• Dr. Assouline is the Director of the Chronic Myelogenous Leukemia Clinic of the Jewish General Hospital and, in this capacity, has contributed to epidemiological research into the outcome of patients treated with tyrosine kinase inhibitors. (ladydavis.ca)
  • Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. (lu.se)
  • A gene known as TJP1 (tight junction protein 1) could help determine which multiple myeloma patients would best benefit from proteasome inhibitors such as bortezomib, as well as combination approaches to enhance proteasome inhibitor sensitivity, according to a study led by The University of Texas MD Anderson Cancer Center . (mdanderson.org)
  • Proteasome inhibitors form the cornerstone of our standard therapy for multiple myeloma. (mdanderson.org)
  • Our findings provide a rationale for use of TJP1 as the first biomarker to select patients who are most and least likely to benefit from proteasome inhibitors. (mdanderson.org)
  • Therefore, these plasma cells were resistant to proteasome inhibitors," said Orlowski. (mdanderson.org)
  • These therapies include novel targeted monoclonal antibody therapies, proteasome inhibitors, histone deacetylase inhibitors, and drugs targeting protein translation. (ladydavis.ca)
  • This article reviews current anticancer small-molecule inhibitors targeting epigenetic modified enzymes and displays their performances in different stages of clinical trials. (frontiersin.org)
  • In this review, we summarize the basic principles manipulating the abovementioned epigenetic pathways and highlight the evidence of the promising clinical and preclinical results using small-molecule inhibitors against chromatin regulators for cancer treatment. (frontiersin.org)
  • Nevertheless, a number of new small molecule inhibitors rationally developed using structural-functional analysis and that affect the intracellular trafficking of the toxin are alternative approaches to the more traditional antibody-based molecules which have also recently demonstrated promise as candidate countermeasures for the treatment of ricin exposure in animal models. (mdpi.com)
  • Pazopanib (paz oh' pa nib) is an orally available, multi-kinase inhibitor, most potently inhibiting the tyrosine kinase receptors of vascular endothelial growth factor (VEGF) 1, 2 and 3 which are associated with tumor growth and angiogenesis. (nih.gov)
  • There does not appear to be cross reactivity in risk for hepatic injury between pazopanib and other kinase inhibitors and, in some situations, switching to another tyrosine kinase receptor inhibitor may be appropriate. (nih.gov)
  • In addition to autoinhibition, CR3 is also inhibited when the protein is not post-translationally phosphorylated at certain serine and tyrosine residues in the CR2 hinge region. (news-medical.net)
  • Pazopanib is a multi-kinase inhibitor active against vascular endothelial growth factor receptors-1, -2 and -3 that is used in the therapy of advanced renal cell carcinoma and soft tissue sarcomas. (nih.gov)
  • RAF genes encode serine and threonine kinase proteins downstream of Ras in the pathway. (news-medical.net)
  • Mutant B-Raf proteins that have been implicated in tumorigenesis often have elevated kinase activity, known as a gain of function mutaion. (news-medical.net)
  • Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)
  • Inhibition of the kinase domain is halted through binding of the Ras-binding domain, or residues 155-227 of the protein, to the Ras-GTP effector domain. (news-medical.net)
  • Kinase inhibitors. (cancercare.org)
  • Kinase proteins send signals to the cell's control center to help tumor cells grow. (cancercare.org)
  • Kinase inhibitors block these proteins. (cancercare.org)
  • Some pharmaceutical companies are developing inhibitors of B-Raf protein as anticancer therapies. (news-medical.net)
  • In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
  • In paper I, we identified and tested novel inhibitors targeting the PIM, PI3K, and mTOR pathways. (lu.se)
  • Targeted therapy drugs are like chemotherapy drugs because they also travel through the bloodstream. (healthline.com)
  • Targeted therapy treatments are meant to spare healthy tissues and cause fewer side effects than chemotherapy. (cancercare.org)
  • Traditional therapies such as surgery, chemotherapy, and radiation therapy are still the main means for the treatment of glioma, but the prognosis of patients with glioma is limited [ 4 ]. (hindawi.com)
  • Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. (lu.se)
  • Palcitoclax [APG-1252] is a novel and potent inhibitor of the Bcl-2 family of proteins and induces apoptosis in tumor cells. (pharmiweb.com)
  • APG-115 is a highly potent MDM2-p53 inhibitor, and our data on liposarcoma presented in last year's ASCO report were promising," said Prof. Xing Zhang, Chief Physician of Melanoma and Sarcoma Medical Oncology Unit of Sun Yat-sen University Cancer Center. (pharmiweb.com)
  • Ricin is a potent (type 2) ribosome-inactivating protein toxin produced in the seeds of the castor bean plant Ricinus communis . (mdpi.com)
  • However, because of its complex metabolism, developing safe and potent HDL raising therapies has been a challege. (eurekaselect.com)
  • Adding chemical groups to the DNA backbone and modifying histone proteins impart distinct characteristics on chromatin architecture. (frontiersin.org)
  • Here, we summarize the different types of epigenetic enzymes which target corresponding protein domains, emphasize DNA methylation , histone modifications, and microRNA-mediated cooperation with epigenetic modification, and highlight recent achievements in developing targets for epigenetic inhibitor therapy. (frontiersin.org)
  • Since 2005, she has been involved in the design and conduct of numerous clinical trials testing novel therapies in patients with leukemia and lymphoma. (ladydavis.ca)
  • The aim of this thesis was to identify and test novel therapies against neuroblastoma. (lu.se)
  • But these medications target and block the growth and spread of cancer by interfering with specific genes, proteins, or blood vessels. (healthline.com)
  • 135 antibodies against 65 mainly immunoregulatory proteins, we of a multitude of different genes (8, 9). (lu.se)
  • Moreover, they demonstrated a previously unknown role for EGFR signaling in myeloma, and for STAT3 in controlling the level of proteasomes in cells, and therefore the cell's ability to break down proteins. (mdanderson.org)
  • This study allows us to identify promising future directions to overcome proteasome inhibitor resistance in patients with high signaling through EGFR/JAK1/STAT3 pathway by offering combination therapies such as bortezomib with either the EGFR inhibitor erlotinib, or a JAK1 inhibitor such as ruxolitinib," said Orlowski. (mdanderson.org)
  • Systemic drug therapies are the main form of treatment for this form of breast cancer. (healthline.com)
  • analyzing the velocity (i.e., the change over time) of the markers, malignancy we could stipulate for each patient the risk of developing metas- tasis after the end of adjuvant systemic therapy. (lu.se)
  • It is approved by the FDA as a first-line therapy for CLL, in combination with the immunotherapy obinutuzumab (Gazyva). (cancercare.org)
  • In this first video activity for our melanoma resource center, expert melanoma faculty will review the mechanisms of novel melanoma therapies, discuss the latest clinical safety and efficacy data for first-line melanoma treatments, and highlight practical applications for this data in clinical practice. (primeinc.org)
  • In human epidermal growth factor receptor 2 (HER2)-positive breast cancer , the cancer cells have too much of a growth protein called HER2. (healthline.com)
  • This gene controls a protein called "epidermal growth factor receptor. (webmd.com)
  • Epigenetic drugs show significant effects on both preclinical and clinical studies in which the target development and research offer a promising direction for cancer therapy. (frontiersin.org)
  • Following successful clinical trials of a gene therapy for Leber hereditary optic neuropathy, Pitceathly and colleagues discuss progress towards genetic therapies for other primary mitochondrial diseases. (nature.com)
  • After decades of effort, epigenetic modification has represented the hallmarks of different cancer types, and the enzymes involved in this process have provided novel targets for antitumor therapy development . (frontiersin.org)
  • It phosphorylates a specific sequence on protein targets. (news-medical.net)
  • Venetoclax (Venclexta) targets the B-cell lymphoma 2 (BCL-2) protein, leading to the death of CLL cells. (cancercare.org)
  • Pazopanib therapy is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe and even fatal cases of clinically apparent acute liver injury. (nih.gov)
  • The mechanism of injury accounting for serum enzyme elevations during pazopanib therapy is not known. (nih.gov)
  • In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)
  • This risk assessment was not dependent on the type of adju- decoding patterns of immunoregulatory serum proteins could re- vant therapy received by the patients. (lu.se)
  • Conse- demonstrated that this protein signature provided an added value quently, using minute amounts of nonfractionated serum (14) and compared with conventional clinical parameters. (lu.se)
  • The 3 types of HAE can be differentiated with complement testing and, in the case of HAE with normal C1 inhibitor levels, genetic testing. (medscape.com)
  • We now have additional therapies that we can add onto or use as an alternative if our patients can't tolerate a statin. (medscape.com)
  • The Medical Advisory Board of the HAE Patient's Association has recommended that patients be free to choose their preferred therapy. (medscape.com)
  • AB-836, our oral capsid inhibitor, demonstrated robust antiviral activity, however, two patients in the 200 mg cohort experienced alanine aminotransferase (ALT) elevations. (biospace.com)
  • This presentation focused on the preliminary safety and virology data from those patients in part 3 of the AB-729-001 clinical trial who completed treatment with AB-729 and, after meeting the protocol-defined criteria, elected to stop their NA-therapy (n=9). (biospace.com)
  • There are new drugs, called targeted therapy, that zero in on the specific mutations you have. (webmd.com)
  • However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. (mdpi.com)
  • I'm very happy to be here today to discuss clinical research in lipid-lowering therapies and lipoprotein-lowering therapies with my colleagues, Drs Budoff and Shubrook. (medscape.com)
  • We stumbled on this new inhibitor molecule that limits growth of cells from breast and other cancers," says Dr. Laporte, who conducts research at the RI-MUHC's Centre for Translational Biology . (rimuhc.ca)
  • The initial data with our drug candidates, including MDM2-p53 inhibitor APG-115, novel Bcl-2/Bcl-xL dual inhibitor palcitoclax or APG-1252, and IAP inhibitor APG-1387, support further study with great potential in combination therapies," said Dr. Dajun Yang, Chairman & CEO of Ascentage Pharma. (pharmiweb.com)
  • Our results suggest that Ras pathway inhibitors in combination with KSP inhibition represent a promising treatment strategy against neuroblastoma. (lu.se)
  • Therefore, we hypothesized that there may be a protein that acts as a tumor inhibitor during these early stages of life, preventing the development of leukemia. (lu.se)
  • Additionally, there is a current lack of licensed medical interventions, with supportive therapy representing the main clinical option. (mdpi.com)
  • Furthermore, no effective therapy exists for the advanced stages of the disease. (lu.se)
  • Targeted therapies focus on binding to specific molecules that are important for cancer cell survival and growth. (cancercare.org)
  • Structure showing how the new Ras inhibitor (orange) interacts between two domains (green and blue) of this small G protein, to block its oncogenic activity. (rimuhc.ca)
  • We identified several drugs with previously unknown activity in neuroblastoma, among them the KSP inhibitor ARRY-520. (lu.se)
  • These findings give us great hope that we can develop new classes of drugs to act on small G proteins in the treatment of triple negative breast cancer. (rimuhc.ca)
  • This helps your doctor decide on your treatment plan and if a targeted therapy is a good idea for you. (webmd.com)
  • Prophylactic treatment includes attenuated androgens and the C1 inhibitor protein product Cinryze. (medscape.com)
  • Consensus for obesity treatment is that clinical therapy should begin with lifestyle changes focusing on behavioral modification, diet, and exercise. (eurekaselect.com)
  • Combinatory treatment of the inhibitors with chemotherapeutic agent cisplatin showed synergistic effects. (lu.se)
  • If androgen therapy is used dosage should be minimized, balancing disease severity with minimizing adverse effects. (medscape.com)
  • The inhibitors demonstrated promising effects in vitro with reduced viability, increased differentiation and cell death of neuroblastoma cells. (lu.se)
  • In paper III, we investigated the effects of inhibitor rigosertib against neuroblastoma. (lu.se)
  • Published this week in Nature Communications , a new study by researchers from the Research Institute of the McGill University Health Centre (RI-MUHC) may lead to the development of new classes of drugs for cancer therapies. (rimuhc.ca)
  • We were not looking for drugs that blocked these small G proteins, but rather ones that inhibit growth factor receptor internalization, a process that also controls hormone responses. (rimuhc.ca)
  • The work uncovers a new inhibitor molecule, which acts in a unique way to target small G proteins involved in cancer. (rimuhc.ca)
  • It catalyzes phosphorylation of serine and threonine on target proteins, converting adenosine triphosphate (ATP) to adenosine diphosphate (ADP). (news-medical.net)
  • These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells. (lu.se)
  • Of the current anti-obesity therapies, orlistat and sibutramine do not raise plasma HDL levels, while rimonabant does directly increase HDL concentrations. (eurekaselect.com)
  • Interestingly, because this molecule acts specifically on the two small G proteins Ras and Arf6, which control mitogenic responses and growth factor receptor internalization, it may confer increased therapeutic advantages in different types of cancer," says Jenna Giubilaro, a graduate student supervised by Dr. Laporte and first author of the publication. (rimuhc.ca)
  • This protein helps your cells grow and divide. (webmd.com)
  • The KRAS gene plays a role in making a protein called K-Ras, which helps cells grow and divide. (webmd.com)
  • This therapy seems to be more focused on LDL-C reduction rather than on increasing high-density lipoprotein cholesterol (HDL-C). I'm obviously very excited to see how this plays out in the large outcome study that is underway now. (medscape.com)
  • When lifestyle modification schemes are unsuccessful, drug therapy is an attractive option. (eurekaselect.com)
  • Hereditary angioedema (HAE) is an autosomal dominant disease caused by low levels of the plasma protein C1 inhibitor (C1-INH). (medscape.com)
  • Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)
  • These guidelines were developed by the Working Group on Antiretroviral Therapy and Medical Management of HIV-Infected Children convened by the National Pediatric and Family HIV Resource Center (NPHRC), the Health Resources and Services Administration (HRSA), and the National Institutes of Health (NIH). (cdc.gov)
  • Novel targeted inhibitors, like heat shock protein 90 inhibitors and deacetylase inhibitors, raise patient's life quality [ 6 ]. (hindawi.com)
  • Liver test abnormalities are frequent during pazopanib therapy and routine monitoring is recommended at 3 to 4 week intervals. (nih.gov)
  • TJP1 has not previously been known to play any role as a mediator of proteasome inhibitor sensitivity in multiple myeloma. (mdanderson.org)
  • Analysis of KSP expression across multiple tumor types demonstrated that neuroblastoma is highly dependent on this protein. (lu.se)
  • I think this is another oral therapy, now once a day, that will allow us to lower LDL-C additionally. (medscape.com)