• Thiosemicarbazones are also widely used as ligands in coordination chemistry. (wikipedia.org)
  • Comparative cytotoxic and biochemical effects of ligands and metal complexes of alpha-N-heterocyclic carboxaldehyde thiosemicarbazones. (nih.gov)
  • In addition, the iron complexes of 1-formylisoquinoline thiosemicarbazone, 2-formylpyridine thiosemicarbazone, and 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone were shown to be three- to sixfold more active than their free ligands as inhibitors of partially purified ribonucleotide reductase to which no iron has been added. (nih.gov)
  • Thiosemicarbazones can coordinate metal ions as neutral ligands (HTSC) or as anionic species (TSC) upon deprotonation at the N(2 ) 4,5,7 . (scielo.br)
  • Data interpretation of the Rh(III) complexes indicates that the ligands of coumarinyl thiosemicarbazone derivatives were formed in stoichiometric ratios as 1:2 (metal: ligand). (deepdyve.com)
  • Tricarbonylrhenium(I) complexes with thiosemicarbazone derivatives of 2-acetylpyridine and 2-pyridine formamide showing two unusual coordination modes of tridentate thiosemicarbazone ligands. (uzh.ch)
  • A series of cobalt(II) and nickel(II) complexes were prepared by reactions with p-dimethylaminobenzaldehyde thiosemicarbazone (Hdmbtsc) in stoichiometric ratio of 1:2 and in the presence of co-ligands pyridine, 1,10 phenanthroline and PPh 3 , which yielded octahedral complexes ( 1-8 ). (ikm.org.my)
  • Among the ligands tested, diacetyl- bis (N 4 -methylthiosemicarbazones) (ATSM) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde Bis (N 4 -methyl)thiosemicarbazone (PTSM) was shown to possess low toxicity (7% lethality at 10 ppm) and glyoxal-bis-thiosemicarbazone (GTS) proved to be a toxic compound even at 1 ppm (20% lethality). (ijps.ir)
  • In the present work, we report the cytotoxicity studies on some in-house synthesized bis-thiosemicarbazone radiopharmaceutical ligands and the results obtained were described. (ijps.ir)
  • The molecules known as bis(thiosemicarbazones) derived from 1,2-diones can act as tetradentate ligands for Cu(ii), forming stable, neutral complexes. (monash.edu)
  • A range of new carboxylate functionalised bis(thiosemicarbazone) ligands and their Cu(II) complexes have been prepared, fully characterised and radiolabeled in high yield with both (64)Cu and (99m)Tc. (ox.ac.uk)
  • Thiosemicarbazone ligands and their metal complexes have been seen to inhibit Topoisomerase II-α, a popular target of chemotherapy, as has been described in the literature. (tntech.edu)
  • The new thiosemicarbazone ligands, pyruvic aldehyde-1-oxime [x]-thiosemicarbazone (PAO-xTSC's) and their metal complexes with Cu(II) have been synthesized. (tntech.edu)
  • Thiosemicarbazones usually act as chelating ligands for metal ions, bonding through sulphur (=S) and azomethine (=N-) groups, although in some cases they behave as mono dentate ligands where they bind through sulphur (=S) only [ 13 ]. (hindawi.com)
  • A sequence of nine thiosemicarbazone based diimine copper(II) complexes derived from three sulfur-containing ligands N -methyl-2- ((1-methyl-1 H -pyrrol-2-yl)methylene)hydrazinecarbothioamide H(L1), N -ethyl-2-((1-methyl-1 H -pyrrol-2-yl)methylene)hydrazinecarbothioamide H(L2), and N -benzyl-2-((1-methyl-1 H -pyrrol-2-yl)methylene)hydrazinecarbothioamide H(L3). (innovareacademics.in)
  • The molecular structures and coordination possibilities of thiosemicarbazone ligands toward the central metal ions have been validated by analytical and spectral techniques such as molar conductance, elemental analysis, ultraviolet-Vis, Fourier-transform infrared, and electron paramagnetic resonance spectroscopy confirms that the thiosemicarbazones ligands are coordinated to copper through NS' donor and NN' donor of diimine. (innovareacademics.in)
  • Anti-proliferative effects of copper(II) complexes with hydroxyquinoline-thiosemicarbazone ligands. (innovareacademics.in)
  • In the present work, a series of salicylaldehyde thiosemicarbazone derivatives have been synthesized and evaluated for their ability to inhibit the PA-Nter catalytic activity. (springer.com)
  • 1902, 35, 2049) have shown that the thiosemicarbazones C:N.NH.CS.NH2, possess the property of forming metallic derivatives, one of the hydrogen atoms being replaced by an equivalent of silver, copper, or mercury. (gla.ac.uk)
  • The known metallic derivatives were found to be unsuitable for this work and the sodium derivative of acetone thiosemicarbazone was the starting material chiefly employed. (gla.ac.uk)
  • Our efforts have focused on the structure-properties relationship in copper(II) derivatives of pyridine-2- carbaldehyde thiosemicarbazone. (eurekaselect.com)
  • Oxalato derivatives with relatively high ferromagnetism and unusually twisted carboxylato groups, structures of thiosemicarbazone-polyoxometalate hybrid systems and nucleic acid base-thiosemicarbazone complexes, reactivity with glutathione, interaction and cleavage of DNA and biological activity against tumoral cell lines are some of the aspects discussed here. (eurekaselect.com)
  • Two series of new aromatic thiosemicarbazone derivatives were synthesized by condensation of N -(4-cyanophenyl)hydrazine carbothioamide ( I ) and N -(4-methylsulfanylphenyl)hydrazine carbothioamide ( II ) with appropriate aromatic aldehydes in order to investigate their antiviral and cytostatic potency. (springer.com)
  • Then, antiviral activity of benzaldehyde thiosemicarbazone derivatives against vaccina virus in mice was found by Hamre, et al. (springer.com)
  • Steroidal thiosemicarbazone derivatives were obtained by the thiosemicarbazide with steroidal ketones. (ovid.com)
  • Based on the structural elements of bioactive 3-substituted indoles, a new series of indole-thiosemicarbazone hybrid derivatives were designed, synthesized, and well-characterized using different spectral techniques. (springer.com)
  • Aiming for films with improved characteristics against bacterial colonization, poly(methyl methacrylate) (PMMA) and polyurethane (PU) films were formed via the spin coating method on silica wafer (SW) substrates, in the absence or presence of four isatin thiosemicarbazone derivatives (ITSCs) in various concentrations. (strath.ac.uk)
  • Methods: Structure-based drug design and Glide docking studies were employed to rationalize the toxicity of a new series of thiosemicarbazone-based indole derivatives against human colon carcinoma (HCT116) cell line. (lettersindrugdesigndiscovery.com)
  • A series of novel anthraquinone thiosemicarbazone derivatives in a tautomerizable keto-imine form was synthesized and tested for their in vitro cytotoxic activity against human cancer cells (HeLa, MDA-MB-361, MDA-MB-453, K562, A549) and human normal MRC-5 cells. (ac.rs)
  • In the present study 17 novel benzaldehyde thiosemicarbazone derivatives were synthesised using 2-methyl-3-thiosemicarbazide as the main reactant and different aromatic aldehydes. (ijpsr.com)
  • The antimicrobial activity and DNA cleavage effectiveness of thiosemicarbazone derivatives and copper(II) complexes were assessed by disc diffusion and agarose gel electrophoresis methods. (innovareacademics.in)
  • Interestingly, copper(II) complexes bearing 1,10-phenanthroline (phen) moiety displayed outstanding results together with N (4)-substituted thiosemicarbazone derivatives and causes complete DNA degradation of SC (supercoiled) pUC18 DNA. (innovareacademics.in)
  • Lapachol was chemically modified to obtain its thiosemicarbazone and semicarbazone derivatives. (bvsalud.org)
  • The thiosemicarbazone and semicarbazone derivatives of lapachol exhibited antimicrobial activity against the bacteria Enterococcus faecalis and Staphylococcus aureus with minimal inhibitory concentrations (MICs) of 0.05 and 0.10 µmol/mL, respectively. (bvsalud.org)
  • The thiosemicarbazone and semicarbazone derivatives were also active against the pathogenic yeast Cryptococcus gattii (MICs of 0.10 and 0.20 µmol/mL, respectively). (bvsalud.org)
  • We synthesised, for the first time , thiosemicarbazone and semicarbazone derivatives of lapachol. (bvsalud.org)
  • The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors. (expasy.org)
  • Thiosemicarbazones and their metal complexes are a broad class of biologically active compounds 1 . (scielo.br)
  • The study of thiosemicarbazones and their metal complexes has become a fruitful area of the coordination chemistry due to the interesting properties exhibited by these compounds, in particular those dealing with the biological activity. (eurekaselect.com)
  • Thiosemicarbazones are important class of synthetic products and potential biologically active compounds. (springer.com)
  • Since the discovery of the antitubercular activity of thiosemicarbazones [ 4 ], a great deal of work has been done on the pharmacology of this type of compounds. (ijpsonline.com)
  • Our literature survey revealed that semicarbazone, thiosemicarbazone and related compounds of 1,3-diketoderivatives have been seldom investigated for their biological activities [ 15 , 16 ]. (ijpsonline.com)
  • This group of compounds belongs to the dipyridyl thiosemicarbazone class that have been shown to have potent and selective activity against a range of different neoplasms in vitro and in vivo. (aspetjournals.org)
  • Structure-activity relationship (SAR) studies revealed that electronic effects of the substituents about the phenyl ring at N4 of the thiosemicarbazone moiety played an important role in enhancing the urease inhibitory potential of some of the synthesized compounds. (eurekaselect.com)
  • In conclusion, the data support further investigation of thiosemicarbazone iron chelators with dual activity as lead compounds for anti-trypanosomal drug development. (ljmu.ac.uk)
  • The aim of this study was to identify a candidate drug for the development of anti-tuberculosis therapy from previously synthesized compounds based on the thiosemicarbazones, semicarbazones, dithio-carbazates and hydrazide/hydrazones compounds. (unesp.br)
  • The best compounds were the thiosemicarbazones (2, 3 and 4) and the hydrazide/hydrazones (14, 15, 16 and 18). (unesp.br)
  • Thiosemicarbazones (TSCs) are synthetic compounds that exhibit several pharmacological activities. (semanticscholar.org)
  • The anti-diabetic effects of hybrid compounds ( 2a-h ) of thiosemicarbazone and triazole containing methoxy groups at C (4) positions were tested against genes involved in glucose metabolism ( Glut-4 , Mef2a and Nrf-1 ) using quantitative real time PCR (qPCR). (biomedcentral.com)
  • Thiosemicarbazones are biologically active compounds which are obtained by the condensation of thiosemicarbazide or a substituted thiosemicarbazide with a suitable aldehyde or ketone. (biomedcentral.com)
  • Focusing on the extensively studied family of thiosemicarbazone (TSC) compounds, we have previously identified 4,4′-dimethoxybenzophenone thiosemicarbazone (T44Bf) as a promising pharmacological compound in a panel of human leukemia cell lines (HL60, U937, KG1a and Jurkat). (elsevier.com)
  • The crystal structure of the magnesium complex of the o -vanillin thiosemicarbazone ligand 1 is also described. (springer.com)
  • The copper complex of 2-formylpyridine thiosemicarbazone was slightly more active than the free ligand against the reductase. (nih.gov)
  • The compound p-acetamidobenzaldehyde thiosemicarbazone, for example, known as thioacetazone, is employed in the clinical treatment of tuberculosis 3 and functions as a potential N-S bidentate ligand. (scielo.br)
  • Usually, this molecule acts as a NNS terdentate ligand and gives rise to [Cu(HL)]2+ / [CuL]+ rigid planar blocks, which can form dimers by bonds through the thiosemicarbazone S atom (S-bridged systems) or the X atom belonging to different coligands (X-bridged systems). (eurekaselect.com)
  • The organoruthenium complex [(η6-p-cym)Ru(η1-S-TSC)Cl2], (1) and (2-acetyl-5-methyl-thiophene thiosemicarbazone) TSC ligand were investigated in vitro for their properties as prospective anti-tumour agents. (omicsonline.org)
  • Previous studies showed that the copper(II) complex of 2-formylpyridine thiosemicarbazone is more powerful antitumour agent than the free ligand [ 8 ]. (ijpsonline.com)
  • Thiosemicarbazone ligand 4Hbatsc = 4-hydroxybenzaldehyde-thiosemicarbazone and its silver(I) complex [Ag(PPh 3 ) 3 (4Hbatsc)]NO 3 were synthesized and characterized by elemental analysis (CHN), FT-IR spectroscopy, and single-crystal X-ray diffraction. (ac.ir)
  • The complex involves the 4H-ba-tsc thiosemicarbazone ligand in an S monodentate binding mode. (ac.ir)
  • The spectral data revealed that the thiosemicarbazone act as bidentate ligand, making use of thionic sulphur and the azomethine nitrogen atom for co-ordination to the central metal atom. (who.int)
  • The FT-IR spectral data suggested the attachment of copper(II) ion to ligand moiety through the azomethine nitrogen, thioketonic sulphur, and phenolic-O. The spectroscopic characterization indicates the dissociation of dimeric complex into mononuclear [Cu(L)Cl] units in polar solvents like DMSO, where L is monoanionic thiosemicarbazone. (hindawi.com)
  • Several alpha-N-heterocyclic carboxaldehyde thiosemicarbazones and their iron and copper complexes have been tested for their cytotoxicity and inhibiting activity against DNA synthesis under controlled metal conditions. (nih.gov)
  • We synthesized 2,3,5,6-tetrafluoro-4-(2-mercaptoetanothiolyl)benzaldehyde (ALD), 5-[(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)thio]-2-furaldehyde thiosemicarbazone (TSC1) and 5-[(4-(trifluoromethyl)phenyl)thio]-2-furaldehyde thiosemicarbazone (TSC2) and used them alone or in combination with subtoxic CDDP concentrations to evaluate cytotoxicity, cytoskeleton integrity and mitochondrial function. (medworm.com)
  • A new series of sixteen N4-aryl substituted 5-chloroisatin-3-thiosemicarbazones 2a-2p has been synthesized, characterized and tested for selected biological activities i.e. cytotoxicity, phytotoxicity and urease inhibition. (eurekaselect.com)
  • A deconstruction approach was herein applied by removing one function at a time from the potent multifunctional thiosemicarbazones 1 and 2, to investigate the contribution to cytotoxicity of each target involved. (wustl.edu)
  • The Zn(II) complexes generally showed significantly greater cytotoxicity than the thiosemicarbazones alone in several tumor cell-types. (edu.au)
  • ChemInform Abstract: A Quantitative Study of Substituted Effects on Oxidative Cyclization of Some 2-Aryl-substituted Aldehyde Thiosemicarbazones Induced by Ferric Chloride and Cupric Perchlorate. (scite.ai)
  • Nickel(II) and copper(I) or copper(II) complexes of thiosemicarbazones derived from 3- and 4-formylpyridine (H3FPT and H4FPT) and 3- and 4-acetylpyridine (H3APT and H4APT) have been prepared and characterized by microanalyses, molar conductivity and magnetic susceptibility measurements and by their NMR (in the case of copper(I) and diamagnetic nickel(II) complexes) and IR spectra. (scielo.br)
  • Literature survey revealed that the transition metal complexes of thiosemicarbazones show antitumour property [ 5 ]. (ijpsonline.com)
  • Mono- and di-nuclear complexes of thiosemicarbazones with copper(I): Synthesis, spectroscopy and structures. (howard.edu)
  • Ethyl chlorocarbonate and phenyl chlorocarbonate have been found to react with the sodium derivative of acetone thiosemicarbazone in benzene suspension, with formation chiefly of the 1-carbethoxy or 1-carbophenoxy thiosemicarbazide R.OOC.NH.NH.CS NH2. (gla.ac.uk)
  • Cytotoxic activities of acetoacetanilide N(4)-methyl(phenyl)thiosemicarbazone (L2H) and its seven different metal complexes were studied. (ijpsonline.com)
  • Hence, it is considered to be worthwhile and interesting to evaluate the antitumour activity of acetoacetanilide N-(4)methyl(phenyl) thiosemicarbazone (AcTSC) and its metal complexes. (ijpsonline.com)
  • An attempt has been made to recycle Styrofoam waste to a novel functional polymer, Phenyl thiosemicarbazone surface (PTS). (edu.pl)
  • Among them, compound 2,4-dihydroxy acetophenone-4-phenyl-3-thiosemicarbazone (d1) had the most potent inhibition activity with the IC50 value of 0.006±0.001mM, displayed as a reversible competitive inhibitor. (naver.com)
  • The mechanism involved in this effect is mediated through the binding of intracellular iron by thiosemicarbazones and other iron chelators, which inhibits HIF-1α degradation ( Le and Richardson, 2004 ). (aspetjournals.org)
  • Trypanotoxic activity of thiosemicarbazone iron chelators. (ljmu.ac.uk)
  • In this study, three newly designed thiosemicarbazone iron chelators, TSC24, Dp44mT and 3-AP, were tested for in vitro activity against bloodstream forms of Trypanosoma brucei and human leukaemia HL-60 cells. (ljmu.ac.uk)
  • Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides. (ox.ac.uk)
  • Synthesis, Crystal Structure, Characterization of zinc(II), Cadmium(II) Complexes with 3-thiophene Aldehyde Thiosemicarbazone (3TTSCH). (ac.ir)
  • Synthesis and characterization of pyruvic aldehyde-1-oxime thiosemicarbazones and their complex formation with Cu(II). (tntech.edu)
  • Therefore, in continuation of ongoing study on thiosemicarbazones and their metal complexes [ 13 , 19 - 22 ], we report herein the synthesis, characterization, and biological studies on copper(II) complexes of (2E)-2-(2-hydroxy-3-methoxybenzylidene)- 4 N -substituted hydrazinecarbothioamides. (hindawi.com)
  • Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells. (oupickylab.org)
  • Thiosemicarbazones are usually produced by condensation of a thiosemicarbazide with an aldehyde or ketone: H2NC(S)NHNH2 + O=CR2 → H2NC(S)NHN=CR2 + H2O In terms of their chemical structures, the CSN3 core atoms are coplanar. (wikipedia.org)
  • Udupa, H. V.K. / Electrolytically generated manganese(III) Sulphate as a redox titrant : Potentiometric determination of thiosemicarbazide, its metal complexes and thiosemicarbazones . (elsevier.com)
  • The affinity of thiosemicarbazones for metal ions is exploited in controlling iron overload. (wikipedia.org)
  • The anticancer agent 3-aminopyridine-2-carboxaldehyde thiosemicarbazone is a ribonucleotide reductase inhibitor. (pubmedcentralcanada.ca)
  • Encouraged by these results and aimed at developing effective anticancer agents, we designed two series of thiosemicarbazones by the pharmacophore hybridization method using two or more different pharmacophores in view of prospecting their cytostatic and antiviral activity (Fig. 1 ). (springer.com)
  • Chandra S, Vandana S. Synthesis, spectroscopic, anticancer and antibacterial studies of ni(II) and cu(II) complexes with 2-carboxybenzaldehyde thiosemicarbazone. (innovareacademics.in)
  • Design and synthesis of novel N()-substituted thiosemicarbazones bearing a pyrrole unit as potential anticancer agents. (innovareacademics.in)
  • The work is under the general supervision of Professor Forsyth J. Wilson and includes the reactions of the semicarbazones and semioxamazones as well as those of the thiosemicarbazones. (gla.ac.uk)
  • A series of novel 8-nitro quinoline-based thiosemicarbazone analogues were synthesized and characterized by various spectroscopic and single crystal X-ray analyses. (physiciansweekly.com)
  • A series of hydroxy- and methoxy-substituted paeonol thiosemicarbazone analogues were synthesized as potential tyrosinase inhibitors and their inhibitory effects on mushroom tyrosinase and inhibitory mechanism were evaluated. (naver.com)
  • Transition Metal Complexes of Phenanthrenequinone Thiosemicarbazone as" by Zahra Afrasiabi Navan, Ekkehard Sinn et al. (mst.edu)
  • Synthesis, crystal structures, biological activities and fluorescence studies of transition metal complexes with 3-carbaldehyde chromone thiosemicarbazone. (innovareacademics.in)
  • All anthraquinone-thiosemicarbazones exhibit calf thymus DNA-binding activity, but no cleavage of plasmid DNA was observed. (ac.rs)
  • Study on the Interaction between Isatin-β-Thiosemicarbazone and Calf Thymus DNA by Spectroscopic Techniques', Iranian Journal of Pharmaceutical Research , 14(1), pp. 111-123. (ac.ir)
  • The interaction between isatin-β-thiosemicarbazone (IBT) and calf thymus DNA (CT-DNA) was investigated in physiological buffer (pH 7.4) using Neutral Red (NR) dye as a spectral probe by UV-Vis absorption and fluorescence spectroscopy, as well as viscosity measurements. (ac.ir)
  • The results from in vitro (panel of pancreatic tumor cells) and in vivo experiments (C57BL/6 bearing KP02 tumor), suggest that while the multifunctional activity was not required for the antitumor activity of these thiosemicarbazones, σ 2 -targeting appeared to allow alternative tumor cell death mechanisms, leading to potent and less toxic off-targets toxicities compared to other thiosemicarbazones devoid of σ 2 -targeting. (wustl.edu)
  • As the di-2-pyridylketone thiosemicarbazone (DpT) and 2-acetylpyridine thiosemicarbazone (ApT) series show potent antitumor activity in vitro and in vivo, we synthesized their fluorescent zinc(II) complexes to assess their intracellular distribution. (edu.au)
  • Coordination via the thionic sulfur and the azomethine nitrogen atom of the thiosemicarbazone to the Ru(II) metal. (ovid.com)
  • High stability mononuclear Ru(η 6 -p-cymene) complexes with (N,S) coordination mode are formed in the acidic pH range, and increasing the pH the predominating dinuclear [(Ru(η 6 -p-cymene)) 2 (L) 2 ] 2+ complex with μ 2 -bridging sulphur donor atoms is formed (where L − is the deprotonated thiosemicarbazone). (elsevier.com)
  • The FT-IR spectroscopy study showed the involvement of nitrogen and sulphur of thiosemicarbazone moiety of PTS for the uptake of Pb(II) ions by five membered chelate formation. (edu.pl)
  • This is the first study to demonstrate direct lysosomal targeting of our novel Zn(II)-thiosemicarbazone complexes that mediate their activity via transmetalation with copper ions and LMP. (edu.au)
  • In some cases, lowering of the thiosemicarbazone s denticity leads to a decrease of activity 2 but the literature reports examples of biologically significant bidentate thiosemicarbazones. (scielo.br)
  • A thiosemicarbazone is an organosulfur compound with the formula H2NC(S)NHN=CR2. (wikipedia.org)
  • Acetone thiosemicarbazone is a chemical compound with the molecular formula C4H9N3S. (wikipedia.org)
  • CuL] + and [CuL 2 ] complexes show much higher stability compared to that of complexes of the reference compound benzaldehyde thiosemicarbazone. (elsevier.com)
  • The MICs for the lapachol-derived thiosemicarbazone against S. aureus, E. faecalis, C. gattii and several isolates of P. brasiliensis indicated that this compound has the potential to be developed into novel drugs to treat infections caused these microbes. (bvsalud.org)
  • Confocal fluorescence imaging and live cell microscopy showed that the Zn(II) complex of our lead compound, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), which is scheduled to enter clinical trials, was localized to lysosomes. (edu.au)
  • Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) is a lead compound of novel thiosemicarbazone anti-cancer drugs, which entered clinical trials in 2016. (edu.au)
  • Herein, we synthesized two novel thiosemicarbazones and an aldehyde to combine with CDDP to enhance efficacy against ER-positive breast MCF7 cancer cells, triple-negative/basal-B mammary carcinoma cells (MDA-MB231) and lung adenocarcinoma (A549) human cells. (medworm.com)
  • Acetone thiosemicarbazone, chemicalland21.com US patent 3637632, Traynor, Lee, "Agents for shortstopping free radical polymerization of vinylidene monomers", issued 1972-Jan-25 Acetone thiosemicarbazone (ATSC) Archived February 27, 2012, at the Wayback Machine, 88chem.com "40 C.F.R.: Appendix A to Part 355-The List of Extremely Hazardous Substances and Their Threshold Planning Quantities" (PDF) (July 1, 2008 ed. (wikipedia.org)
  • Preliminary work on the action of the amines on the thiosemicarbazones showed that aniline reacts with acetone thiosemicarbazone at 160 C. with vigorous evolution of ammonia and formation of a resinous product which could not be purified. (gla.ac.uk)
  • Benzylamine reacts with acetone thiosemicarbazone at 140-145C , ammonia is evolved and a mixture of products formed, while with acetophenone thiosemicarbazone benzylamine reacts at a temperature of 130-135 C. with formation chiefly of the corresponding 4-benzyl thiosemiearbazone C:N.NH.CS. (gla.ac.uk)
  • Listing your company for Acetone Thiosemicarbazone allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo! (poulvet.com)
  • Pyridoxal (vitamin B-6 aldehyde) thiosemicarbazone (B6TSC) is deprotonated to its anion (B6TSC - H+) in basic solution at pH = 9. (uni-regensburg.de)
  • The reactions of the sodium derivative with ethyl bromide, propyl bromide, n-butyl bromide, benzyl chloride and allyl iodide were investigated, with the result that a new series of S-alkylated thiosemicarbazones has been obtained. (gla.ac.uk)
  • Another attempt to obtain an optically active thiosemicarbazone by the action of 1-dimethylchlorosuccinate on the sodium derivative gave a solid of low melting point which did not contain sulphur or nitrogen and was not, therefore, further investigated. (gla.ac.uk)
  • Carbon dioxide is also formed, together with varying amounts of diethyl carbonate or diphenyl carbonate and the carboethoxy or carbophenoxy derivative of the thiosemicarbazone. (gla.ac.uk)
  • We previously reported that a thiosemicarbazone derivative, NSC73306, is cytotoxic to carcinoma cells that overexpress functional P-glycoprotein, and it resensitizes these cells to chemotherapeutics. (aacrjournals.org)
  • The thiosemicarbazone derivative of 9,10-phenanthrenequinone, 1, and its metal complexes were synthesized. (mst.edu)
  • In addition, the lapachol thiosemicarbazone derivative was active against 11 clinical isolates of Paracoccidioides brasiliensis , with MICs ranging from 0.01-0.10 µmol/mL. (bvsalud.org)
  • Metal complexes of N-heterocyclic thiosemicarbazones derived from 2-formylpyridine (H2FPT) and 2-acetylpyridine (H2APT) were extensively described in the literature 2 , but very few works deal with those derived from 3- and 4-formylpyridine (H3FPT, H4FPT, Fig. 1 ) and 3- and 4-acetylpyridine (H3APT, H4APT, Fig. 1 ). (scielo.br)
  • A family of heterocyclic thiosemicarbazone dyes (3a-f and 4) containing furyl groups was synthesized in good yields, characterized and their response in acetonitrile in the presence of selected anions was studied. (upv.es)
  • A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. (nih.gov)
  • In this study, a Cu(2+) chelate of the novel thiosemicarbazone NSC 689534 was evaluated for in vitro and in vivo anti-cancer activity. (nih.gov)
  • Previously, we reported in vitro cytostatic and broad-spectrum antiviral activity of the thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their platinum(II) and palladium(II) complexes [ 9 ]. (springer.com)
  • In order to establish a structure-activity relationship, the hydrazone analogue of the most active thiosemicarbazone has also been evaluated. (springer.com)
  • 9 - 17 The thiosemicarbazone 18 - 20 and purine nitrile 21 , 22 scaffolds have well established activity against both mammalian and protozoan cathepsins. (pubmedcentralcanada.ca)
  • In addition, the thiosemicarbazones have been reported to have antimalarial activity 19 , 23 - 26 , though they may act through alternative targets. (pubmedcentralcanada.ca)
  • Thiosemicarbazones have a wide range of pharmacological activity that is linked to their ability to chelate transition metals such as copper, iron or zinc. (ukessays.com)
  • 13 This biological activity is useful for both the imaging and therapeutic activity of the thiosemicarbazone complexes. (ukessays.com)
  • For example, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (commercially known as Triapine) inhibited the biosynthesis of DNA in murine leukemia L1210 cells by blocking the activity of ribonucleotide reductase [ 5 ]. (springer.com)
  • Thiosemicarbazones exercise their biological activity in mamalian cells by inhibiting ribonucleotide reductase, a necessary enzyme in the synthesis of DNA precursors [ 6 ]. (ijpsonline.com)
  • Recently, it has been shown that substitution on the 4th nitrogen of thiosemicarbazone can enhance its biological activity [ 14 ]. (ijpsonline.com)
  • IMSEAR at SEARO: Synthesis and biological activity of acetylacetone thiosemicarbazone and their metallic complexes. (who.int)
  • Structure-antiproliferative activity studies on l-proline- and homoproline-4-N-pyrrolidine-3-thiosemicarbazone hybrids and their nickel(ii), palladium(ii) and copper(ii) complexes. (innovareacademics.in)
  • Our findings further describe a novel activity for a benzophenone thiosemicarbazone and propose T44Bf as a promising anti-mitotic prototype to develop chemotherapeutic agents to treat acute leukemia malignancies. (elsevier.com)
  • Moreover, in recent years, the thiosemicarbazones as corrosion inhibitors have been widely studied and have shown their good inhibition efficiency [ 13 - 17 ]. (hindawi.com)
  • Studies on iron and copper complexes have shown that they can be more active in the inhibition of DNA synthesis than the free thiosemicarbazone [ 7 ]. (ijpsonline.com)
  • Paeonol thiosemicarbazone analogues have been found exhibiting more remarkable inhibition than their indexcompounds on mushroom tyrosinase. (naver.com)
  • A series of ruthenium( II ) complexes incorporating a thiosemicarbazone chelate tethered with a diphenylphosphine pendant have been studied. (rsc.org)
  • Ru(II) steroidal metal complexes were synthesized by the reaction of dichlorodicarbonyl ruthenium(II) [Ru(CO)2Cl2]n with Steroidal thiosemicarbazones. (ovid.com)
  • Structures of the steroidal thiosemicarbazone and their metal complexes were confirmed by the FT-IR, 1H NMR, 13C NMR, Fab-Mass spectroscopy and elemental analysis. (ovid.com)
  • N-(4-Acetyl-5-aryl-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-benzothiazol-2-yl-acetamides 7a-c were synthesized by cyclization of the appropriate thiosemicarbazones 6a-c in acetic anhydride. (mdpi.com)
  • This balance may be perturbed by symptomatic toxicity levels during 3-aminopyridine-2-carboxaldehyde thiosemicarbazone therapy. (pubmedcentralcanada.ca)
  • Recently, the small molecule thiosemicarbazone NSC73306 was shown to possess a unique property that exploits P-glycoprotein expression and function to induce toxicity ( 19 , 20 ) while not itself being a substrate for P-glycoprotein ( 19 , 20 ). (aacrjournals.org)
  • Two Schiff bases, namely benzoin thiosemicarbazone (BTSC) and para-anisaldehyde semicarbazone (PAS), were synthesized and characterized. (medicaljournal-ias.org)
  • Copper bis -thiosemicarbazones (Cu-bTSC) have attracted attentions as possible positron emission tomography (PET) radiopharmaceuticals and have already been tested in various human studies. (ijps.ir)
  • A simple, rapid, selective and sensitive spectrophotometric method for the determination of palladium is proposed using piperonal thiosemicarbazone (PATS) as a reagent. (elsevier.com)
  • The Influence of Substituents at C2 Carbon of Thiosemicarbazones on the Bonding Pattern of Bis(diphenylphopshano)alkanes in Palladium(II) Complexes. (howard.edu)
  • Fig. 1 (a) Thiosemicarbazone organocatalyst scaffold used in this study. (rsc.org)
  • A novel 8-nitro quinoline-thiosemicarbazone analogues induces G1/S & G2/M phase cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway. (physiciansweekly.com)
  • Dimethylaminobenzaldehyde thiosemicarbazone (Hdmbtsc) is reported to form complexes with mercury and zinc [14]. (ikm.org.my)
  • Some thiosemicarbazones have medicinal properties, e.g. the antiviral metisazone and the antibiotic thioacetazone. (wikipedia.org)
  • We have studied the inhibitory effect of some Monoterpenic Thiosemicarbazones on steel corrosion in 1 M HCl solution. (hindawi.com)
  • Kinetics studies confirmed first-order dependence with respect to both DHP and alcohol concentrations, and the overall second-order rate constant, k 2 , was determined by non-linear regression (see ESI for details † ) for a range of thiosemicarbazones, 1a-h and 3a-b ( Fig. 2 ). (rsc.org)
  • Studies in vivo demonstrated that a novel thiosemicarbazone, namely di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone hydrochloride, completely inhibited the growth of pancreatic cancer xenografts with no evidence of marked alterations in normal tissue histology. (aspetjournals.org)
  • All the spectral studies authenticated that the square planar geometry of the thiosemicarbazone copper(II) complexes 1-9. (innovareacademics.in)
  • Syntheses and X-ray crystallographic studies of {[Ni(en)2(pot)2]0.5CHCl3} and [Ni(en)2](3-pytol)2. (howard.edu)