AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
ThrombosisVenous ThrombosisCoronary ThrombosisSinus Thrombosis, IntracranialIntracranial ThrombosisCarotid Artery ThrombosisAnticoagulantsSagittal Sinus ThrombosisPhlebographyIntracranial Embolism and ThrombosisIliac VeinThrombophiliaFemoral VeinUpper Extremity Deep Vein ThrombosisPortal VeinCerebral VeinsHeparinFactor VFibrinolytic AgentsHemostasisHeparin, Low-Molecular-WeightCavernous Sinus ThrombosisBlood CoagulationAntiphospholipid SyndromeVena Cava, InferiorThromboembolismPlatelet Aggregation InhibitorsLateral Sinus ThrombosisBleeding TimeThrombectomyFibrin Fibrinogen Degradation ProductsStentsProtein S DeficiencyTreatment OutcomePlatelet AggregationMesenteric VeinsSubclavian VeinDrug-Eluting StentsProthrombinRisk FactorsPopliteal VeinJugular VeinsBlood PlateletsVenous ThromboembolismHemorrhageAntibodies, AntiphospholipidProtein C DeficiencyCranial SinusesActivated Protein C ResistanceLupus Coagulation InhibitorPlatelet ActivationThromboplastinTime FactorsThrombolytic TherapyWarfarinFollow-Up StudiesRenal VeinsSplenic VeinUltrasonography, Doppler, DuplexBudd-Chiari SyndromeAntithrombin III DeficiencyRetrospective StudiesFibrinolysisAxillary VeinMesenteric Vascular OcclusionProtein CPostthrombotic SyndromeAspirinCatheterization, Central VenousGraft Occlusion, VascularFibrinVena Cava FiltersFibrinogenPostphlebitic SyndromeAntithrombinsArteriovenous Shunt, SurgicalProspective StudiesTiclopidinePartial Thromboplastin TimeRecurrenceTomography, X-Ray ComputedBlood Coagulation TestsAngioplasty, Balloon, CoronarySirolimusCatheters, IndwellingCoronary RestenosisAntibodies, AnticardiolipinStockings, CompressionThrombocythemia, EssentialCatheterization, PeripheralBlood Coagulation FactorsEnoxaparinVascular PatencyVeinsBlood Coagulation DisordersAcute DiseaseThrombocytopeniaSuperior Sagittal SinusProsthesis DesignProtein S
ArteriosclerosisInflammationNitric oxideEndotheliumPathwaysDysfunctionHaemostasisAngiogenesisPlatelet activationBiologyPermeabilityArterialOxidative stressImprove endothelial functionSuggesting endothelial cellsCellsPlateletsClinicalProteinsAtherosclerosis2019Hemostasis2023ProteinBiomarkersVenousMechanismHomeostasisTissuePulmonaryFibrinogenCellRisk of vascularDevelopment of vascularDiseaseDiseasesFunctionMechanismsVEGFMoleculesRoleMorbidity and mortaSystemicHypoxiaCerebralBlood-brain bMiceCardiovascular events
Arteriosclerosis1
  • Flavor additives used in electronic cigarettes and related tobacco products could impair blood vessel function and may be an early indicator of heart damage, according to new laboratory research in Arteriosclerosis, Thrombosis and Vascular Biology , an American Heart Association journal. (sciencedaily.com)
Inflammation10
  • 2015 ) HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. (academictree.org)
  • The vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. (bvsalud.org)
  • Pathophysiological mechanisms included vascular endotheliopathy, increased inflammation and macrophage activation, neutrophil extracellular traps, antiphospholipid antibody production and obesity/adipose tissue signalling. (touchoncology.com)
  • These abnormalities accelerate the processes that lead to vascular disease, including inflammation, thrombosis and atherosclerotic plaque formation. (ox.ac.uk)
  • In previous work, we have used both clinical studies and experimental models to explore the role of endothelial nitric oxide synthase and its regulation by tetrahydrobiopterin in vascular disease, in particular the inflammation associated with atherosclerotic plaque formation. (ox.ac.uk)
  • The title of my presentation that was given there is Eicosapentaenoic Acid or EPA modulates the expression or proteins linked to platelet activation and thrombosis in vascular endothelial cells during inflammation. (cardiologytalk.com)
  • So the objective of our study was to evaluate the effect of inflammation on the expression of proteins in human endothelial cells. (cardiologytalk.com)
  • This monolayer of cells is an important endocrine organ, and has been shown to play a major role in regulating blood fluidity, the transfer of solutes and macromolecules, immune responses and inflammation. (beckman.com)
  • Systemic hypertension, hypercholesterolaemia and diabetes are associated with endothelial dysfunction that promotes inflammation, oxidation of lipoproteins, smooth-muscle proliferation, extracellular matrix deposition or lysis, accumulation of lipid-rich material, platelet activation, thrombus formation and insulin resistance. (radcliffecardiology.com)
  • Several of the flavorings -- menthol, clove, vanillin, cinnamon and burnt flavoring -- resulted in higher levels of an inflammatory marker and lower levels of nitric oxide, a molecule that inhibits inflammation and clotting, and regulates vessels' ability to widen in response to greater blood flow. (sciencedaily.com)
Nitric oxide6
  • We aim to understand how early changes in the endothelium and vascular wall are related to the initiation and development of vascular diseases, with a particular focus on nitric oxide signalling. (ox.ac.uk)
  • Production of NO, by nitric oxide synthase enzymes, is highly regulated and depends on the co-factor tetrahydrobiopterin, which is made within endothelial cells. (ox.ac.uk)
  • In studies of patients with diabetes and coronary artery disease, we have examined changes in endothelial function, and nitric oxide and tetrahydrobiopterin levels, and how these relate to the clinical features of disease. (ox.ac.uk)
  • Statins reduce low-density lipoprotein (LDL) cholesterol and improve endothelial function via stimulation of nitric oxide (NO) synthase activity, and mediate antioxidant effects that result in enhanced NO bioactivity. (radcliffecardiology.com)
  • Researchers found all nine flavors were dangerous to cells in the laboratory at the highest levels tested and all the flavorings impaired nitric oxide production in endothelial cells in culture (outside of the body). (sciencedaily.com)
  • Various mechanisms, including endothelial cell nitric oxide and prostacyclin, promote blood fluidity by preventing platelet aggregation and dilating intact blood vessels. (msdmanuals.com)
Endothelium8
  • The vascular endothelium, the innermost layer of blood vessels, provides a dynamic interface between the circulating blood and various tissues/organs and thereby maintaining tissue homeostasis. (nature.com)
  • Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)
  • Transport of macromolecules across vascular endothelium and its modification by fluid mechanical forces are important for normal tissue function and in the development of atherosclerosis. (imperial.ac.uk)
  • However, the routes by which macromolecules cross endothelium, the hemodynamic stresses that maintain endothelial physiology or trigger arterial disease, and the dependence of transendothelial transport on hemodynamic stresses are controversial. (imperial.ac.uk)
  • Endothelial cells (ECs) form the endothelium, a layer of single-cell thickness that coats the interior wall of all blood vessels including arteries, capillaries, and veins. (beckman.com)
  • These mediators are no longer produced when the vascular endothelium is disrupted. (msdmanuals.com)
  • Endothelial dysfunction refers to a condition whereby the inner linings of the endothelium fail to function properly. (smartacademicwriting.com)
  • Remember, the endothelium plays an important role in regulating blood clotting but this function is likely to be affected by several conditions including metabolic syndrome, hypertension, smoking and inactivity. (smartacademicwriting.com)
Pathways5
  • It is hypothesized, but not proven, that Pin1 might also be regulated by proteolytic pathways. (wikipedia.org)
  • Bone cells respond to mechanical forces that regulate pathways involved in new bone deposition. (umass.edu)
  • Tight junctional adaptor molecules in the cytosol, which link the tight junction complex to the cytoskeleton and to signaling pathways, play an important role in the control of vascular barrier function. (meduniwien.ac.at)
  • Research has shown that pharmaceuticals have the potential to ameliorate AD by reducing neuroinflammation mainly through regulating inflammatory signaling pathways such as NF-κB, MAPK, NLRP3, PPARs, STAT3, CREB, PI3K/Akt, Nrf2 and their respective signaling pathways. (bvsalud.org)
  • Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism : novel point of convergence between electrophilic and unfolded protein stress pathways. (unibas.ch)
Dysfunction13
  • SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury. (nature.com)
  • The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
  • We envisage further development of cellular models and suitable animal models mimicking endothelial dysfunction aspect of COVID-19 being able to accelerate the discovery of new drugs targeting endothelial dysfunction in pan-vasculature from COVID-19 patients. (nature.com)
  • A number of viral species, such as dengue, ebola and cytomegalovirus can infect endothelial cells (ECs) and cause endothelial dysfunction [ 5 ]. (nature.com)
  • Fig. 1: SARS-CoV-2 induced endothelial dysfunction. (nature.com)
  • SARS-CoV-2 infection alters the balance of endothelial protective molecules and endothelial damaging molecules, leading to endothelial dysfunction. (nature.com)
  • However, when oxidative stress triggers endothelial dysfunction, it can lead to chronic cardiovascular diseases (CVDs). (bvsalud.org)
  • In this review, based on bibliometric studies, we first discussed the relationship between oxidative stress-induced endothelial dysfunction and CVDs, then summarized the role of melatonin in the treatment of atherosclerosis, hypertension, myocardial ischemia-reperfusion injury, and other CVDs. (bvsalud.org)
  • His research aims to develop clinical biomarkers and novel therapeutics for (physio)pathological conditions associated with neurodegeneration and/or endothelial dysfunction, notably stroke, hypertension, diabetes and ageing. (nottingham.ac.uk)
  • All of these consequences of endothelial dysfunction and insulin resistance may contribute to the development and clinical expression of atherosclerosis. (radcliffecardiology.com)
  • The process starts with endothelial dysfunction. (smartacademicwriting.com)
  • According to Balasubramaniam, Viswanathan, Marshall and Zaman (2012) endothelial dysfunction is characterized by an imbalance between vasodilating and vasoconstricting substances and an increase in leucocyte adhesion, hence leading to vascular reactivity. (smartacademicwriting.com)
  • Ultimately, endothelial dysfunction leads to atherosclerosis. (smartacademicwriting.com)
Haemostasis3
Angiogenesis2
  • These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
  • We have previously shown that VWF itself regulates angiogenesis, raising the hypothesis that some of the angiogenic activity of VWF may be mediated by its interaction with Angpt-2. (imperial.ac.uk)
Platelet activation4
Biology1
Permeability2
  • We investigate these adaptor proteins and have shown that they can be used to regulate vascular permeability. (meduniwien.ac.at)
  • 4 In addition, vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates endothelial survival, proliferation, differentiation, and vascular permeability, and has been shown to be an important candidate for cancer therapy as it is upregulated in many tumors. (beckman.com)
Arterial8
  • Stroke is caused not only by arterial thrombosis but also by cerebral venous thrombosis. (frontiersin.org)
  • The purpose of this study was to review the pathophysiology mechanisms and clinical features of arterial and venous thrombosis and to provide guidance for further research on the pathophysiological mechanism, clinical diagnosis, and treatment of venous thrombosis. (frontiersin.org)
  • This review summarizes the pathophysiological mechanisms, etiology, epidemiology, symptomatology, diagnosis, and treatment heterogeneity of venous thrombosis and compares it with arterial stroke. (frontiersin.org)
  • To date, there are more extensive and comprehensive studies on arterial thrombosis, with few clinical and basic studies on venous thrombosis, which greatly limits our understanding of venous thrombosis and the development of related drugs. (frontiersin.org)
  • The molecular pathological hallmarks of arterial stroke and cerebral venous thrombosis. (frontiersin.org)
  • To establish an experimental animal model to directly modulate smooth muscle cell-derived TFPI on the development of arterial thrombosis, transgenic mice in which a cDNA encoding murine TFPI is expressed from the murine SM22α promoter were generated. (elsevierpure.com)
  • Primordial endothelial cells specialize into tissue-specific phenotypes of arterial, venous, hemogenic, and lymphatic subtypes with distinct functions for vascular development. (beckman.com)
  • Through this work, we identify potential plasma biomarker candidates for the clinical assessment of vascular health and risk stratification, diagnosis and prognosis of diseases of the cardiovascular system, such as venous and arterial thrombosis and COVID-19 complications. (uit.no)
Oxidative stress1
  • Melatonin, a natural antioxidant, has been shown to inhibit oxidative stress and stabilize endothelial function, providing cardiovascular protection. (bvsalud.org)
Improve endothelial function2
  • We have carried out clinical trials of treatments to increase tetrahydrobiopterin levels and improve endothelial function. (ox.ac.uk)
  • Experimental and clinical studies demonstrated that combined statins and RAS blockades improve endothelial function as reflected by improved flow-mediated dilation, improved fibrinolysis potential and reduced oxidant stress, inflammatory markers and insulin sensitivity. (radcliffecardiology.com)
Suggesting endothelial cells1
  • Dimethylpyrazine/strawberry flavor had that effect even at very low levels, suggesting endothelial cells are especially sensitive to it. (sciencedaily.com)
Cells32
  • Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by sensing pathogen/danger signals and secreting vasoactive molecules. (nature.com)
  • My research explores how blood flow perturbations caused by the stent design contribute to in-stent restenosis and thrombosis, studying the impact of the fluid forces on blood components and endothelial cells. (umass.edu)
  • In endothelial and epithelial cells the tight junctional complex safeguards barrier function. (meduniwien.ac.at)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • Major impairment of IS was confirmed by reduced upstream and downstream mTOR molecules which regulate fundamental cells metabolic functions. (biomedcentral.com)
  • It can promote vasodilation, reduce blood pressure and promote the dissolution of thrombosis by regulating the function of endothelial cells. (creativebiomart.net)
  • These factors cause damage to endothelial cells, leading to the acceleration of CVD progression. (bvsalud.org)
  • T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis. (unibas.ch)
  • Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival. (unibas.ch)
  • Considerable evidence from basic and clinical experiment has demonstrated that pulmonary vascular remodeling caused by impairment of endothelial cells (ECs), pulmonary artery spasm, adhesion and mligration of inflammatory cells to the pulmonary artery wall, adventitial fibrosis, intimal occlusive fibrosis, and fibrinoid necrosis are typical pathological features in many forms of PH. (imrpress.com)
  • TFPI is expressed by both endothelial and smooth muscle cells in the vasculature and circulates at low levels. (elsevierpure.com)
  • In situ hybridization confirmed that expression of the transgene was limited to medial vascular smooth muscle cells. (elsevierpure.com)
  • This monolayer of cells acts as a barrier to separate the vascular lumen from surrounding tissues and regulates the passage of fluid and nutrients between the two. (beckman.com)
  • Endothelial cells form a semi-permeable barrier between the blood and surrounding tissues within all blood vessels in the body. (beckman.com)
  • The primary focus of the Translational Vascular Research group is the study of endothelial cells that line the inside of all blood vessels. (uit.no)
  • Our research is based around the identification of genes that are highly specifically expressed in endothelial cells (compared to other cell types) and the role of these genes in vascular function. (uit.no)
  • Dr Bayraktutan is the Chief investigator of the Dunhill Medical Trust EPC study investigating the specific effect of ageing on the circulatory level and functional aspects of endothelial progenitor cells as well as the diagnostic and prognostic value of endothelial progenitor cells in elderly patients with lacunar or cortical stroke. (nottingham.ac.uk)
  • Prognostic, Diagnostic and Therapeutic Potential of Endothelial Progenitor Cells for Patients with Ischaemic Stroke: hype or hope BIOCELL. (nottingham.ac.uk)
  • Treatment with Outgrowth Endothelial Cells Protects Cerebral Barrier against Ischaemic Injury Cytotherapy. (nottingham.ac.uk)
  • Outgrowth Endothelial Progenitor Cells Restore Cerebral Barrier Function Following Ischaemic Damage: the impact of nox2 inhibition European Journal of Neuroscience. (nottingham.ac.uk)
  • Platelets (small circulating blood cells) are involved in blood clotting to prevent excessive bleeding, however, their inappropriate activation under pathological conditions leads to thrombosis resulting in major cardiovascular diseases such as heart attack and stroke. (findaphd.com)
  • We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
  • Flavoring chemicals widely used in e-cigarettes and other tobacco products may be toxic to the cells that line and regulate blood vessel function. (sciencedaily.com)
  • The adverse effects observed with chemical flavor additives on endothelial cells could be early warning signs of future heart disease, researchers say. (sciencedaily.com)
  • The team also exposed commercially-available human aortic endothelial cells to the flavorings. (sciencedaily.com)
  • The majority of VWF is synthesized by endothelial cells (ECs) and stored in Weibel-Palade bodies (WPB). (imperial.ac.uk)
  • 2009) Progestin and thrombin regulate tissue factor expression in human term decidual cells. (scirp.org)
  • Initial platelet adhesion is to long strings of von Willebrand factor (VWF) that have been previously secreted by, and anchored to, stimulated endothelial cells. (msdmanuals.com)
  • [ 18 ] Centrally, thick-walled vessels are present with hobnail endothelial cells. (medscape.com)
  • Thick-walled blood vessels with (plump) hobnail endothelial cells and abundant eosinophils. (medscape.com)
Platelets1
  • The ischemic stroke accounts for the 87% of all cases, which results from the cerebral arteries occlusion due to thrombosis, atherosclerosis and platelets plug ( 3 ). (frontiersin.org)
Clinical9
  • Of translational relevance, several candidate drugs which are endothelial protective have been shown to improve clinical manifestations of COVID-19 patients. (nature.com)
  • Future research planned includes determining the molecular basis for fluid flow-induced differences in endothelial cell migration, optimization of streamlined stent design, and pre-clinical studies of streamlined stents in coronary heart disease animal models. (umass.edu)
  • Because most acute cardiovascular events are associated with thrombosis, intensive antiplatelet therapy offers a major clinical benefit to diabetic patients. (aging-us.com)
  • Since the onset of the global pandemic, various reports of abnormal haematological parameters and clinical sequelae of thrombosis have been reported. (touchoncology.com)
  • Due to the lack of a full understanding of venous thrombosis, as well as its diverse clinical manifestations and neuroimaging features, there are often delays in admission for it, and it is easy to misdiagnose. (frontiersin.org)
  • The aim is to provide a reference for a comprehensive understanding of venous thrombosis and a scientific understanding of various pathophysiological mechanisms and clinical features related to venous thrombosis, which will contribute to understanding the pathogenesis of intravenous stroke and provide insight into diagnosis, treatment, and prevention. (frontiersin.org)
  • Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke Stem Cell Reviews and Reports. (nottingham.ac.uk)
  • Background: A major clinical feature of severe coronavirus diease 2019 (COVID-19) is microvascular thrombosis linked to endothelial cell activation. (imperial.ac.uk)
  • The triad of hemolytic anemia, pancytopenia, and thrombosis makes PNH a unique clinical syndrome. (medscape.com)
Proteins3
  • The enzyme binds to a subset of proteins and thus plays a role as a post phosphorylation control in regulating protein function. (wikipedia.org)
  • Therefore, tight junction adaptor proteins, such as cingulin and its interaction domains with the cytoskeleton and exchange factors of RhoGTPases could be used to protect barrier function in endothelial junct ions. (meduniwien.ac.at)
  • The absence of these regulating proteins results in uncontrolled amplification of the complement system. (medscape.com)
Atherosclerosis1
  • The majority of studies focus on the inner and medial vascular layers, which are affected at the development of atherosclerosis. (hindawi.com)
20191
  • 2019 ) Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes. (academictree.org)
Hemostasis2
20232
Protein2
  • For this reason, they are extensively used in a wide range of applications from protein production to bacterial biofilms and endothelial cell experiments. (imperial.ac.uk)
  • The IS regulates critical cell functions including molecular-regulated cellular metabolite fluxes, protein and energetic metabolism, cell proliferation and apoptosis with consequent regulation of cell life including endothelial homeostasis and blood coagulation. (biomedcentral.com)
Biomarkers1
  • The aim of this study was to develop a method to evaluate IS in peripheral lymphocytes to identify altered intracellular molecules in patients with MetS to use as risk biomarkers of vascular thrombosis. (biomedcentral.com)
Venous3
  • Early exercise for acute deep venous thrombosis (DVT) improves the patient's symptoms and does not increase the risk of pulmonary embolism. (biomedcentral.com)
  • Venous thrombosis, the particular type, accounts for 0.5-1% of all strokes. (frontiersin.org)
  • Thrombosis also form in cerebral venous, which is termed as cerebral venous thrombosis(CVT), a particular type of cerebrovascular disease, characterized by intracerebral hemorrhage and infarction, associated with increased intracranial pressure due to cerebrospinal fluid absorption and cerebral venous drainage, accounting for 0.5-1% of strokes ( 4 ). (frontiersin.org)
Mechanism2
  • This paper provides an overview of the normal anatomy of vasa vasorum and potential mechanism of plaque formation due to vascular injury (vasa vasorum) and microhemorrhage. (hindawi.com)
  • However, the mechanism of pulmonary vascular remodeling has not been fully elucidated, there is still a lack of effective drugs to prevent and reverse pulmonary vascular remodeling. (imrpress.com)
Homeostasis2
  • Vascular barrier function is critical for the maintenance of blood flow and tissue homeostasis. (meduniwien.ac.at)
  • 2015 ) Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. (academictree.org)
Tissue2
  • Such hydrogels can accurately sense distinct physiological and external factors such as temperature and biologically active molecules, so they may in turn actively and promptly adjust their response, by regulating their own biological effects, thereby promoting damaged tissue repair. (bvsalud.org)
  • Tissue factor pathway inhibitor (TFPI) is a Kunitz-type protease inhibitor that regulates the extrinsic pathway of coagulation by inhibiting the factor VIIa/tissue factor (TF) catalytic complex. (elsevierpure.com)
Pulmonary4
  • The occurrence and development of PH is closely related to pulmonary vascular remodeling and abnormal function. (imrpress.com)
  • Pulmonary hypertension (PH) is a chronic and progressive disease characterized by enhanced pulmonary vascular resistance and elevated pulmonary artery pressure resulted from pulmonary vascular remodeling and vasoconstriction [ 1 ]. (imrpress.com)
  • Pulmonary vascular remodeling is the result, and, likely, contributes to increased pulmonary vascular pressures by increasing pulmonary vascular resistance [ 6 , 7 ]. (imrpress.com)
  • Intercellular communication, a key process in pulmonary vascular remodeling, is originally believed to be achieved by either direct cell-to-cell contact or paracrine effects. (imrpress.com)
Fibrinogen3
Cell6
  • MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. (wikipedia.org)
  • Cardiovascular stents, fluid flow and endothelial cell phenotype. (umass.edu)
  • Initial results have demonstrated that by introducing this novel engineering approach to stent design, the local blood flow field is changed yielding an anti-thrombotic endothelial cell phenotype, accelerated cell motility (wound healing), and decreased thrombus formation. (umass.edu)
  • A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice. (ox.ac.uk)
  • ABDULKADIR, RR, ALWJWAJ, M, RAKKAR, K and OTHMAN, OA, Outgrowth Endothelial Cell Conditioned Medium Negates TNF-alpha-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms Stem Cell Reviews and Reports. (nottingham.ac.uk)
  • Likewise, we also apply synthetic chemistry to generate cell-target specific molecules in order to control thrombosis and inflammatory responses. (findaphd.com)
Risk of vascular2
  • Moreover, administration of exogenous hormones may cause worsening of migraine as may expose migrainous women to an increased risk of vascular disease. (biomedcentral.com)
  • A reduced expression of mTOR may reflect an increased risk of vascular thrombosis. (biomedcentral.com)
Development of vascular1
Disease6
  • Thus, COVID-19 is deemed as a (micro)vascular and endothelial disease. (nature.com)
  • In fact, migraine with aura represents a risk factor for stroke, cardiac disease, and vascular mortality. (biomedcentral.com)
  • My goal is to understand the molecular and cellular mechanisms that cause chronic kidney and vascular disease (CKD / CVD). (sheffield.ac.uk)
  • Furthermore, this transgenic mouse model should prove useful for studying the role of TFPI in the development and progression of vascular disease. (elsevierpure.com)
  • The appearance of Kimura disease on imaging modalities, including CT scanning and MRI, is variable and is thought to be due, at least in part, to the variable degrees of vascular proliferation and fibrosis within individual lesions. (medscape.com)
  • C), coronary artery aneurysms, and thrombosis in patients with Kawasaki disease in a Southern Han Chinese population. (cdc.gov)
Diseases2
  • There are differences in expression among different vascular beds, inflicting a range of vascular diseases. (hindawi.com)
  • Applying these findings, we try to develop a new treatment strategy against diseases characterized by vascular leak, such as, cancer, allergic reactions, burn injuries or sepsis. (meduniwien.ac.at)
Function1
  • 7. Vaiyapuri S, Ali MS, Moraes LA, Sage T, Lewis KR, Jones CI, Gibbins JM (2013) Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signalling. (findaphd.com)
Mechanisms1
VEGF1
Molecules1
  • The identification of the key molecules that accurately regulate the activation of these receptors may provide a novel approach for antiplatelet therapy. (aging-us.com)
Role4
  • GP IIb/IIIa receptor activation plays an important role in thrombosis. (aging-us.com)
  • The kininogen additive pathway is a complex signal pathway that plays an important role in the vascular system. (creativebiomart.net)
  • A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance. (ox.ac.uk)
  • Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)
Morbidity and morta2
  • Unfortunately 1/3 of patients with bare metal stents (BMS) suffer from restenosis of the coronary artery, and about 1-2% of patients with DES suffer from in-stent thrombosis, leading to significant morbidity and mortality. (umass.edu)
  • The loss of CD55 and CD59 renders PNH erythrocytes susceptible to intravascular hemolysis, which can lead to thrombosis and to much of the morbidity and mortality of PNH. (medscape.com)
Systemic1
  • Taken together, these data indicated that local VSMC-specific TFPI overexpression attenuated ferric chloride-induced thrombosis without systemic or hemostatic effects. (elsevierpure.com)
Hypoxia1
  • Levy, A.P., Levy, N.S. and Goldberg, M.A. (1996) Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. (scirp.org)
Cerebral1
Blood-brain b1
  • 2017 ) Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. (academictree.org)
Mice2
  • After undergoing IVC ultrasound within 24 h post-operation to confirm DVT formation, mice without thrombosis were excluded. (biomedcentral.com)
  • In a ferric chloride-induced model of carotid thrombosis, homozygotic transgenic mice demonstrated resistance to thrombotic occlusion compared to wildtype littermates. (elsevierpure.com)
Cardiovascular events1
  • Vertebral Tortuosity Is Associated With Increased Rate of Cardiovascular Events in Vascular Ehlers-Danlos Syndrome. (cdc.gov)