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  • platelet
  • Both groups of patients (i.e. nonresponders to immunosuppressive therapy and responders with persistent thrombocytopenia) require regular platelet transfusions, which are expensive and inconvenient, and are a risk for further serious bleeding complications. (clinicaltrials.gov)
  • Because a paucity of megakaryocytes and decreased platelet production is responsible for thrombocytopenia in aplastic anemia patients, we now propose this Phase 2, non-randomized pilot study of eltrombopag in aplastic anemia patients with immunosuppressive therapy refractory thrombocytopenia. (clinicaltrials.gov)
  • Severe plastic anemia can lead to problems with bone marrow platelet production and result in low blood platelet counts, which require frequent platelet transfusions to improve blood clotting. (clinicaltrials.gov)
  • Clinical
  • Duke University School of Medicine also includes PhD programs in the basic sciences and education and training programs in other health professions, including the top-ranked Physician Assistant and Doctor of Physical Therapy programs, a Primary Care Leadership Track, Master of Biomedical Sciences, MS and PhD in Biostatistics, and Master of Management in Clinical Informatics. (wikipedia.org)
  • medical
  • Working under the supervision of Bruce (AACR Award), and in association with Till and McCulloch and a vibrant group of graduate students and post-doctoral fellows, Eaves completed his PhD in Medical Biophysics at the University of Toronto with a thesis entitled Studies on the Control of Murine Bone Marrow Function (1974). (wikipedia.org)
  • In May 2012, Pluristem reported that its experimental PLacental eXpanded cells were injected into the muscles of a 7-year-old Romanian girl undergoing treatment for bone marrow aplasia disease at the Hadassah Medical Center in Jerusalem. (wikipedia.org)
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
  • experimental
  • Our subsequent experimental work focused upon practical applications of BOEC: their use for gene therapy, tissue engineering, assessment of mutant gene effect, and discovery of heterogeneity in endothelial biology. (jci.org)
  • tissues
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • laboratory
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • enzyme
  • Enzyme replacement therapy is available to treat mainly Fabry disease and Gaucher disease, and people with these types of sphingolipidoses may live well into adulthood. (wikipedia.org)
  • Since the implementation of enzyme replacement therapy for Hunter syndrome, lifespans for those without mental handicaps are expected to lengthen since their physical disease appears to improve or stabilize with such treatment. (wikipedia.org)
  • Procedure
  • citation needed] A variation on the Carticel technique, called matrix-associated autologous chondrocyte transplantation (MACT), grows the patient's cells in a 3D matrix of resorbable tissue which is implanted via an open or arthroscopic procedure. (wikipedia.org)
  • cells
  • The hematopoietic cells are able to go to the bone marrow through tracking mechanisms. (wikipedia.org)
  • Diamond-Blackfan anemia is characterized by normocytic or macrocytic anemia (low red blood cell counts) with decreased erythroid progenitor cells in the bone marrow. (wikipedia.org)
  • In some individuals, the disease comes to light only after the cancerous cells overwhelm the bone marrow resulting in anemia producing tiredness or weakness. (wikipedia.org)
  • Treatment
  • Development of the new methods of treatment of children with acquired and inherited bone marrow failures. (fnkc.ru)
  • Autologous matrix-induced chondrogenesis, which is also known as AMIC, is a biological treatment option for articular cartilage damage bone marrow stimulating technique in combination with a collagen membrane. (wikipedia.org)
  • While the initial treatment is to address the underlying disease, ultimately the therapy is directed to the management of portal hypertension. (wikipedia.org)
  • Results
  • Methods and Results- Immediately after hindlimb ischemia was created, rats were randomized to receive AM infusion plus bone marrow-derived mononuclear cell (MNC) transplantation (AM+MNC group), AM infusion alone (AM group), MNC transplantation alone (MNC group), or vehicle infusion (control group). (ahajournals.org)
  • This is in contrast to Shwachman-Bodian-Diamond syndrome, in which the bone marrow defect results primarily in neutropenia, and Fanconi anemia, where all cell lines are affected resulting in pancytopenia. (wikipedia.org)
  • CLL results in the build up of B cell lymphocytes in the bone marrow, lymph nodes, and blood. (wikipedia.org)
  • occupational
  • In many cases, spinal cord injuries require substantial, long-term physical and occupational therapy in rehabilitation, especially if they interfere with activities of daily living. (wikipedia.org)
  • model
  • Thus, the purposes of the present study were (1) to investigate whether local infusion of AM enhances the angiogenic potency of MNC transplantation in a rat model of hindlimb ischemia and (2) to investigate the effects of AM on the survival, adhesion, and differentiation of transplanted MNCs. (ahajournals.org)
  • group
  • This protocol resulted in the creation of 4 groups: (1) AM infusion plus MNC transplantation (AM+MNC group, n=10), (2) AM infusion plus PBS injection (AM group, n=10), (3) vehicle infusion plus MNC transplantation (MNC group, n=10), and (4) vehicle infusion plus PBS injection (control group, n=10). (ahajournals.org)
  • Rose J. P. and Weis, J., Sound meditation in oncological rehabilitation: a pilot study of a receptive music therapy group using the monochord. (wikipedia.org)
  • failure
  • Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably, pain. (wikipedia.org)
  • common
  • The most common and frequently used combination or synthesis comprises meditation music and receptive music therapy, guided imagery, relaxation, some form of meditative practice, and journaling. (wikipedia.org)
  • Regenerative Medicine
  • In 2006 Eaves retired as required by provincial law at that time, becoming Professor Emeritus of Hematology and spending more time on several companies he founded to further the fields of cellular therapy and regenerative medicine - STEMCELL Technologies, STEMSOFT Software Inc. and Malachite Management Inc. These companies continue to grow under his leadership and by 2016, STEMCELL had over 900 employees making Canada's largest biotechnology company. (wikipedia.org)
  • pilot study
  • Pilot study evaluating the effect of massage therapy on stress, anxiety and aggression in a young adult psychiatric inpatient unit. (nih.gov)
  • tiredness
  • Large numbers of leukemia cells accumulate very quickly in the blood and bone marrow, leading to symptoms such as tiredness , easy bruising , and susceptibility to infections. (medicinenet.com)
  • examination
  • Seven years after BMT, thrombocytopenia developed and marrow examination confirmed t-MDS, with a characteristic karyotype 46.XX,inv(3)(q21:q26), del(5)(q13),add(17)(p11). (hku.hk)
  • disease
  • In May 2012, Pluristem reported that its experimental PLacental eXpanded cells were injected into the muscles of a 7-year-old Romanian girl undergoing treatment for bone marrow aplasia disease at the Hadassah Medical Center in Jerusalem. (wikipedia.org)
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
  • treatment
  • The reader is advised to consult with a physician or other medical professional and to check product information (including packaging inserts) for changes and new information regarding dosage, precautions, and contra indication before administering any drug, herb, supplement, compound, therapy or treatment discussed herein. (cancerconnect.com)
  • Massage therapy for the treatment of depression: a systematic review. (nih.gov)
  • diseases
  • In addition, substrate reduction therapy, a method used to decrease the production of storage material, is currently being evaluated for some of these diseases. (wikipedia.org)