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  • apoptotic
  • Some inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10), NF-κB p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. (springer.com)
  • Rats
  • Shiao Ding, Yang Yang, and Ju Mei, "Protective Effects of L-Malate against Myocardial Ischemia/Reperfusion Injury in Rats," Evidence-Based Complementary and Alternative Medicine , vol. 2016, Article ID 3803657, 9 pages, 2016. (hindawi.com)
  • Male Sprague-Dawley rats were subjected to 30 min of occlusion of left coronary anterior descending artery followed by reperfusion for 90 min. (frontiersin.org)
  • Male Sprague-Dawley rats were randomly allocated to 5 groups (20 animals/group): sham, I/R, Que postconditioning, Que+LY294002 [a phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway inhibitor], and LY294002+I/R. I/R was produced by 30-min coronary occlusion followed by 2-h reperfusion. (scielo.br)
  • Adult male SD rats ( n = 8/each group) were randomized: group 1 (sham-operated control), group 2 (IR, 30-min ischemia/72 h reperfusion), group 3 (IR-SS31 (2 mg intra-peritoneal injection at 30 min/24 h/48 h after IR)), group 4 (IR-mitochondria (2 mg/derived from donor liver/intra-venous administration/30 min after IR procedure)), and group 5 (IR-SS31-mitochondria). (mdpi.com)
  • Diabetic rats were subjected to 45 min of ischemia, followed by 3 h of reperfusion. (hindawi.com)
  • PPCI
  • The goal of my PhD was to investigate this phenomenon in human patients treated with PPCI, with particular emphasis on T cell kinetics, their relationship to I/R injury, and the potential mechanisms involved. (bl.uk)
  • Moreover
  • Moreover, SN increased myocardial NO metabolites, superoxide, and their cytotoxic reaction product peroxynitrite, upregulated inducible NO synthase expression, and decreased endothelial NOS phosphorylation. (sigmaaldrich.com)
  • occlusion
  • Rg1 (5 mg/kg/h) was continuously administrated intravenously 30 min before occlusion until the end of reperfusion. (frontiersin.org)
  • Although associated with re-occlusion of the coronary artery or re-imposition of hypoxia in cell culture, the reference to ischemia has been dropped. (springer.com)
  • Tissue
  • Tissue samples were obtained after 4 h reperfusion to determine expression of receptor-interacting protein 1 (RIP1) and activated caspase 3 by Western blot analysis. (springer.com)
  • Evidence
  • Evidence from animal studies points to a role for lymphocytes, and in particular T cells, in myocardial I/R injury, but this has not yet been studied in humans. (bl.uk)
  • protection
  • Bolli R, Becker L, Gross G, Mentzer RM, Jr., Balshaw D, Lathrop DA (2004) Myocardial protection at a crossroads: The need for translation into clinical therapy. (springer.com)
  • function
  • The lack of ATP during ischemia ceases function of the 3Na + -2K + ATPase, thereby exacerbating the intracellular Na + overload. (jci.org)
  • clinical
  • In this study, we performed meta-analysis to assess the clinical effectiveness of using exosomes in ischemia/reperfusion injury based on the reports published between January 2000 and September 2015 and indexed in the PUBMED and Web of Science databases. (hindawi.com)