Therapies can cause ocular toxicity. Medical search. Frequent questions

Background/aims The aim of this study was to evaluate the long-term corneal toxicity of topical chemotherapy with 1% 5-fluorouracil (5-FU) as a sole or adjuvant treatment of ocular surface squamous neoplasia (OSSN). (bmj.com)
Clinical confocal microscopy was used to check for 5-FU long-term corneal toxicity. (bmj.com)
Washington, DC -Long-term use of latanoprost (Xalatan, Pfizer) does not increase the risk of corneal toxicity when compared with other glaucoma medications, according to data from a 5-year post-marketing surveillance study. (ophthalmologytimes.com)

In this trial, patients received LYTGOBI orally once daily at a dose of 20mg until disease progression or unacceptable toxicity. (biospace.com)
Patients received mirvetuximab soravtansine at 6 mg/kg (based on adjusted ideal body weight) as an intravenous infusion every 3 weeks until disease progression or unacceptable toxicity. (ascopost.com)
The recommended mirvetuximab soravtansine dose is 6 mg/kg adjusted ideal body weight administered once every 3 weeks (21-day cycle) as an intravenous infusion until disease progression or unacceptable toxicity. (ascopost.com)
Heparanase (HPSE) plays an important role in supporting and promoting myeloma progression, maintenance of plasma cell stemness, and resistance to therapy. (bvsalud.org)

To evaluate the frequency and characteristics of sub-clinical ocular surface squamous neoplasia (OSSN) detected by high-resolution anterior segment tomography (HR- OCT) in patients with clinically unapparent disease following topical treatment. (biomedcentral.com)
Ocular surface squamous neoplasia (OSSN) represents the most common epithelial squamous tumor of the ocular surface [ 1 ]. (biomedcentral.com)

The purpose of this study is to report the clinical features and outcomes of ocular surface toxicity following depatuxizumab mafoditin (ABT-414) therapy for unresectable glioblastoma. (liverpool.ac.uk)
There are very few data on the effectiveness of currently available therapeutics and on the outcomes of ocular mpox virus This guidance will be updated as new data become available. (cdc.gov)

Understand the incidence of ocular toxicities observed in pivotal trials evaluating novel agents and strategies demonstrating efficacy in the management of patients with various tumor types, and educate individuals about to commence therapy with these approaches regarding the potential development of these adverse events and what to do if they are suspected. (researchtopractice.com)
Unicycive Therapeutics Inc. has announced key efficacy findings with UNI-494 in animal models of geographic atrophy (GA). UNI-494 is a mitochondrial potassium channel (mitoKATP) activator in development for treating diseases affected by mitochondrial dysfunction, such as kidney, liver and ocular diseases. (bioworld.com)
In the efficacy-evaluable population of patients who had platinum-resistant, measurable disease and received at least one dose of therapy (n = 104), the confirmed overall response rate was 31.7% (95% confidence interval [CI] = 22.9%-41.6%) and median duration of response was 6.9 months (95% CI = 5.6-9.7 months). (ascopost.com)
This ongoing Phase 1/2 trial, which is sub-study 3 of GSK's DREAMM-5 platform trial (NCT04126200), aims to determine if low-dose belamaf in combination with nirogacestat results in similar efficacy with an improved ocular toxicity profile compared to belamaf alone at a higher dose. (advfn.com)
Patients may receive corticosteroid therapy or cytotoxic drugs depending on the severity of the disease, as controlled trials have demonstrated the efficacy of immunosuppressive therapy in the treatment of BS (5). (researchsquare.com)
Among numerous immunosuppressants, azathioprine (AZA) is a well-established medication that plays a useful role in the treatment of various autoimmune diseases, and recent studies have confirmed its efficacy in patients with BS, particularly in individuals with ocular pathology. (researchsquare.com)
Despite their efficacy, these novel therapies are associated with adverse events (AEs) and the potential for considerable toxicity. (ahdbonline.com)

Treatments discussed include cyclin-dependent kinase 4/6 inhibitors, antibody drug conjugates, and targeted therapies against phosphatidylinositol-4,5-bisphosphate-3-kinase catalytic subunit alpha ( PIK3CA ), estrogen receptor 1 ( ESR1 ), and poly[ADP-ribose] polymerase (PARP), among others. (amegroups.org)
What is the role of maintenance therapy with PARP inhibitors? (jnccn.org)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)

Appreciate the pathophysiology, frequency and severity of ocular toxicities associated with the administration of specific anticancer therapies for various solid tumors and hematologic cancers. (researchtopractice.com)
[ 11 ] The IL-6 level is associated with disease severity and was found to correlate with tear film and ocular surface parameters (eg, tear film break-up time, Schirmer test, tear clearance, goblet cell density, keratoepithelioplasty score). (medscape.com)
Researchers and drug developers should be prepared for some level of immunologic response when conducting gene therapy but the duration and severity should be less than is experienced in other sites. (ondrugdelivery.com)
Conclusion Administration of azathioprine with due attention to the signs, symptoms, and severity of the disease, results in a reduced rate of adverse events and resolution of the ocular involvement in patients with BS. (researchsquare.com)
The present cross-sectional study was therefore designed to investigate the frequency of clinical side effects of different dosages of AZA in patients with BS with different levels of severity of ocular involvement. (researchsquare.com)

This review will highlight evidence from experimental studies identifying components of the ocular ECS and discuss the functional role of the ECS during different ocular inflammatory disease states, including uveitis and corneal keratitis. (frontiersin.org)
In this educational review, we outline the ideal characteristics of drugs for uveitis and review the data to support the use of current and emerging therapies in this context. (dovepress.com)
It is crucial that we continue to develop new therapies for use in uveitis that aim to suppress disease activity, prevent accumulation of damage, and preserve visual function for patients with the minimum possible side effects. (dovepress.com)
The uveitis specialist may be confronted by a small, localized area of inflammation in a single tissue in a non-sight-threatening location, or widespread blinding inflammation involving almost all ocular tissues. (dovepress.com)
Ocular involvement, especially panuveitis (anterior and posterior uveitis), is a result of irreversible, progressive, ischemic changes in the retina and optic disc (2). (researchsquare.com)

The distribution of grade 3-4 neurologic ir-AEs frequency was 0.7% among patients receiving anti-CTLA-4 (ipilimumab and tremelimumab), 0.4% among patients receiving anti-PD1 (nivolumab, pembrolizumab, lambrolizumab, and pidilizumab), and 0.7% among patients receiving a combination therapy (anti-CTLA-4 + anti-PD1) [ 20 ]. (hindawi.com)

the changes seen here were seen from 1 month postoverdose and are secondary to the widespread quinine-induced retinal toxicity. (bmj.com)
Over 6 months, her visual fields expanded significantly ( figure 3B ), reflecting partial recovery of retinal function following quinine toxicity. (bmj.com)
Retinal toxicity is the most serious potential complication of hydroxychloroquine therapy. (ccjm.org)

1986. Effect of pretreatment with hepatic microsomal enzyme inducers on the toxicity of diazinon in calves. (cdc.gov)

The treatment of ocular diseases has benefited tremendously from the resurgence of gene therapy. (ondrugdelivery.com)
Two ocular characteristics make gene therapy advantageous and, in some cases, the only option for some genetic diseases, cancers and viral infections. (ondrugdelivery.com)
Aetna considers the use of chelation therapy experimental and investigational in the prevention and treatment of cancer, cardiovascular disease (e.g., atherosclerotic cardiovascular disease , coronary artery disease, individuals who had a myocardial infarction), neurodegenerative diseases (e.g. (aetna.com)
Of these diseases, ocular inflammation presents a significant medical problem, given that current clinical treatments can be ineffective or are associated with intolerable side-effects. (frontiersin.org)
Perioperative Care of the Surgical Patient With Eye Pathologies This review summarizes potential perioperative ocular complications as well as anesthetic implications for patients with diseases of the eye who undergo nonocular surgery. (medscape.com)
Current Research and Scholarly Interests Yasir's primary focus is on early identification of ocular diseases and objective assessment of response to therapy via biomarker (imaging and molecular) discovery and endpoints development for clinical trials. (stanford.edu)
Hydroxychloroquine is a well-established and effective therapy for systemic and cutaneous lupus and other autoimmune diseases. (ccjm.org)

Footnotes *Testing of whole blood lead level is the most sensitive and specific means in assessing lead toxicity. (aetna.com)
Aetna considers the dimercaptosuccinic acid (DMSA) or ethylenediaminetetraacetic (EDTA) provocative chelation/mobilization test experimental and investigational as a means of diagnosing lead toxicity because of insufficient evidence of its effectiveness. (aetna.com)
Women workers may be more susceptible to lead toxicity than men, and they develop more central nervous system manifestations than men. (cdc.gov)

Given equivalent doses, small children are usually at the greatest risk for systemic toxicity such as adrenal suppression, Cushing's syndrome and intracranial hypertension because of their larger skin surface to body mass ratios. (drugs.com)
Arsenic trioxide dust is readily absorbed from the lungs, but inhaled quantities are usually insufficient to cause acute systemic toxicity. (cdc.gov)

I started my dermatology residency 36 years ago and have been using field therapy throughout my entire clinical career, mostly with 5-FU. (aad.org)
Acute quinine toxicity produces a well-recognised constellation of clinical effects, known as cinchonism. (bmj.com)
There are therapies being tested in clinical trials, some in GI cancers and pancreatic, and they are shifting towards a multimodality approach including the use of nutrition, exercise, and of a drug to combat the anorexia, hyper-metabolism, and muscle wasting associated with cancer. (cholangiocarcinoma.org)
Becker's demonstration of the marked ocular hypotensive effect of acetazolamide in glaucoma patients led to the widespread clinical use of oral CAIs for the treatment of glaucoma and to numerous clinical and laboratory evaluations of acetazolamide and other CAIs. (entokey.com)
Group 1 included individuals whose clinical resolution of OSSN aligned with complete resolution on HR-OCT. Group 2 (sub-clinical OSSN group) included individuals with clinical OSSN resolution but with features of persistent disease on HR- OCT. Patients excluded included those treated at an outside institution and those who used topical therapy as a surgical adjunct. (biomedcentral.com)
We found that at least 17% of individuals with apparent clinical resolution of OSSN have sub-clinical disease detected on HR-OCT. This information can be used to optimize treatment and extend therapy past the point of clinical resolution. (biomedcentral.com)
When treating OSSN with medical therapy, most clinicians will provide topical therapy based on the clinical observation of tumor resolution. (biomedcentral.com)

Participants were excluded if they had corneal disorders, ocular conditions requiring ongoing treatment, Grade >1 peripheral neuropathy, or noninfectious interstitial lung disease. (wikipedia.org)
Ocular disease patients can receive vectors through topical eye drops, oral medication or injections. (ondrugdelivery.com)
The components of the ECS, including endocannabinoids, their cognate enzymes and cannabinoid receptors, are localized in the eye, and evidence indicates that ECS modulation plays a role in ocular disease states. (frontiersin.org)
Although the optimal treatment for sarcoidosis remains unclear, corticosteroid therapy has been the mainstay of therapy for those with significantly symptomatic or progressive pulmonary disease or serious extrapulmonary disease [ 10 , 11 ]. (ersjournals.com)
Thyroid Eye Disease: Navigating the New Treatment Landscape Recent advancements have led to the development of novel targeted therapies for thyroid eye disease. (medscape.com)
Strategies for Managing Ocular Surface Disease in Glaucoma Recent advances have led to new options for the diagnosis and treatment of ocular surface disease in patients with glaucoma. (medscape.com)
Building from the initial diagnostic approach, we describe how to pragmatically layer options by appropriate line of therapy and personalized drivers of disease to aid in treatment decision making step-by-step. (amegroups.org)
[ 5 ] As data emerge related to the spectrum of phenotypes of disease caused by the current viral clade, additional information on the true rate of ocular involvement may become available. (cdc.gov)
If ocular involvement of mpox virus is suspected, then ophthalmologic consultation should be strongly considered for a thorough evaluation and continued monitoring of the patient's condition and extent of disease, especially in cases of vision changes, eye pain, or increasing redness. (cdc.gov)
The disease control rate was 88% among patients without prior FGFR inhibitor therapy and 80% among those with such prior therapy. (cholangiocarcinoma.org)
Recurrence in Group 1 was noted in 10 patients (12%) while no recurrences occurred in Group 2, the cohort with subclinical disease that received the extended medical therapy. (biomedcentral.com)
Immunotherapies and targeted therapies are associated with improved disease control and significantly increased survival times in metastatic melanoma, which has dramatically improved the outlook for this patient population. (ahdbonline.com)
Metabolic or Respiratory Acidosis: Potassium-conserving therapy should be initiated only with caution in severely ill patients in whom metabolic or respiratory acidosis may occur, e.g. patients with cardiopulmonary disease or decompensated diabetes. (janusinfo.se)
Dexamethasone phosphate/DEMO is indicated in the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with body weight at least 40 kg) who require supplemental oxygen therapy. (who.int)

Hormone therapy for breast cancer should not be confused with menopausal hormone therapy (MHT)-treatment with estrogen alone or in combination with progesterone to help relieve symptoms of menopause . (thecancerspecialist.com)
Aetna considers laboratory testing medically necessary for heavy metal poisoning (e.g., arsenic, cadmium, copper, gold, iron, mercury) for members with specific signs and symptoms of heavy metal toxicity and/or a history of likely exposure to heavy metals. (aetna.com)
Aetna considers laboratory testing for manganese medically necessary for persons with specific signs and symptoms of manganese toxicity (dyscoordination, loss of balance, confusion) who have a history of likely exposure to high levels of manganese (e.g., occupational exposures to manganese aerosols or dust in the welding or steel industries, exposure to high levels of manganese in contaminated drinking water, suspected manganese toxicity in persons on chronic total parenteral nutrition). (aetna.com)
Ocular signs and symptoms of three patients treated with ABT-414 during a phase III trial for glioblastoma multiforme were evaluated. (liverpool.ac.uk)
The initiation of artificial tears and lubricant ointment was enough to control the ocular surface signs and symptoms. (liverpool.ac.uk)
The constellation of facial and ocular symptoms was observed in association with systemic symptoms (e.g., fever, painful cervical adenopathy) and risk factors for sexual transmission. (cdc.gov)
Perform monthly ophthalmological exams including assessment of visual acuity, slit lamp exam, fundoscopy, and optical coherence tomography during first 4 months of therapy and every 3 months afterwards, and urgently for visual symptoms. (unboundmedicine.com)

Ocular complications associated cases with onset dates after October 2021 were report- with acute monkeypox virus infection, DRC. (cdc.gov)

2 , 14 ] As a result, the use of laetrile has greatly diminished, but the compound continues to be manufactured and administered as an anticancer therapy, primarily in Mexico, and in some clinics in the United States. (cancer.gov)

Ocular involvement is a potentially debilitating manifestation for people experiencing mpox virus infection. (cdc.gov)
In the current ongoing mpox virus outbreak, ocular involvement has been uncommon with retrospective evidence reporting that less than 1% of individuals had eye involvement. (cdc.gov)
Corneal scarring and vision loss are potential severe consequences of ocular involvement of mpox virus infection. (cdc.gov)
Methods We carried out a cross-sectional study of 165 patients with a confirmed diagnosis of BS who had ocular involvement. (researchsquare.com)
The patient is especially at risk for herpes simplex virus-1 (HSV-1) with ocular involvement because of her history of eczema. (chop.edu)

Therapy with topical corticosteroids rarely produces these effects but should be administered cautiously nonetheless in patients with diabetes mellitus, glucose intolerance, or a predisposition to hyperglycemia. (drugs.com)
Twenty-two patients (53.7%) underwent topical 5-FU as a sole treatment, and 19 patients (46.3%) as adjuvant and/or debulking therapy. (bmj.com)
Conclusion Topical 5-FU, as a sole or combined therapy, must be considered a long-term safe and effective treatment for patients affected by OSSN. (bmj.com)
Therapy with sunscreens, topical corticosteroids, and antimalarial agents is often effective. (medscape.com)
Furthermore, there are local toxicity issues with topical agents that can be avoided using oral regimens. (chop.edu)
Patients undergoing primary therapy with topical 5-fluorouracil 1% (5-FU) (4 times a day for 7 days with a 21-day break) or interferon-alpha-2b (IFN) (4 times a day) were reviewed. (biomedcentral.com)
However, toxicity (epiphora due to secondary lacrimal canalicular blockade) and marketing problems have led to the discontinuation of the development of topical cidofovir. (arvojournals.org)

Contaminated soil may also be a source of significant arsenic exposure in children, although it is not likely that children would ingest sufficient arsenic-contaminated soil to cause significant acute toxicity. (cdc.gov)

Laetrile has been used for cancer treatment both as a single agent and in combination with a metabolic therapy program that consists of a specialized diet, high-dose vitamin supplements, and pancreatic enzymes . (cancer.gov)

The ocular hypotensive effects of cannabinoids, specifically, have generated considerable interest over the last few decades largely due to their potential use in the treatment of glaucoma. (frontiersin.org)
he elected to evaluate acetazolamide as an ocular hypotensive agent in glaucoma patients. (entokey.com)

Discontinue hydroxychloroquine if renal toxicity is suspected or demonstrated by tissue biopsy in any organ system. (nih.gov)
Deprescribing Guidance for Hydroxychloroquine Drug Interactions This study assessed the burden of potentially inappropriate medications that could be deprescribed if necessary to initiate treatment with hydroxychloroquine or other potential COVID-19 therapies. (medscape.com)

Appraise the role of multidisciplinary specialists such as ophthalmologists and other eye-care professionals in the diagnosis and management of ocular toxicities, and effectively collaborate with these clinicians to offer best-practice care for patients at high-risk for or with a suspected or confirmed diagnosis of these toxicities. (researchtopractice.com)

Toxicities, all of which were grade 1/2, included ocular flashes in 10 patients, peripheral edema in three, skin rash in one, and erectile dysfunction in one. (cancertherapyadvisor.com)
5.5 mg/dL, no ocular disorders, and no Grade 2 or higher adverse reactions. (unboundmedicine.com)

Aviceda Therapeutics LLC has completed IND-enabling good laboratory practice (GLP) toxicity studies of its lead ophthalmic drug candidate, AVD-104, in nonhuman primates and rabbits. (bioworld.com)
Cyagen Biomodels LLC has established a strategic collaboration with Neurophth Therapeutics Inc. to codevelop next-generation AAV gene therapy vectors for specific types of genetic ophthalmic disorders. (bioworld.com)
Effective treatments for these patients represent a holy grail of ocular therapeutics. (reviewofophthalmology.com)

Adenovirus ocular infections (epidemic keratoconjunctivitis [EKC], follicular conjunctivitis, and pharyngeal conjunctival fever) are the most common ocular viral infections worldwide. (arvojournals.org)

However, neither ocular toxicity from nutmeg ingestion is diagnosed by renal clearance, which consists of decontamination before patient entry into the stomach unless there is a possibility. (oaksofwellington.com)
Diabetes Mellitus: To minimise the risk of hyperkalaemia in known or suspected diabetic patients, the status of renal function should be determined before initiating therapy. (janusinfo.se)

For use in certain endocrine and non-endocrine disorders responsive to corticosteroid therapy. (who.int)

Clear evidence that long-term, low-dose tamoxifen treatjent can induce ocular toxicity. (springermedizin.de)
No maximum tolerated dose was found despite some toxicities. (cholangiocarcinoma.org)
consider alternative therapy or ↓ dose of OCT2 substrate. (unboundmedicine.com)

Toxicity usually results from ingestion. (cdc.gov)

Ocular side-effects in breast cancer patients treated with tamoxifen and toremifene: a randomized follow-up. (springermedizin.de)
26. Heier J S, Dragoo R A, Enzenauer R W: Screening for ocular toxicity in asymptomatic patients treated with tamoxifen. (9dok.net)

This activity is intended for medical oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of ocular toxicities associated with anticancer therapies. (researchtopractice.com)
Recall strategies commonly employed to identify ocular toxicities in individuals receiving anticancer treatment, and use this information to appropriately intervene in patients for whom these side effects are suspected or diagnosed. (researchtopractice.com)
Gene therapy is not a new treatment, having been used to alter abnormal or mutated genes and produce valuable proteins since the 1970s. (ondrugdelivery.com)
Hormone therapy (also called hormonal therapy, hormone treatment, or endocrine therapy) slows or stops the growth of hormone-sensitive tumors by blocking the body's ability to produce hormones or by interfering with effects of hormones on breast cancer cells. (thecancerspecialist.com)
Candidate ECS targeted therapies will be discussed, drawing on experimental results obtained from both ocular and non-ocular tissue(s), together with their potential application for the treatment of ocular inflammation and pain. (frontiersin.org)
In extension, with sharp-witted toxicity reporting, either past the physi- cian or patient, it may be profound to control as a service to treatment, timing, amount of tissue irradiated, and medical comorbidities. (wgc2010.sk)
Sparingvision SAS has obtained FDA clearance for its IND application for SPVN-06, its lead gene-independent therapy for the treatment of retinitis pigmentosa (RP). (bioworld.com)
Their inclusion should not be viewed as an endorsement of the content of the websites, or of any treatment or product, by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board or the National Cancer Institute . (cancer.gov)
In particular, drug delivery is impaired by the blood-brain barrier, and cerebral toxicity limits the use of treatment modalities. (medscape.com)
The pace of advances in the treatment of hormone-receptor positive metastatic breast cancer (HR + MBC) has introduced nuance and complexity in choosing between available agents as patients and physicians explore options across lines of therapy. (amegroups.org)
As children tend to have difficulty with eyedrop regimens, oral therapy is a desirable treatment option. (chop.edu)
These findings suggest that incremental costs associated with treatment-related AEs among elderly patients with metastatic melanoma were substantial, but the risks for and costs of the various types of AEs differed by therapy. (ahdbonline.com)
For the first-line treatment of metastatic melanoma, the National Comprehensive Cancer Network guidelines now recommend targeted therapy with combination BRAF/MEK inhibition (for patients with BRAF mutations), or immunotherapy with anti-PD-1 monotherapy or combined anti-PD-1/CTLA-4 antibodies (regardless of BRAF status). (ahdbonline.com)

Gastrointestinal, respiratory, and hematologic AEs were more common in patients who received immunotherapy, whereas general and administration-site AEs and other AEs (eg, fatigue, infections, muscular weakness) were more frequent in patients who received targeted therapy. (ahdbonline.com)

In this paper, a modified Delphi method was used to develop an expert consensus on the use of repository corticotrophin injection therapy for pulmonary sarcoidosis, including dosing, concomitant medications, contraindications and adverse event management. (ersjournals.com)
Extrapulmonary tuberculosis should be managed according to the principles and with the drug regimens outlined for pulmonary tuberculosis, except for children who have miliary tuberculosis, bone/joint tuberculosis, or tuberculous meningitis who should receive a minimum of 12 mo of therapy. (cdc.gov)

Gene therapy began to gain steam in 2008 and, by the first half of 2021, the number of active cell and gene therapy developers worldwide had reached 1,195. (ondrugdelivery.com)

21. Griffin JD, Garnick MB: Eye toxicity of cancer chemotherapy: a review of the literature. (9dok.net)

To compare the costs and frequency of AEs associated with immunotherapy and with targeted therapy in elderly patients with metastatic melanoma. (ahdbonline.com)
Patients included had to have ≥1 diagnoses of metastatic melanoma and ≥1 claims for an immunotherapy or targeted therapy. (ahdbonline.com)
We compared the 30-day expenditures of patients with and without each AE using a generalized linear model to determine the incremental cost per AE in patients who received immunotherapy or targeted therapy. (ahdbonline.com)
We also compared the mean costs of AEs associated with immunotherapy and targeted therapy. (ahdbonline.com)

In hypertension, it is used as an adjunct to prolonged therapy with thiazides and similar agents to prevent potassium depletion. (janusinfo.se)

In conclusion, ABT-414 therapy may cause transient ocular surface toxicity. (liverpool.ac.uk)

LYTGOBI is an effective, well-tolerated therapy for patients with intrahepatic CCA that can be taken orally," said Tim Whitten, President and CEO of Taiho Oncology, Inc. "This approval is an important milestone for patients and may provide hope for improved outcomes. (biospace.com)
This paper was partially presented at the International Congress of Ocular Oncology, 8-12 September 2009, Cambridge, UK. (bmj.com)

Researchers first viewed ocular immunologic privilege as an experimental phenomenon explained by the eye's unique anatomical features. (ondrugdelivery.com)
Experts do not fully understand the complexities of immunologic privilege but they do know that the ocular microenvironment regulates antigens within the eye via anti-inflammatory proteins and neuropeptides. (ondrugdelivery.com)
2 The anterior chamber, subretinal space and vitreous cavity all enjoy immunologic privilege and are thus good candidates for ocular gene therapy. (ondrugdelivery.com)

These data provide further validation of the mechanistic approach supporting nirogacestat's ability to enhance the activity of BCMA-directed therapies across modalities. (advfn.com)

Adverse events included hand-foot syndrome, stomatisis (mouth sores), nail toxicities, ocular toxicities, dry mouth, hair loss, and dry eyes, all resulting from on-target inhibition of FGFR2 in these other organs. (cholangiocarcinoma.org)

Furthermore, a prominent comorbidity of ocular inflammation is pain, including neuropathic pain, for which therapeutic options remain limited. (frontiersin.org)
A look at the attributes of perennial allergy and therapies designed to combat the chronic inflammation it engenders. (reviewofophthalmology.com)
This month, we examine the attributes of our patients with perennial allergy, and review current and potential therapies that are designed to combat the chronic inflammation often associated with these individuals' allergic response to persistent allergens in their environment. (reviewofophthalmology.com)

These two types of therapy produce opposite effects: hormone therapy for breast cancer blocks the growth of HR-positive breast cancer, whereas MHT can stimulate the growth of HR-positive breast cancer. (thecancerspecialist.com)
For this reason, when a woman taking MHT is diagnosed with HR-positive breast cancer she is usually asked to stop that therapy. (thecancerspecialist.com)
There have been no approved therapies for platinum resistant ovarian cancer since 2014, so [this] action by the FDA is a very significant milestone. (ascopost.com)
13 ] Laetrile supporters viewed this reversal as an attempt by the U.S. government to block access to new and promising cancer therapies , and pressure mounted to make laetrile available to the public. (cancer.gov)
Over the last decade, the improvements in survival achieved with new therapies for metastatic breast cancer (MBC) have been groundbreaking. (amegroups.org)

Ocular port pediatric AHUE cases in Japan and compare them monkeypox--United States, July-September 2022. (cdc.gov)

Immunotherapies and targeted therapies have drastically improved survival in metastatic melanoma, but they can cause a range of adverse events (AEs). (ahdbonline.com)

Dexamethasone phosphate/DEMO is recommended for systemic administration by intravenous or intramuscular injection when oral therapy is not feasible or desirable in the following conditions. (who.int)

Tumors that are hormone insensitive do not have hormone receptors and do not respond to hormone therapy. (thecancerspecialist.com)
Response to therapy was assessed by Response Evaluation Criteria in Solid Tumors. (cancertherapyadvisor.com)
Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)

Other inorganic arsenic compounds may vary somewhat in relative toxicity, and organic arsenic compounds appear to be essentially nontoxic. (cdc.gov)
Compounds used in therapy may have potentiating toxic effects. (cdc.gov)

Provide support for the initial therapy for a brief classification of antidysrhythmics such as clinitron bed, or activities for clients, such as. (oaksofwellington.com)

Anatomy27

Organisms7

Diseases56

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology3

Phenomena and Processes21

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science2

Health Care19

Geographicals1

Corneal toxicity3

Progression4

Surface squamous neoplasia2

Outcomes of ocular2

Efficacy7

Inhibitors3

Severity5

Uveitis5

Neurologic1

Retinal3

Hepatic1

Diseases7

Lead toxicity3

Systemic toxicity2

Clinical7

Disease14

Symptoms7

Complications1

Anticancer Therapy1

Involvement5

Topical7

Acute1

Metabolic1

Hypotensive2

Hydroxychloroquine2

Diagnosis and management1

Grade2

Therapeutics3

Conjunctivitis1

Renal2

Disorders1

Dose3

Ingestion1

Patients treated2

Treatment13

Gastrointestinal1

Pulmonary2

20211

Chemotherapy1

Immunotherapy4

Hypertension1

Conclusion1

Oncology2

Immunologic3

Modalities1

Nail1

Inflammation3

Cancer5

20221

Metastatic1

Dexamethasone1

Tumors3

Compounds2

Classification1