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  • moiety
  • The pyrophosphate moiety is essential for submicromolar binding affinity, but unexpectedly, it does not appear to be strictly necessary for modulation of gene expression. (rsc.org)
  • These are thiamine derivatives in which the hydroxyl group of the ethanol moiety is substituted by a phosphate group. (ecmdb.ca)
  • The TPP-bound aptamer adopts a uniquely folded structure in which one sensor helix arm (P2/P3) forms an intercalation pocket for the pyrimidine moiety of TPP, and the other sensor helix arm (P4/P5) offers a water-lined binding pocket for the pyrophosphate moiety of TPP that engages bivalent metal ions ( Fig. 1 ) ( 15 ⇓ - 17 ). (pnas.org)
  • derivatives
  • A strategy to counter multiple pathways of biochemical dysfunction linked to the development of vascular complications emerged from recent advances in understanding of the cell biology of diabetic complications: high-dose therapy with thiamine and related derivatives such as benfotiamine. (springer.com)
  • TPP riboswitches, sometimes present in tandem ( 13 , 14 ), control genes that are involved in the transport or synthesis of thiamine and its phosphorylated derivatives. (pnas.org)
  • transketolase
  • Erythrocyte activity of transketolase, the concentrations of thiamine and related phosphorylated metabolites in plasma, erythrocytes and urine, and markers of metabolic control and vascular dysfunction were determined. (springer.com)
  • intermediate
  • Here, we characterized a new reaction catalyzed by TrpD that resulted in the formation of the purine/thiamine intermediate metabolite phosphoribosylamine (PRA). (nih.gov)
  • found
  • It may contribute to binding via long-range electrostatic interactions and/or by exerting an electron withdrawing effect on the pyrimidine ring, allowing its presence to be sensed indirectly and thereby allowing discrimination between thiamine (and its phosphate esters ) and other aminopyrimidines found in vivo . (rsc.org)