CarcinomaCellsEpithelialMetastaticMutationTumorsColorectalTesticular cancerLungStomachCompositionsResistanceChemotherapyMetastasisSignificantlyMalignantSurvival ratesPrevalenceLiverCSCsIncidenceProgressionCarcinogenesisOutcomesTissuesDevelopmentDetectionDiseasesCommonHigherTreatmentPatientLiteratureStrategiesArticle
Carcinoma4
- Teratocarcinoma refers to a germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both. (wikipedia.org)
- The accepted pathogenetic model is a complex network including SOX2, SOX17, OCT3/4 and PRAME, which modulates the epigenetic transcription of numerous downstream genes and drives a divergent gene expression profile resulting in the transition from pure S (P-S) to S component (S-C) of mixed germ cell tumors of the testis (M-GCTT), and finally to embryonal carcinoma (EC). (bvsalud.org)
- Nasopharyngeal carcinoma (NPC) is a distinctive type of head and neck cancer with special racial and geographic distributions. (biomedcentral.com)
- The paternal cell lines are (1) the p53-wt (wild type) pluripotent gonadal germ cell tumor cell line NTERA-2, (2) the p53-mutated pluripotent extragonadal nonseminomatous germ cell tumor cell line NCCIT and (3) the p53-wt nullipotent embryonal cell carcinoma 2102EP, derived from a primary human testicular teratocarcinoma. (biomedcentral.com)
Cells16
- Targeted therapies specifically target cancer cells while sparing healthy cells, leading to fewer side effects and improved patient outcomes. (patentpc.com)
- Immunotherapies harness the body's immune system to recognize and destroy cancer cells, offering a novel and effective treatment option. (patentpc.com)
- Cancer stem cells (CSCs) are considered to be critically involved in the recurrence and metastasis of NB and are isolated as NB spheres. (oncotarget.com)
- Accumulating evidence has shown that cancer stem cells (CSCs) are a small subpopulation of tumor cells that exhibit the properties of self-renewal, differentiation into various tumor cell types, tumorigenicity, and chemo/irradiation resistance [ 1 ]. (oncotarget.com)
- Therefore, CSCs have become promising target cancer cells for preventing cancer relapse and improving the prognosis of tumor patients [ 3 ]. (oncotarget.com)
- The following text points out several possibilities and chemical pathways in which "Intume" chlorine dioxide intervention can destroy tumors and prevent proliferation of cancer cells. (justia.com)
- Cancer cells are rich in polyamines which is necessary for survival and growth of tumors. (justia.com)
- ix Capacity of cancer tissue to produce abundant PA likely contributes to cancer cell's higher growth rates.ix ,x High concentrations of PA enhance cancer cells to invade, and is associated with less apoptosis and increased expression of the genes affecting metastasis.ix ,xi The association of increased polyamine synthesis and cancer was first reported in the late 1960s. (justia.com)
- Cell culture and drug treatment method conditions Human neuron committed teratocarcinoma, mouse motor neuron derived cells and SMA type I pa tient fibroblasts were maintained in regular problems in Dulbeccos modified Eagle medium supplemented with 10% fetal calf serum, 1% antibiotics and two mM glutamate. (srcpathway.com)
- Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
- Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. (nature.com)
- In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
- At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
- We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. (biomedcentral.com)
- Therefore, investigations on testing and maintaining the integrity of genomic DNA within precancerous stem cells (pCSCs), which are within the framework of the cancer stem cell (CSC) hypothesis, are necessary. (biomedcentral.com)
- Induced pluripotent stem cells (iPSCs) are useful for the development of therapies in regenerative medicine, analysis of pathogenesis, and exploration of candidate drugs. (bvsalud.org)
Epithelial2
- In general, all patients with malignant GCTs have the same staging surgery that is done for epithelial ovarian cancer. (wikipedia.org)
- Notch signaling has been implicated in many microenvironmental processes associated with cancer progression such as vascular remodeling, immunosuppression, epithelial to mesenchymal transition (EMT), as well as maintenance of the CSC pool 21 . (nature.com)
Metastatic1
- The present invention relates to compositions and methods for treating cancerous tumors, including naïve, metastatic and recurrent cancers. (justia.com)
Mutation1
- The observation that one inch of cancerous liver tissue can have more than 100 000 000 mutations and an identical mutation can result in different phenotypes, depending on the environment surrounding that mutation, makes it very unlikely that mutations by themselves are causative of most cancers. (4open-sciences.org)
Tumors8
- They are broadly divided in two classes: The germinomatous or seminomatous germ-cell tumors (GGCT, SGCT) include only germinoma and its synonyms dysgerminoma and seminoma. (wikipedia.org)
- The nongerminomatous or nonseminomatous germ-cell tumors (NGGCT, NSGCT) include all other germ-cell tumors, pure and mixed. (wikipedia.org)
- Compared with germinomatous tumors, nongerminomatous tumors tend to grow faster, have an earlier mean age at time of diagnosis (around 25 years versus 35 years, in the case of testicular cancers), and have a lower five-year survival rate. (wikipedia.org)
- They are found in:[citation needed]} head inside the cranium - pineal and suprasellar locations are most commonly reported inside the mouth - a fairly common location for teratoma neck mediastinum - account for 1% to 5% of all germ cell neoplasms pelvis, particularly sacrococcygeal teratoma In females, GCTs account for 30% of ovarian tumors, but only 1 to 3% of ovarian cancers in North America. (wikipedia.org)
- In younger women, they are more common, thus in patients under the age of 21, 60% of ovarian tumors are of the germ-cell type, and up to one-third are malignant. (wikipedia.org)
- Targeted treatments, such as immunotherapy, hormonal therapy and kinase inhibitors, are being evaluated for tumors that do not respond to chemotherapy. (wikipedia.org)
- Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent widely used in the treatment of several solid tumors, among them testicular cancer, lung cancer, breast cancer, and bladder cancer. (biomedcentral.com)
- Beside intrinsic resistance, acquired or gradually developing resistance has been observed in tumors under therapy. (biomedcentral.com)
Colorectal1
- In their meta-analysis, Kinkel et al compared US, CT, MRI, and fluorodeoxyglucose (FDG) imaging in the detection of liver metastases from colorectal, gastric, and esophageal cancers and concluded that, with an equivalent specificity, FDG positron emission tomography (PET) is the most sensitive noninvasive imaging modality for the diagnosis of liver metastases. (medscape.com)
Testicular cancer1
- In males, GCTs of the testis occur typically after puberty and are malignant (testicular cancer). (wikipedia.org)
Lung1
- According to the American Cancer Society (ACS), the 5-year relative survival rate differs significantly according to cancer type with higher rates ≥90% for prostate cancer, melanoma, skin and female breast cancer compared to lower rates ≤18% in liver, lung, and pancreatic cancer [ 1 ]. (4open-sciences.org)
Stomach1
- The antibodies can be used to target carcinomas in the brain, skin and bone, as well as cancers of the lungs, esophagus or stomach, liver, gallbladder, pancreas. (patentpc.com)
Compositions11
- The market for compositions for the treatment and detection of cancer has witnessed significant growth in recent years. (patentpc.com)
- Compositions for the treatment and detection of cancer play a crucial role in improving patient outcomes and saving lives. (patentpc.com)
- As a result, there is a pressing need for advanced compositions that can effectively treat and detect cancer at an early stage. (patentpc.com)
- Compositions such as targeted therapies, immunotherapies, and precision medicine have emerged as promising approaches in the fight against cancer. (patentpc.com)
- The market for compositions for the treatment and detection of cancer is also driven by increased research and development activities. (patentpc.com)
- Pharmaceutical and biotechnology companies are investing heavily in developing innovative compositions that can effectively target and treat various types of cancer. (patentpc.com)
- Compositions such as liquid biopsies, molecular diagnostics, and imaging techniques have shown great promise in detecting cancer at its earliest stages, enabling timely intervention and treatment. (patentpc.com)
- The market for compositions for the treatment and detection of cancer is highly competitive, with numerous players vying for market share. (patentpc.com)
- These companies are constantly striving to develop innovative compositions that can address the unmet needs of cancer patients. (patentpc.com)
- In conclusion, the market for compositions for the treatment and detection of cancer is witnessing significant growth due to the rising incidence of cancer, advancements in technology, increased research and development activities, and the growing importance of early cancer detection. (patentpc.com)
- As the global burden of cancer continues to increase, the demand for effective and innovative compositions will only continue to rise. (patentpc.com)
Resistance1
- Resistance to cisplatin is a serious obstacle to effective cancer therapy. (biomedcentral.com)
Chemotherapy3
- Patients with germ-cell cancer often need to be treated with combination chemotherapy for at least three cycles, but female patients with early-stage disease may not require this treatment. (wikipedia.org)
- The prognosis for GBM is poor despite the availability of many treatments including surgery, radiotherapy, and chemotherapy. (patentpc.com)
- Interest in targeting polyamine metabolism as a potential strategy for cancer chemotherapy was stimulated in the early 1970s. (justia.com)
Metastasis1
- Only the has-miR-10b involved in breast cancer invasion and metastasis and has-miR-512-3p appeared to be up-regulated (2-3-fold) in all three cell lines. (biomedcentral.com)
Significantly2
- Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. (biomedcentral.com)
- While more advanced cancer stages reveal significantly lower survival rates [ 1 ] they may just represent clinical empiricism [ 4 , 5 ] and do not explain the origin of cancer. (4open-sciences.org)
Malignant1
- Presently, the likelihood of an oral potentially malignant disorder (OPMD) progressing to oral cancer is determined according to histopathological findings, which are susceptible to inadequate and/or subjective qualitative interpretations [ 5 ]. (biomedcentral.com)
Survival rates3
- Early detection plays a crucial role in improving survival rates and reducing the burden of cancer. (patentpc.com)
- Background: Despite the use of aggressive therapy, survival rates among high-risk neuroblastoma (NB) patients remain poor. (oncotarget.com)
- Despite success in some cancer survival rates, these numbers differ by race, ethnicity, socioeconomics, health policy, geography, and age so the overall survival numbers ignore the large variations within any given group. (4open-sciences.org)
Prevalence2
- With the increasing prevalence of cancer worldwide, there is a growing need for innovative and effective solutions to combat this deadly disease. (patentpc.com)
- The increasing prevalence of risk factors such as tobacco use, unhealthy diets, physical inactivity, and exposure to carcinogens has contributed to the growing burden of cancer. (patentpc.com)
Liver1
- Plain chest radiographs are routinely obtained in patients who are suspected of having cancer and are also used in the staging of cancer, but plain abdominal radiography has a limited role in the investigation of liver metastases. (medscape.com)
CSCs2
- Importantly, CSCs are intrinsically more therapy resistant than their more differentiated progeny 5 . (nature.com)
- Thus, a better understanding of the in vivo mechanisms that regulate CSCs is essential for the development of more effective anti-cancer therapies. (nature.com)
Incidence1
- One of the key drivers of this market is the rising incidence of cancer. (patentpc.com)
Progression2
- A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
- Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
Carcinogenesis1
- There is a kind of zeitgeist that findings in genetics, namely somatic mutations, are reflexively viewed as being causative for carcinogenesis, although some 80% of all cancers are presently termed "sporadic" (i.e., with no proven cause). (4open-sciences.org)
Outcomes1
- From a "birds-eye" view, it may appear that we have made little progress in eradicating cancer and that outcomes are largely based on the merits, or lack thereof, of any selected therapy " meaning to reach the proposed vision " Imagine a world without cancer " [ 6 ], we need to work much harder to understand the as yet unanswered questions that surround the origins of most cancers. (4open-sciences.org)
Tissues2
- CT permits better evaluation of the involvement of extrahepatic tissues, including the bones, bowel, lymph nodes, and mesentery. (medscape.com)
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Development4
- These companies are collaborating with academic institutions and research organizations to accelerate the discovery and development of new therapies. (patentpc.com)
- Collectively, these results indicate that CFC1 is a candidate molecule for the development of CSC-targeted therapy for NB. (oncotarget.com)
- INTRODUCTION: Melanoma-associated antigen A2 (MAGE-A2) is a member of the cancer-testis antigen family differentially overexpressed in a variety of malignancies and is associated with tumor development. (bvsalud.org)
- Human Cripto-1, also known as teratocarcinoma-derived growth factor-1 (TDGF-1), is a member of the Epidermal growth factor-cripto FRL1 cryptic (EGF-CFC) family (Cripto in humans, FRL1 in Xenopus, and Cryptic in mice), which is indispensable for early embryonic development[ 4 ]. (biomedcentral.com)
Detection1
- Advancements in technology have revolutionized the field of cancer treatment and detection. (patentpc.com)
Diseases1
- Epidemiologically, cancer is an age-related disease which will be a major burden to healthcare worldwide along with neurologic, cardiovascular diseases, and diabetes [ 3 ]. (4open-sciences.org)
Common1
- It is one of the most common cancers in Southeast Asia and Southern China. (biomedcentral.com)
Higher1
Treatment3
- Chlorine dioxide (ClO2), a strong oxidant, can safely be injected into a subject's body, including a tumor, although the compound has not yet been utilized as a cancer treatment in this manner. (justia.com)
- For p38 inhibitor treatment method, NT2 have been seeded in six effectively plates and pre handled with p38 inhibitor SB239063 for 2 h followed by BAY fifty five 9837 therapy read this post here for 24 h. (srcpathway.com)
- 30%, which is poor given the improvements in cancer treatment. (biomedcentral.com)
Patient1
- If the patient has finished having children, the surgery involves complete staging, including salpingoophorectomy on both sides, as well as hysterectomy. (wikipedia.org)
Literature1
- We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
Strategies1
- The vast majority of anticancer strategies are symptomatic but in order to achieve some tangible progress, we need to identify the cause(s) of the majority of cancers. (4open-sciences.org)
Article1
- No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. (mdpi.com)