Therapies human and animal models. Medical search. Frequent questions

Once generated, we will use these rat models to assess the safety and therapeutic potential of cells derived from human pluripotent stem cells. (ca.gov)
These drug encapsulated albumin nanoparticles, unlike the free drug demonstrate better in vitro therapeutic efficacy against human lung and breast cancer cell lines, as assessed by cell viability assay and morphological analyses. (rsc.org)
The purpose is to develop a mouse model of bladder cancer that better represents the human disease to better understand the biology and identify novel therapeutic targets. (osu.edu)
In the study , researchers labeled ofatumumab, a recently developed anti-CD20 fully human antibody, with 177 Lu, a widely used therapeutic radioisotope that can kill cancer cells. (worldhealth.net)
They then determined the in vitro characteristics of [ 177 Lu]Lu-ofatumumab, estimated human dosimetry, and evaluated its therapeutic effectiveness for non-Hodgkin lymphoma in a mouse model. (worldhealth.net)
The excellent therapeutic results in this animal model of human B cell lymphoma suggest that this curative treatment should be tested in humans with non-Hodgkin lymphoma," noted Wahl. (worldhealth.net)
3D cell culture models of cancer are currently being developed to recapitulate in vivo physiological conditions and to assess therapeutic responses. (awionline.org)
Since pharmaceutical interest in this disease is low, two EU-supported projects (EURAMAN and HUE-MAN) within the 5th and 6th framework program, respectively have worked towards developing the recombinant human enzyme (rhLAMAN) as a therapeutic agent for patients suffering from alpha-Mannosidosis. (europa.eu)
In line with our plans we have been able to demonstrate the safety and clinical efficacy of rhLAMAN as an effective therapeutic agent for treatment of the human disease alpha-Mannosidosis in clinical trial Phases 1 and 2. (europa.eu)
The use of animals facilitates the process of teaching and learning, and stimulates physical and therapeutic activities. (scielo.br)
Human-animal therapeutic relationship goes far in history and reports are extant on such practice in the writings and myths of Ancient Rome ( Levinson 1965 Levinson L.M. 1965. (scielo.br)
The first attempts in the use of animals for therapeutic purposes occurred in Brazil in 1955 ( Dotti 2005 Dotti J. 2005. (scielo.br)
Progress in this branch of synthetic biology has yielded remarkable therapeutic advances in gene therapy well beyond the achievements of conventional drugs and biologic agents. (cdc.gov)
We describe the possible mechanisms of action by which this BRMG helps in alleviating the symptoms of DMD by targeting smooth muscle dystrophin, in addition to its advantages over other therapeutic modalities, as well as how it can serve as a valuable adjunct to existing therapies. (bvsalud.org)
Nevertheless, striking new data from cer agents from Volume 100A of these studies show increased risks the IARC Monographs are used to Therapeutic applications and of almost all site-specific cancers make qualitative comparisons be- trends in use that emerge during the fol ow-up tween cancers induced in humans period. (who.int)
indicate tative comparisons of carcinogens been narrowed and their therapeutic that no agents classified as carci- with respect to potency in humans use has declined, with the possible nogenic to humans (Group 1) are and in experimental animals are exception of cyclophosphamide. (who.int)

Rats have long been used as models that better replicate human physiology and pathophysiology than do mice and are the preferred model for the study of many human diseases. (ca.gov)
We describe in both mice and humans a previously unrecognized pathway for the activation of tumor antigen-specific T-cell immunity that involves secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs). (nih.gov)
Mice injected with human B cell lymphoma were either untreated, treated with unlabeled ofatumumab, treated with 8.51 MBq of [ 177 Lu]Lu-IgG, or treated with 0.74 MBq or 8.51 MBq of [ 177 Lu]Lu-ofatumumab. (worldhealth.net)
Mice treated with the other therapies or left untreated, on the other hand, continued to show tumor cells present," Wahl explained. (worldhealth.net)
We assessed the effect of Chop deletion in multiple mouse models of type 2 diabetes and found that Chop -/- mice had improved glycemic control and expanded β cell mass in all conditions analyzed. (jci.org)
Bioluminescence images of untreated and treated mice with human B cell lymphoma. (medicalxpress.com)

2023. Are currently selected laboratory animals useful in the research of how female hormones influence orthodontic biomechanics? (awionline.org)

They are 3-dimensional, complex, multicellular structures that can be derived from patient specific human induced pluripotent stem cells (hiPSCs). (nature.com)

2022. The promise of behavioral tracking systems for advancing primate animal welfare. (awionline.org)
2022. Animal welfare considerations when conducting OECD test guideline inhalation and toxicokinetic studies for nanomaterials. (awionline.org)
Kyuhwan Shim et al, Cure of Disseminated Human Lymphoma with [177Lu]Lu-Ofatumumab in a Preclinical Model, Journal of Nuclear Medicine (2022). (medicalxpress.com)

These findings suggest that a lethal lung disease can be targeted and corrected in a human lung organoid model in vitro . (nature.com)
To understand the various mechanisms driving disease, it is important to have a good model system in vitro that can recapitulate the in vivo disease process. (nature.com)
Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)
It showed favorable in vitro characteristics and dosimetry estimates that support the feasibility of human translation. (worldhealth.net)
Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
2) Methods: A literature search was conducted and included any study that evaluated the effects or mechanisms of antioxidants in the healing process (in vitro, animal models or human studies). (mdpi.com)
Scaffolds such as human amniotic membrane (hAM) are commonly employed for the in vitro culture and as a carrier during in vivo transplantation. (bvsalud.org)
RESULTS: The 3H Thymidine assay's results showed that TGP allowed human-donor cornea-derived LSCs to proliferate well in vitro, compared to hAM and the cells encapsulated in TGP and transplanted ex vivo onto a human cadaver donor cornea denuded of its epithelium, migrated on the ocular surface, and proliferated to form a continuous layer in 25 days. (bvsalud.org)
CONCLUSION: TGP is found to be a multipurpose scaffold for (i) in vitro culture, (ii) ex vivo encapsulation, and in vivo transplantation (iii), enabling engraftment of LSCs in this study, with potentials to extend its application in cell-based therapies in several regenerative medicine approaches. (bvsalud.org)

Use of rats to model human disease, however, has been limited until recently by the difficulty in modifying rat genes to mimic human conditions. (ca.gov)
We are also investigating therapies that revert the methylation of genes that appear critical to the bladder cancer phenotype. (osu.edu)
Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)
If successful, the planned research could be instrumental in developing new therapies that reestablish normal pathways between specific genes and protein pathways, leading to a restoration of normal tooth development. (dentalproductsreport.com)
To define genes and or proteins that contribute to the metastatic phenotype of metastasis in osteosarcoma, we have utilized a cross-species comparative approach that includes murine, canine, and human systems for gene identification and evaluation. (vin.com)
This approach has leveraged the availability of murine, canine, and human genomes, to survey the expression of genes in normal and diseased tissues and then identify either patterns of gene expression of individual genes responsible for or associated with metastasis. (vin.com)
A second capability of synthetic biology involves the re-design of existing genes, cells or organisms for the purpose of gene therapy. (cdc.gov)
Modification of existing genes in living animal and human cells is enabled by engineered nucleases such as meganucleases, zinc finger nucleases, transcription activator-like effector-based nucleases, and the CRISPR-Cas system. (cdc.gov)

We proposed to use the classical embryonic stem cell-based gene-targeting technology to generate rat models mimicking human heart failure, diabetes and neurodegenerative diseases. (ca.gov)
4) Generated a motor neuron reporter human embryonic stem cell line. (ca.gov)
The embryonic stem cell-based gene-targeting technology was used for the generation of these rat models. (ca.gov)
Using the small animal model embryonic stem cell-based gene-targeting technology that we developed, we will create small animal models for heart failure, diabetes and neurodegenerative diseases. (ca.gov)
Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)

Although larger animal models are useful, they are extraordinarily expensive and, consequently, experimental opportunities and replications are very limited. (ca.gov)
Experimental therapies for HD currently are being tested in animal models and human trials. (medscape.com)
Humane Intervention Points: Refining endpoint terminology to incorporate non-euthanasia intervention options to improve animal welfare and preserve experimental outcomes. (awionline.org)
An additional source of quantita- erations for compounds that cause of tumour-free animals by 50% (Gold tive data on cancer risks is the group cancer in experimental animals. (who.int)
Such data chal enge the "ca- and in experimental animals, with The four anticancer agents dis- nonical" site-specificity of carcino- reference to the possible underlying cussed here were first used in clin- ical practice in the 1960s, but since genesis. (who.int)

Here we show that the success of some protocols for anticancer therapy depends on innate and adaptive antitumor immune responses. (nih.gov)

Lentiviral (LV) vectors of the Retroviridae family show interesting properties for monogenic gene therapy, since they integrate into the host genome and allow long-lasting gene expression 22 . (nature.com)
They are being used to explore gene function and create disease models and they hold great promise for human gene therapy. (ddw-online.com)
For many scientists, the next step is to begin to manipulate these genome sequences for a variety of specific goals, including analysis of gene function, creating models of human disease, generating better models for drug discovery and, ultimately, human gene therapy. (ddw-online.com)
We seek two talented and motivated postdocs to join the laboratory of Dr Christian Mueller in the Horae Gene Therapy Center at the University of Massachusetts Medical School. (umassmed.edu)
Under the leadership of Dr GuangPing Gao, the UMMS GTC is one of the top US gene therapy centers, focusing its research efforts on rare diseases of the liver, CNS, and eye, with a state-of-the-art vector core that handles vector production for its researchers. (umassmed.edu)
Projects will include early stage research on genome editing for ALS, an IND-enabling study in non-human primates for a gene therapy candidate for ALS, and an IND-enabling study in non-human primates for a gene therapy candidate for HD. (umassmed.edu)
Advancing gene therapy for epilepsy. (lu.se)

Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. (nature.com)
In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)

As stem cell-based therapies move towards clinical application, it is clear that more relevant animal models are required to demonstrate the safety and efficacy of stem cells for specific human diseases. (ca.gov)
Rats are the preferred animal model for many human diseases. (ca.gov)
These diseases are characterized by the loss of specific cell types and can be treated and potentially cured with stem cell-based therapies. (ca.gov)
Using this technology, we will develop immunodeficient rats and rat models for heart failure, diabetes and neurodegenerative diseases. (ca.gov)
Our project will provide the research community with the tools and technology necessary to overcome the current constraints of mouse models and will serve as a better investigative platform for understanding the progression and treatment of human diseases. (ca.gov)
These diseases can be potentially improved or even cured by cell replacement-based therapies. (ca.gov)
Infectious diseases are the leading cause of human death worldwide. (a-star.edu.sg)
She began to wonder whether animals got other human diseases. (sciencebasedmedicine.org)
The pathogens from animal diseases can adapt to humans, as in the case of HIV. (sciencebasedmedicine.org)
Nevertheless, exactly because I had no other options, little by little, I became more and more comfortable at interacting with patients, and skillful in recognizing signs and symptoms of various diseases and disorders that can affect human beings, which are skills that serve me well until this day. (bvsalud.org)
Genetic diseases that are linked to mutant ALLELES on the Y CHROMOSOME in humans (Y CHROMOSOME, HUMAN) or the Y chromosome in other species. (bvsalud.org)
Included here are animal models of human Y-linked diseases. (bvsalud.org)
During my thesis, we evaluated whether cell-derived strategies, in this case, extracellular vesicles (EVs) could be a potential new therapy to repair salivary gland injury and restore function following radiotherapy or in autoimmune diseases. (lu.se)

In hyperbaric oxygen therapy (HBOT), the subject is placed in a chamber containing 100% oxygen gas at a pressure of more than one atmosphere absolute. (mdpi.com)
Hyperbaric oxygen therapy (HBOT) is breathing 100% oxygen while under increased atmospheric pressure. (medscape.com)

The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333. (cdc.gov)
Core Centers provide shared resources to support research to develop and test new therapies for CF and to foster collaborations among institutions with a strong existing research base in CF. The NIDDK currently supports seven CF Research and Translation Centers located at institutions with documented programs of research excellence in basic and clinical CF Research. (nih.gov)

Before human stem cells can be used in clinical trials, however, their safety and efficacy need to be tested in animal models. (ca.gov)
Initial articles in this special issue describe common pre-clinical (animal) testing paradigms used to assess potential otoprotective drug agents and design-related factors that impact translation of promising agents into human clinical trials. (cdc.gov)
Within the clinical trials, the dose levels based on the results in the non-clinical tests, were confirmed and a minimum effective dose in humans established. (europa.eu)

Furthermore, environmental estrogens, such as Bisphenol A, activate MCs in preclinical models but their impact on pain pathways or migraine is understudied. (frontiersin.org)

The field of comparative oncology is uniquely positioned to take advantage of the completed canine genome to improve our understanding of cancer therapy and biology. (vin.com)
Used most often when referring to the study of cancers seen in companion (pet) animals, comparative oncology describes a discipline that integrates the study of naturally occurring cancers in animals into studies of human cancer. (vin.com)

The main goal of this project is to develop rat models for assessing the safety and efficacy of human stem cell grafts. (ca.gov)
This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
Among them niclosamide has shown tremendous anti-cancer potential as demonstrated in a surfeit of human cancer cell lines and animal models. (rsc.org)
This work is being conducted in cell lines and animal models and being validated in human tissue. (osu.edu)
Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
Future work will explore additional MM cell lines with heterogeneous LAT1 expression and response to melphalan therapy. (snmjournals.org)
In the last decade, the availability of autologous stem cell transplantation and combination therapies consisting of immunomodulatory drugs, proteasome inhibitors, and other chemotherapeutics has improved median 5-y survival from 34.6% in 2004 to 49.6% in 2013 ( 3 , 4 ). (snmjournals.org)
Therapies for senescent cell clearance as a treatment for aging are going to be an ongoing concern within the next few years. (fightaging.org)
Thus, naively, a hypothetical highly efficient senescent cell clearance therapy might work just fine in a 40-something adult, with tissues containing comparatively few senescent cells, while having a strong chance of killing patients in their 70s, with tissues containing many more senescent cells and also possessed of less resilient organs. (fightaging.org)
In both genetic and diet-induced models of insulin resistance, CHOP deficiency improved β cell ultrastructure and promoted cell survival. (jci.org)
We use rodent models of stroke combined with biomaterial techniques, stem cell transplants, and microfabrication to achieve these aims and evaluate our methods with behavior testing and various imaging techniques. (stanford.edu)
Cell Therapy for Parkinsons Disease: What Next? (lu.se)
Here we investigated the characteristics of a population of pancreatic cancer tumorspheres derived from different human pancreatic cancer cell lines and a primary line from a genetically engineered KPC mouse model, using flow cytometry and western blotting to analyse surface and stemness markers. (lu.se)
Exploring the potential of human-derived cell lines and glial cell line-derived neurotrophic factor for network inhibition. (lu.se)
In Papers I and Paper III of my thesis, we examined stem cell-derived therapies' potential on two most common conditions of xerostomia, which are acute irradiated and chronic immune dysregulation-caused salivary gland hypofunction. (lu.se)

We will use these models to assess human cellular therapies. (ca.gov)
They can be used to study cellular and metabolic biology without the use of an animal model or fetal tissue. (nature.com)
We are currently exploring the extent to which the non-neuronal pathologies described in animal models are also seen in human post-mortem material and are using cellular models to determine the vulnerabilities of SMA cells to hypoxic environments. (abdn.ac.uk)

These rats models are highly valuable to many investigators in California and across the world with diverse research interests. (ca.gov)
We will distribute the rat models produced in this project to investigators upon request. (ca.gov)
The investigators note that BDNF and other neurotrophic-based pharmaceutical therapies have shown "great promise" in slowing and even arresting neurodegenerative processes in animals, but attempts to harness the protective power of BDNF in human neurodegeneration have thus far failed. (medscape.com)

Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44). (uib.no)

Recent years have witnessed major advances in the ability of computerized systems to track the positions of animals as they move through large and unconstrained environments. (awionline.org)
Recent advances in cryo-electron tomography allow us to model the majority of the immature retroviral lattice, except the six-helix bundle domain," said Goh. (sciencedaily.com)
These operations are made possible by recent advances in DNA synthesis and DNA sequencing, providing standardized DNA "parts," modular protein assemblies, and engineering models. (cdc.gov)

In Jamaica, the greatest mortality occurs between 6 and 12 months old when 10% of patients die despite considerable experience in the diagnosis and therapy of the condition and absence of malaria. (who.int)

We invite you to discover our Post-doctoral Research Training Program for Doctors of Physical Therapy (DPT) supported by the NIH-funded Research Training in Sensorimotor Neurorehabilitation (SNR) T32 grant. (northwestern.edu)
Applicants to the program should have some research experience or have graduated from a research-intensive Doctoral Physical Therapy program. (northwestern.edu)
This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research. (awionline.org)
Refinement is one of the ethical pillars of the use of animals in research. (awionline.org)
As part of the Department of Health and Human Services' implementation of e-Government the NIH will gradually transition each research grant mechanism to electronic submission through Grants.gov and the use of the SF 424 Research and Related (R&R) forms. (nih.gov)
A new imaging agent, 68Ga-ABY-025, can predict early metabolic response to human epidermal growth factor receptor 2 (HER2)-targeted treatment in HER2-positive metastatic breast cancer patients, according to new research published in the September issue of The Journal of Nuclear Medicine. (news-medical.net)
The research team plans to begin their investigation of this problem using mouse models, and colleagues at Cincinnati Children's Hospital Medical Center, the University of Lausanne, the University of Pittsburgh, and the Perelman School of Medicine will also contribute to the effort. (dentalproductsreport.com)
His current research focus is on the study of the human fungal pathogen Candida albicans. (a-star.edu.sg)
Fortunately this issue is well understood in the research community, so no such highly efficient therapy is ever going to be produced. (fightaging.org)
Research also demonstrated that children like and support the use of animals in the school. (scielo.br)
Scientists from the Max Planck Institute for Heart and Lung Research and Giessen University have now succeeded for the first time in an animal model in not only halting the progression of the disease, but also in reversing it with the help of an inhalation therapy. (medicalnewstoday.com)
Improved surveillance, epidemiological research and development of new therapies and vaccines are important, and the momentum of recent gains in terms of better understanding of disease patterns should be maintained to enable the global community to answer the remaining questions about this disease. (who.int)
Secreted EVs from stem cells have become a hot topic with high research and clinical interest since they avoid concerns about the risks associated with directly injecting stem cells into the human body. (lu.se)

We focus on (recurrent) UTI due to (particularly) resistant micro-organisms (BRMO), UTI in patients after renal transplantation, the role of the microbioma and complications of antibiotic therapy such as Clostridioides difficile infections. (lumc.nl)
Blood cultures were positive for B. pseudomallei, and both patients recovered following appropriate antibiotic therapy. (cdc.gov)

We are modeling specific genetic changes identified in human bladder tumors in mouse models of bladder cancer. (osu.edu)
Synthetic biology promises tremendous societal benefits in treating human genetic disease. (cdc.gov)

A sexually transmitted disease in animals can become a human disease where infection is by ingestion, like brucellosis. (sciencebasedmedicine.org)
Until 1971, children in the United States infection in humans as well as produce infectious virus that received an orthopoxvirus vaccine (to prevent smallpox) as part can be transmitted to others ( 3 ). (cdc.gov)
HA567 trade name] is indicated for the prophylaxis against human immunodeficiency virus type 1 infection in infants of HIV-infected mothers. (who.int)
It is recommended that therapy is given only on the advice of a physician experienced in treating HIV infection. (who.int)

We discuss the efficacy of HBOT in treating neurological conditions and neurodevelopmental disorders in both humans and animal models. (mdpi.com)
The journey to translate an animal model to humans is daunting, but these studies are the first steps to find new therapies to treat devastating craniofacial disorders. (dentalproductsreport.com)
Today, the most promising therapy for lysosomal storage disorders including alpha-Mannosidosis is Enzyme Replacement Therapy (ERT) where the respective enzyme lacking in the patient is produced by recombinant approaches and then introduced into the blood stream, from where it is internalized by the cells and reaches the lysosomes replacing the missing endogenous enzyme. (europa.eu)
and the first therapy sessions with animals in people with psychic disorders occurred in Germany in 1867. (scielo.br)
eating disorders also occur in animals when stress and fear inhibit feeding. (sciencebasedmedicine.org)

The pig-derived scaffold is advantageous over other models, including synthetics, because it is processed without chemicals or enzymes, which helps it retain more natural properties, McNulty suggests in the release. (ptproductsonline.com)

Then, to translate the knowledge from Paper I and III, a new model that could use human samples needed to be found, this is Paper II, in which we developed a bioengineered model for salivary gland disease that can be used to evaluate regeneration and test pharmaceutical trials (like EV therapy). (lu.se)

He had promising results in a mouse model with induced cancers, but needed to study the treatment in animals with spontaneously occurring tumors, intact immune systems, and a longer life span. (sciencebasedmedicine.org)
The features of cancers in pet dogs that may uniquely contribute to our understanding of cancer pathogenesis, progression and therapy have been recently reviewed. (vin.com)
Of most interest to the study of cancer biology is the biological complexity of cancers seen in pet animals. (vin.com)
A natural consequence of this heterogeneity is the same deadly features of human cancers including acquired resistance to therapy, recurrence, and metastasis. (vin.com)
Accordingly, cancers in pet animals capture the 'essence' of the problem of cancer seen in human patients. (vin.com)
The integration of these naturally occurring cancers into the study of cancer biology and therapy provides an opportunity to answer questions not answered in conventional model systems. (vin.com)
For relatively rare human cancers such as osteosarcoma, these problems are amplified. (vin.com)

Animal test alternatives: Refinement, reduction, replacement. (cdc.gov)

Several genetically modified rats that are essential for the generation of rat disease models mentioned above have been generated. (ca.gov)
We are still in the process of generating the remaining genetically modified rats that are also essential for the production of the three rat disease models. (ca.gov)
If testing is successful in humans, this would represent an excellent new treatment option for patients with this disease. (worldhealth.net)
Although no therapy is currently available to delay the onset of symptoms or prevent the progression of the disease, symptomatic treatment of patients with Huntington disease (HD) may improve the quality of life and prevent complications. (medscape.com)
In elderly patients with suspected prostate cancer, PSMA PET/CT can diagnose advanced disease and aid in therapy selection without the need for a biopsy. (news-medical.net)
Children identified at birth avoid the malnutrition that was the common presenting sign for CF. In addition, these patients benefit from many new forms of therapy that are being developed to aggressively eradicate bacterial colonization of the lung, control inflammation and lung damage, treat diabetes and liver disease and provide nutritional support. (nih.gov)

Alternating electric field therapy, sometimes called tumor treating fields (TTFields), is a type of electromagnetic field therapy using low-intensity, intermediate frequency electrical fields to treat cancer. (wikipedia.org)
This therapy also led to significant reductions in serum levels of tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6), two inflammatory cytokines associated with SLE. (nature.com)
18 F-FDOPA PET/CT complemented 18 F-FDG PET/CT in imaging melphalan therapy response in preclinical extramedullary MM. 18 F-FDOPA uptake was linked to LAT1 expression and melphalan response, with longitudinal imaging suggesting stabilization of LAT1 levels and melphalan tumor cytotoxicity. (snmjournals.org)
Indeed, for both human and canine cancer patients afflicted with osteosarcoma, the most common primary tumor of bone, metastasis to the lungs is the most common cause of death. (vin.com)

However, it is readily apparent that mouse physiology and behavior is not optimal for studying many human conditions, and this has often led to translation failures. (ca.gov)
The rat is widely accepted as more similar to the human in its physiology and therefore superior to the mouse, especially for metabolic, cardiac and neurological studies. (ca.gov)

A new model of progressive pulmonary fibrosis in rats. (cdc.gov)

Refining cages for social housing of non-human primates on ADME studies. (awionline.org)

In this work niclosamide was encapsulated into albumin nanoparticles through a desolvation method to improve its scope of application in cancer therapy. (rsc.org)

It is, however, quite possible for a therapy to be too good at killing senescent cells. (fightaging.org)

In this study, patients with glioblastoma that had recurred after initial conventional therapy were randomized to treatment either with a TTFields device (NovoTTF-100A / Optune) or with their treating physician's choice of standard chemotherapy. (wikipedia.org)
Animal testing was and remains the only method of introducing a certain treatment and medical procedure on humans. (awionline.org)
The rabbit has become a preferred animal model for investigating the pathogenesis and treatment of. (awionline.org)
Animal Assisted Therapy (AAT) is used for the assistance and treatment in humans and educational projects where animals are used as co-therapists or co-educators. (scielo.br)
Animal Assisted Therapy (AAT) was used for the treatment of patients with mental illnesses for the first time and intuitively in 1792. (scielo.br)
The administration of the treatment in the form of a nasal spray would offer a relatively effortless form of therapy. (medicalnewstoday.com)

Ultrasonography is currently used in human medicine as a surgical tool for guided biopsies and this idea can be applied to. (awionline.org)

One of them was from a well-known dye family that is used in fluorescence experiments in animals and humans and even in the clinic: Cy7. (rug.nl)

Also, the structure is more porous than other models and even regular meniscus tissue, which allows new cells to move into it more easily to integrate with damaged tissue. (ptproductsonline.com)

In humans, LAMAN deficiency results in progressive mental retardation, skeletal changes, hearing loss and recurrent infections and many patients die during early childhood. (europa.eu)

Interim analysis showed a statistically significant benefit in median survival for patients treated with TTFields plus conventional therapy (temozolomide, radiation, and surgery) versus patients treated with conventional therapy alone, a result which led the trial's independent data monitoring committee to recommended early study-termination. (wikipedia.org)
Importance: Gefapixant represents an emerging therapy for patients with refractory or unexplained chronic cough. (researchgate.net)
Although this chemotherapy with immunotherapy combination is usually initially effective, many patients don't respond or relapse, so we need improved therapies," said Richard L. Wahl, MD, the Elizabeth E. Mallinckrodt Professor and director of Mallinckrodt Institute of Radiology at Washington University School of Medicine in St. Louis, Missouri. (worldhealth.net)
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has issued a new consensus statement to provide standardized guidance for the selection and management of metastatic castrate-resistant prostate cancer (mCRPC) patients being treated with 177Lu-PSMA radionuclide therapy. (news-medical.net)
Combination therapies involving melphalan, a small-molecule DNA alkylating agent, are commonly prescribed to patients with relapsed or refractory MM, necessitating the stratification of responding patients to minimize toxicities and improve quality of life. (snmjournals.org)
Thus, stratification of melphalan-responsive patients in the MM patient population is critical for reducing therapy-induced toxicities. (snmjournals.org)
Final Report Summary - ALPHA-MAN (Clinical development of Enzyme Replacement Therapy in alpha-Mannosidosis patients using recombinant human enzyme. (europa.eu)
Other studies would have to show, however, whether the results achieved in the animal model are also applicable to human patients. (medicalnewstoday.com)
It wasn't until the early 2000s that American doctors began to recognize a similar phenomenon in human patients, takotsubo or stress-induced cardiomyopathy . (sciencebasedmedicine.org)
This provides limited opportunities to study these events in human patients. (vin.com)

2021. Management of morbidity and mortality in a New Zealand white rabbit model of steroidinduced osteonecrosis of the femoral head. (awionline.org)

While otoprotective drugs will ultimately be developed for use by specific noise -exposed populations, there has been little effort to develop pre-clinical (animal) models that accurately model exposure hazards across diverse human populations. (cdc.gov)

1979. In vivo measurement of actinides in the human lung. (cdc.gov)

Biochemical findings in animals exposed to ozone and nitrogen dioxide included increased lung content of DNA, protein, collagen, and elastin, which was about 300% higher than the control values. (cdc.gov)

Laboratory Animals 56(5), 482-489. (awionline.org)
Animal tests performed using OECD guidelines, especially when the good laboratory practice (GLP) principle is applied, reduce the duplication. (awionline.org)

What that safe pace will turn out to be in humans is an open question, to be answered by experimentation, trials, and further studies, but the mouse data suggests it can be fairly rapid - just not all at once, immediately. (fightaging.org)
Hands-on experience with relevant mouse models as well as excellent knowledge of CRISPR-based genome editing are required. (umassmed.edu)
Objectives: In this study, we used an obese and diabetic mouse model to compare two strains of Aureobasidium pullulans (AFO-202 and N-163) produced beta-glucans (ß-glucans), which alleviate lipotoxicity. (bvsalud.org)

METHODS: Sixteen discarded human corneas were used to isolate the corneal epithelium which was cultured in TGP and hAM. (bvsalud.org)

The OECD test guidelines for animal experiments play an important role in evaluating the chemical hazards. (awionline.org)
We will test the safety and effectiveness of candidate peptides in humans. (lumc.nl)

Phospholipase D activity in human platelets is inhibited by protein kinase A, involving inhibition of phospholipase D1 translocation. (uib.no)

self-injury also occurs in animals and probably represents grooming gone awry. (sciencebasedmedicine.org)

In a study published recently in the journal Scientific Reports , Duke scientists describe a more organic model - a scaffold derived from a pig's meniscus, which performed better in lab tests than healing without a scaffold. (ptproductsonline.com)

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