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  • Glioma
  • Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma. (wikipedia.org)
  • pathway
  • The Ras/Raf/MAPK pathway is activated in the majority of advanced HCCs, as a result of increased signaling induced from upstream growth factors, such as epidermal growth factor (EGF), hepatocyte growth buy Argatroban factor (HGF), or insulin-like growth factor (IGF), and also because of inactivation of tumor suppressor genes, including PTEN (3, 4). (researchhunt.com)
  • In one case study, a patient with advanced metastatic vulvar epithelioid sarcoma showed a partial resolution of both lung and pleural metastases when pazopanib was administered, whereas all other therapies had failed MET (mesenchymal to epithelial transition) is another biological pathway that is likely involved in the development and progression of epithelioid sarcoma. (wikipedia.org)
  • vascular
  • Some of the experimental uses for the Lentivirus vector have been in gene therapy of diseases like Diabetes mellitus, Murine haemophilia A, prostate cancer, chronic granulomatous disease, and vascular gene therapy. (wikipedia.org)
  • In a study designed to enhance the outcomes of vascular transplant through vascular endothelial cell gene therapy, the third generation of Lentivirus showed to be effective in the delivery of genes to moderate venous grafts and transplants in procedures like coronary artery bypass. (wikipedia.org)
  • VEGF (vascular endothelial growth factor) is often over-expressed in epithelioid sarcoma. (wikipedia.org)
  • Endocrine Therapies
  • At present, due to the lack of predictive biomarkers that can identify subgroups of patients that will derive the largest benefit from endocrine therapies, treatment decisions regarding the choice between endocrine therapy and chemotherapy are based on clinical criteria such as disease-free interval, extent of visceral metastatic involvement, and degree of symptoms. (biomedcentral.com)
  • PDGFR
  • Pazopanib is another buy Argatroban potent, multi-target receptor tyrosine kinase inhibitor of VEGFR-1, -2, and -3, PDGFR- and -, and c-kit, and has demonstrated in buy Argatroban vivo anti-tumor effect in HCC xenografts (11). (researchhunt.com)
  • patient
  • Factors such as patient fitness, baseline swallow, airway functional status, and others are considered before determining the treatment plan. (wikipedia.org)
  • subgroup
  • However, it will be critical to develop clinical tools that can reliably identify the subgroup of patients most likely to benefit from endocrine therapy alone, and those who might benefit from alternative approaches. (biomedcentral.com)
  • gene
  • In addition, due to the non-pathogenic nature of rAAV, it has emerged as a desirable vector for performing gene therapy in live patients. (wikipedia.org)
  • Another emerging application of rAAV based genome editing is for gene therapy in patients, due to the accuracy and lack of off-target recombination events afforded by the approach. (wikipedia.org)
  • Gene rearrangements, leading to the expression of constitutively activated fusion tyrosine kinase receptors, have been increasingly identified as a common feature of malignancies over the last three decades, and success has been demonstrated using these rearrangements as targets for drug development. (wikipedia.org)
  • Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentivirus. (wikipedia.org)
  • The Lentivirus is unique in that it has been the basis of research using viruses in gene therapy. (wikipedia.org)
  • To be effective in gene therapy, there must be insertion, alteration and/or removal of host cell genes. (wikipedia.org)
  • To do this scientists use the Lentivirus' mechanisms of infection to achieve a desired outcome to gene therapy. (wikipedia.org)
  • A draw back to this therapy is explained in the study that long-term gene expression may require the use of promoters and can aid in a greater trans-gene expression. (wikipedia.org)
  • biological
  • When clinical criteria support its use, endocrine therapy is typically administered alone, but future options might include poly-endocrine therapy or combination with new biological agents. (biomedcentral.com)
  • cancer therapy
  • Mendelsohn remains on the faculty as co-director of the new Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy. (wikipedia.org)
  • Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy (David A. Karnofsky Research Award Lecture). (wikipedia.org)
  • Horizon Discovery: Genesis (rAAV) Cellectis:Meganucleases[permanent dead link] Invitrogen: FLP Sigma-Aldrich: Zinc Fingers AAV FLP-FRT recombination Genome engineering Homologous recombination in viruses Technological applications Cancer therapy Plasmid Recombinant AAV mediated genome engineering Synthetic lethality Zinc finger nuclease Torrance CJ, Agrawal V, Vogelstein B, Kinzler KW (October 2001). (wikipedia.org)