AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth CareGeographicals
Thrombolytic TherapyStreptokinaseTissue Plasminogen ActivatorFibrinolytic AgentsMyocardial InfarctionPlasminogen ActivatorsAnistreplaseUrokinase-Type Plasminogen ActivatorStrokePulmonary EmbolismBrain IschemiaTreatment OutcomeHeparinCerebral HemorrhageMyocardial ReperfusionTime FactorsEmbolectomyThrombosisAcute DiseaseCoronary Care UnitsFibrinolysisHeart Rupture, Post-InfarctionIntracranial ThrombosisHemorrhageElectrocardiographyIntracranial HemorrhagesAngioplasty, Balloon, CoronaryFibrinolysinCarotid Artery ThrombosisInfusions, IntravenousProspective StudiesCoronary ThrombosisCoronary AngiographyEmergency Medical ServicesRecurrenceIntracranial Embolism and ThrombosisInjections, IntravenousRecombinant ProteinsVascular PatencyEmergenciesInfusions, Intra-ArterialTomography, X-Ray ComputedIntracranial EmbolismVenous ThrombosisCerebral InfarctionHirudin TherapyEmergency TreatmentAnticoagulantsCreatine KinaseEmergency Medical TechniciansRadionuclide VentriculographyRetrospective StudiesHospital MortalityInjections, Intra-ArterialThrombectomyReperfusionFibrinopeptide ACerebral AngiographyFollow-Up StudiesFibrinogenFibrinEye HemorrhagePatient SelectionNewfoundland and LabradorHeart RuptureRandomized Controlled Trials as TopicCatheterization, PeripheralStreptodornase and StreptokinaseSurvival AnalysisAspirinAngiographyEcchymosisPredictive Value of TestsInfarction, Middle Cerebral ArteryRisk FactorsCerebrovascular DisordersDrug Therapy, CombinationBlood CoagulationPrognosisArterial Occlusive DiseasesFibrin Fibrinogen Degradation ProductsHospitals, CommunityCardiac CatheterizationShock, CardiogenicVentricular Septal RupturePlasminogenInfarction, Anterior Cerebral ArteryRegistriesSurvival RateMultivariate AnalysisIliac VeinHemostasisVena Cava FiltersHirudinsThrombophlebitisCommunity MedicinePlatelet Aggregation InhibitorsEmbolismVentricular Dysfunction, RightVentricular Function, Left
MyocardialThrombolysisTissue plasminogIschaemicBenefits of thrombolytic therapyPulmonaryIschemic stroke patientsCoronaryReperfusion therapyThrombosisReceive thrombolyticDrip and shipPatients with ST-segment elevationStreptokinaseOutcomeAlteplaseTreatmentRtPAAorticFibrinolytic therapyAngioplastyCardiogenic shockHours after acuteArterialExacerbationInfarctionEmergentContraindicationsSTEMIDiagnosisTherapeuticMortalityStroke therapyCardiac careOnsetIntracerebral hemorrhageTimeAntiplatelet TherapyEndovascular therapy
Myocardial30
Thrombolysis9
  • Fibrin-bound plasminogen will be converted by thrombolytic drugs to plasmin, the rate-limiting step in thrombolysis. (medscape.com)
  • The Ministry of Public Health and the National Health Security Office (NHSO) had accepted the use of intravenous thrombolysis as the standard treatment of acute ischemic stroke in 2008. (springer.com)
  • 18 years with hospitalizations associated with acute PE and thrombolysis in the 2016 Nationwide Readmissions Database. (qxmd.com)
  • Systemic thrombolysis is used more often than CDT in patients with acute PE, in particular among those with a greater prevalence of high-risk features. (qxmd.com)
  • Mathematical modelling of intravenous thrombolysis in acute ischaemic stroke: effects of dose regimens on levels of fibrinolytic proteins and clot lysis time. (imperial.ac.uk)
  • The spontaneous recanalization rate is unclear but is likely poor, 6 and Lindsberg and Mattle 7 have suggested that death and dependency rates in those treated with intravenous thrombolysis are similar to those treated with IA therapies. (ajnr.org)
  • The study team assessed the effect of treatment delay, age, and stroke severity on the effect of intravenous thrombolysis with alteplase in 6756 patients with acute ischemic stroke who participated in 9 major trials of thrombolysis for treatment of stroke. (medscape.com)
  • The central premise of acute stroke thrombolysis is the recovery of the ischemic penumbra ( 6 , 7 ). (spandidos-publications.com)
  • Intravenous thrombolysis (IVT) is a standard procedure for the treatment of patients with acute ischemic stroke (AIS). (frontiersin.org)
Tissue plasminog9
Ischaemic4
  • Computed tomography (CT) must be done before thrombolytic treatment of hyperacute ischaemic stroke, but the significance of early ischaemic change on CT is unclear. (nih.gov)
  • Patients who have had ischaemic ECG changes, or cardiac troponin release or raised CK-MB enzyme demonstrated at any time during admission, have a confirmed acute coronary syndrome. (bmj.com)
  • Methods and analysis We will conduct a search for the studies comparing collateral blood flow-based imaging with CT perfusion using the DEFUSE 3 or DAWN criteria in selecting patients with acute ischaemic stroke undergo EVT in the Web of Science, PubMed, EMBASE and the Cochrane Library databases between November 2017 and November 2021. (bmj.com)
  • 1 Subsequently, the DEFUSE 3 2 and DAWN 3 trials have revealed that patients who had an acute ischaemic stroke (AIS) beyond 6 hours due to large vessel occlusion (LVO) can benefit from EVT by using strict imaging selection criteria. (bmj.com)
Benefits of thrombolytic therapy1
Pulmonary5
Ischemic stroke patients4
  • This study aimed to assess the time to treatment and outcomes among acute ischemic stroke patients who received thrombolytic treatment in the Chulalongkorn Stroke Network by 1. (springer.com)
  • Acute ischemic stroke patients who received thrombolytic treatment during January 2016-December 2017 in the Chulalongkorn Stroke Network were studied. (springer.com)
  • Despite the increasing number of patients receiving thrombolytic treatment, this figure is relatively low compared to the number of all ischemic stroke patients. (springer.com)
  • Acute ischemic stroke patients who arrive at this hospital within 2 hours of time last known well and for whom IV alteplase was initiated at this hospital within 3 hours of time last known well (i.e., drip and ship patients). (jointcommission.org)
Coronary7
  • for the Acute Coronary Syndrome Quality Improvement in Kerala (ACS QUIK) Investigators. (imperial.ac.uk)
  • Patients with a suspected acute coronary syndrome should be observed, with repeat 12 lead ECG recording, during symptoms if the opportunity arises. (bmj.com)
  • Patients with a confirmed acute coronary syndrome should be admitted to a cardiac care unit or high dependency unit with continuous ECG rhythm monitoring. (bmj.com)
  • Confirmed acute coronary syndrome. (bmj.com)
  • Antithrombotic Therapy in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Undergoing Percutaneous Coronary Intervention: A North American Perspective: 2021 Update. (duke.edu)
  • 1- Many patiensts with acute coronary symptoms do not have classic text book symptoms. (highbloodpressuremed.com)
  • Timely coronary reperfusion (e.g., angioplasty, thrombolytic therapy) and arrhythmia control can reduce morbidity and mortality in persons experiencing AMI ( 2 ). (cdc.gov)
Reperfusion therapy3
  • Our aim was to look at the combined results of these trials and to ascertain which reperfusion therapy is most effective. (nih.gov)
  • This approach to reperfusion therapy has also been labeled a pharmacoinvasive approach. (wikidoc.org)
  • Although not specifically addressed in the guidelines, LBBB plus hemodynamic instability or LBBB plus Sgarbossa criteria should probably still result in acute reperfusion therapy. (medscape.com)
Thrombosis5
  • Evidence to guide patient selection for IA therapy in acute basilar artery thrombosis is lacking. (ajnr.org)
  • We included 40 consecutive patients with basilar artery thrombosis treated with IA therapy. (ajnr.org)
  • Low GCS score did not correlate with poor neurologic outcome in patients with acute basilar artery thrombosis managed with IA therapy. (ajnr.org)
  • Acute basilar artery thrombosis is an infrequent but catastrophic subtype of posterior circulation ischemic stroke that carries a mortality rate of 80%-90% without treatment. (ajnr.org)
  • Only 1 multicenter randomized controlled trial assessed IA therapy efficacy for acute basilar thrombosis. (ajnr.org)
Receive thrombolytic2
  • Ideally, you should receive thrombolytic medicines within the first 30 minutes after arriving at the hospital for treatment. (medlineplus.gov)
  • For at least 2 decades, we've been taught that patients presenting with cardiac symptoms plus a presumed-new left bundle branch block (LBBB) pattern on the ECG should be treated for STEMI and receive thrombolytic medications or immediate cardiac catheterization. (medscape.com)
Drip and ship2
  • Telestroke-assisted thrombolytic treatment with secondary transfer to the CSC (drip-and-ship) 3. (springer.com)
  • Thrombolytic treatment with drip and ship method under teleconsultation is feasible in Thailand. (springer.com)
Patients with ST-segment elevation1
  • We did a search of published work and identified 23 trials, which together randomly assigned 7739 thrombolytic-eligible patients with ST-segment elevation AMI to primary PTCA (n=3872) or thrombolytic therapy (n=3867). (nih.gov)
Streptokinase1
  • Streptokinase infusion initially yielded conflicting results until the Gruppo Italiano per la Sperimentazione della Streptochinasi nell'Infarto Miocardico (GISSI) trial in 1986, which validated streptokinase as an effective therapy and established a fixed protocol for its use in AMI. (medscape.com)
Outcome5
  • The degree of recanalization was directly related to time to therapy and associated with good clinical outcome without an increase in the rate of adverse effect. (ajnr.org)
  • We investigated the effect of vessel recanalization on clinical outcome following local thrombolytic therapy of AIS patients. (ajnr.org)
  • Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. (nih.gov)
  • We hypothesize that low GCS does not correlate with poor outcome and that it should not preclude IA therapy. (ajnr.org)
  • however, as the NINDS investigators concluded, the earlier that IV thrombolytic therapy is initiated, the better the patient outcome. (jointcommission.org)
Alteplase3
  • The administration of IV alteplase to carefully screened, eligible patients with acute ischemic stroke has been shown to be beneficial in several clinical trials. (jointcommission.org)
  • Based on the results of these studies, the Food and Drug Administration (FDA) approved the use of intravenous alteplase for the treatment of acute ischemic stroke when given within 3 hours of stroke symptom onset. (jointcommission.org)
  • Although the benefit of IV alteplase has been well established, only a minority of patients with acute ischemic stroke actually receive this medication across the United States. (jointcommission.org)
Treatment16
  • Primary PTCA is more effective than thrombolytic therapy for the treatment of ST-segment elevation AMI. (nih.gov)
  • Our stroke network consists of different levels of spoke hospitals, ranging from community hospitals where thrombolytic treatment is not available, to those capable of onsite thrombolytic therapy. (springer.com)
  • Referral from community hospital to the CSC for thrombolytic treatment (ship-and-drip). (springer.com)
  • The national thrombolytic treatment for acute ischemic stroke rate has been increased from 0.38% in 2008 [ 1 ] to 4.36% in 2015 [ 6 ]. (springer.com)
  • The complexity of the stroke fast track system, which requires multidisciplinary team, management in a timely manner, and lack of stroke specialists limits the availability of thrombolytic treatment in Thailand mainly to provincial and university hospitals. (springer.com)
  • The aim of this study is to evaluate time to treatment and clinical outcomes of patients receiving thrombolytic treatment among different thrombolytic delivery protocol in the Chulalongkorn Stroke Network. (springer.com)
  • Thrombolytic medicines are approved for the emergency treatment of stroke and heart attack . (medlineplus.gov)
  • This CT score is simple and reliable and identifies stroke patients unlikely to make an independent recovery despite thrombolytic treatment. (nih.gov)
  • The following conditions will always exclude patients for treatment: Severe aortic valve insufficiency Aortic dissection Severe aortoiliac occlusive disease and bilateral carotid stenosis The following conditions make IABP therapy inadvisable except under pressing circumstances: Prosthetic vascular grafts in the aorta Aortic aneurysm Aortofemoral grafts Sepsis IABP has a beneficiary effect to the struggling heart. (wikipedia.org)
  • A 7-year-old castrated male Pomeranian was evaluated on emergency for diagnostic work-up and treatment for acute nonpainful paraparesis. (hindawi.com)
  • Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation. (duke.edu)
  • In addition to physical examination findings, D-dimer and echocardiography were guiding parameters in the evaluation of treatment discontinuation and thrombus resolution in patients presenting to the outpatient clinic for discontinuation of treatment for acute PTE. (researchsquare.com)
  • We retrospectively reviewed the data of patients diagnosed with PTE who had received the required duration of anticoagulant therapy according to their risk factors and presented for treatment discontinuation to the Atatürk University Chest Diseases Outpatient Clinic between January 2015 and September 2019. (researchsquare.com)
  • Overview -Although β 2 agonists are known to have benefit in the treatment of acute asthma, there is less evidence that ipratropium bromide offers additional advantages over this standard treatment. (bmj.com)
  • Design -Meta-analysis of trials comparing use of ipratropium bromide as an adjuvant treatment in the treatment of patients with an acute exacerbation of asthma. (bmj.com)
  • Our Principal Investigators have played key roles in shaping the modern approach to stroke treatment such as establishing the evidence base for stroke unit care, thrombolytic therapy and stroke prevention. (gla.ac.uk)
RtPA1
  • A total of 24% and 69% of patients had complete and any recanalization, respectively, following endovascular rtPA therapy of AIS. (ajnr.org)
Aortic2
  • Surgical aortic thrombectomy was performed, and antithrombotic therapy was instituted. (hindawi.com)
  • 6- A high index of suspicion is necessary to avoid missing the diagnosis of acute aortic dissection or pericarditis. (highbloodpressuremed.com)
Fibrinolytic therapy3
  • The magnitude and nature of cardiac injury after primary PCI is very different from that seen after fibrinolytic therapy or after a completed infarct. (hcplive.com)
  • Stated simply, this is performance of a PCI in a closed artery following fibrinolytic therapy. (wikidoc.org)
  • Stated simply, this is performance of a PCI in an open artery following fibrinolytic therapy. (wikidoc.org)
Angioplasty1
Cardiogenic shock1
  • The patient, a 48-year-old woman, was in cardiogenic shock and unresponsive to traditional therapy. (wikipedia.org)
Hours after acute2
  • The use of intravenous tPA within 3 hours after acute ischemic stroke has been proved to increase the number of good outcomes. (umn.edu)
  • Troponin levels peak at 14 hours after acute MI, peak again several days later (biphasic peak), and remain abnormal for 10 days. (medscape.com)
Arterial1
Exacerbation2
  • Jackson I, Pajjuru V, Varghese M, Nayfeh A, Millner P, Landeen C, Walters R, Andukuri V. In-Hospital Outcomes of Acute COPD Exacerbation in Elderly Patients with Demetia: A Nationwide Analysis. (creighton.edu)
  • Impact Of Anemia On Mortality Of Patients With Acute COPD Exacerbation. (creighton.edu)
Infarction1
  • Reversible intracardial mechanical defects complicating infarction, i.e. acute mitral regurgitation and septal perforation. (wikipedia.org)
Emergent1
  • We identified short-term and long-term clinical outcomes of death, non-fatal reinfarction, and stroke, and did subgroup analyses to assess the effect of type of thrombolytic agent used and the strategy of emergent hospital transfer for primary PTCA. (nih.gov)
Contraindications1
  • Recent recommendations from the American Heart Association/American Stroke Association and FDA remove or make less specific many previous contraindications and warnings for therapy. (jointcommission.org)
STEMI1
  • These studies demonstrated a reduction in infarct size and improvement in clinical end points with early administration of intravenous beta-blocker therapy in animal models of STEMI as well as in patients presenting with STEMI. (hcplive.com)
Diagnosis1
  • This characteristic could make troponin T (in combination with CK-MB) useful for retrospective diagnosis of acute MI in patients who seek care very late. (medscape.com)
Therapeutic1
  • Effects of low-dose triple combination therapy on therapeutic inertia and prescribing patterns in hypertension - results from the TRIUMPH trial. (imperial.ac.uk)
Mortality2
  • Association Between Thrombolytic Door-to-Needle Time and 1-Year Mortality and Readmission in Patients With Acute Ischemic Stroke. (duke.edu)
  • however, for the large majority of patients lacking access to advanced therapies stroke mortality and residual morbidity remain high and many patients become incapacitated by motor and cognitive deficits, with loss of independence in activities of daily living. (mdpi.com)
Stroke therapy1
  • Recanalization, however, remains the main goal of endovascular stroke therapy. (ajnr.org)
Cardiac care1
  • This article will provide an overview of the use of thrombolytic agents in modern cardiac care, with particular reference to their impact on the Accident and Emergency department. (kingston.ac.uk)
Onset2
  • Inclusion criteria for thrombolytic therapy were 18 years of age or older, presenting within 6 hours of stroke symptoms onset with initial National Institute of Health Stroke Scale (NIHSS) of 8 or more, except for aphasia and visual field deficit, and normal initial head CT scan. (ajnr.org)
  • Troponin T and I can be detected in serum within the first few hours after onset of acute MI. (medscape.com)
Intracerebral hemorrhage2
  • However, tPA is a toxic therapy that carries a substantial risk of intracerebral hemorrhage. (umn.edu)
  • Immediate lowering of SBP to less than 140 mm Hg in adults with spontaneous intracerebral hemorrhage (ICH) who present within 6 hours of the acute event and have an SBP between 150 mm Hg and 220 mm Hg is not of benefit to reduce death or severe disability and can be potentially harmful. (medscape.com)
Time10
  • hence, the importance of time for thrombolytic therapy. (medscape.com)
  • When adjusted to time to therapy and vessel occluded, these results lessened but remained significant. (ajnr.org)
  • RESULTS: Median times for the interval between arrival at the hospital and acquisition of a diagnostic electrocardiogram (door-to-electrocardiography time) and the interval between arrival and start of thrombolytic therapy (door-to-drug time) were 6 minutes and 34 minutes, respectively. (uncg.edu)
  • Statistical significance was demonstrated between time to IA therapy within 6 hours and mRS ≤ 2. (ajnr.org)
  • 3 - 9 , 11 - 14 Presenting clinical status, GCS score, age, and time to intervention influence the decision to proceed with IA therapy. (ajnr.org)
  • To increase the accuracy of the identification of the ischemic penumbra, extension of the thrombolytic time window is necessary. (spandidos-publications.com)
  • Introduction Perfusion imaging according to the DEFUSE 3 or DAWN criteria has been applied to select patients with large vascular occlusive stroke undergo endovascular therapy (EVT) in the extended time window. (bmj.com)
  • As many as 1/3 do not develop any changes at al.Because ECG changes are not always seen with acute MI and serum markers may take time to evolve, the key determinant wheather or not to hospitalize a patient with chest pain remains the clinical history. (highbloodpressuremed.com)
  • Reducing the time from the initial occurrence of symptoms to hospital arrival can increase the likelihood that these therapies are used early in the course of AMI. (cdc.gov)
  • Three (12.5%) patients received thrombolytic therapy within the recommended 30-min time frame. (bvsalud.org)
Antiplatelet Therapy1
  • Of these, 14 patients were treated with regular antiplatelet agents (aspirin plus clopidogrel) and 59 patients were treated with tirofiban within 24 h of IVT, followed by regular antiplatelet therapy. (frontiersin.org)
Endovascular therapy2
  • however, endovascular therapy can only be performed in selected high-performing stroke centers. (frontiersin.org)
  • Endovascular therapy (EVT) has become a standard care for patients with large vessel occlusive stroke within 6 hours. (bmj.com)