• The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. (justia.com)
  • The compounds of formula (I) may comprise one or more asymmetric carbon atoms- They may therefore exist in the form of enantiomers or of diastereoisomers. (allindianpatents.com)
  • The present invention relates to 5,6-diphenyl- pyridine-3-carboxamide derivatives, to the preparation thereof and to the application thereof in therapeutics. (allindianpatents.com)
  • The invention discloses a preparation method of a quinazolinyl butylene amide compound, which effectively reduces the generation of impurities in the synthesis process by selecting a proper mixed alkali system and using a mixture of 1, 5-diaza-bicyclo [4.3. (lookchem.com)
  • The invention provides a novel preparation method of an afatinib compound. (lookchem.com)
  • Raw materials and reagents used in the preparation method have the advantages of low cost, stable chemical property and convenience in long-term storage and the content of an impurity cis-isomer in the prepared afatinib compound is very low. (lookchem.com)
  • The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate ("cGMP"), and are generally suitable for the therapy and prophylaxis of diseases or disorders which are associated with a disturbed cGMP balance. (justia.com)
  • The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and disorders and for preparing pharmaceuticals for this purpose. (justia.com)
  • and also the salts, the sol vat es and the hydrates thereof. (allindianpatents.com)
  • The compounds of formula (I) may exist in the form of bases or of addition salts with acids. (allindianpatents.com)
  • These salts are advantageously prepared with pharmaceutically acceptable salts, but the salts of other acids that are useful, for example, for purifying or isolating the compounds of formula (I) are also part of the invention. (allindianpatents.com)
  • The compounds according to the present invention are useful as inhibitors of PERK. (justia.com)
  • Mol-Instincts supplies 35 constant properties of pure organic compounds. (molinstincts.com)
  • Mol-Instincts possesses 11 temperature-dependent properties of pure organic compounds. (molinstincts.com)
  • A process for the synthesis of quinazolinone containing compounds which may be useful for the treatment of cancer, is hereby disclosed. (justia.com)
  • The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. (justia.com)
  • The invention further relates to a method for production and therapeutic application thereof. (allindianpatents.com)
  • These enantiomers and diastereoisomers, and also the mixtures thereof, including the racemic mixtures, are part of the invention. (allindianpatents.com)
  • the compound of the formula VI and dimethylamine finally synthesize the compound of the formula VII, that is to say, an afatinib refined product is obtained. (lookchem.com)
  • With respect to the latter methods, a cellulose acylate film containing a triazine compound added is disclosed in JP-A-2003-344655. (justia.com)
  • Based on the above investigation, the inventors have found that the alignment is not inhibited due to the hydrophobic compound in the case of using a retarder with high self-associating property, to achieve both the higher retardation and smaller retardation changes by humidity. (justia.com)
  • Multiple sets of information for the compounds with high drug-likeness score are readily accessible. (molinstincts.com)
  • However, as a result of intense research, the inventors have found that, in the case of adding the above mentioned triazine compound together with another hydrophobic compound to a cellulose acylate film, the retardation properties are deteriorated. (justia.com)
  • Further, the inventors have found out that the retardation properties of the triazine compound are reduced in the presence of the hydrophobic compound because the alignment of the triazine compound is inhibited by the hydrophobizing agent in the cellulose acylate film. (justia.com)
  • Some compounds have also become subject to illicit use as designer drugs. (wikipedia.org)
  • The present invention discloses oxindole compounds and a single step, one pot reaction for the synthesis of oxindole derivates via a solvent free Passerini reaction of isocyanides, isatins and carboxylic acids. (justia.com)
  • The reaction of bromo- or iodoaromatics to give Grignard compounds succeeds in the absence of traces in the haloaromatic which react with the Grignard functionality in almost all cases in good to very good yields. (justia.com)
  • From the point of view of process engineering, preparing Grignard compounds from chloro- or fluoroaromatics is also problematic because the reaction frequently does not start at all at first only then to light off very suddenly and in an often uncontrolled fashion. (justia.com)
  • A mercapto compound having a specific structure is included in the photosensitive resin composition, and includes an acid generator which generates acid upon exposure to an irradiated active ray or radiation, and a resin whose solubility in alkali increases under the action of acid. (justia.com)
  • A method is provided for the reduction or elimination of malodors from indoor air using vapor phase hydrogen peroxide generated from either evaporation from a pH neutral to mildly acidic aqueous-based liquid composition or sublimation from a solid composition containing at least one pH neutral to mildly acidic solid hydrogen peroxide-containing compound. (patentsencyclopedia.com)
  • The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective amount of ifetroban, or a pharmaceutically acceptable salt thereof. (justia.com)
  • Unfortunately there are numerous cases in which, starting from the corresponding chloro- or fluoroaromatics, the Grignard compounds can only be obtained in poor yields, using specialized, often expensive solvents or using expensive activation methods for the magnesium metal. (justia.com)
  • Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic amino moiety (2-aza-bicyclo[2.2.1]heptane) were designed using molecular modelling methods, synthesised, and found to be potent DPP-4 (dipeptidyl peptidase-4) inhibitors. (bvsalud.org)
  • The vapor phase hydrogen peroxide (VPHP) engages a media coated with at least one transitional metal element or compound in the presence of air that contains malodorous compounds. (patentsencyclopedia.com)