• During growth, genes associated with protein ubiquitination/deubiquitination, cell cycle progression, and proteasomal degradation were affected, while genes linked to protein and carbohydrate catabolism were affected during early development. (frontiersin.org)
  • Palmitoylation bicycling is important in cell signaling by marketing the motion of protein to different sites of actions inside the cell[1C9]. (epf2013.org)
  • Fluorescently-labeled tripeptide substrates representing the palmitoylation motif of ras proteins were used to characterize the activity of palmitoylation enzymes, known as acyltransferases, extracted from numerous cancer cell lines. (epf2013.org)
  • For instance, palmitoylation from the development associated proteins, GAP-43, really helps to direct the proteins towards the plasma membrane, where it really is involved with neuronal growing and development, the expansion and branching of neuronal axon ideas especially, or development cones[20C23]. (epf2013.org)
  • Oddly enough, GAP-43 proteins appearance in axons continues to be unchanged between development and the ultimate development of older synapses[26]. (epf2013.org)
  • Palmitoylation, as a result, may be the change between axon maturation and development, than absolute protein expression rather. (epf2013.org)
  • To increase product titers and reduce premature pathway termination products, we conducted in vivo and in vitro analyses to understand and improve the specificity of the acyl-CoA thioesterase enzyme, which releases fatty acids from CoA. (rhea-db.org)
  • Future studies focusing on role of lipid modifications in cilia biology will help understand how cilia maintain a complement of specific proteins that allows for specific functions. (bladeresearchinc.com)