Therapy in adrenocortical. Medical search. Frequent questions

Adrenocortical insufficiency (AI) occurs mainly in paediatric age and it can be the first manifestation of the disease in some cas. (endocrine-abstracts.org)
Drug-induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. (nih.gov)
Preoperatively, and in the event of serious trauma or illness, in patients with known adrenal insufficiency or when adrenocortical reserve is doubtful. (nih.gov)
Shock unresponsive to conventional therapy if adrenocortical insufficiency exists or is suspected. (nih.gov)

Martin Fassnacht, MD, from the University of Würzburg in Germany, and colleagues randomized 304 patients with advanced adrenocortical carcinoma to receive mitotane plus either EDP every four weeks or streptozocin every three weeks. (cancertherapyadvisor.com)

Genomic and sequence variants of protein kinase A regulatory subunit type 1beta (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome. (ukw.de)

Unresectable or widely disseminated tumors may be palliated by adrenolytic therapy with mitotane, antihormonal drugs (i.e., ketoconazole and metyrapone), systemic chemotherapy, and/or radiation therapy. (cancer.gov)
Adrenocortical carcinoma (ACC) can be classified into functioning and nonfunctioning tumors by clinical and biochemical assessment. (cancer.gov)
Only 2% of tumors that are less than 4 cm are adrenocortical carcinomas. (medscape.com)
Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
The incidence of adrenocortical tumors in children is extremely low (only 0.2% of pediatric cancers). (oncolink.org)
Adrenocortical tumors appear to follow a bimodal distribution, with peaks during the first and fourth decades. (oncolink.org)
Childhood adrenocortical tumors typically present during the first 5 years of life (median age, 3-4 years), although there is a second, smaller peak during adolescence. (oncolink.org)
Internationally, however, the incidence of adrenocortical tumors appears to vary substantially. (oncolink.org)
Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. (oncolink.org)
Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil. (oncolink.org)
Biology, clinical characteristics, and management of adrenocortical tumors in children. (oncolink.org)
Rodriguez-Galindo C: Adrenocortical tumors in children. (oncolink.org)
Germline TP53 mutations are almost always the predisposing factor for adrenocortical tumors. (oncolink.org)
In the non-Brazilian cases, relatives of children with adrenocortical tumors often, although not invariably, have a high incidence of nonadrenal cancers (Li-Fraumeni syndrome). (oncolink.org)
Morning levels of plasma cortisol in patients with adrenal carcinoma and ectopic ACTH producing tumors were reduced on the average to about one half of the pretreatment levels, and in patients with adrenal hyperplasia to about two thirds of the pretreatment levels, during 1-3 months of therapy with Aminoglutethimide. (wikidoc.org)
Advanced-stage tumors usually require a combination of surgery, chemotherapy, and/or radiation therapy to provide a complete response. (medscape.com)
First German Guideline on Diagnostics and Therapy of Clinically Non-Functioning Pituitary Tumors. (ukw.de)
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors. (lysodren.com)
Radiation therapy is sometimes a treatment for tumors. (medlineplus.gov)

Adrenocortical carcinoma (ACC) is a rare tumor with an annual incidence of 2 cases per 1 million population. (cancer.gov)
Initial evaluation should include careful endocrine studies to reveal any excessive hormone production by the tumor, which can serve as a tumor marker during therapy. (cancer.gov)
Proposal for modification of the ENSAT staging system for adrenocortical carcinoma using tumor grade. (cancer.gov)
Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive tumor, with a poor prognosis and median survival of 3-4 years. (endocrine-abstracts.org)
Adrenocortical carcinoma (ACC) is a rare malignant tumor with an incidence rate of approximately 0.7/million to 2.0/million in the population [ 1 ]. (aging-us.com)
Replacing tumor suppressor microRNAs (miRNAs) offer a novel therapy, however systemic delivery remains challenging. (oncotarget.com)
In a review of 551 cases of adrenocortical carcinoma, mitotane induced a tumor response in 35% of patients. (medscape.com)
Adrenocortical carcinoma (ACC), a rare tumor has the propensity to produce and secrete steroids with the most frequent condition is a cortisol-secreting ACC causing Cushingoid phenotype. (jofem.org)
A novel therapeutic approach that combines human epidermal growth receptor factor 2 (HER2)-targeted therapies with the cholesterol-lowering drug lovastatin can reduce the number of cancer treatments required to prevent tumor growth. (phys.org)
Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone-producing tumor with variable prognosis. (bvsalud.org)

Also, adrenocortical carcinomas feature among new research submitted as abstracts, and the findings have the potential to improve the diagnostics of these cancers (Oral communications 1.2: Focal DNA methylation measurement in adrenocortical carcinoma and 1.4: Urine steroid metabolomics is a highly sensitive tool for postoperative recurrence detection in adrenocortical carcinoma ). (medscape.com)

Adrenocortical carcinoma (ACC) (also known as adrenal cortical carcinoma) is a rare malignancy with a poor prognosis, affecting 1-2 people per million per year year. (medscape.com)
Survival analysis revealed that a low NRP1 expression in adrenocortical carcinoma (ACC), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), low-grade glioma (LGG), and stomach adenocarcinoma (STAD) was associated with poor prognosis. (hindawi.com)
Xu F , Guan Y , Ma Y , Xue L , Zhang P , Yang X , Chong T , . Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical carcinoma. (aging-us.com)
Adrenocortical carcinoma (ACC) has a poor prognosis with significant unmet clinical need due to late diagnosis, high rates of recurrence/metastasis and poor response to conventional treatment. (oncotarget.com)
Libé R. Adrenocortical carcinoma (ACC): diagnosis, prognosis, and treatment. (lysodren.com)

Fruzaqla is an inhibitor of all three VEGF receptor kinases and is indicated for patients already treated with fluoropyrimidine, oxaliplatin, and irinotecan chemotherapy, an anti-VEGF therapy and if medically appropriate, an anti-EGFR therapy. (pharmaceutical-technology.com)
The chemotherapy-free Fruzaqla, marketed as Elunate in China by Eli Lilly, will compete with Taiho and Servier's chemotherapy Lonsurf in combination with the targeted therapy bevacizumab. (pharmaceutical-technology.com)
Cancer therapy, including radiotherapy and chemotherapy, and surgical treatment for cancer can result in POI. (medscape.com)
Chemotherapy largely has been unsuccessful in treating adrenocortical carcinoma. (medscape.com)

What Is the Optimal Duration of Adjuvant Mitotane Therapy in Adrenocortical Carcinoma? (ukw.de)

Dexamethasone phosphate/DEMO is recommended for systemic administration by intravenous or intramuscular injection when oral therapy is not feasible or desirable in the following conditions. (who.int)
Intravenous fluid therapy provides numerous benefits to our sick patients, which include providing for rehydration, correction of hypotension, correction of electrolyte disturbances, a route for administering parenteral nutrition, and a route for the administration of many important medications. (vin.com)
Following along the lines that no medication is perfectly safe, this paper will review the types of various complications that can arise from intravenous fluid therapy. (vin.com)
This is a frequent and sometimes serious complication associated with intravenous fluid therapy. (vin.com)
Etomidate is the only intravenous medical therapy for hypercortisolemia [ 2 ]. (jofem.org)

Although several studies have shown partial or even complete remission, there is no convincing evidence that systemic therapy will improve the survival duration of patients with adrenal cancer. (cancer.gov)
HealthDay News) - For patients with advanced adrenocortical cancer, mitotane plus a combination of etoposide, doxorubicin, and cisplatin (EDP) is superior to streptozocin-mitotane for rates of response and progression-free survival, but does not improve overall survival, according to a study published online May 2 in the New England Journal of Medicine . (cancertherapyadvisor.com)
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Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). (oncolink.org)
Monitored by immuno-PET scans, this combination therapy has the potential to personalize treatment for cancer patients and spare them from harmful side effects. (phys.org)
Targeting the HER2 protein, which is commonly expressed in ovarian cancer, the therapy (anti-HER2 225Ac-PRIT) is a potential treatment for the otherwise incurable disease. (phys.org)
In elderly patients with suspected prostate cancer, a prostate-specific membrane antigen positron emission tomography (PSMA PET) CT scan can diagnose advanced disease and aid in therapy selection without the need for a biopsy. (phys.org)
Adrenocortical carcinoma (ACC) is a rare aggressive form of cancer that grows in the outer part of the adrenal glands. (lysodren.com)
Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: proposal for a Revised TNM Classification. (lysodren.com)
Metastatic and recurrent adrenocortical cancer is not defined by its genomic landscape. (cdc.gov)

Time activity curves derived from "50% cut-off" ROIs based on an isocontour function whereby the pixels with SUVs between 50 to 100% of the highest radioactivity concentration were delineated, showed a significant decrease of the SUVs in normal adrenal glands and in adrenocortical adenomas after cortisone treatment. (nih.gov)
The performance of the adrenal glands is most often impaired due to extensive use of cortisone therapy for nonendocrine diseases, such as arthritis and asthma. (newrootsherbal.com)

If glucocorticoid replacement therapy is needed, 20-30 mg of hydrocortisone orally in the morning will replace endogenous secretion. (wikidoc.org)

Ribeiro RC, Figueiredo B: Childhood adrenocortical tumours. (oncolink.org)
Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation. (oncolink.org)
In this study, MVW-PCA was applied to 14 dynamic 11C-metomidate-PET (MTO-PET) examinations of 7 patients with small adrenocortical tumours. (nih.gov)

Adrenocortical carcinoma (ACC) is rare with an incidence of 0.7 - 2.0 per million per year. (jofem.org)

CORTENEMA® is indicated as adjunctive therapy in the treatment of ulcerative colitis, especially distal forms, including ulcerative proctitis, ulcerative proctosigmoiditis, and left-sided ulcerative colitis. (drugs.com)

A 68-year-old woman with a large right upper quadrant primary adrenocortical carcinoma with curvilinear calcification. (medscape.com)
Primary pigmented nodular adrenocortical disease (PPNAD) was first coined in 1984 by Carney et al. (wikipedia.org)

A detailed hormonal workup is also recommended to identify potential autonomous excess of glucocorticoids, sex hormones, mineralocorticoids, and adrenocortical steroid hormone precursors. (medscape.com)

Responses to the First Radioactive Iodine Treatment After Targeted Therapy for Aggressive Papillary Thyroid Cancers. (ucsf.edu)

LN-145 is a ready-to-infuse, autologous TIL therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI and further optimized by Iovance for the treatment of patients with metastatic NSCLC. (moffitt.org)

Naturally occurring glucocorticoids (hydrocortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. (drugs.com)
Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. (nih.gov)

In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated. (drugs.com)
Prior to the 1970s, systemic corticosteroids were used as standard therapy for patients with EMM and SJS. (jcadonline.com)
Inhaled corticosteroids remain the most important therapy for chronic asthma in both adults and children. (nature.com)

Pituitary disease and tuberculosis also lead to adrenocortical failure. (newrootsherbal.com)
Today, with the advancements in localization, Cushing disease is treated with bilateral adrenalectomy only when ablation of the pituitary through radiation or surgery has failed or when medical therapy does not control secretion. (medscape.com)

While on corticosteroid therapy patients should not be vaccinated against smallpox. (drugs.com)
For use in certain endocrine and non-endocrine disorders responsive to corticosteroid therapy. (who.int)

Medicines, or radiation therapy aim to reduce the risk of recurrence. (lysodren.com)

For first-line therapy, the investigators found that, compared with those in the streptozocin-mitotane group, patients in the EDP-mitotane group had a significantly higher response rate (23.2 vs. 9.2%) and longer median progression-free survival (5.0 vs. 2.1 months). (cancertherapyadvisor.com)
The median duration of progression-free survival was 5.6 months in the EDP-mitotane group and 2.2 months in the streptozocin-mitotane group among 185 patients who received the alternative regimen as second-line therapy. (cancertherapyadvisor.com)
For patients who did not receive the alternative second-line therapy, overall survival was superior with EDP-mitotane vs. streptozocin-mitotane (17.1 vs. 4.7 months). (cancertherapyadvisor.com)
Although a significant improvement in overall survival was not achieved with EDP plus mitotane as first-line therapy, this regimen had higher antitumor efficacy as both first- and second-line therapy than did streptozocin plus mitotane, with a similar rate of serious adverse events," the authors write. (cancertherapyadvisor.com)

ENSAT registry-based randomized clinical trials for adrenocortical carcinoma. (ukw.de)

This might improve the precision of PET measurements, for instance in therapy monitoring as well as for delineation of the tumour in radiation therapy planning. (nih.gov)
ESMO advises that radiation therapy should be avoided if possible in TP53 mutations carriers, after multidisciplinary discussion, and annual whole-body magnetic resonance imaging (MRI) is recommended. (medscape.com)

In severe cases unresponsive to NSAID therapy, steroid medication (Prednisone) can be used. (rxmed.com)

Adrenocortical response should be followed by careful monitoring of plasma cortisol levels until the desired level of suppression is achieved. (wikidoc.org)
Above this dose a proportion of patients may show some adrenocortical suppression, though it is unlikely to be of clinical importance. (nature.com)
At above-licensed doses, biochemical adrenocortical suppression can occur with some unusual but documented cases of clinical Addisonian crisis. (nature.com)

Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties. (drugs.com)
long-term dependence on steroid therapy, if more than 5-10mg/day of prednisolone is required to keep the disease in control- steroid-sparing IMT is indicated. (aao.org)

Therapy should be initiated with 250 mg orally four times daily, preferably at 6-hour intervals. (wikidoc.org)
Patients with chronic asthma should be advised that the effect of Intal Inhaler therapy is dependent upon its administration at regular intervals, as directed. (globalrph.com)

Dose reduction or temporary discontinuation of therapy may be required in the event of adverse effects, including extreme drowsiness , severe skin rash , or excessively low cortisol levels. (wikidoc.org)

The patient was admitted to the intensive care unit with severe diabetic ketoacidosis which needed aggressive fluid resuscitation and insulin therapy. (cancerindex.org)

The alternative treatment was given as second-line therapy for patients with disease progression. (cancertherapyadvisor.com)

Results: Hydrocortisone substitution therapy is often given in doses of 10-25 mg/day, timed according to the circadian rhythm. (uni-wuerzburg.de)

Adrenocortical carcinoma in the United States: treatment utilization and prognostic factors. (cancer.gov)
Systemic treatment of adrenocortical carcinoma in children: data from the German GPOH-MET 97 trial. (oncolink.org)
While the treatment of choice for aldosteronomas is surgical extirpation, the treatment of choice for IAH is medical therapy with aldosterone antagonists. (medscape.com)
Patients of childbearing potential or those with partners of childbearing potential must be willing to practice an approved method of highly effective birth control during treatment and for 12 months after receiving all protocol-related therapy. (moffitt.org)
Dexamethasone phosphate/DEMO is indicated in the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with body weight at least 40 kg) who require supplemental oxygen therapy. (who.int)
Glucocorticoid substitution therapy has been in use for 50 years but is not a wholly adequate treatment. (uni-wuerzburg.de)
After improvement, may consider transitioning to lower-potency corticosteroid, using intermittent therapy, and combining treatment with noncorticosteroidal agents. (pdr.net)

If improvement occurs, it will ordinarily occur within the first 4 weeks of administration as manifested by a decrease in the severity of clinical symptoms of asthma, or in the need for concomitant therapy, or both. (globalrph.com)

Focused Update on AAV-Based Gene Therapy Clinical Trials for Inherited Retinal Degeneration. (cdc.gov)

Adrenocortical disease in ferretes occurs due to early altering, usually before five weeks of age. (newstrendline.com)

This data is the first study in ACC investigating the possibility of miRNAs replacement as a novel therapy. (oncotarget.com)
Patients eventually become euthyroid (i.e. not left with hyper or hypothyroidism) Patients with lymphocytic thyroiditis - may develop persistent goiter (enlarged thyroid ) and thyroid failure, which can be treated with thyroid replacement therapy. (rxmed.com)
Wei J, Johansen KL, McCulloch CE, Lipkowitz M, Weir M, Lin F, Campese VM , Smogorzewski M, Ku E. Association Between APOL1 Genotype and Need for Kidney Replacement Therapy in Patients Without Diabetes: Does Age Matter? (usc.edu)
This guideline covers renal replacement therapy (dialysis and transplantation) and conservative management for people with chronic kidney disease stages 4 and 5. (bvsalud.org)

Introduction: Radioactive iodine (131I) therapy is a safe and cost-effective choice in Graves' disease (GD). (endocrine-abstracts.org)
Patients with a positive 21OH-Ab or adrenocortical antibodies test should be referred to an endocrinologist to test adrenal function and rule out Addison disease. (medscape.com)
Because Aminoglutethimide does not affect the underlying disease process, it is used primarily as an interim measure until more definitive therapy such as surgery can be undertaken or in cases where such therapy is not appropriate. (wikidoc.org)
The duration of the therapy depends on factors such as the topical corticosteroid potency, disease severity and anatomic location, and age. (pdr.net)
Adrenocortical disease is a common problem in ferrets. (newstrendline.com)
The significant false-positive rate of metastases on bone scans means that definitive therapy for local disease may have been withheld from patients inappropriately. (phys.org)

Successful therapy of this condition starts with appropriate management of the animal environment and the selection of therapeutic combinations that safely address the long-term and short term needs of the animal. (dvm360.com)
The management of bilateral adrenal hyperplasia is centered on medical therapy. (medscape.com)

Conclusion: Important measures for the prevention of adrenocortical crises include improved care by treating physicians, education of patients and their families, the provision of emergency identifying documents, and the prescription of glucocorticoid emergency kits. (uni-wuerzburg.de)

Anatomy15

Organisms3

Diseases35

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes14

Disciplines and Occupations1

Insufficiency4

Advanced adrenocortical carcinoma1

Patients with adrenocortical1

Tumors19

Tumor10

Carcinomas1

Prognosis5

Chemotherapy4

Mitotane therapy1

Intravenous5

Cancer11

Cortisone2

Glucocorticoid replacement therapy1

Tumours3

Incidence1

Ulcerative colitis1

Primary2

Hormones1

Cancers1

Metastatic1

Glucocorticoids2

Corticosteroids3

Pituitary2

Corticosteroid therapy2

Recurrence1

Survival4

ENSAT1

Radiation2

Unresponsive1

Suppression3

Prednisolone2

Intervals2

Discontinuation of therapy1

Aggressive1

Progression1

Doses1

Treatment7

Asthma1

Clinical Trials1

Occurs1

Replacement4

Disease6

Management2

Conclusion1