Therapies tumor cell cycle. Medical search. Frequent questions

Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed. (bmj.com)
In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
Pro-growth signals from the tumor microenvironment, as well as the cell-intrinsic response to radiation therapy, drove the mesenchymal shift through a stress-response pathway mediated by AP1. (ucsf.edu)
The tumor microenvironment (TME) promotes BCSC survival and cancer progression, and targeting the TME can aid in successful immunotherapy. (hindawi.com)
The microenvironment surrounding tumor tissues provides a favorable niche for bacteria to inhabit. (nature.com)
The module will include the importance of cancer stem cells and the tumour microenvironment, the spread of cancer and therapeutic advances. (york.ac.uk)
Challenges include finding the right target to direct the T cells, the ability to expand in an often-immunosuppressive tumor microenvironment, yielding an effective antitumor response, and avoiding adverse side effects. (aacr.org)
I studied the tumor microenvironment of liver cancer during my graduate training in Hong Kong. (stanford.edu)
Findings suggest therapeutic strategies should be aimed at interfering with cancer cell reprogramming of microenvironment cues ( Nature ). (frontlinegenomics.com)
In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)

In line with this observation, elevated extracellular lactate concentrations up to 40 mM and corresponding low extracellular pH (pH e ) have been found in solid tumors under hypoxic conditions [ 18 - 22 ]. (hindawi.com)
Background Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a promising immunotherapeutic approach for patients with advanced solid tumors. (bmj.com)
In September 2021, GeoVax expanded its immuno-oncology pipeline and added a new technology platform through the acquisition of exclusive rights to Gedeptin ® , a novel patented product for the treatment of solid tumors through a gene therapy strategy known as GDEPT (Gene-Directed Enzyme Prodrug Therapy). (gabio.org)
The purpose of this is to evaluate the safety, effectivess, pharmacokinetics, and pharmacodynamics of FT-2102 as a single agent and in combination with other anti-cancer drugs in patients with advanced solid tumors and gliomas. (mayo.edu)
Part 1: A single agent, open-label study in up to five cohorts (glioma, hepatobiliary tumors, chondrosarcoma, intrahepatic cholangiocarcinoma, and other IDH1 mutant solid tumors) that will include a Phase 1 dose confirmation followed by a Phase 2 investigation of clinical activity in up to 4 cohorts. (mayo.edu)
Other solid tumors that have relapsed or refractory to standard-of-care therapy with no other available therapeutic options. (mayo.edu)
Gedeptin ® is a novel patented product/technology for the treatment of solid tumors through a gene therapy strategy known as Gene-Directed Enzyme Prodrug Therapy (GDEPT). (geovax.com)
A Phase 1 dose-ranging study, evaluating the safety of a single cycle of Gedeptin ® therapy, found the therapy well-tolerated, with evidence of a reduction in tumor size in patients with solid tumors. (geovax.com)
A pair of studies presented at the AACR Annual Meeting 2019 demonstrated encouraging clinical outcomes with two different chimeric antigen receptor (CAR) T-cell therapies for patients with advanced solid tumors. (aacr.org)
Given the success of CAR T-cell therapies for blood cancers, the most anticipated next step in the field is the development of this type of immunotherapy for solid tumors. (aacr.org)
Developing CAR T-cell therapies for solid tumors, however, has been challenging, and researchers in the field have had several failed attempts. (aacr.org)
This recent review article summarizes the challenges with developing CAR T-cell therapy for solid tumors and strategies to overcome the hurdles, and lists some of the ongoing clinical trials in which CAR T cells that target tumor antigens, including GD2, CEA, and EGFR, are being currently tested against a variety of solid tumors. (aacr.org)
Data presented here at the conference have demonstrated that it is possible to develop CAR T-cell therapies for solid tumors that are not only safe but also yield clinical benefit for patients. (aacr.org)
If this approach is successful, 2 million patients with mesothelin-expressing solid tumors per year in the United States will be eligible for this treatment," said Prasad S. Adusumilli, MD , who presented the study. (aacr.org)
This article in Cancer Discovery reviews the types of solid tumors that express mesothelin, and the potential of mesothelin-directed CAR T-cell therapy to treat such malignancies. (aacr.org)

p53 is a tumour suppressor protein involved in maintenance of genomic stability of the cell. (uib.no)
Interleukin-24 (IL-24) is an important immune mediator, as well as a broad-spectrum tumor suppressor. (techscience.com)
A recent link of the p53 tumor suppressor gene to Huntington disease and potentially other neurodegenerative diseases supports this notion. (the-scientist.com)
This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
The tumor suppressor factor p53 has been extensively studied for its role in cancer and is also known to play an important role in regulating CVDs. (bvsalud.org)

Chemotherapy plays a role in adjuvant therapy for high-grade uterine sarcomas, in addition to high-grade, recurrent, or metastatic endometrial cancer. (medscape.com)
Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
The patient demographics, tumor characteristics, context of STZ chemotherapy, and patient outcome were collected and assessed. (cancerindex.org)
Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
BCSCs can develop into many cell types and repopulate heterogeneous tumors following conventional chemotherapy or radiotherapy [ 4 , 6 ]. (hindawi.com)
The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
Chemotherapy is used to kill cancer cells with medicines delivered in varied cycles through either an IV or a pill. (nortonhealthcare.com)
Chemotherapy has been shown to enrich cancer stem cells in tumors. (aacrjournals.org)
Recently, we demonstrated that administration of chemotherapy to human bladder cancer xenografts could trigger a wound-healing response that mobilizes quiescent tumor stem cells into active proliferation. (aacrjournals.org)
This phenomenon leads to a loss of sensitivity to chemotherapy partly due to an increase in the number of tumor stem cells, which typically respond to chemotherapy-induced cell death less than more differentiated cells. (aacrjournals.org)
The current treatments for melanoma are surgery, which is performed in the early stages of the disease, and neoadjuvant treatments for advanced patients, including chemotherapy, radiotherapy, targeted therapy, immunotherapy and combination therapy [ 2 , 3 ]. (medsci.org)
Systems of this type have been widely used in the modeling of cell-cycle specific cancer chemotherapy over a prescribed therapy horizon for both homogeneous and heterogeneous tumor populations. (aimsciences.org)
These results will be applied to a model for cell cycle specific cancer chemotherapy with cytotoxic and cytostatic agents. (aimsciences.org)
The aim of this study was to determinate the effect of different chemotherapy protocols used in the clinic on tumor stem cell markers in vitro . (isciii.es)
Although surgical resection can be applied when the tumor is well defined (20% of cases) 1 , most patients with pancreatic cancer are treated with chemotherapy. (isciii.es)
In the latest years, people discovered that there is certainly a little subpopulation of cells in tumors, which play a essential function in the resistance of cancer to radiotherapy and chemotherapy. (immune-source.com)
Anticipated to undergo 3 cycles of chemotherapy (solid tumour cancer participants) OR autologous stem cell transplantation (haematological cancers - HSCT participants). (who.int)
Timing of intervention: Solid tumours - from mucositis daily questionnaire (MDQ) score >1 in first cycle of chemotherapy to end of cycle 3. (who.int)
Gut distress determined by the Mucositis Daily Questionnaire (MDQ) for up to 3 cycles of chemotherapy and calculated as area under the curve and adjusted per cycle (AUC MDQ/cycle) [The MDQ is assessed daily for the duration of each treatment cycle up to a maximum of 3 full cycles. (who.int)
AUC for solid tumour patients will be assessed over the 3rd full cycle of chemotherapy after starting medicinal cannabis. (who.int)
Epirubicin may increase your risk for developing leukemia (cancer of the white blood cells), especially when it is given in high doses or together with certain other chemotherapy medications. (medlineplus.gov)
Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. (lu.se)
Treatment usually involves removing the uterus, ovaries, and fallopian tubes and sometimes involves removing nearby lymph nodes, often followed by radiation therapy and sometimes by chemotherapy or hormone therapy. (msdmanuals.com)

is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
The increasing need for innovative medications and improved therapies are used to targets for cancer immunotherapy. (pharmiweb.com)
Antitumor immunotherapy using monoclonal antibodies is considered selective and efficient in the treatment of different types of tumors, but its cost and toxic effects limit its application. (researchgate.net)
The news follows directly on the heels of recent preclinical data presented at the Society for Immunotherapy of Cancer (SITC) 35th Anniversary Annual Meeting of the company's other immunotherapy candidate NKX019, which is currently being investigated for B cell lymphoma and acute lymphoblastic leukemia. (biospace.com)
NKX101, an "off-the-shelf" immunotherapy, uses natural killer cells obtained from the peripheral blood of healthy donors and is engineered with membrane-bound interleukin 15 and a chimeric antigen receptor (CAR) targeting NKG2D ligands found on tumor cells. (biospace.com)
Among these, targeted therapy and immunotherapy are now the current main therapeutic procedure in melanoma. (medsci.org)
CAR T-cell therapy is a type of immunotherapy in which T cells are removed from a patient's body and genetically modified so that they can recognize the patient's cancer cells. (aacr.org)

The drug caused the woman's tumor to shrink, and her cancer remained progression-free for nearly three years, until a metastatic skin lesion was detected in 2013. (news-medical.net)
We will discuss the key features of cancer biology, such as deregulated cell cycle progression, growth, invasion and metastasis. (york.ac.uk)
For instance, RUNX2 is involved in the progression of various tumor types, such as osteosarcoma, renal cell carcinoma, gastric cancer and breast cancer ( 15 - 20 ). (spandidos-publications.com)
Of note, other studies have also indicated the involvement of RUNX2 in breast cancer stem cells (BCSCs) and breast cancer progression ( 22 , 23 ). (spandidos-publications.com)
The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
SVC112 increased cell-cycle progression delay and slowed DNA repair following radiation, enhancing colony and sphere formation radiation effects. (nih.gov)
Here at Stanford, I am using different genome editing tools and mouse models to investigate the role of macrophages in promoting tumor progression and immune tolerance in liver cancer. (stanford.edu)
The study identified 2 genes known to contribute to tumor progression and 8 known to be present in tumor cells but which have unknown functions. (frontiersin.org)
Results from a recent Phase 3 clinical trial suggest gene therapy treatment for motor neurone disease (MND) can slow and reduce progression of the disease. (frontlinegenomics.com)
For optimal responses, DNA repair must coordinate with other cellular processes, such as cell-cycle progression and programmed cell death. (the-scientist.com)
All somatic eukaryotic cells arrest progression through the cell cycle when their DNA is damaged, presumably because optimal repair of the damage would be a mechanistic challenge if the cell continued to replicate DNA or segregate chromosomes. (the-scientist.com)

In Trp53KO/C-MycOE mice and mice with tumors grown from Hepa1-6 cells, injection of the combination of anti-PD1 and anti-TIGIT significantly reduced tumor growth, increased the ratio of cytotoxic to regulatory T cells in tumors, and prolonged survival.PVRL1, which is up-regulated by HCC cells, stabilizes cell surface PVR, which interacts with TIGIT, an inhibitory molecule on CD8+ effector memory T cells. (stanford.edu)

Breast cancer stem cells (BCSCs) play a critical role in chemoresistance, metastasis, and poor prognosis of breast cancer. (hindawi.com)
New antitumor strategies using drugs targeted to intracellular signaling involved in cell proliferation and survival, angiogenesis, and metastasis have become promising in recent years. (researchgate.net)
Here, we determined that upregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known as NCOA2, drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. (jci.org)
Metabolic profiling of human prostate tumors identified a massive increase in the SRC-2-driven metabolic signature in metastatic tumors compared with that seen in localized tumors, further implicating SRC-2 as a prominent metabolic coordinator of cancer metastasis. (jci.org)
Biology of Metastasis - Adhesion Molecules and Cell-Cell/Matrix Interactions 1 (Migration) ( MSc Oncology , A34C02/L/05 Tumour Physiology) (2015-present). (nottingham.ac.uk)
Biology of Metastasis - Adhesion Molecules and Cell-Cell/Matrix Interactions 2 (Invasion) ( MSc Oncology , A34C02/L/05 Tumour Physiology) (2015-present). (nottingham.ac.uk)
Lung tumor stem cells are a subpopulation of cells important for lung tumor development, metastasis, and medication resistance. (immune-source.com)
In addition, they are responsible for tumor development and metastasis also. (immune-source.com)

A Phase 1/2 trial is currently enrolling to evaluate the safety and efficacy of repeat cycles of Gedeptin therapy in patients with recurrent head and neck squamous cell carcinoma (HNSCC), with tumors accessible for injection and no curable treatment options. (gabio.org)
Besides, 12% of patients have second- or third-degree skin reactions that are sensitive to light, and about 18% of patients develop cutaneous squamous-cell carcinoma and keratoacanthoma or occurred at the same time [ 6 ]. (medsci.org)
NCT03754933 ) is evaluating the safety and efficacy of repeat cycles of Gedeptin ® therapy in patients with recurrent head and neck squamous cell carcinoma (HNSCC), with tumor(s) accessible for injection and no curable treatment options. (geovax.com)
Phase 1/2 Trial - Gedeptin ® - A Phase 1/2 trial (NCT03754933) evaluating the safety and efficacy of repeat cycles of Gedeptin therapy in patients with recurrent head and neck squamous cell carcinoma (HNSCC) that have tumor(s) accessible for injection and no curable treatment options, is ongoing at Stanford University in collaboration with Emory University. (geovax.com)
Cancer stem cells (CSC) drive growth, therapy resistance, and recurrence in head and neck squamous cell carcinoma (HNSCC). (nih.gov)
SIGNIFICANCE: Inhibiting protein elongation with SVC112 reduces tumor growth in head and neck squamous cell carcinoma and increases the effects of radiation by targeting the cancer stem cell pool. (nih.gov)
A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)

This was the first time that researchers were able to comprehensively map intra-cellular signaling in the tumor-anatomical niches of recurrent GBM and identify novel cell-extrinsic therapeutic targets. (ucsf.edu)
The identified potential therapeutic targets of HNK (PTTH) included CCND1 , SIRT2 , AURKB , VEGFA , HDAC1 , CASP9 , HSP90AA1 , and HSP90AB1 , which can potentially inhibit the cell cycle of mBCSCs. (hindawi.com)
Overall, this study proposes a new strategy for the bacteria-mediated delivery of therapeutic proteins to tumors. (nature.com)
The emerging technology known as targeted therapy facilitates selective delivery of chemotherapeutic agents involving therapeutic genes and drugs to tumor sites, which enhances the therapeutic efficacy and reduces side effects 2 . (nature.com)
It enables in situ delivery of the produced bioactive molecules to tumor site, which improves the therapeutic efficacy. (nature.com)
The impact of the p53 status of tumor cells on extrinsic apoptosis signaling should be considered, especially in the context of therapeutic approaches that aim to restore p53 function to enable cell death. (uni-muenchen.de)
Cancer Cell Metabolism: Unique Features Inform New Therapeutic Opportunities. (nyas.org)
Results We discovered that neoantigen-specific TIL clones were predominantly CD4 + T cells and were present in both therapeutic responders and non-responders. (bmj.com)
In this discussion article on the basis of the developed hypothesis of induced bioregulation of tumor cells we have proposed a conceptually different methodological concept of therapeutic correction brain tumors - cytoregulatory therapy which is based on using induced regional multipotent stem cells as the main approach in the central nervous system tumors. (genescells.ru)
Moreover, therapeutic strategies aimed at mitochondrial-related molecules and mitochondrial replacement therapy have demonstrated their advantageous potential. (bvsalud.org)
Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. (lu.se)
In vitro cell culture systems are instrumental in the development of therapeutic targets. (cdc.gov)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)

Our results further indicate that MCT4 promotes proliferation and survival by altered cell cycle regulation and cell death mechanisms. (hindawi.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
Preclinical models predict that blockade of the coinhibitory molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA4) on lymphocytes results in the release of a cell cycle inhibitory checkpoint, allowing lymphocyte proliferation, tumor targeting, and regression. (snmjournals.org)
Molecular imaging with the PET probe 18 F-FLT allows mapping and noninvasive imaging of cell proliferation in secondary lymphoid organs after CTLA4 blockade in patients with metastatic melanoma. (snmjournals.org)
A clear example of the critical role of CTLA4 on tolerance is the striking phenotype of CTLA4 knock-out mice, which develop rapid T-cell proliferation and autoimmune infiltration of multiple organs shortly after birth ( 6 , 7 ). (snmjournals.org)
In addition, AKT/mTOR signaling and MAPK signaling were inhibited by JIB extract to suppress melanoma cell growth and proliferation. (medsci.org)
Results suggest leukocyte and T-cell proliferation have improved predictability performance over tumour mutational burden ( Nature ). (frontlinegenomics.com)
Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
The intricate web of cancer biology is governed by the active participation of long non-coding RNAs (lncRNAs), playing crucial roles in cancer cells' proliferation, migration, and drug resistance. (bvsalud.org)

This brain tumor type is highly proliferative and shows an infiltrative growth pattern, accounting for the high recurrence rates in patients. (hindawi.com)
Our survey showed the clinical benefit and safety of STZ therapy for Japanese patients with unresectable NET. (cancerindex.org)
The oncology segment held the highest market size of around USD 85.48 million in 2018 owing to huge patient base and increasing need for novel therapies for the treatment of cancer patients. (pharmiweb.com)
Although the trial wasn't designed to test whether the combination is more effective against breast tumors than paclitaxel, the patients' responses were promising. (news-medical.net)
In patients with renal failure or highly aggressive disease, therapy with vincristine, Adriamycin (doxorubicin), and dexamethasone (VAD) may be preferred. (medscape.com)
In elderly patients or patients in whom autologous transplantation is not possible in the future, melphalan and prednisone (MP) therapy is preferred because of its ease of administration and low toxicity. (medscape.com)
It is indicated as monotherapy, in combination with dexamethasone, or in combination with lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma in patients who have received at least 1 prior line of therapy. (medscape.com)
Patients' cases are presented to a group of multidisciplinary providers, and treatment plans are discussed in the Breast Tumor Board. (nortonhealthcare.com)
We tested the role of whole-body molecular imaging in patients with advanced melanoma receiving the CTLA4-blocking antibody tremelimumab, allowing the analysis of changes in glucose metabolism using the PET probe 18 F-FDG and cell replication with the PET probe 3′-deoxy-3′- 18 F-fluorothymidine ( 18 F-FLT). (snmjournals.org)
Monoclonal antibodies blocking CTLA4 induce regression of immunogenic tumors in mice ( 8 ) and are being pursued as a treatment approach for patients with cancer. (snmjournals.org)
The emerging clinical data suggest that a subset of patients with metastatic melanoma treated with CTLA4-blocking antibodies, in the range of 5%−15%, achieve durable objective tumor responses. (snmjournals.org)
The primary outcome measures include the incidence of treatment-emergent adverse events and the proportion of patients experiencing dose-limiting toxicities of the therapy. (biospace.com)
Patients with AML who relapse following front-line therapy are at high risk of experiencing poor outcomes, despite recent breakthroughs in treatment research, according to a statement made by Carlos Bachier, M.D., Director of Cellular Therapy Research, Sarah Cannon Research Institute and Program Director for Sarah Cannon Center for Blood Cancer at TriStar Centennial Medical Center in Nashville, Tennessee. (biospace.com)
Additionally, this research has demonstrated clinical responses in patients with relapsed/refractory AML who received non-engineered allogeneic NK cells as a treatment in some single-center studies. (biospace.com)
With its amplified NKG2D targeting and enhanced NK cell engineering," added Dr. Rajangam, "NKX101 has the potential to improve upon this earlier clinical experience with non-engineered NK cells and to activate a deep and robust immune response in AML patients. (biospace.com)
Methods We analyzed infused TIL products from metastatic melanoma patients previously treated with ACT for the presence of neoantigen-specific T cells. (bmj.com)
During the meeting several analyses will be presented in patients with haemophilia A, paroxysmal nocturnal hemoglobinuria (PNH), immune thrombocytopenia (ITP), relapsed or refractory diffuse large b-cell lymphoma, myelofibrosis, and haemophagocytic lymphohistiocytosis. (centralillinoisproud.com)
Patients will be enrolled across 4 different disease cohorts, examining the effect of FT-2102 + azacitidine (glioma and chondrosarcoma), FT-2102+nivolumab (hepatobiliary tumors) and FT-2102+gemcitabine/cisplatin (intrahepatic cholangiocarcinoma). (mayo.edu)
Phase 2 Trials - GEO-CM04S1 - GEO-CM04S1 is being studied in a Phase 2 clinical trial (NCT04977024) as a primary vaccine for immunocompromised cancer patients who have difficulty producing antibodies and largely depend on T cells to protect against the virus responsible for COVID-19. (geovax.com)
Current standard methods of curing patients with brain tumors targeted to complete elimination of tumor cells from the body are of low effectiveness. (genescells.ru)
The U.S. Food and Drug Administration has approved two CAR T-cell therapies for blood cancers so far: tisagenlecleucel (Kymriah) for treating certain patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma (NHL), and axicabtagene ciloleucel (Yescarta) for treating certain adults with NHL. (aacr.org)
In a phase I clinical trial , a team of researchers from Memorial Sloan Kettering Cancer Center tested whether mesothelin-directed CAR T cells that they developed would be safe and effective in patients with malignant pleural disease from mesothelioma and lung and breast cancer. (aacr.org)
Using an interventional radiology procedure, the investigators injected IcasM28z CAR T cells directly into the pleural cavity in 21 patients with malignant pleural disease (19 with malignant pleural mesothelioma, one with metastatic lung cancer, and one with metastatic breast cancer). (aacr.org)
The molecular biology and genetics of brain tumour cells grown as 3D cultures better resembles the biology of the patients' tumour, when compared to traditional 2D cultures. (nottingham.ac.uk)
Epirubicin is used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. (medlineplus.gov)
At a median follow-up of 27.7 months, the 3-year invasive disease-free survival (IDFS) rate was 90.4% for patients who received the combination, compared with 87.1% for patients who received endocrine therapy alone. (medscape.com)
These recurrences can be quite delayed, and for our patients with node-negative disease, to this point, we haven't seen any improvements with the addition of a CDK4/6 inhibitor to endocrine therapy for early- stage breast cancer. (medscape.com)
She noted, however, that to date, the absolute benefit of the combination over endocrine therapy alone has been modest, at 3.3%, but that the difference may be important to many patients who feel that they need to do everything they can to prevent disease recurrence. (medscape.com)
Adams and Nanda both noted that the addition of ribociclib to endocrine therapy increases the treatment burden for patients because it requires a commitment of at least 3 years and more frequent monitoring, especially in the first few months of therapy, compared with endocrine therapy alone. (medscape.com)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
Patients usually do not seek counseling until the tumors are large because small tumors cause little distress and may not be noticed by the patient. (cdc.gov)
Several academic and industry efforts are well under owned subsidiary Cyto Therapeutics, it had received way to produce dopaminergic neurons from stem approval by the Australian government to conduct a cells under conditions compliant with use in patients. (lu.se)
A second press release [2] has indicated stem cell source, resulting in widespread excitement that the program is planning to move forward very rapidly, with all of the patients being enrolled in the Correspondence to: Roger A. Barker, John van Geest Centre first quarter of 2016 and interim results being shared for Brain Repair, Department of Clinical Neurosciences, Univer- in October 2016. (lu.se)

Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)
However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. (nih.gov)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
For instance, as reviewed by Li et al ( 3 ), triple-negative breast cancer (TNBC) may have worse cause-specific survival and overall survival than the non-TNBC counterpart in all stages and substages, regardless of influencing factors from univariate and multivariate analyses (e.g., tumor grade, age, ethnicity, surgery and radiation treatments). (spandidos-publications.com)
Reversible proteasome inhibition disrupts pathways supporting cell growth, thus decreasing cancer cell survival. (medscape.com)
Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. (jci.org)
SRC-2 is essential for prostate cancer cell survival. (jci.org)
Nude mice were injected via the tail vein with PC-3 cells stably expressing shNT, sh18, and sh19 ( n = 7), and growth and survival of the cells in mouse lungs were analyzed after 5 weeks. (jci.org)
F ) Clonogenic survival assay in the stable PC-3 cells shNT, sh18, and sh19 expressing GFP adenovirus, SRC-2 adenovirus, or FASN adenovirus to rescue the defective survival phenotype in SRC-2-depleted cells. (jci.org)
Essential Biotechnology has a new approach to cancer therapy based on the discovery of a molecule that serves as a nexus in regulating tumor cell survival. (lesi.org)
Key international collaborations include Johns Hopkins University, Mayo Clinic and University of Louvain, with a research highlight demonstrating a long-term survival benefit in orthotopic brain tumour models when combined chemotherapeutics are delivered at neurosurgery via a biodegradable paste ( Clinical Cancer Research 25 (16): 5094-5106, 2019). (nottingham.ac.uk)
Abstract Glioma is the most common primary malignant brain tumor with a poor survival rate. (techscience.com)
An evolving paradigm expanding the genetic basis of cancer suggests that developmental programs indelibly imprint restricted repertoires of homeostasis, forming the substrate for lineage-dependent tumor induction by deregulation of tissue-specific survival pathways. (jefferson.edu)
CHICAGO -The combination of ribociclib (Kisqali) and endocrine therapy has already been shown to yield a significant survival advantage for women with metastatic, hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer. (medscape.com)
As previously reported by Medscape Medical News , the combination of ribociclib and standard-of-care endocrine therapy was the first to show an improvement in overall survival among women with metastatic HR+/HER2- breast cancer. (medscape.com)
In vivo, combination treatment resulted in slower tumor growth and increased survival of neuroblastoma PDX models. (lu.se)
KSP inhibition caused tumor regression in vivo and resulted in increased survival of multiple PDX models. (lu.se)
In vivo, rigosertib treatment resulted in decreased tumor growth and increased survival of PDX mice. (lu.se)
Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)

They found that cells in this surgical margin acted as niches of recurrence where non-malignant glia were broadcasting pro-growth signals that influenced the tumor cells to regrow. (ucsf.edu)
These paracrine (cell extrinsic) signals stimulated the activator protein (AP1) pathway, leading to mesenchymal transition, therapy resistance and tumor recurrence. (ucsf.edu)
The recurrence and drug resistance of breast cancer are intractable due to the presence of breast cancer stem cells (BCSCs), which are adequate to initiate tumor formation and refractory to conventional remedies. (spandidos-publications.com)
The goal of radiation therapy is to kill cancer cells and prevent recurrence of the disease using X-rays and other types of radiation. (nortonhealthcare.com)
Cancer stem cells are responsible for tumor chemoresistance and recurrence in adjuvant and metastatic settings. (isciii.es)
Recurrence and chemoresistance in pancreatic cancer are largely related to cancer stem cells. (isciii.es)

The researchers add that certain plant hormones including IAA should be further studied for anti-tumor action, given that they alter the cell cycle in ways promising for eliminating cancerous cells. (sciencedaily.com)
In the ongoing open-label, 27-participant Phase I trial , Nkarta is evaluating the safety, pharmacokinetics and preliminary anti-tumor activity of NKX101. (biospace.com)
Hence, this study aimed to investigate the anti-tumor and synergistic potential of J. indica Bertol. (medsci.org)
Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)

Malignant gliomas are the most common primary malignant brain tumors with an increasing incidence of up to nine per 100,000 habitants over the last years [ 1 , 2 ]. (hindawi.com)

For this work, I have used patient-derived xenograft mouse models and neuroblastoma cells grown as 3D tumor organoids. (lu.se)

After decades of effort, epigenetic modification has represented the hallmarks of different cancer types, and the enzymes involved in this process have provided novel targets for antitumor therapy development . (frontiersin.org)
Consequently, when cell cycle arrest was deactivated by adding caffeine, the antitumor activity of TRAIL was decreased. (uni-muenchen.de)
Antitumor therapies targeted to reduce the induction, recruitment, or suppressive activities of the immune cells have been investigated. (researchgate.net)
In GDEPT, a vector is used to selectively transduce tumor cells with a nonhuman gene, which expresses an enzyme that can convert a nontoxic prodrug into a very toxic antitumor compound. (gabio.org)
An increasing number of studies have emphasized the antitumor effects of TPL on non-small cell lung cancer (NSCLC). (techscience.com)
Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. (techscience.com)
After this record, people discovered that thioridazine possesses antitumor impact in many types of tumors [13C15]. (immune-source.com)

1. Equipped with HlyE, EcNe significantly caused tumor regression in mice xenografted with human colorectal cancer cells. (nature.com)
SVC112 alone inhibited the growth of patient-derived xenografts (PDX), and SVC112 combined with radiation resulted in tumor regression in HPV-positive and HPV-negative HNSCC PDXs. (nih.gov)

He currenty leads research programmes in neurosurgically-applied drug delivery, brain tumour heterogeneity and brain tumour metabolism as Associate Professor, with a grant portfolio of £6M since 2013. (nottingham.ac.uk)
Single cell RNA sequencing of endothelial cell heterogeneity in breast cancer identifies lipid-processing subtype that could offer a potential route for future treatment regimes ( Nature ). (frontlinegenomics.com)

Monocarboxylate transporter 4 (MCT4, SLC16A3 ) is elevated under hypoxic conditions in many malignant tumors including gliomas. (hindawi.com)
This in turn renders the supply of oxygen in tumor vasculature insufficient, consequently leading to formation of hypoxia or anoxia regions in malignant tumors. (nature.com)

It can be used in small tumors in certain cases. (nortonhealthcare.com)

Now the same combination has also shown benefit in early-stage HR+/HER2- breast tumors. (medscape.com)

‌TBXT transcribes genes that form notochord cells, which are responsible for the flexibility, length, and balance of the spine, including tail vertebrae. (wikipedia.org)
To identify genes that can functionally substitute for oncogenic RAS, we systematically expressed 15,294 open reading frames in a human KRAS-dependent colon cancer cell line engineered to express an inducible KRAS-specific shRNA. (nih.gov)
By examining samples taken from a patient through the course of her treatment with palbociclib, the team found that as the tumors became resistant, the cells more than doubled their expression of several cell-cycle-driving genes, including PLK1, TOP2A, CDK1, and BUB1. (news-medical.net)
Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
Future analyses will include polymorphisms in additional genes encoding enzymes important in carcinogen metabolism, DNA repair, cell cycle control, and immune function, and additional occupational exposures. (cdc.gov)

Overall, these findings highlight the potential of HNK as an immunotherapeutic agent for mBCSCs by modulating the tumor immune environment. (hindawi.com)
Histone Deacetylase (HDAC) inhibitors are anti-cancer compounds that helps the body's own immune cells to recognize and attack tumour cells. (pharmiweb.com)
Histone Deacetylase (HDAC) inhibitors induce cancer cell cycle arrest, differentiation and cell death, reduce angiogenesis and modulate immune response. (pharmiweb.com)
Consequently, they thrived in the hypoxic/necrotic regions of tumors to evade clearance by the immune system. (nature.com)
Many tumor microenvironments, including lymphoma and carcinoma, are enriched in immune suppressive cells that contribute to immune exhaustion by means expression of inhibitory ligands, suppressive cytokines, and tumor-promoting factors. (researchgate.net)
The cytotoxic T lymphocyte-associated antigen 4 (CTLA4) is a coinhibitory activation-induced surface receptor on T cells that functions as a major negative regulator of anti-self-immune responses. (snmjournals.org)
The investigation of NKG2D-targeting and the tumor-killing potential of an engineered innate immune cell type is a promising new approach. (biospace.com)
VLPs mimic a natural infection, triggering the body to produce a robust and durable immune response with both antibodies and T cells. (gabio.org)
Immune checkpoint inhibitors are effective in the treatment of some hepatocellular carcinomas (HCCs), but these tumors do not always respond to inhibitors of programmed cell death 1 (PDCD1, also called PD1). (stanford.edu)
This suppresses the ant-tumor immune response. (stanford.edu)
Study identifies mutated processes that acts as predictors for immune checkpoint inhibitor therapy response. (frontlinegenomics.com)

To identify what drives treatment resistance to standard therapy, as well as the cellular source of recurrent disease, UCSF researchers used single-nucleus RNA, open-chromatin, spatial profiling to analyze 86 primary-recurrent, patient-matched, paired GBM specimens. (ucsf.edu)
Recurrent tumors are highly aggressive, potentially cross-drug resistant, highly metastatic, and have a poor prognosis. (hindawi.com)

Primarily, p53 protects the cell from malignant transformation through cell cycle arrest and apoptosis. (uib.no)
A better understanding of apoptosis signaling is needed in order to combine cytostatic drugs in a more efficient way and to develop new targeted therapies. (uni-muenchen.de)
Conventional cytotoxic drugs and new therapies target p53, a key regulator of apoptosis. (uni-muenchen.de)
TRAIL, Tumor necrosis factor Related Apoptosis Inducing Ligand). (uni-muenchen.de)
As described in the literature, wildtype p53 leaded to an increase in intrinsic cell death, whereas different p53 mutations reduced apoptosis. (uni-muenchen.de)
As a next step we studied the influence of cell cycle arrest induced by p53 activation on TRAIL apoptosis sensitivity (Ehrhardt/Wachter et al. (uni-muenchen.de)
2013). Cell cycle arrest was induced in tumor cell lines and patient samples in G0, G1 or G2 with cytostatic drugs, phase-specific inhibitors or RNA interference against cyclinB and E. Molecular or biochemical arrest at any point of the cell cycle augmented the rate of apoptosis by TRAIL. (uni-muenchen.de)
The extrinsic apoptosis by TRAIL was increased in senescent tumor cells. (uni-muenchen.de)
Additionally, JIB extract induced B16/F10 cell apoptosis via the caspase cascade. (medsci.org)
Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
Indeed, in colons of mice carrying mutations in Apc (ApcMin/+) or exposed to the carcinogen azoxymethane, elimination of GCC increased tumor initiation by corrupting genomic integrity in the context of disabled compensatory apoptosis. (jefferson.edu)

Finally, MCT4 inhibition mitigates the induction of angiogenesis, suggesting that MCT4 also plays a crucial role in tumor-related angiogenesis. (hindawi.com)
The occurrence of angiogenesis in tumors develops irregular and poorly-organized blood vessels. (nature.com)

Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
Nutlin-3 and VPA in combination was found to show a synergistic effect in vitro in an AML cell line expressing wild type p53 (MOLM-13). (uib.no)
elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)
In vitro, VG9-IL-24 induced an increased number of apoptotic cells and blocked colorectal cancer cells in the G 2 /M phase of the cell cycle. (techscience.com)
The inhibitors demonstrated promising effects in vitro with reduced viability, increased differentiation and cell death of neuroblastoma cells. (lu.se)
A robust in vitro cell culture system supporting HBV and HDV infections (HBV/HDV) is a critical prerequisite to studying HBV/HDV pathogenesis, the complete life cycle of HBV/HDV infections, and consequently identifying new therapeutics. (cdc.gov)
In vitro cell culture models have evolved with significant improvements over several decades. (cdc.gov)

Despite occasional cases of expansion of melanoma-specific T cells ( 14 , 15 ), the bulk of the data suggest that there is no detectable expansion of tumor antigen-specific lymphocytes, in particular when focusing on CD8+ T-cell responses. (snmjournals.org)
The most consistent effects in peripheral blood cells after administering anti-CTLA4 antibodies have been limited to marginal increases in the surface expression of nonspecific activation markers predominantly on CD4+ T lymphocytes ( 16 - 18 ). (snmjournals.org)
tumors were analyzed by mass cytometry using markers to detect T cells and other lymphocytes. (stanford.edu)

Here, we summarize the different types of epigenetic enzymes which target corresponding protein domains, emphasize DNA methylation , histone modifications, and microRNA-mediated cooperation with epigenetic modification, and highlight recent achievements in developing targets for epigenetic inhibitor therapy. (frontiersin.org)
SVC112 had greater antiproliferative effects on HNSCC cells compared with the FDA-approved translation inhibitor omacetaxine mepesuccinate (HHT). (nih.gov)
The new results come from an interim analysis of the phase 3 randomized NATALEE trial , which is comparing maintenance therapy with the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor ribociclib plus endocrine therapy with an aromatase inhibitor to endocrine therapy alone. (medscape.com)

In mice T is expressed in the inner cell mass of the blastocyst stage embryo (but not in the majority of mouse embryonic stem cells) followed by the primitive streak (see image). (wikipedia.org)
We investigated mechanisms of resistance of liver tumors in mice to infiltrating T cells.Mice were given hydrodynamic tail vein injections of clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR-Cas9) and transposon vectors to disrupt Trp53 and overexpress C-Myc (Trp53KO/C-MycOE mice). (stanford.edu)
some mice were given intraperitoneal injections of antibodies against PD1, T-cell immunoreceptor with Ig and ITIM domains (TIGIT), or CD8 before the cancer cells were injected. (stanford.edu)
Tumors from mice given anti-PD1 had larger numbers of memory CD8+ T cells (CD44+CD62L-KLRG1int) and T cells that expressed PD1, lymphocyte activating 3 (LAG3), and TIGIT compared with mice not given the antibody. (stanford.edu)
these effects were not observed in mice with depletion of CD8+ T cells. (stanford.edu)
Experiments were performed using female FVB wild-type (WT), C57BL/6 WT, and G protein-coupled estrogen receptor 1 knockout (GPER-1 KO) mice and H9c2 cells. (bvsalud.org)

The incidence of this tumour is fairly low, with two to three cases per 100 000 people in Europe and North America. (bmj.com)
Melanoma is the most malignant and lethal skin tumor owing to its high metastatic ability and the incidence of melanoma has been increasing over the years. (medsci.org)
Recently, in Finland, the United Kingdom, the Netherlands, the United States, and Sweden, incidence of OSCC has increased, and an increase in the proportion of HPV-positive tumors was noted. (cdc.gov)
In the USA, obesity has recent- obesity is associated with progres- aberrations of cancer cells, summa- ly surpassed tobacco use as the sion but not incidence [9]. (who.int)

The proteasome pathway is an enzyme complex existing in all cells, which degrades ubiquitinated proteins that control the cell cycle and cellular processes and maintains cellular homeostasis. (medscape.com)

Myc) and tumour suppressors (e.g. p53). (york.ac.uk)

Breast cancer stem cells (BCSCs) are one of the main factors driving chemoresistance, thereby contributing to poor prognosis and clinical outcomes [ 3 - 5 ]. (hindawi.com)
For instance, a recent study by our group reported the facilitating effect of RUNX2 during aggressiveness and chemoresistance of TNBC cells via activating MMP1, which was significantly associated with poor prognosis ( 21 ). (spandidos-publications.com)
In this ongoing work, we examined the impact of thioridazine on LCSCs world development, chemoresistance, cell cycle, and in vivo prohibitory function. (immune-source.com)

They compared the expression of signal receptors to that of their known ligands, between the different cell populations sequenced. (ucsf.edu)

Hepatobiliary cancer that is relapsed/refractory or intolerant to approved standard-of-care therapy (included: hepatocellular carcinoma, bile duct carcinoma, intrahepatic cholangiocarcinoma or other hepatobiliary carcinomas). (mayo.edu)

Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
In prostate cancer cells, SRC-2 stimulated reductive carboxylation of α-ketoglutarate to generate citrate via retrograde TCA cycling, promoting lipogenesis and reprogramming of glutamine metabolism. (jci.org)

Hormonal therapy also has a role in adjuvant therapy in receptor-positive uterine cancers. (medscape.com)
Palbociclib targets the rapid division of tumor cells by inhibiting the activity of the enzymes CDK4 and CDK6, which help drive cell division and are upregulated in most cancers. (news-medical.net)
Our corporate focus continues to be on the advancement of our ongoing clinical programs for our novel Gedeptin ® cancer therapy targeting advanced head & neck cancers and, our SARS-CoV-2/Covid19 vaccine, stated David Dodd, GeoVax's Chairman and CEO. (geovax.com)
Recent work has demonstrated that DNA-damage pathways are activated very early in the process of tumor development, 89 and elegant epidemiologic studies demonstrated long ago that exposure to environmental agents contributes to the development of the vast majority of human cancers. (the-scientist.com)
They are named tumor control cancers or cells initiating cells [4]. (immune-source.com)
After that, tumor control cells had been reported in different types of malignancies, including lung tumor, gastric tumor, human brain cancers, liver organ cancers, and digestive tract cancers [7C11]. (immune-source.com)
After the breakthrough discovery of tumor control cells, analysts attempted to appearance for effective techniques to focus on cancers control cells. (immune-source.com)
Scheduled to receive mucotoxic, systemic cancer therapy for advanced solid and haematological cancers. (who.int)
Approximately 75 to 80% of endometrial cancers are adenocarcinomas, which develop from gland cells. (msdmanuals.com)
The introduction of HPV vaccines has also drawn more attention to the fact that HPV is associated not only with cervical cancer and genital warts but also with other tumors, such as head neck and anogenital cancers ( 3 ). (cdc.gov)

This leads to activation of p53 and the p53 pathway in cancer cells with wild type p53, subsequently inhibiting tumour growth. (uib.no)
The therapy causes DNA breaks, inhibiting DNA replication and shutting down the cell cycle to prevent tumour growth. (pharmaceutical-technology.com)
It is an alkylating agent, and its mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. (medscape.com)
these 2 events, in turn, can inhibit growth of neoplastic cells. (medscape.com)
This type of therapy uses medications to stop the growth of cancer cells that rely on hormones. (nortonhealthcare.com)
A ) Representative images depicting the growth of the stable C4-2 cells shNT, sh18, and sh19 in soft agar assay 2 weeks after plating. (jci.org)
G ) Relative growth of C4-2 and PC-3 cells stably expressing shNT that were either untreated or treated with DMSO or BPTES (1 μM) for 4 days. (jci.org)
Single-cell and spatial transcriptomics reveals the hierarchical nature of tumour growth in metastatic melanoma. (frontlinegenomics.com)
5 Conversely, p53 induction by oxidative damage may help reduce the development of atherosclerosis, perhaps by suppressing the growth or enhancing the death of cells involved in causing atherosclerotic lesions. (the-scientist.com)
This is certainly the initial function on tumor control cells in solid growth [6]. (immune-source.com)
Tumor growth usually starts at the lower part of the chest. (medscape.com)
It works by slowing or stopping the growth of cancer cells in your body. (medlineplus.gov)
Principles of how dysregulation causes tumour growth and deviant embryonic development. (lu.se)

In the press release , the company claims that its therapy has improved the drug resistance and safety of the API compared to other irinotecan drugs. (pharmaceutical-technology.com)
Lab dish studies of tumor cells that develop resistance to palbociclib revealed similar changes. (news-medical.net)
Using mathematical models, we show that characteristics of the tumor cell hierarchy can be crucial for determining the sensitivity of tumors to drug therapy, under the assumption that stem cell enrichment is the primary basis for drug resistance. (aacrjournals.org)
However, the resistance to radiotherapy or chemo- is a big issue for lung cancer therapy [1C3]. (immune-source.com)

However, the molecular mechanisms of action of HNK in BCSCs, as well as its effects on the cell cycle, remain unclear. (hindawi.com)
This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)
There has been a great deal of interest shown in defining the mechanisms by which anti-CTLA4 antibodies induce tumor regressions in humans. (snmjournals.org)
Thus, we must rely on the elegant mechanisms our cells have developed to repair damage. (the-scientist.com)
Single-strand breaks are easily fixed, but double-strand breaks require the complex mechanisms of nonhomologous end-joining and homologous recombination, the latter only being useful in late S, G 2 or M phases of the cell cycle, when homologous chromosomes are present in the cell. (the-scientist.com)
3 Such cellular-suicide mechanisms can eliminate cells that could present problems for the whole organism because of alterations in the DNA or difficulties in dealing with stressful stimuli. (the-scientist.com)
Mechanisms for maintaining genetic information during cell division and the generation of genetic variation: replication, mitosis, meiosis, recombination. (lu.se)
Mechanisms that regulate development from single cell to multicellular organisms. (lu.se)
Cell culture systems contribute to identifying molecular mechanisms for HBV and HDV propagation, finding drug targets for antiviral therapies, and testing antiviral agents. (cdc.gov)

This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)

CD4 + TIL demonstrated an effector T cell response with cytotoxicity toward autologous tumor in a major histocompatibility complex class II-dependent manner. (bmj.com)

Should a new mutation arise in the spike antigen that interferes with antibody recognition, a person vaccinated with our vaccine may still have substantial T cell immunity against both the nucleocapsid and spike antigens. (geovax.com)

With access to thirty years' worth of GBM's, the scientists were able to present novel cell-intrinsic and cell-extrinsic targets as well as a single-cell multi-omics atlas of GBM under therapy. (ucsf.edu)
Finally, the interaction between HNK and two HNK-targets regulating the cell cycle was analyzed using molecular docking analysis. (hindawi.com)
however, these factors have potential as cancer therapy targets. (jci.org)
Recently, the development of the HepG2-NTCP sec+ cell line, expressing the sodium taurocholate co-transporting polypeptide receptor (NTCP) and self-assembling co-cultured primary human hepatocytes (SACC-PHHs) has opened new perspectives for a better understanding of HBV and HDV lifecycles and the development of specific antiviral drug targets against HBV/HDV infections. (cdc.gov)

SVC112 preferentially inhibited cancer cells compared with patient-matched cancer-associated fibroblasts, whereas HHT was equally toxic to both. (nih.gov)

Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. (techscience.com)

Most naïve T cells do not express surface CTLA4 because of its binding to AP50, a subunit of the clathrin adaptor AP-2 protein ( 2 ). (snmjournals.org)
D ) Quantification of Ki67-stained cells (antibody epitope reacts with human Ki67 protein) in mouse lung sections from shNT-, sh18-, and sh19-injected animals. (jci.org)
JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)
The CAR T cells the team developed, called IcasM28z, target the cell-surface protein, mesothelin, which is expressed on the majority of cancer cells. (aacr.org)
protein sorting and protein maturation by passage through the cytoplasmic organelles of the cell. (lu.se)
Analysis of KSP expression across multiple tumor types demonstrated that neuroblastoma is highly dependent on this protein. (lu.se)

extract (JIB extract) for melanoma cells. (medsci.org)
For instance, vemurafenib is a targeted therapy for melanoma with BRAF gene mutation. (medsci.org)

Combination Phase 2 (beyond Safety Lead-in): have received no more than 1 cycle of gemcitabine/cisplatin therapy. (mayo.edu)

Nearly half showed long term shrinkage or disappearance of detectable tumors. (news-medical.net)

They then validated that cells from these populations physically interact and signal in situ, using spatial transcriptomics. (ucsf.edu)
These populations of cells have control cell properties. (immune-source.com)

Some combined groups screened the anticancer stem cells medication through little molecule screen. (immune-source.com)
discovered that the traditional antipsychotic medication, thioridazine, demonstrated great anticancer control cells capability [12]. (immune-source.com)

Malignancies involving mesothelial cells that normally line the body cavities, including the pleura (see the image below), peritoneum, pericardium, and testis, are known as malignant mesothelioma. (medscape.com)

While it is well understood that doxorubicin activates p53 and induces cell-cycle arrest, we observed that cell-cycle arrest disabled inactivation of anti-apoptotic Bcl-2-family members by vincristine. (uni-muenchen.de)
The engagement of CTLA4 by costimulatory molecules results in decreased T-cell receptor signaling, interleukin 2 transcription ( 3 ), and cell cycle arrest at the G1 stage, with the final result of inducing T-cell anergy ( 4 , 5 ). (snmjournals.org)
2 Cell-cycle arrest occurs at multiple stages: G 1 , S, and G 2 /M. (the-scientist.com)
Treatment of neuroblastoma PDX cells with ARRY-520 resulted in mitotic arrest and subsequent cell death. (lu.se)
Rigosertib reduced cell viability of neuroblastoma cells and caused cell cycle arrest in the G2/M phase. (lu.se)

Intriguingly, our model predicts a weaker response to therapy if there is negative feedback from differentiated tumor cells that inhibits the rate of tumor stem cell division. (aacrjournals.org)
After analyzing different tumor stem cell markers (SOX2, OCT4, CD133, CD44 and CD24) in pancreatic cancer cells treated with different chemotherapeutic protocols by means of RT-qPCR, Oxaliplatin and Gemcitabine in monotherapy were the chemotherapies that selected the most cancer stem cells while the FOLFIRI protocol decreased them. (isciii.es)
Haematopoeitic stem cell transplant (HSCT) recipients - from day of admission (~day -7) to day +35. (who.int)
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)

The publication, accessible here , reports data showing that GEO-CM04S1 produced robust neutralizing antibodies and T cells against SARS-CoV-2 with no significant side effects. (geovax.com)

Current standard of care involves maximal surgical resection followed by concurrent therapy with radiation and the DNA alkylating agent temozolomide. (bmj.com)
They found that some cells shift to a mesenchymal, radiation-resistant phenotype (state) as a stress response following standard therapy. (ucsf.edu)
It may be used to shrink a tumor before surgery, to kill cancer cells that remain in the body after surgery or radiation or to treat tumors that have developed in other areas of the body. (nortonhealthcare.com)
Tell your doctor if you have or have ever had any type of heart disease or radiation (x-ray) therapy to the chest area. (medlineplus.gov)

They are highly resistant to treatment and have defied all attempts at precision therapy. (ucsf.edu)
Since all the specimens came from UCSF, we know that the treatment histories are homogeneous, in that each patient received only standard-of-care therapy. (ucsf.edu)
Here we report a severe life-threatening complication of treatment with streptozotocin in a patient with pancreatic island-cell carcinoma. (cancerindex.org)
This symposium presents a remarkable opportunity to convene with other researchers, clinicians, and industry leaders to discuss the extraordinary progress and immense potential of new drug therapies and technologies in paving the way for a brighter future in cancer treatment. (nyas.org)
We will devise a personalized plan of care for you, based on the type and stage of your tumor and overall treatment goals. (nortonhealthcare.com)
To date, the significant clinical benefit achieved with CAR T cell therapies in the treatment of B cell lymphomas and acute lymphocytic leukemia has not extended to AML or other myeloid malignant disorders," Bachier said. (biospace.com)
In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. (mayo.edu)
New semirational bioengineering strategy for AAV vector development provides increased potency and specificity for gene therapy treatment of muscular dystrophy and other muscle disorders ( Science ). (frontlinegenomics.com)
During summer 2014, a 63-year-old woman with symptomatic high tumor burden follicular lymphoma achieved a complete clinical and radiologic response to induction treatment with 6 cycles of bendamustine and obinutuzumab, then began maintenance therapy with obinutuzumab for 8 weeks. (cdc.gov)
Furthermore, even when standardized treatment is used and tumors are at the same stage and have similar histologic features, it is difficult to predict the outcome. (cdc.gov)
Breast cancer treatment can be improved with biomarkers for early detection and individualized therapy. (cdc.gov)
We present the case of a 30-year-old woman with findings of massive ovarian oedema on ultrasound imaging, and a discussion and literature review aiming to clarify that this is a benign tumour-like condition which every gynaecologist can encounter and that the most appropriate treatment is conservative surgery. (who.int)

Another plant hormone, indole acetic acid (IAA), kills off cancer cells upon exposure to high-energy excited dyes in photodynamic therapy. (sciencedaily.com)
Palbociclib effectively halts the cell cycle before that point, and thus in principle can synchronize cancer cells in a way that makes them more vulnerable to a closely following dose of paclitaxel. (news-medical.net)
Cycling cells are required for vincristine to kill cancer cells efficiently. (uni-muenchen.de)
The lymph nodes are the filters of the blood stream and catch the cancer cells before they can spread to the rest of the body. (nortonhealthcare.com)
The modified T cells, when reintroduced into the patient's body, multiply and attack cancer cells. (aacr.org)

A key feature will be molecular strategies for cancer therapy. (york.ac.uk)
Our findings indicate that tumor associated macrophages including Kupffer cells, have a profound impact on liver cancer and I am studying the molecular basis for these effects. (stanford.edu)
Through hypoxia-inducible factor 1 (HIF-1) which elicits various molecular events, cells are able to overcome low O2. (stanford.edu)
The course is an optional second-cycle course for a degree of Bachelor or Master of Science in Biology and Molecular Biology. (lu.se)

Bacterial cancer therapy was developed using probiotic Escherichia coli Nissle 1917 (EcN) for medical intervention of colorectal cancer. (nature.com)
The first solid tumor exomes to be investigated were from 11 breast and 11 colorectal cancer tissue samples. (frontiersin.org)

Strategies for gene therapy and production of medicines via genetically-modified organisms (expression vectors and viral vectors). (lu.se)

Anatomy18

Organisms10

Diseases53

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes63

Disciplines and Occupations1

Information Science4

Health Care3

Microenvironment10

Solid tumors15

Suppressor6

Chemotherapy23

Immunotherapy7

Progression11

Reduced tumor growth1

Metastasis8

Squamous cell carc9

Therapeutic13

Proliferation11

Patients33

Survival20

Recurrence6

Anti-tumor4

Common primary malignant brain1

Grown as 3D1

Antitumor7

Regression2

Heterogeneity2

Malignant tumors2

Small tumors1

Breast tumors1

Genes5

Immune11

Recurrent2

Apoptosis11

Angiogenesis2

Vitro8

Lymphocytes3

Inhibitor3

Mice6

Incidence4

Proteins1

Suppressors1

Chemoresistance3

Ligands1

Refractory1

Metabolism2

Cancers10

Growth13

Resistance4

Mechanisms9

Heterogeneous tumor1

Autologous1

Antigens1

Targets4

Preferentially1

Cytotoxic1

Protein6

Melanoma2

Cisplatin1

Detectable1

Populations2

Anticancer2

Malignancies1

Arrest5

Stem cell7

Antibodies1

Radiation4

Treatment12

Cancer cells5

Molecular4

Colorectal cancer2

Gene therapy1