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  • nonsteroidal anti-
  • Aspirin-induced asthma, also termed Samter's triad, Samter's syndrome, aspirin-exacerbated respiratory disease (AERD), and recently by an appointed task force of the European Academy of Allergy and Clinical Immunology/World Allergy Organization (EAACI/WAO) Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease (N-ERD). (wikipedia.org)
  • inhibitor
  • The extent and nature of NSAID or COX-2 inhibitor interactions with aspirin in influencing both cardiovascular and gastrointestinal outcomes needs clarifying. (bmj.com)
  • Often a combination of aspirin plus an ADP/P2Y inhibitor (such as clopidogrel, prasugrel, ticagrelor, or another) is used in order to obtain greater effectiveness than with either agent alone. (wikipedia.org)
  • inflammation
  • Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever. (wikipedia.org)
  • He found that cutting the guinea pigs' vagus nerve did not affect the action of bradykinin or the inhibitory effect of aspirin-evidence that aspirin worked locally to combat pain and inflammation, rather than on the central nervous system. (wikipedia.org)
  • dose aspirin
  • This phenomenon is related to disease severity and is largely suppressable by low-dose aspirin. (unich.it)
  • Now, a US team at Duke University claims that taking low-dose aspirin alongside Vioxx might prevent these side effects, reports the journal Cell Metabolism. (pharmatimes.com)
  • The inhibition of COX-1 is sufficient to explain why low dose aspirin is effective at reducing cardiac events. (wikipedia.org)
  • In the United States low dose aspirin is deemed reasonable in those between 50 and 70 years old who have a more than 10% risk of cardiovascular disease and are not at an increased risk of bleeding who are otherwise healthy. (wikipedia.org)
  • low-dose aspirin increases the risk of major bleeding 2-fold compared with placebo. (wikipedia.org)
  • However, the annual incidence of major bleeding due to low-dose aspirin is modest-only 1.3 patients per thousand higher than what is observed with placebo treatment. (wikipedia.org)
  • Treatment of approximately 800 patients with low-dose aspirin annually for cardiovascular prophylaxis will result in only 1 additional major bleeding episode. (wikipedia.org)
  • urinary
  • After aspirin administration, the urinary 11dhTxB2 of CAD patients with and without DM were significantly lower than their baseline value (856 ± 748 pg/mg, 1054 ± 859 pg/mg, P (ovid.com)
  • gastrointestinal
  • However, he pointed out that unwanted gastrointestinal side effects from aspirin, such as bleeding, would still need to be closely monitored. (pharmatimes.com)
  • In addition to the typical respiratory reactions, about 10% of patients with AERD manifest skin symptoms like urticaria and/or gastrointestinal symptoms such as abdominal pain or vomiting during their reactions to aspirin. (wikipedia.org)
  • platelet activation
  • By targeting platelet activation and endothelial dysfunction, aspirin and statins have the potential to improve outcomes in patients with pulmonary arterial hypertension (PAH). (acc.org)
  • lipoxins
  • Aspirin-modified COX-2 produces lipoxins, most of which are anti-inflammatory. (wikipedia.org)
  • The lipoxins and epi-lipoxins are potent anti-inflammatory agents and may contribute to the overall activities of the two COX's as well as to aspirin. (wikipedia.org)
  • patients
  • 0.0001) and IHD patients not on aspirin (P = 0.028). (unich.it)
  • 0.0001) than IHD patients not on aspirin. (unich.it)
  • 0.0001), sCD40L (P = 0.007) and 2,3-dinor-6-keto-PGF(1alpha) (P = 0.005) than HF patients not treated with aspirin. (unich.it)
  • On multiple linear regression analysis, higher NT-pro-BNP levels, lack of aspirin therapy and sCD40L, predicted 11-dehydro-TXB(2) excretion rate in HF patients (R(2) = 0.771). (unich.it)
  • The current trial was a phase II trial designed to study the feasibility of the use of aspirin and simvastatin in patients with PAH. (acc.org)
  • Aspirin and statin would each be safe and efficacious compared with placebo in patients with PAH. (acc.org)
  • In a 2x2 factorial design, patients with PAH were randomized to either aspirin 81 mg daily or matching placebo, or simvastatin 40 mg daily or matching placebo. (acc.org)
  • arterial
  • Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). (wikipedia.org)
  • acute
  • Our aim is to study the roles of acute hyperglycemia and hyperlipidemia on aspirin function in diabetic subjects with and without cardiovascular disease. (hindawi.com)
  • Aspirin is generally ineffective for those pains caused by muscle cramps, bloating, gastric distension, or acute skin irritation. (wikipedia.org)
  • Abstract
  • Corgenix is presenting an abstract on aspirin effect and diabetesduri. (bio-medicine.org)
  • Corgenix is presenting an abstract on aspirin effect and diabetes during the general poster session on Saturday, June 7 in Hall D from 11:30 a.m. until 1:30 p.m. (bio-medicine.org)
  • widely
  • Aspirin is one of the most widely used medications globally, with an estimated 40,000 tonnes (44,000 tons) (50 to 120 billion pills) consumed each year. (wikipedia.org)
  • Aspirin or other over-the-counter analgesics are widely recognized as effective for the treatment of tension headache. (wikipedia.org)
  • Heinrich Dreser's explanation, widely accepted since the drug was first brought to market, was that aspirin relieved pain by acting on the central nervous system. (wikipedia.org)
  • asthma
  • The disorder typically progresses to asthma, then nasal polyposis, with aspirin sensitivity coming last. (wikipedia.org)
  • The respiratory reactions to aspirin vary in severity, ranging from mild nasal congestion and eye watering to lower respiratory symptoms including wheezing, coughing, an asthma attack, and in rare cases, anaphylaxis. (wikipedia.org)
  • There may be a relationship between aspirin-induced asthma and TBX21, PTGER2, and LTC4S. (wikipedia.org)
  • mechanisms
  • There is some evidence that aspirin is effective at preventing colorectal cancer, though the mechanisms of this effect are unclear. (wikipedia.org)
  • stroke
  • It is important that individuals taking aspirin to lower the risk of a heart attack or stroke consult a physician to determine what dose, frequency and type of aspirin is appropriate for them to achieve the most benefit with the fewest side effects. (bio-medicine.org)