The thioesterase activity is performed by members of the acyl-CoA thioesterase (ACOT) family. (wikipedia.org)
Hypothetical1
mouse-adcl3 Mus musculus (Mouse) Arylacetamide deacetylase-like 3 , mouse-adcl4 Mus musculus (Mouse) Arylacetamide deacetylase-like 4 Hypothetical esterase/lipase/thioesterase family active site containing protein , mouse-aryla Mus musculus (Mouse) arylacetamide deacetylase and 5033417e09rik protein , mouse-Q8BLF1 Mus musculus (Mouse) KIAA1363 NCEH1 neutral cholesterol ester hydrolase 1 B230106I24RIK , mouse-b1avu7 Mus musculus (Mouse). (inra.fr)
Family1
Thioesterases are enzymes which belong to the esterase family. (wikipedia.org)
Lipase3
CGI-58 contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. (nih.gov)
Interestingly, CGI-58 differs from other members of the esterase/lipase/thioesterase subfamily in that its putative catalytic triad contains an asparagine in place of the usual serine residue. (nih.gov)
Thioesterases are enzymes which belong to the esterase family. (wikipedia.org)
Saccharomyces cerevisiae expresses a 67.8 kDa homodimeric serine thioesterase, S-formylglutathione hydrolase (SFGH), that is 39.9% identical with human esterase D. Both enzymes possess significant carboxylesterase and S-formylglutathione thioesterase activity but are unusually resistant to organophosphate (OP) inhibitors. (inrae.fr)
Protein2
Also, the structure of the human acyl-protein thio-esterase of 56 kDa (see figure for a piece of the initial electron density map with a fragment of a b -sheet) was recently solved from brominated crystals using single-wavelength data in the laboratory of Zygmunt Derewenda of the University of Virginia in Charlottesville (the protein came from Teresa Jones of NIDDK). (nih.gov)
esterase fromdeep-sea hydrothermal vent of the East Pacific Rise (EprEst) uncultured bacterium pet-28a est-OKK esterase , 9bact-a0a0k1z4z5 uncultured bacterium Alpha/beta hydrolase fold protein LIPESV12_26 , 9bact-g3c5s4 uncultured bacterium. (inra.fr)
Human1
Compound A34 exhibited outstanding inhibitory activity against human sEH, with an IC(50) value of 0.04 +/- 0.01 nM and a K(i) value of 0.2 +/- 0.1 nM. (inra.fr)
Activity2
Thioesterases exhibit esterase activity (splitting of an ester into acid and alcohol, in the presence of water) specifically at a thiol group. (wikipedia.org)
We also characterized three histidine substitutions near the oxyanion hole, G57H, L58H, and M162H, which significantly decrease esterase activity. (inrae.fr)
Structure1
The structure of the W197I variant is the first reported cysteine sulfenic acid in a serine esterase. (inrae.fr)
Cells2
The TCR repertoires of iTreg and ex-iTreg cells exhibited almost no overlap, which indicates that the two populations are clonally unrelated and maintained by different selective pressures. (gsea-msigdb.org)
Systemic lupus erythematosus (SLE) is an autoimmune disease in which dysfunctional T cells exhibit abnormalities in metabolism. (nih.gov)
Role1
thus, the cysteine sulfenic acid may play a role in the regulation of a "D-type" esterase. (inrae.fr)