation needed] Compression of blood vessels may also lead to brain ischemia, by blocking the arteries that carry oxygen to the brain. (wikipedia.org)
  • More common causes are aneurysms of the aorta or ischemia after aortic surgery, compression of vascular structures by tumors, thrombosis or embolism and arterio-venous malformations. (fortunejournals.com)
  • Accordingly, this discovery raised the possibility of intervening after brain ischemia before the damage becomes irreversible. (wikipedia.org)
  • We observed a large amount of variation in the dementia incidence rates over time and that the hazard ratio increased every year. (preprints.org)
  • The causes of brain ischemia vary from sickle cell anemia to congenital heart defects. (wikipedia.org)
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison to the average population. (wikipedia.org)
  • citation needed] Congenital heart defects may also cause brain ischemia due to the lack of appropriate artery formation and connection. (wikipedia.org)
  • The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
  • Risk factors for mesenteric ischaemia include coronary arterial disease, valvular heart disease, heart failure or a history of emboli, generalized atherosclerosis or a hypercoagulable state. (medneg.com.au)
  • Autonomic and hormonal input modulate multiple facets of cellular electrophysiology - action potential duration, ion channel kinetics and intracellular calcium dynamics (just to name a few) - which translate into macroscopic manifestations of autonomic modulation such as heart rate variability, atrioventricular (AV) conduction time and QT interval variability. (aerjournal.com)
  • This timing makes postconditioning relevant from the clinical perspective, in which limitation of irreversible myocardial damage following a coronary thrombosis and ST-elevation myocardial infarction remains a major objective [3]. (justia.com)
  • Ischaemia to the intestinal lining results in a release of toxins, bacteria and vasoactive mediators so that there is a systemic response to the iscahaemia. (medneg.com.au)
  • [ 15 ] expanding the treatment window from 3 hours to 4.5 hours after symptom onset. (medscape.com)
  • citation needed] Late onset depression is increasingly seen as a distinct sub-type of depression, and can be detected with an MRI. (wikipedia.org)
  • Prevention of hypoglycaemia is an important part of diabetes mellitus management and strategies include patient education, glucose monitoring, appropriate adjustment of diet and medications in relation to everyday circumstances including physical exercise, and the application of new technologies such as real-time continuous glucose monitoring, modified insulin pumps and the artificial pancreas. (nature.com)
  • Mesenteric ischaemia is a blockage or interruption in the blood flow of the intestine. (medneg.com.au)
  • Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand. (wikipedia.org)
  • Ischemia leads to alterations in brain metabolism, reduction in metabolic rates, and energy crisis. (wikipedia.org)
  • Brain ischemia has been linked to a variety of diseases or abnormalities. (wikipedia.org)
  • The diagnosis of the disease of mesenteric ischaemia can be difficult. (medneg.com.au)